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EP4004212
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| EP4004212 - METHODS OF CONTROLLING CANNABINOID SYNTHESIS IN PLANTS OR CELLS AND PLANTS AND CELLS PRODUCED THEREBY [Right-click to bookmark this link] | Status | Request for examination was made Status updated on 29.04.2022 Database last updated on 02.09.2024 | |
| Former | The international publication has been made Status updated on 05.02.2021 | ||
| Former | unknown Status updated on 04.09.2020 | Most recent event Tooltip | 26.07.2023 | New entry: Renewal fee paid | Applicant(s) | For all designated states The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Institute) Volcani Center P.O. Box 15159 7528809 Rishon-Lezion / IL | [N/P] |
| Former [2022/22] | For all designated states The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Institute) Volcani Center P.O. Box 15159 7528809 Rishon-LeZion / IL | Inventor(s) | 01 /
FLAISHMAN, Moshe Arie 24 David Elazar Street 4626009 Herzliya / IL | 02 /
SHAFRAN-TOMER, Hadas 11A Har Ha'Zofim Street 7662098 Rehovot / IL | 03 /
COHEN PEER, Reut 14 Yitzhak Rabin Street 5551019 Kiryat-Ono / IL | 04 /
COHEN, Oded 20 Eithan Street 7290500 Nir Zvi / IL | [2022/22] | Representative(s) | Luppi, Emanuele Brunacci & Partners S.r.l. Via Pietro Giardini, 625 41125 Modena (MO) / IT | [2022/22] | Application number, filing date | 20761640.0 | 29.07.2020 | [2022/22] | WO2020IL50835 | Priority number, date | US201962880136P | 30.07.2019 Original published format: US 201962880136 P | [2022/22] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2021019536 | Date: | 04.02.2021 | Language: | EN | [2021/05] | Type: | A1 Application with search report | No.: | EP4004212 | Date: | 01.06.2022 | Language: | EN | The application published by WIPO in one of the EPO official languages on 04.02.2021 takes the place of the publication of the European patent application. | [2022/22] | Search report(s) | International search report - published on: | EP | 04.02.2021 | Classification | IPC: | C12N15/82, C07K14/415, A01H5/00 | [2022/22] | CPC: |
C12N15/8243 (EP,IL,US);
C07K14/415 (EP,IL,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/22] | Title | German: | VERFAHREN ZUR STEUERUNG DER CANNABINOID-SYNTHESE IN PFLANZEN ODER ZELLEN UND NACH DIESEM VERFAHREN HERGESTELLTE PFLANZEN UND ZELLEN | [2022/22] | English: | METHODS OF CONTROLLING CANNABINOID SYNTHESIS IN PLANTS OR CELLS AND PLANTS AND CELLS PRODUCED THEREBY | [2022/22] | French: | MÉTHODES DE RÉGULATION DE LA SYNTHÈSE DE CANNABINOÏDES CHEZ LA PLANTE OU DANS DES CELLULES ET PLANTES ET CELLULES AINSI PRODUITES | [2022/22] | Entry into regional phase | 28.02.2022 | National basic fee paid | 28.02.2022 | Designation fee(s) paid | 28.02.2022 | Examination fee paid | Examination procedure | 28.02.2022 | Amendment by applicant (claims and/or description) | 28.02.2022 | Examination requested [2022/22] | 28.02.2022 | Date on which the examining division has become responsible | Fees paid | Renewal fee | 29.11.2022 | Renewal fee patent year 03 | 26.07.2023 | Renewal fee patent year 04 | Penalty fee | Additional fee for renewal fee | 31.07.2022 | 03 M06 Fee paid on 29.11.2022 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [XY]WO2015196275 (NAT RES COUNCIL OF CANADA NRC [CA]) [X] 1-22 * page 5, line 18 - page 6, line 6 * * page 19, lines 19-32; example -; claim -; sequences 5,6 * [Y] 1-22; | [Y]WO2018057385 (22ND CENTURY LTD LLC [US]) [Y] 1-22* paragraph [0061]; claim -; sequence 30 *; | [YD] - HARM VAN BAKEL ET AL, "The draft genome and transcriptome of Cannabis sativa", GENOME BIOLOGY, BIOMED CENTRAL LTD, (20111020), vol. 12, no. 10, doi:10.1186/GB-2011-12-10-R102, ISSN 1465-6906, page R102, XP021114902 [YD] 1-22 * page 10, column 2, paragraph 2 - page 11, column 1, paragraph 1 * DOI: http://dx.doi.org/10.1186/gb-2011-12-10-r102 | by applicant | US3791932 | US3839153 | US3850752 | US3850578 | US3853987 | US3867517 | US3879262 | US3901654 | US3935074 | US3984533 | US3996345 | US4034074 | US4098876 | EP0067553 | EP0194809 | US4666828 | US4683202 | WO8706261 | JPS6314693 | EP0278667 | US4801531 | US4855237 | US4876276 | US4879219 | US4945050 | US4987071 | US5011771 | US5034323 | US5192659 | WO9307278 | US5227537 | US5231020 | US5254678 | US5272057 | US5281521 | US5316931 | US5434295 | US5464765 | US5693507 | US5759829 | WO9836083 | WO9853083 | WO9932619 | US5942657 | WO9949029 | WO9953050 | WO9961631 | WO0049035 | US6326527 | WO0200904 | US2002048814 | US6423885 | US6452067 | US6573099 | US2003175965 | US2003180945 | US6646805 | US6777588 | US2004214330 | US8021867 | US8119381 | US8124369 | US8129134 | US8133697 | US8143015 | US8143016 | US8148098 | US8163514 | US8304222 | US2015067922 | US2016102316 | US2018222879 | US2018292369 | US2019134532 | US2019201809 | US2019214145 | - CONSROE et al., J. Clin. Pharmacol., (19810000), vol. 21, pages 428S - 436S | - AGURELL et al., Pharmacol. Rev., (19860000), vol. 38, pages 31 - 43 | - Proc. Natl. Acad. Sci. U.S.A., (19920000), vol. 89, no. 22, pages 10915 - 9 | - S. B. NEEDLEMANC. D. WUNSCH, "A general method applicable to the search of similarities in the amino acid sequence of two proteins", Journal of Molecular Biology, (19700000), vol. 48, pages 443 - 53 | - HALPERIN, E.FAIGLER, S.GILL-MORE, R., "FramePlus: aligning DNA to protein sequences", Bioinformatics, (19990000), vol. 15, pages 867 - 873 | - SARDANA et al., Plant Cell Reports, (19960000), vol. 15, pages 677 - 681 | - MURRAY et al., Nuc Acids Res., (19890000), vol. 17, pages 477 - 498 | - ANGELLBAULCOMBE, EMBO J., (19970000), vol. 16, pages 3675 - 3684 | - ANGELLBAULCOMBE, Plant J., (19990000), vol. 20, pages 357 - 362 | - STOUTJESDIJK et al., Plant Physiol., (20020000), vol. 129, pages 1723 - 1731 | - CHUANGMEYEROWITZ, Proc. Natl. Acad. Sci. USA, (20000000), vol. 97, pages 4985 - 4990 | - WATERHOUSEHELLIWELL, Nat. Rev. Genet., (20030000), vol. 4, pages 29 - 38 | - PANDOLFINI et al., BMC Biotechnology, vol. 3, page 7 | - PANSTRUGA et al., Mol. Biol. Rep., (20030000), vol. 30, pages 135 - 140 | - SMITH et al., Nature, (20000000), vol. 407, pages 319 - 320 | - WESLEY et al., Plant J., (20010000), vol. 27, pages 581 - 590 | - WANGWATERHOUSE, Curr. Opin. Plant Biol., (20010000), vol. 5, pages 146 - 150 | - HELLIWELLWATERHOUSE, Methods, (20030000), vol. 30, pages 289 - 295 | - BRUMMELL et al., Plant J., (20030000), vol. 33, pages 793 - 800 | - METTE et al., EMBO J, (20000000), vol. 19, pages 5194 - 5201 | - MATZKE et al., Curr. Opin. Genet. Devel., (20010000), vol. 11, pages 221 - 227 | - SCHEID et al., Proc. Natl. Acad. Sci., USA, (20020000), vol. 99, pages 13659 - 13662 | - AUFSAFTZ et al., Proc. Nat'l. Acad. Sci., (20020000), vol. 99, no. 4, pages 16499 - 16506 | - SIJEN et al., Curr. Biol., (20010000), vol. 11, pages 436 - 440 | - WATERHOUSE et al., Proc. Natl. Acad. Sci. USA, (19980000), vol. 95, pages 13959 - 13964 | - JAVIER et al., Nature, (20030000), vol. 425, pages 257 - 263 | - PERRIMAN et al., Proc. Natl. Acad. Sci. USA, (19950000), vol. 92, no. 13, pages 6175 - 6179 | - "Expressing Ribozymes in Plants", FEYTERGAUDRON, Methods in Molecular Biology, Humana Press Inc., vol. 74 | - BUDHAGATAPALLI NAGAVENI et al., Targeted Modification of Gene Function Exploiting Homology-Directed Repair of TALEN-Mediated Double-Strand Breaks in Barley, (20150900), vol. 5, no. 9, pages 1857 - 1863 | - ZHAO YONGPING et al., "An alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design", Scientific Reports, (20160000), vol. 6, no. 23890 | - JINEK et al., Science, (20120000), vol. 337, pages 816 - 821 | - RAN et al., Genome engineering using the CRISPR-Cas9 system nature protocols, (20130000), vol. 8, no. 11, pages 2281 - 2308 | - CERTO, MT et al., Nature Methods, (20120000), vol. 9, pages 073 - 975 | - REYON et al., Nature Biotechnology, (20120500), vol. 30, no. 5, pages 460 - 5 | - MILLER et al., Nat Biotechnol., (20110000), vol. 29, pages 143 - 148 | - CERMAK et al., Nucleic Acids Research, (20110000), vol. 39, no. 12, page e82 | - ZHANG et al., Nature Biotechnology, (20110000), vol. 29, no. 2, pages 149 - 53 | - IZSVAKIVICS, Molecular Therapy, (20040000), vol. 9, pages 147 - 156 | - WILSON et al., Molecular Therapy, (20070000), vol. 15, pages 139 - 145 | - KAWAKAMI et al., PNAS, (20000000), vol. 97, no. 21, pages 11403 - 11408 | - MISKEY et al., Nucleic Acids Res., (20031201), vol. 31, no. 23, pages 6873 - 6881 | - POTRYKUS, I., Annu. Rev. Plant. Physiol., Plant. Mol. Biol., (19910000), vol. 42, pages 205 - 225 | - SHIMAMOTO et al., Nature, (19890000), vol. 338, pages 274 - 276 | - KLEE et al., Annu. Rev. Plant Physiol., (19870000), vol. 38, pages 467 - 486 | - "Cell Culture and Somatic Cell Genetics of Plants", PASZKOWSKI et al., Molecular Biology of Plant Nuclear Genes, Academic Publishers, (19890000), vol. 6, pages 52 - 68 | - DAWSON, W. O. et al., Virology, (19890000), vol. 172, pages 285 - 292 | - TORIYAMA, K. et al., Bio/Technology, (19880000), vol. 6, pages 1072 - 1074 | - ZHANG et al., Plant Cell Rep., (19880000), vol. 7, pages 379 - 384 | - FROMM et al., Nature, (19860000), vol. 319, pages 791 - 793 | - NEUHAUSSPANGENBERG, Physiol. Plant., (19900000), vol. 79, pages 213 - 217 | - NEUHAUS et al., Theor. Appl. Genet., (19870000), vol. 75, pages 30 - 36 | - DEWET et al., Experimental Manipulation of Ovule Tissue, (19850000), pages 197 - 209 | - OHTA, Proc. Natl. Acad. Sci. USA, (19860000), vol. 83, pages 715 - 719 | - GLUZMAN, Y. et al., Communications in Molecular Biology: Viral Vectors, Cold Spring Harbor Laboratory, (19880000), pages 172 - 189 | - TAKAMATSU et al., EMBO J., (19870000), vol. 6, pages 307 - 311 | - FRENCH et al., Science, (19860000), vol. 231, pages 1294 - 1297 | - TAKAMATSU et al., FEBS Letters, (19900000), vol. 269, pages 73 - 76 | - FRESHNEY, Culture of Animal Cells - A Manual of Basic Technique, Appleton & Lange, (19940000), vol. I-III | - "Recombinant DNA", WATSON et al., Scientific American Books | - Genome Analysis: A Laboratory Manual Series, Cold Spring Harbor Laboratory Press, (19980000), vol. 1-4 | - PCR Protocols: A Guide To Methods And Applications, Academic Press, (19900000), vol. 1-317 | - TALAVERA, G.CASTRESANA, J., "Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments", Systematic Biology, (20070000), vol. 56, pages 564 - 577 | - ANDRE, C. M.HAUSMAN, J. F.GUERRIERO, G., "Cannabis sativa: the plant of the thousand and one molecules", Frontiers in plant science, (20160000), vol. 7, page 19 | - "Constituents of Cannabis sativa", ELSOHLY, M.GUL, W., Handbook of Cannabis, Oxford University Press, (20140000), vol. 3-22 | - FLORES-SANCHEZ, I. J.VERPOORTE, R., "Secondary metabolism", Cannabis. Phytochem. Rev., (20080000), vol. 7, pages 615 - 639, XP019613387 | - HANUS, L. O.MEYER, S. M.MUDOZ, E.TAGLIALATELA-SCAFATI, O.APPENDINO, G., "Phytocannabinoids: a unified critical inventory", Nat. Prod. Rep., (20160000), vol. 33, doi:10.1039/C6NP00074F, pages 1357 - 1392, XP055592830 DOI: http://dx.doi.org/10.1039/C6NP00074F | - KOJOMA, M.SEKI, H.YOSHIDA, S.MURANAKA, T., "DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in ''drug-type'' and ''fiber-type'' Cannabis sativa L", Forensic Science International, (20060000), vol. 159, no. 2-3, doi:10.1016/j.forsciint.2005.07.005, pages 132 - 140, XP025086277 DOI: http://dx.doi.org/10.1016/j.forsciint.2005.07.005 | - "Molecular targets of the phytocannabinoids: a complex picture", TURNER, S. E.WILLIAMS, C. M.IVERSEN, L.WHALLEY, B. J., Phytocannabinoids, Springer International Pu, (20170000), pages 103 - 101 | - LAVERTY KUSTOUT JMSULLIVAN MJSHAH HGILL NHOLBROOK LDEIKUS GSEBRA RHUGHES TR, A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci., (20190000), vol. 29, no. 1, pages 146 - 156 | - RUSSO, E. B.TAMING, T. H. C., "Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects: Phytocannabinoid-terpenoid entourage effects", Br. J. Pharmacol, (20110000), vol. .163, doi:10.1111/j.1476-5381.2011.01238.x, pages 1344 - 1364, XP055420723 DOI: http://dx.doi.org/10.1111/j.1476-5381.2011.01238.x | - SIRIKANTARAMAS, S.MORIMOTO, S.SHOYAMA, Y.ISHIKAWA, Y.WADA, Y.SHOYAMA, Y., "The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Al-tetrahydrocannabinolic acid synthase from Cannabis sativa L", J. Biol. Chem., (20040000), vol. 279, doi:10.1074/jbc.M403693200, pages 39767 - 39774, XP055389916 DOI: http://dx.doi.org/10.1074/jbc.M403693200 | - TAURA, F.DONO, E.SIRIKANTARAMAS, S.YOSHIMURA, K.SHOYAMA, Y.MORIMOTO, S., "Production of Delta(1)-tetrahydrocannabinolic acid by the biosynthetic enzyme secreted from transgenic Pichia pastoris", Biochem. Biophys. Res. Commun., (20070000), vol. 361, doi:10.1016/j.bbrc.2007.07.079, pages 675 - 680, XP055389856 DOI: http://dx.doi.org/10.1016/j.bbrc.2007.07.079 | - VAN BAKEL, H.STOUT, J. M.COTE, A. G.TALLON, C. M.SHARPE, A. G.HUGHES, T. R., "The draft genome and transcriptome of Cannabis sativa", Genome Biol., (20110000), vol. 12, doi:10.1186/gb-2011-12-10-r102, page R102, XP021114902 DOI: http://dx.doi.org/10.1186/gb-2011-12-10-r102 | - VOLKOW, N. D.BALER, R. D.COMPTON, W. M.WEISS, S. R., "Adverse health effects of marijuana use", New England Journal of Medicine, (20140000), vol. 370, no. 23, pages 2219 - 2227 | - WEIBLEN, G. D.WENGER, J. P.CRAFT, K. J.ELSOHLY, M. A.MEHMEDIC Z.TREIBER, E. L. et al., "Gene duplication and divergence affecting drug content in Cannabis sativa", New Phytol., (20150000), vol. 208, pages 1241 - 1250, XP002765783 |