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Extract from the Register of European Patents

EP About this file: EP4057989

EP4057989 - 1-(((2S,3S,4S)-3-ETHYL-4-FLUORO-5-OXOPYRROLIDIN-2-YL)METHOXY)-7-METHOXYISOQUINOLINE-6-CARBOXAMIDE COMBINATIONS AND ORAL DOSAGE FORMS [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  19.08.2022
Database last updated on 02.11.2024
FormerThe international publication has been made
Status updated on  21.05.2021
Formerunknown
Status updated on  27.11.2020
Most recent event   Tooltip01.12.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
Pfizer Inc.
66 Hudson Boulevard East
New York, NY 10001-2192 / US
[2023/14]
Former [2022/38]For all designated states
Pfizer Inc.
235 East 42nd Street
New York, NY 10017 / US
Inventor(s)01 / HUTCHINS, Allan Joseph
c/o Pfizer Inc. 445 Eastern Point Road Bldg. 98
Groton, Connecticut 06340 / US
02 / MACDONALD, Bruce Clinton
c/o Pfizer Inc. 445 Eastern Point Road Bldg. 98
Groton, Connecticut 06340 / US
03 / RAO, Vikram Rama
c/o Pfizer Inc. 610 Main Street
Cambridge, Massachusetts 02139 / US
04 / TANG, Degui
c/o Pfizer Inc. 445 Eastern Point Road Bldg. 98
Groton, Connecticut 06340 / US
05 / YU, Weili
c/o Pfizer Inc. 445 Eastern Point Road Bldg. 98
Groton, Connecticut 06340 / US
 [2022/38]
Representative(s)Pfizer
European Patent Department
23-25 avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
[2022/38]
Application number, filing date20808525.811.11.2020
[2022/38]
WO2020IB60627
Priority number, dateUS201962935450P14.11.2019         Original published format: US 201962935450 P
US202063024174P13.05.2020         Original published format: US 202063024174 P
[2022/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021094953
Date:20.05.2021
Language:EN
[2021/20]
Type: A1 Application with search report 
No.:EP4057989
Date:21.09.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 20.05.2021 takes the place of the publication of the European patent application.
[2022/38]
Search report(s)International search report - published on:EP20.05.2021
ClassificationIPC:A61K9/00, A61K9/20, A61K31/4439, A61P17/10, A61P19/02, A61K31/519, A61K45/06, A61K9/28
[2022/38]
CPC:
A61K9/0004 (EP,IL,KR,US); A61K31/4725 (EP,IL,KR,US); A61K9/2054 (KR,US);
A61K31/519 (EP,IL,KR,US); A61K9/2009 (US); A61K9/2018 (EP,IL,US);
A61K9/2027 (US); A61K9/2031 (US); A61K9/2853 (US);
A61K9/2866 (EP,IL,US); A61P17/10 (EP,IL); A61P19/02 (EP,IL,KR);
A61P29/00 (KR); A61K2300/00 (KR); A61K9/0053 (US) (-)
C-Set:
A61K31/4725, A61K2300/00 (EP);
A61K31/519, A61K2300/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/38]
TitleGerman:1-(((2S,3S,4S)-3-ETHYL-4-FLUOR-5-OXOPYRROLIDIN-2-YL)METHOXY)-7-METHOXYISOCHINOLIN-6-CARBOXAMID KOMBINATIONEN UND ORALE DOSIERUNGSFORMEN[2022/38]
English:1-(((2S,3S,4S)-3-ETHYL-4-FLUORO-5-OXOPYRROLIDIN-2-YL)METHOXY)-7-METHOXYISOQUINOLINE-6-CARBOXAMIDE COMBINATIONS AND ORAL DOSAGE FORMS[2022/38]
French:COMBINAISONS DE 1-(((2S,3S,4S)-3-ÉTHYL-4-FLUORO-5-OXOPYRROLIDIN-2-YL)MÉTHOXY)-7-MÉTHOXYISOQUINOLÉINE-6-CARBOXAMIDE ET FORMES PHARMACEUTIQUES ORALES[2022/38]
Entry into regional phase14.06.2022National basic fee paid 
14.06.2022Designation fee(s) paid 
14.06.2022Examination fee paid 
Examination procedure13.05.2022Amendment by applicant (claims and/or description)
14.06.2022Examination requested  [2022/38]
14.06.2022Date on which the examining division has become responsible
Fees paidRenewal fee
30.11.2022Renewal fee patent year 03
30.11.2023Renewal fee patent year 04
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Cited inInternational search[IAY]WO2014147526  (PFIZER [US]) [I] 1 * examples 2,3 * [A] 2-7,11-16[Y] 1;
 [YA]US2019092750  (LEE KATHERINE LIN [US], et al) [Y] 1 * claims 1,5,8,9 * * the whole document * [A] 2-7,11-16;
 [IAY]  - Pfizer, "A 12 WEEK RANDOMIZED, DOUBLE-BLIND, DOUBLE DUMMY, PARALLEL GROUP, ACTIVE AND PLACEBO-CONTROLLED, MULTICENTER STUDY TO ASSESS THE EFFICACY AND SAFETY PROFILE OF PF-06650833 IN SUBJECTS WITH ACTIVE RHEUMATOID ARTHRITIS WITH AN INADEQUATE RESPONSE TO METHOTREXATE", (20170808), pages 1 - 150, URL: https://clinicaltrials.gov/ProvidedDocs/00/NCT02996500/Prot_001.pdf, (20210121), XP055767751 [I] 8-10 * page 20, paragraph 3 * * the whole document * [A] 2-7,11-16 [Y] 1
by applicantUS3247066
 US3952741
 US4519801
 EP0357369
 US5358502
 US5612059
 US5698220
 WO0142246
 WO02096909
 WO03048162
 WO2005053653
 US2005181062
 US2005186285
 US2007248671
 US2008199527
 WO2015083028
 WO2015150995
 US9937181
    - FIRESTEINMCLNNES, Immunity, (20170221), vol. 46, no. 2, pages 183 - 196
    - N. SUZUKIT. SAITO, Trends in Immunology, (20060000), vol. 27, page 566
    - T. W. KIMK. STASCHKEK. BULEKJ. YAOK. PETERSK.-H. OHY. VANDENBURGH. XIAOW. QIANT. HAMILTON, Journal of Experimental Medicine, (20070000), vol. 204, page 1025
    - J. FRACZEKT. W. KIMH. XIAOJ. YAOQ. WENY. LIJ.-L. CASANOVAJ. PRYJMAX. LI, Journal of Biological Chemistry, (20080000), vol. 283, page 31697
    - M. KOZICZAK-HOLBROA. LITTLEWOOD-EVANSB. POLLINGERJ. KOVARIKJ. DAWSONG. ZENKEC. BURKHARTM. MULLERH. GRAM, Arthritis & Rheumatism, (20090000), vol. 60, page 1661
    - M. HERNANDEZJ. F. BASTIAN, Current Allergy and Asthma Reports, (20060000), vol. 6, page 468
    - E. LAVINER. SOMECHJ. Y. ZHANGA. PUELX. BOSSUYTC. PICARDJ. L. CASANOVAC. M. ROIFMAN, Journal of Allergy and Clinical Immunology, (20070000), vol. 120, page 948
    - M. REKHTERK. STASCHKET. ESTRIDGEP. RUTHERFORDN. JACKSOND. GIFFORD-MOOREP. FOXWORTHYC. REIDYX.-D. HUANGM. KALBFLEISCH, Biochemical and Biophysical Research Communications, (20080000), vol. 367, page 642
    - O'NEILL, L. A., "Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases", Curr Opin Pharmacol, (20030000), vol. 3, no. 4, page 396
    - KANZLER, H et al., "Therapeutic targeting of innate immunity with toll-like receptor agonists and antagonists", Nature Medicine, (20070000), vol. 13, page 552
    - WAGNER, H., "Endogenous TLR ligands and autoimmunity", Advances in Immunol, (20060000), vol. 91, page 159
    - NGO, V. N. et al., "Oncogenically active MyD88 mutations in human lymphoma", Nature, (20110000), vol. 470, doi:10.1038/nature09671, page 115, XP055141842

DOI:   http://dx.doi.org/10.1038/nature09671
    - Org. Processs Res. Dev., (20180000), vol. 22, pages 1835 - 1845
    - THORARENSEN et al., J. Med. Chem., (20170000), vol. 60, pages 1971 - 1993
    - Remington: The Science and Practice of Pharmacy, (20060000), pages 950 - 1
    - C.-M. ANDERSSONA. HALLBERGT. HOEGBERG, "Advances in the development of pharmaceutical antioxidants", Advances in Drug Research, (19960000), vol. 28, pages 65 - 180
    - HERBIG et al., J. Controlled Release, (19950000), vol. 35, pages 127 - 136
    - "Impurities in Drug Products", WATERMAN et al., Handbook of Isolation and Characterization of Impurities in Pharmaceuticals, (20030000), pages 75 - 85
    - "Colorimetric determination of hydrogen peroxide", G. M. EISENBERG, Ind. Eng. Chem. (Anal. Ed., (19430000), vol. 15, pages 327 - 328
    - M. ASHRAF-KHORASSANI et al., "Purification of pharmaceutical excipients with supercritical fluid extraction", Pharm. Dev. Tech., (20050000), vol. 10, pages 1 - 10
    - YOSHINO, Capsugel Symposia Series; Current Status on Targeted Drug Delivery to the Gastrointestinal Tract, (19930000), pages 185 - 190
    - KHOSLADAVIS, Int. J. Pharmaceut., vol. 62, no. 1990, pages R9 - R11
 US19930023227
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