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Extract from the Register of European Patents

EP About this file: EP4051287

EP4051287 - OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  05.08.2022
Database last updated on 14.11.2024
FormerThe international publication has been made
Status updated on  10.05.2021
Most recent event   Tooltip13.09.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Otonomy, Inc.
4796 Executive Drive
San Diego, California 92121 / US
[2022/36]
Inventor(s)01 / FOSTER, Alan
4796 Executive Drive
San Diego, California 92121 / US
02 / PIU, Fabrice
4796 Executive Drive
San Diego, California 92121 / US
03 / JACQUES, Bonnie Elizabeth
4796 Executive Drive
San Diego, California 92121 / US
04 / URIBE, Phillip Michael
4796 Executive Drive
San Diego, California 92121 / US
05 / SZOBOTA, Stephanie
4796 Executive Drive
San Diego, California 92121 / US
06 / MATHUR, Pranav Dinesh
4796 Executive Drive
San Diego, CA 92121 / US
 [2022/36]
Representative(s)FRKelly
Waterways House
Grand Canal Quay
Dublin D02 PD39 / IE
[N/P]
Former [2022/36]FRKelly
27 Clyde Road
Dublin D04 F838 / IE
Application number, filing date20882822.830.10.2020
[2022/36]
WO2020US58423
Priority number, dateUS201962928196P30.10.2019         Original published format: US 201962928196 P
[2022/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021087408
Date:06.05.2021
Language:EN
[2021/18]
Type: A1 Application with search report 
No.:EP4051287
Date:07.09.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 06.05.2021 takes the place of the publication of the European patent application.
[2022/36]
Search report(s)International search report - published on:US06.05.2021
(Supplementary) European search report - dispatched on:EP23.11.2023
ClassificationIPC:A61K31/65, A61P27/16, A61K9/00, A61K9/06, A61K31/17, A61K31/513, A61K31/52, A61K47/14, A61K47/28, A61K47/32, A61K31/53, A61K47/02, A61K47/10
[2023/32]
CPC:
A61K31/513 (EP,IL,KR,US); A61K9/0046 (EP,IL,KR); A61K31/17 (EP,IL);
A61K31/505 (KR); A61K31/52 (EP,IL); A61K31/53 (EP,IL,KR);
A61K47/02 (EP,IL,KR); A61K47/10 (EP,IL,KR); A61K47/12 (KR);
A61K47/14 (EP,IL,KR); A61K47/28 (EP,IL); A61K47/32 (EP,IL,KR);
A61K9/0019 (EP,IL,KR); A61K9/06 (EP,IL,KR); A61P27/16 (EP,IL,KR,US) (-)
Former IPC [2022/36]A61K31/65, A61P27/16
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/36]
TitleGerman:OHRENFORMULIERUNGEN FÜR MEDIKAMENTENINDUZIERTE OTOTOXIZITÄT[2022/36]
English:OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY[2022/36]
French:FORMULATIONS OTIQUES POUR L'OTOTOXICITÉ INDUITE PAR UN MÉDICAMENT[2022/36]
Entry into regional phase29.04.2022National basic fee paid 
29.04.2022Search fee paid 
29.04.2022Designation fee(s) paid 
29.04.2022Examination fee paid 
Examination procedure29.04.2022Examination requested  [2022/36]
19.12.2022Loss of particular rights, legal effect: Claims
18.01.2023Despatch of communication of loss of particular rights: Claims {1}
11.06.2024Amendment by applicant (claims and/or description)
11.06.2024Date on which the examining division has become responsible
Fees paidRenewal fee
28.04.2023Renewal fee patent year 03
27.10.2023Renewal fee patent year 04
12.09.2024Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
31.10.202203   M06   Fee paid on   28.04.2023
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[A]WO03061574  (UNIV MICHIGAN [US], et al) [A] 1 * abstract * * claim - *;
 [X]WO2004043447  (SEPRACOR INC [US], et al) [X] 1 * abstract * * page 2, line 15 - page 3, line 20 * * page 3, lines 23-25 * * page 17, line 23 - page 20, line 2 * * page 19, lines 16-17 * * page 35; examples 2-3 * * claim - *;
 [A]  - AKBORN A ET AL, "INTRACOCHLEAR ADMINISTRATION OF THIOUREA PROTECTS AGAINST CISPLATIN-INDUCED OUTER HAIR CELL LOSS IN THE GUINEA PIG", HEARING RESEARCH, ELSEVIER SCIENCE PUBLISHERS , AMSTERDAM, NL, (20030701), vol. 181, no. 1/02, doi:10.1016/S0378-5955(03)00181-3, ISSN 0378-5955, pages 109 - 115, XP001180020 [A] 1 * abstract *

DOI:   http://dx.doi.org/10.1016/S0378-5955(03)00181-3
 [A]  - VIDEHULT PERNILLA ET AL, "Kinetics of Cisplatin and Its Monohydrated Complex with Sulfur-Containing Compounds Designed for Local Otoprotective Administration", EXPERIMENTAL BIOLOGY AND MEDICINE, GB, vol. 231, no. 10, doi:10.1177/153537020623101009, ISSN 1535-3702, (20061101), pages 1638 - 1645, URL: http://journals.sagepub.com/doi/pdf/10.1177/153537020623101009, XP093055836 [A] 1 * abstract * * page 1639; figure 1 * * page 1642; table 1 *

DOI:   http://dx.doi.org/10.1177/153537020623101009
 [A]  - AXELSTAD M ET AL, "Developmental neurotoxicity of Propylthiouracil (PTU) in rats: Relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 232, no. 1, doi:10.1016/J.TAAP.2008.05.020, ISSN 0041-008X, (20081001), pages 1 - 13, (20080623), XP025429611 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.taap.2008.05.020
 [T]  - TANABE KATSUYA ET AL, "A patient with sudden hearing loss induced by propylthiouracil", HELIYON, GB, (20210201), vol. 7, no. 2, doi:10.1016/j.heliyon.2021.e06196, ISSN 2405-8440, page e06196, XP093099383 [T] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.heliyon.2021.e06196
International search[XYA]US2005101534  (ZEPP CHARLES M [US], et al) [X] 1-12, 14-19, 24, 33-40 * ; para [0005]-[0006], [0087], [0090]-[0099], [0111], [0122], [0129], [0136], [0142], [0147], [0150], [0155], [0157] * [Y] 20-23, 25-32 [A] 13;
 [A]WO2016020408  (SENSORION [FR]) [A] 1-40* ; entire document *;
 [A]WO2019157370  (DECIBEL THERAPEUTICS INC [US]) [A] 1-40 * ; entire document *;
 [Y]US2019298799  (LICHTER JAY [US], et al) [Y] 20-23, 25-32 * ; para [0013], [0015], [0027], [0029], [0033], [0061], [0064], [0077], [0122], [0439] *;
 [A]  - Anonymous , "5-Acetyl-3-(P-tolyl)-2-thiouracil | C13H12N2O2S", PubChem COMPOUND, (20050913), Database accession no. CID 4170383, XP055932241 [A] 13 * ; pg. 2 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.