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Extract from the Register of European Patents

EP About this file: EP4081527

EP4081527 - THE COMBINATION OF CYCLIN DEPENDENT KINASE 7 INHIBITOR AND IMMUNOTHERAPY FOR TREATMENT OF CANCER [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  30.09.2022
Database last updated on 14.11.2024
FormerThe international publication has been made
Status updated on  07.07.2021
Most recent event   Tooltip15.07.2024Change - representative 
Applicant(s)For all designated states
Dana-Farber Cancer Institute, Inc.
450 Brookline Avenue
Boston, MA 02215 / US
For all designated states
New York University
70 Washington Square South
New York, NY 10012-1091 / US
[2022/44]
Inventor(s)01 / GRAY, Nathanael, S.
26 Greenview Avenue
Boston, MA 02130 / US
02 / WONG, Kwok-kin
49 Columbia Road
Arlington, MA 02474 / US
03 / ZHANG, Hua
30 Waterside Plaza, Apt 32h
New York, NY 10010 / US
04 / ROSS, Camilla, Laulund Christensen
9 Leonard Avenue
Cambridge, MA 02139 / US
 [2022/44]
Representative(s)Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
[N/P]
Former [2022/44]HGF
HGF Limited
1 City Walk
Leeds LS11 9DX / GB
Application number, filing date20908219.716.12.2020
[2022/44]
WO2020US65267
Priority number, dateUS201962953376P24.12.2019         Original published format: US 201962953376 P
[2022/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021133601
Date:01.07.2021
Language:EN
[2021/26]
Type: A1 Application with search report 
No.:EP4081527
Date:02.11.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 01.07.2021 takes the place of the publication of the European patent application.
[2022/44]
Search report(s)International search report - published on:US01.07.2021
(Supplementary) European search report - dispatched on:EP12.12.2023
ClassificationIPC:A61K31/4162, C07D487/04, A61P35/00, C07D487/10, A61K31/454, A61K45/06
[2024/02]
CPC:
A61K31/4162 (EP,US); A61K31/454 (EP); A61K31/7048 (US);
A61K33/243 (US); A61K39/3955 (US); A61K45/06 (EP);
A61P11/00 (US); A61P35/00 (EP,US); C07D487/04 (EP);
C07D487/10 (EP) (-)
C-Set:
A61K31/4162, A61K2300/00 (EP);
A61K31/454, A61K2300/00 (EP)
Former IPC [2022/44]C07D487/04, A61P35/00, A61K31/4162, C07D487/10, A61K31/454, A61K45/06
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/44]
TitleGerman:KOMBINATION EINES CYCLINABHÄNGIGEN KINASE-7-INHIBITORS UND EINER IMMUNTHERAPIE ZUR BEHANDLUNG VON KREBS[2022/44]
English:THE COMBINATION OF CYCLIN DEPENDENT KINASE 7 INHIBITOR AND IMMUNOTHERAPY FOR TREATMENT OF CANCER[2022/44]
French:ASSOCIATION D'UN INHIBITEUR DE KINASE 7 DÉPENDANTE DE CYCLINES ET D'UNE IMMUNOTHÉRAPIE POUR LE TRAITEMENT DU CANCER[2022/44]
Entry into regional phase22.07.2022National basic fee paid 
22.07.2022Search fee paid 
22.07.2022Designation fee(s) paid 
22.07.2022Examination fee paid 
Examination procedure22.07.2022Examination requested  [2022/44]
08.07.2024Amendment by applicant (claims and/or description)
08.07.2024Date on which the examining division has become responsible
Fees paidRenewal fee
22.07.2022Renewal fee patent year 03
15.11.2023Renewal fee patent year 04
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Documents cited:Search[XYI]WO2016105528  (DANA FARBER CANCER INST INC [US]) [X] 1-4,6,11,13,15 * p. 206, cl. 56, middle; cl. 1, 70-86 ; [00266]; [0019]; 00289] * [Y] 1-15 [I] 1-15;
 [XY]WO2017160717  (MEMORIAL SLOAN KETTERING CANCER CENTER [US]) [X] 1-3,6,11,13,15 * claims, in particular cl. 1, 9, 21, 36; Fig. 15; example 2. * [Y] 1-15;
 [XP]WO2020100944  (UBE INDUSTRIES [JP]) [XP] 1-3,6,11,13,15 * claim 5 p. 89/90; example 7; cl. 19-20 *;
 [XP]WO2020140098  (DANA FARBER CANCER INST INC [US]) [XP] 1-3,6,11,13,15 * claim 1; compounds on p. 179/180; [00259], 00237, e.g. with alemtuzumab (p. 120), pembrolizumab (p. 122) *;
 [E]WO2021016388  (DANA FARBER CANCER INST INC [US]) [E] 1-4,6,11,13,15 * compounds on p. 160-165, 152; §0232 *;
 [E]WO2021026109  (DANA FARBER CANCER INST INC [US]) [E] 1-3,6,13,15* claims 1, 34, 37-41; [0146] *
International search[A]US2009221632  (FANCELLI DANIELE [IT], et al) [A] 2 * ; paragraph [0769] *;
 [X]US2019055248  (GRAY NATHANAEL S [US], et al) [X] 1-14, 34-35, 50-54 * ; abstract; paragraphs [0017], [0019], [0084], [0107]-[0115], [0117]-[0124], [0189], [0215], [0217], [0222], [0246], [0292], [0304], [0336], [0346], [0362], [0378], [0394], [0402], [0404], [0448], [0452], [0482], [0487], [0511] *;
 [A]  - BRASCA, M et al., "Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles:ldentification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing", Bioorganic and Medicinal Chemistry, (20100301), vol. 18, no. 5, doi:10.1016/j.bmc. 2010.01.04 2, pages 1844 - 1853, XP026925757 [A] 2

DOI:   http://dx.doi.org/10.1016/j.bmc.2010.01.042
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