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Extract from the Register of European Patents

EP About this file: EP4054652

EP4054652 - SYNTHETIC MODIFIED RNA AND USES THEREOF [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  12.08.2022
Database last updated on 01.10.2024
FormerThe international publication has been made
Status updated on  14.05.2021
Most recent event   Tooltip01.10.2024Change - representative 
Applicant(s)For all designated states
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place
New York, NY 10029 / US
[2022/37]
Inventor(s)01 / ZANGI, Lior
c/o One Gustave L. Levy Place
New York, NY 10029 / US
02 / HADAS, Yoav
c/o One Gustave L. Levy Place
New York, NY 10029 / US
03 / SULTANA, Nishat
c/o One Gustave L. Levy Place
New York, NY 10029 / US
 [2022/37]
Representative(s)Schlich
9 St Catherine's Road
Littlehampton
West Sussex BN17 5HS / GB
[N/P]
Former [2022/37]Boynton, Juliette Alice, et al
Schlich
9 St. Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Application number, filing date20883694.006.11.2020
[2022/37]
WO2020US59482
Priority number, dateUS201962932255P07.11.2019         Original published format: US 201962932255 P
[2022/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021092440
Date:14.05.2021
Language:EN
[2021/19]
Type: A1 Application with search report 
No.:EP4054652
Date:14.09.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 14.05.2021 takes the place of the publication of the European patent application.
[2022/37]
Search report(s)International search report - published on:US14.05.2021
(Supplementary) European search report - dispatched on:EP19.10.2023
ClassificationIPC:A61K48/00, C12N9/16, C12N15/62
[2022/37]
CPC:
C12N9/18 (EP,US); C12N15/11 (US); A61P1/16 (US);
A61P9/00 (US); C12N15/62 (EP); A01K2207/30 (EP);
A01K2227/105 (EP); A01K2267/0375 (EP); A61K48/0066 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/37]
TitleGerman:SYNTHETISCHE MODIFIZIERTE RNA UND VERWENDUNGEN DAVON[2022/37]
English:SYNTHETIC MODIFIED RNA AND USES THEREOF[2022/37]
French:ARN MODIFIÉ SYNTHÉTIQUE ET SES UTILISATIONS[2022/37]
Entry into regional phase11.05.2022National basic fee paid 
11.05.2022Search fee paid 
11.05.2022Designation fee(s) paid 
11.05.2022Examination fee paid 
Examination procedure11.05.2022Examination requested  [2022/37]
03.05.2024Amendment by applicant (claims and/or description)
03.05.2024Date on which the examining division has become responsible
Fees paidRenewal fee
28.11.2022Renewal fee patent year 03
27.11.2023Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XAY]WO2013151665  (MODERNA THERAPEUTICS [US]) [X] 7 * figure 1; claim 1 * [A] 1-6,8-13 [Y] 14,15;
 [YA]WO2018035253  (CHILDRENS MEDICAL CENTER [US]) [Y] 7,14,15 * claims 1,11,12,15 * [A] 1-6,8-13;
 [YA]  - YOSHIMURA ET AL, "Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, (20080306), vol. 369, no. 3, doi:10.1016/J.BBRC.2008.02.120, ISSN 0006-291X, pages 939 - 942, XP022572215 [Y] 7,14,15 * figure 1 * [A] 1-6,8-13

DOI:   http://dx.doi.org/10.1016/j.bbrc.2008.02.120
 [YA]  - BRUXEL E M ET AL, "Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate", THE PHARMACOGENOMICS JOURNAL, NATURE PUBLISHING GROUP, GB, vol. 13, no. 5, doi:10.1038/TPJ.2012.25, ISSN 1470-269X, (20120612), pages 476 - 480, (20120612), XP037747193 [Y] 7,14,15 * page 479, column l, paragraph 2 * [A] 1-6,8-13

DOI:   http://dx.doi.org/10.1038/tpj.2012.25
 [YA]  - KIRTIKA H ASRANI ET AL, "Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA", vol. 15, no. 6, doi:10.1080/15476286.2018.1450054, ISSN 1555-8584, (20180326), pages 756 - 762, RNA BIOLOGY 2011 JAN-FEB,, URL: https://www.tandfonline.com/doi/pdf/10.1080/15476286.2018.1450054, (20180326), XP002793471 [Y] 7,14,15 * abstract * [A] 1-6,8-13

DOI:   http://dx.doi.org/10.1080/15476286.2018.1450054
 [YA]  - RASMUSSEN HENRIK BERG ET AL, "Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures", DRUG METABOLISM AND PERSONALIZED THERAPY, (20180328), vol. 33, no. 1, doi:10.1515/dmpt-2017-0023, ISSN 2363-8907, pages 3 - 14, XP093090420 [Y] 7,14,15 * page 5 * [A] 1-6,8-13

DOI:   http://dx.doi.org/10.1515/dmpt-2017-0023
 [IP]  - SULTANA NISHAT ET AL, "Optimization of 5' Untranslated Region of Modified mRNA for Use in Cardiac or Hepatic Ischemic Injury", MOLECULAR THERAPY- METHODS & CLINICAL DEVELOPMENT, GB, (20200601), vol. 17, doi:10.1016/j.omtm.2020.03.019, ISSN 2329-0501, pages 622 - 633, XP055936600 [IP] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.omtm.2020.03.019
International search[X]US2004005564  (MAURO VINCENT P [US], et al) [X] 46-49 * entire document *;
 [A]US2004076954  (CALDWELL JEREMY S [US], et al) [A] 1-11,46-49 * entire document *;
 [Y]US2011150774  (RIVIER MICHEL [FR], et al) [Y] 4-11 * entire document *;
 [Y]WO2015105191  (JUNTENDO EDUCATIONAL FOUNDATION [JP], et al) [Y] 11 * entire document *;
 [XY]WO2019077001  (CUREVAC AG [DE]) [X] 1-3 * entire document * [Y] 4-11;
 [A]US2019117733  (CHIEN KENNETH R [US], et al) [A] 1-11,46-49* entire document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.