Extract from the Register of European Patents

EP About this file: EP4048278

EP4048278 - METHODS OF TREATING HEMATOLOGICAL MALIGNANCIES USING 2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZ YL)AMINO)ISOINDOLINE-1,3-DIONE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.09.2024
Database last updated on 09.04.2026
FormerThe patent has been granted
Status updated on  29.09.2023
FormerGrant of patent is intended
Status updated on  18.05.2023
FormerRequest for examination was made
Status updated on  29.07.2022
FormerThe international publication has been made
Status updated on  01.05.2021
Formerunknown
Status updated on  24.11.2020
Most recent event   Tooltip06.09.2024No opposition filed within time limitpublished on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Celgene Corporation
Route 206 & Province Line Road
Princeton, NJ 08543 / US
[2024/14]
Former [2022/35]For all designated states
Celgene Corporation
86 Morris Avenue
Summit, NJ 07901 / US
Inventor(s)01 / ANTON, Maria Soraya, Carrancio
c/o Signal Pharmaceuticals, LLC 10300 Campus
Point Drive, Suite 100
San Diego, CA 92121 / US
02 / BUCHHOLZ, Tonia J.
c/o Celgene Corporation 1500 Owens Street, Suite
600
San Francisco, CA 94185 / US
03 / KASIBHATLA, Shailaja
c/o Signal Pharmaceuticals, LLC 10300 Campus
Point Drive, Suite 100
San Diego, CA 92121 / US
04 / LOPEZ-GIRONA, Antonia
c/o Signal Pharmaceuticals, LLC 10300 Campus
Point Drive, Suite 100
San Diego, CA 92121 / US
05 / NARLA, Rama, Krishna
c/o Signal Pharmaceuticals, LLC 10300 Campus
Point Drive, Suite 100
San Diego, CA 92121 / US
06 / POURDEHNAD, Michael
c/o Celgene Corporation 1500 Owens Street, Suite
600
San Francisco, CA 94185 / US
 [2022/35]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2022/35]
Application number, filing date20807558.020.10.2020
[2022/35]
WO2020US56408
Priority number, dateUS201962924028P21.10.2019         Original published format: US 201962924028 P
[2022/35]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021080935
Date:29.04.2021
Language:EN
[2021/17]
Type: A1 Application with search report 
No.:EP4048278
Date:31.08.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 29.04.2021 takes the place of the publication of the European patent application.
[2022/35]
Type: B1 Patent specification 
No.:EP4048278
Date:01.11.2023
Language:EN
[2023/44]
Search report(s)International search report - published on:EP29.04.2021
ClassificationIPC:A61K31/5377, A61P35/00
[2022/35]
CPC:
A61P35/00 (EP,IL,KR); A61K31/5377 (EP,IL,KR,US); A61K9/0053 (IL,KR,US);
A61P35/02 (KR)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/35]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR BEHANDLUNG HÄMATOLOGISCHER MALIGNOME MIT 2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZ YL)AMINO)ISOINDOLINE-1,3-DION[2022/35]
English:METHODS OF TREATING HEMATOLOGICAL MALIGNANCIES USING 2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZ YL)AMINO)ISOINDOLINE-1,3-DIONE[2022/35]
French:PROCÉDÉS DE TRAITEMENT DE MALIGNITÉS HÉMATOLOGIQUES À L'AIDE DE 2-(2,6-DIOXOPIPÉRIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZÉTIDIN-1-YL)MÉTHYL)BENZ YL)AMINO)ISOINDOLINE-1,3-DIONE[2022/35]
Entry into regional phase20.04.2022National basic fee paid 
20.04.2022Designation fee(s) paid 
20.04.2022Examination fee paid 
Examination procedure20.04.2022Examination requested  [2022/35]
20.04.2022Date on which the examining division has become responsible
02.12.2022Amendment by applicant (claims and/or description)
19.05.2023Communication of intention to grant the patent
25.09.2023Fee for grant paid
25.09.2023Fee for publishing/printing paid
25.09.2023Receipt of the translation of the claim(s)
Opposition(s)02.08.2024No opposition filed within time limit [2024/41]
Fees paidRenewal fee
03.05.2022Renewal fee patent year 03
13.09.2023Renewal fee patent year 04
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Cited inInternational search[YP] WO2019209692  (CELGENE CORP et al.)
 [YP] WO2020210418  (CELGENE CORP et al.)
by applicantUS201962924028
   RAJKUMAR ET AL., NATURE REVIEWS CLINICAL ONCOLOGY, vol. 11, 2014, pages 628 - 630
   "Remington's Pharmaceutical Sciences,", 1990, MACK PUBLISHING
   "Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING
   JACQUES, J. ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY-INTERSCIENCE
   WILEN, S. H. ET AL., TETRAHEDRON, vol. 33, 1977, pages 2725
   ELIEL, E. L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
   WILEN, S. H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
   TODD, M.: "Separation Of Enantiomers : Synthetic Methods", 2014, WILEY-VCH VERLAG GMBH & CO. KGAA
   TODA, F.: "Enantiomer Separation: Fundamentals and Practical Methods", 2007, SPRINGER SCIENCE & BUSINESS MEDIA
   SUBRAMANIAN, G.: "Chiral Separation Techniques: A Practical Approach", 2008, JOHN WILEY & SONS
   AHUJA, S.: "Chiral Separation Methods for Pharmaceutical and Biotechnological Products", 2011, JOHN WILEY & SONS
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