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Extract from the Register of European Patents

EP About this file: EP4008784

EP4008784 - GUIDE RNA FOR TARGETED-EDITING WITH FUNCTIONAL BASE SEQUENCE ADDED THERETO [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  29.03.2024
Database last updated on 18.11.2024
FormerRequest for examination was made
Status updated on  06.05.2022
FormerThe international publication has been made
Status updated on  05.02.2021
Most recent event   Tooltip29.03.2024Withdrawal of applicationpublished on 01.05.2024  [2024/18]
Applicant(s)For all designated states
Astellas Pharma Inc.
5-1, Nihonbashi-Honcho 2-Chome
Chuo-ku
Tokyo 103-8411 / JP
For all designated states
Fukuoka University
19-1 Nanakuma 8-chome
Jonan-ku
Fukuoka-shi, Fukuoka 814-0180 / JP
[2022/23]
Inventor(s)01 / YOSHIMI Eiji
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho
2-chome, Chuo-ku
Tokyo 103-8411 / JP
02 / MORIYA Yukari
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho
2-chome, Chuo-ku
Tokyo 103-8411 / JP
03 / MANDA Mariko
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho
2-chome, Chuo-ku
Tokyo 103-8411 / JP
04 / FUKUDA Masatora
c/o Fukuoka University, 19-1, Nanakuma 8-chome,
Jonan-ku
Fukuoka-shi, Fukuoka 814-0180 / JP
 [2022/23]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2022/23]
Application number, filing date20846396.831.07.2020
[2022/23]
WO2020JP29386
Priority number, dateJP2019014187501.08.2019         Original published format: JP 2019141875
[2022/23]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021020550
Date:04.02.2021
Language:JA
[2021/05]
Type: A1 Application with search report 
No.:EP4008784
Date:08.06.2022
Language:EN
[2022/23]
Search report(s)International search report - published on:JP04.02.2021
ClassificationIPC:C12N15/11, A61K31/7105, A61K48/00, C12N1/15, C12N1/19, C12N1/21, C12N5/10, C12N9/78, C12N15/09, C12N15/55, C12N15/63
[2022/23]
CPC:
C12N15/11 (EP,US); C12N9/78 (EP,CN); C12N15/102 (EP,US);
A61K31/7105 (EP,CN,US); A61K48/005 (CN); C12N15/85 (CN);
C12N5/0686 (CN); C12N5/10 (US); C12Y305/04 (CN);
C12N15/907 (EP); C12N2310/11 (EP,US); C12N2310/531 (EP,US);
C12N2510/00 (CN); C12N2750/14143 (EP); C12N2800/107 (CN) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/23]
TitleGerman:GIUDE-RNA FÜR TARGET-EDITIERUNG MIT HINZUGEFÜGTER FUNKTIONELLER BASENSEQUENZ[2022/23]
English:GUIDE RNA FOR TARGETED-EDITING WITH FUNCTIONAL BASE SEQUENCE ADDED THERETO[2022/23]
French:ARN GUIDE POUR ÉDITION CIBLÉE AVEC SÉQUENCE DE BASE FONCTIONNELLE AJOUTÉE À CELUI-CI[2022/23]
Entry into regional phase17.02.2022Translation filed 
17.02.2022National basic fee paid 
17.02.2022Search fee paid 
17.02.2022Designation fee(s) paid 
17.02.2022Examination fee paid 
Examination procedure17.02.2022Examination requested  [2022/23]
07.09.2022Amendment by applicant (claims and/or description)
25.03.2024Application withdrawn by applicant  [2024/18]
Fees paidRenewal fee
25.07.2022Renewal fee patent year 03
14.07.2023Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A]US2003148519  (ENGELKE DAVID R [US], et al)[A] 1-31;
 [A]WO2017010556  (UNIV FUKUOKA [JP]) [A] 1-31;
 [Y]US2019093098  (STAFFORST THORSTEN [DE], et al) [Y] 1-31 * claims 1, 10, paragraph [0029], fig. 1, 3 *;
 [Y]WO2019111957  (UNIV FUKUOKA [JP], et al) [Y] 1-31 * claims 1, 9, examples, fig. 1, 2B, 3-4, 8, tables 6, 8, 15 *;
 [Y]  - Nahar Smita, Sehgal Paras, Azhar Mohd, Rai Manish, Singh Amrita, Sivasubbu Sridhar, Chakraborty Debojyoti, Maiti Souvik, "A G-quadruplex motif at the 3' end of sgRNAs improves CRISPR-Cas9 based genome editing efficiency", Chem. Commun., (20180000), vol. 54, pages 2377 - 2380, XP055789487 [Y] 1-31 * , abstract, page 2378, left column, lines 11-16, page 2378, right column, lines 12-23, fig. 3 *

DOI:   http://dx.doi.org/10.1039/C7CC08893K
 [Y]  - GOOD, P. D. et al., "Expression of small, therapeutic RNAs in human cell nuclei", Gene Ther., (19970000), vol. 4, doi:10.1038/sj.gt.3300354, pages 45 - 54, XP000646610 [Y] 1-31 * , abstract, page 46, left column, line 11 to page 48, right column, line 8, fig. 1, 3-4, table 1 *

DOI:   http://dx.doi.org/10.1038/sj.gt.3300354
 [A]  - Jacqueline Wettengel; Philipp Reautschnig; Sven Geisler; Philipp J Kahle; Thorsten Stafforst, "Harnessing human ADAR2 for RNA repair-Recoding a PINKI mutation rescues mitophagy", Nucleic Acids Res., (20170000), vol. 45, pages 2797 - 2808, XP055329586 [A] 1-31 * , entire text *

DOI:   http://dx.doi.org/10.1093/nar/gkw911
by applicantDE102015012522
 WO2016097212
 WO2017010556
 WO2017050306
 WO2017220751
 WO2018041973
 WO2018134301
 WO2019111957
    - Nature, (19960000), vol. 379, pages 460 - 464
    - FEBS Letters, (20060000), vol. 580, pages 2301 - 2305
    - Ann. Rev. Biochem., (20100000), vol. 79, pages 321 - 349
    - Science, (20190000), vol. 365, pages 382 - 386
    - Nucleic Acids Research, (20170000), vol. 45, pages 2797 - 2808
    - Nat. Biotechnol., (20190000), vol. 37, pages 133 - 138
    - Scientific Reports, (20170000), vol. 7, page 41478
    - Cell. Mol. LifeSci., (20060000), vol. 63, pages 901 - 908
    - Biol. Cell, (20080000), vol. 100, pages 125 - 138
    - J. Am. Chem. Soc., (20020000), vol. 124, pages 10966 - 10967
    - Nucleic Acids Research, (20160000), vol. 44, pages 9555 - 9564
    - Cell, (19890000), vol. 59, pages 871 - 880
    - EMBO Reports, (20150000), vol. 16, pages 910 - 922
    - Chem. Commun., (20180000), vol. 54, pages 2377 - 2380
    - Gene Ther, (19970000), vol. 4, pages 45 - 54
    - Nat. Biotechnol., (20020000), vol. 20, pages 497 - 500
    - Mol. Ther., (20030000), vol. 7, pages 237 - 247
    - Nucleic Acids Research, vol. 31, page e100
    - Biochemistry, (20180000), vol. 57, pages 1640 - 1651
    - RNA, (20110000), vol. 2, pages 761 - 771
    - Biophysical Chemistry, (20130000), vol. 180, no. 181, pages 110 - 118
    - ACS Chemical Biology, (20060000), vol. 1, pages 761 - 765
    - Biophysical J, (20170000), vol. 113, pages 257 - 267
    - J. Mol. Biol., (19700000), vol. 48, pages 443 - 453
    - Int. J. Biochem. Mol. Biol., (20130000), vol. 4, pages 27 - 40
    - Integr. Biol., (20090000), vol. 1, pages 499 - 505
    - Trends in Biochemical Sciences, (20010000), vol. 26, pages 376 - 384
    - RNA, (20010000), vol. 7, pages 846 - 858
    - Bioinformatics, (20090000), vol. 25, pages 3244 - 3250
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.