-
EP4045494
European procedure
- EP About this file
- EP Legal status
- EP Federated register
- EP Event history
- EP Citations
- EP Patent family
- EP All documents
Extract from the Register of European Patents
EP About this file: EP4045494
| EP4045494 - SYNTHESIS OF 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE [Right-click to bookmark this link] | Status | The patent has been granted Status updated on 08.09.2023 Database last updated on 05.07.2024 | |
| Former | Grant of patent is intended Status updated on 07.05.2023 | ||
| Former | Request for examination was made Status updated on 22.07.2022 | ||
| Former | The international publication has been made Status updated on 24.04.2021 | ||
| Former | unknown Status updated on 27.10.2020 | Most recent event Tooltip | 31.05.2024 | Lapse of the patent in a contracting state New state(s): ES, HR, NO, PL, RS | published on 03.07.2024 [2024/27] | Applicant(s) | For all designated states Esco Aster Pte. Ltd. 67 Ayer Rajah Crescent, 02-01 Singapore 139950 / SG | [2023/40] |
| Former [2022/34] | For all designated states Esco Aster Pte. Ltd. 21 Changi South Street 1 Singapore 486777 / SG | Inventor(s) | 01 /
ABRAHAM RAJKUMAR, Gurubatham c/o Esco Aster Pte. Ltd. 21 Changi South Street 1 Singapore 486777 / SG | 02 /
LIN, Xiangliang c/o Esco Aster Pte. Ltd. 21 Changi South Street 1 Singapore 486777 / SG | [2022/34] | Representative(s) | Mewburn Ellis LLP Aurora Building Counterslip Bristol BS1 6BX / GB | [2022/34] | Application number, filing date | 20792606.4 | 13.10.2020 | [2022/34] | WO2020EP78761 | Priority number, date | SG20191009596R | 14.10.2019 Original published format: SG10201909596R | [2022/34] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2021074138 | Date: | 22.04.2021 | Language: | EN | [2021/16] | Type: | A1 Application with search report | No.: | EP4045494 | Date: | 24.08.2022 | Language: | EN | The application published by WIPO in one of the EPO official languages on 22.04.2021 takes the place of the publication of the European patent application. | [2022/34] | Type: | B1 Patent specification | No.: | EP4045494 | Date: | 11.10.2023 | Language: | EN | [2023/41] | Search report(s) | International search report - published on: | EP | 22.04.2021 | Classification | IPC: | C07D401/14 | [2022/34] | CPC: |
C07D401/14 (EP,CN,US);
C07D401/04 (CN,KR,US);
Y02P20/55 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/34]
| Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | SYNTHESE VON 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZOL-1,3-DIAMIN | [2022/34] | English: | SYNTHESIS OF 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE | [2022/34] | French: | SYNTHÈSE DE 6-MÉTHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZÈNE-1,3-DIAMINE | [2022/34] | Entry into regional phase | 05.05.2022 | National basic fee paid | 05.05.2022 | Designation fee(s) paid | 05.05.2022 | Examination fee paid | Examination procedure | 23.06.2021 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 05.05.2022 | Examination requested [2022/34] | 05.05.2022 | Date on which the examining division has become responsible | 24.11.2022 | Amendment by applicant (claims and/or description) | 08.05.2023 | Communication of intention to grant the patent | 29.08.2023 | Fee for grant paid | 29.08.2023 | Fee for publishing/printing paid | 29.08.2023 | Receipt of the translation of the claim(s) | Fees paid | Renewal fee | 02.02.2023 | Renewal fee patent year 03 | Penalty fee | Additional fee for renewal fee | 31.10.2022 | 03 M06 Fee paid on 02.02.2023 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | ES | 11.10.2023 | HR | 11.10.2023 | PL | 11.10.2023 | RS | 11.10.2023 | NO | 11.01.2024 | GR | 12.01.2024 | IS | 11.02.2024 | [2024/27] |
| Former [2024/20] | GR | 12.01.2024 | |
| IS | 11.02.2024 | Cited in | International search | [Y]WO2004005281 (NOVARTIS AG [CH], et al) [Y] 12,13* page 24, last paragraph to page 25, line 15; pages 37-38, Example 1b and Example 1c *; | [A]US2006173182 (KANKAN RAJENDRA N [IN], et al) [A] 1-10 * [0025]; [0027], compound (IV) to compound (II); [0036]-[0037] *; | [X]CN100537563C (ZHEJIANG PROV ACADEMY OF MEDIC [CN]) [X] 14-21 * claim 1, wherein R1 is hydrogen, R2 is methyl and R3 is "nitro, amino, dialkyl group substituted-amino, hydroxyl, carboxyl, carboxylic esters, acid amides" *; | [YA]WO2013035102 (NATCO PHARMA LTD [IN], et al) [Y] 22-24 * page 15, Scheme D, in particular compound (III) to compound (V); see also page 15, Scheme D: compound (V) to compound (VI) in 80% yield and 99.4% HPLC purity * [A] 1-10; | [Y]WO2015087343 (LAURUS LABS PRIVATE LTD [IN]) [Y] 12,13,22-24 * page 9, steps a) to c); page 10, lines 1-9; examples, in particular Examples 1 to 3 *; | [XY]CN105801559 (UNIV BEIJING CHEMICAL TECH) [X] 11,14-21 * [0015]; [0038]; [0048]; examples, e.g. Examples 5-8 * [Y] 22-24; | [Y]US2018334449 (SHI JINPU [CN], et al) [Y] 12,13,22-24 * page 1, compound (4) to compound (5); [0125], Example 1 *; | [A] - BAMBOROUGH ET AL, "N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM , NL, (2007), vol. 17, no. 15, doi:10.1016/J.BMCL.2007.04.029, ISSN 0960-894X, pages 4363 - 4368, XP022144705 [A] 1-10 * page 4365, Table 1; page 4368, point 12 * DOI: http://dx.doi.org/10.1016/j.bmcl.2007.04.029 |