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EP About this file: EP4069315

EP4069315 - STABILIZATION OF RETROMER FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS [Right-click to bookmark this link]
Status	Request for examination was made Status updated on 09.09.2022 Database last updated on 20.12.2024
Former	The international publication has been made Status updated on 11.06.2021
Most recent event Tooltip	09.09.2024	The date on which the examining division becomes responsible, has been established
	09.09.2024	Amendment by applicant
Applicant(s)	For all designated states The Trustees Of Columbia University In The City Of New York 412 Low Memorial Library 535 W. 116th Street New York, NY 10027 / US
	For all designated states Cornell University Center for Technology Licensing at Cornell University (CTL) 395 Pine Tree Road Suite 310 Ithaca, New York 14850 / US
	For all designated states Meiragtx UK II Limited 92 Britannia Walk London N1 7NQ / GB
	[2022/41]
Inventor(s)	01 / SMALL, Scott A. c/o THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 / US
	02 / PETSKO, Gregory c/o THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 / US
	03 / QURESHI, Yasir H. c/o THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 / US
	04 / WAKSAL, Samuel D. c/o THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 / US
	05 / FORBES, Alexandria c/o THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 / US
	06 / COX, Rebecca c/o THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 / US
	[2022/41]
Representative(s)	EIP Fairfax House 15 Fulwood Place London WC1V 6HU / GB
	[2022/41]
Application number, filing date	20896932.9	07.12.2020
	[2022/41]
	WO2020US63627
Priority number, date	US201962943999P	05.12.2019 Original published format: US 201962943999 P
	US202063074578P	04.09.2020 Original published format: US 202063074578 P
	[2022/41]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2021113824
	Date:	10.06.2021
	Language:	EN
	[2021/23]
	Type:	A1 Application with search report
	No.:	EP4069315
	Date:	12.10.2022
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 10.06.2021 takes the place of the publication of the European patent application.
	[2022/41]
Search report(s)	International search report - published on:	US	10.06.2021
	(Supplementary) European search report - dispatched on:	EP	19.02.2024
Classification	IPC:	A61K48/00, A61P25/28, C07K14/47, C12N15/86	[2022/41]
	CPC:	A61P25/28 (EP,IL,KR); A61K48/005 (EP,IL,KR); C07K14/47 (EP,IL,KR,US); C12N15/86 (EP,IL,KR); C12N2750/14143 (EP,IL,KR); C12N2830/008 (EP,IL,KR); (+) C12N2830/40 (EP,IL,KR); C12N2830/50 (EP,IL,KR) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/41]
Title	German:	STABILISIERUNG VON RETROMER ZUR BEHANDLUNG DER ALZHEIMER-KRANKHEIT UND ANDERER NEURODEGENERATIVER ERKRANKUNGEN	[2022/41]
	English:	STABILIZATION OF RETROMER FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS	[2022/41]
	French:	STABILISATION DE RÉTROMÈRE PERMETTANT LE TRAITEMENT DE LA MALADIE D'ALZHEIMER ET D'AUTRES TROUBLES NEURODÉGÉNÉRATIFS	[2022/41]
Entry into regional phase	04.07.2022	National basic fee paid
	04.07.2022	Search fee paid
	04.07.2022	Designation fee(s) paid
	04.07.2022	Examination fee paid
Examination procedure	06.09.2013	Amendment by applicant (claims and/or description)
	04.07.2022	Examination requested [2022/41]
	06.09.2024	Date on which the examining division has become responsible
Fees paid	Renewal fee
	27.12.2022	Renewal fee patent year 03
	27.12.2023	Renewal fee patent year 04
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[Y]US2008214482 (SMALL SCOTT [US], et al) [Y] 1-14 * abstract * * paragraph [0058] - paragraph [0060]; claims 14,19-21.27 *;
		[A]WO2015181526 (UNIV LEICESTER [GB]) [A] 1-14* abstract *;
		[Y]WO2019070894 (PREVAIL THERAPEUTICS INC [US]) [Y] 1-14 * abstract *;
		[Y] - LI JIAN-GUO ET AL, "Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 25, no. 10, doi:10.1038/S41380-019-0364-X, ISSN 1359-4184, (20190207), pages 2630 - 2640, (20190207), XP037255000 [Y] 1-14 * abstract * * page 2631, column 1, paragraph 1 * * page 2636, column 1, paragraph 2 - column 2, paragraph 1 * * page 2638, column 2, paragraph 2; figures 1,6 * DOI: http://dx.doi.org/10.1038/s41380-019-0364-x
		[Y] - KIM E ET AL, "Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 403, no. 2, doi:10.1016/J.BBRC.2010.10.121, ISSN 0006-291X, (20101210), pages 167 - 171, (20101030), XP027552617 [Y] 1-14 * abstract * * page 171, column 1, paragraph 2 * DOI: http://dx.doi.org/10.1016/j.bbrc.2010.10.121
		[Y] - ATSUHITO FUSE ET AL, "VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, (20150501), vol. 589, no. 13, doi:10.1016/J.FEBSLET.2015.04.040, ISSN 0014-5793, pages 1430 - 1436, XP071254614 [Y] 1-14 * abstract * * page 1431, column 1, paragraph 4 * * page 1433, column 2, paragraph 2; figure 2 * DOI: http://dx.doi.org/10.1016/j.febslet.2015.04.040
		[Y] - Neufeld Jessi, "Biomarkers of Alzheimer-Associated Endosomal Dysfunction", THESES DOCTORAL, Columbia University, (20180101), URL: https://academiccommons.columbia.edu/doi/10.7916/D80Z8KB7, (20220426), XP055915358 [Y] 1-14 * page 18, paragraph 3 - page 22, paragraph 1 * * page 24 * * page 48 * * page 94; figures 1.8,3.3 *
		[Y] - COLLINS BRETT M. ET AL, "Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex", TRAFFIC, DK, (20080311), vol. 9, no. 3, doi:10.1111/j.1600-0854.2007.00688.x, ISSN 1398-9219, pages 366 - 379, XP093127268 [Y] 1-14 * abstract * * page 376, column 2, paragraph 4; figures 1-6 * DOI: http://dx.doi.org/10.1111/j.1600-0854.2007.00688.x
	International search	[Y]US2007099251 (ZHANG HUI [US], et al) [Y] 25-28, 45-48 * entire document *;
		[A]US2008214482 (SMALL SCOTT [US], et al) [A] 1-13, 15-28, 35-57* entire document *;
		[A]US2014371098 (LÜKING ANGELIKA [DE], et al) [A] 1-13, 15-28, 35-57 * entire document *;
		[A]US2016184454 (ABELIOVICH ASA [US]) [A] 1-13, 15-28, 35-57 * entire document *;
		[Y]US2017191999 (MACIP SALVADOR [GB]) [Y] 21-24, 41-44 * entire document *;
		[Y]US2018193414 (GREENBERG KENNETH P [US], et al) [Y] 50-54 * entire document *;
		[XY]US2019241633 (FOTIN-MLECZEK MARIOLA [DE], et al) [X] 1-13, 15-19, 35-39, 49, 55-57 * entire document * [Y] 21-28, 41-48, 50-54

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