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Extract from the Register of European Patents

EP About this file: EP4085141

EP4085141 - GENOME EDITING USING REVERSE TRANSCRIPTASE ENABLED AND FULLY ACTIVE CRISPR COMPLEXES [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  07.10.2022
Database last updated on 02.09.2024
FormerThe international publication has been made
Status updated on  10.07.2021
Most recent event   Tooltip02.09.2024The date on which the examining division becomes responsible, has been established 
02.09.2024Amendment by applicant 
Applicant(s)For all designated states
The Broad Institute, Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
77 Massachusetts Avenue
Cambridge, MA 02139 / US
[2022/45]
Inventor(s)01 / ZHANG, Feng
c/o 415 Main Street
Cambridge, Massachusetts 02142 / US
02 / STRECKER, Jonathan
c/o 415 Main Street
Cambridge, Massachusetts 02142 / US
03 / LI, David
c/o 77 Massachusetts Avenue
Cambridge, Massachusetts 02139 / US
 [2022/45]
Representative(s)V.O.
P.O. Box 87930
2508 DH Den Haag / NL
[2022/45]
Application number, filing date20911273.930.12.2020
[2022/45]
WO2020US67535
Priority number, dateUS201962955224P30.12.2019         Original published format: US 201962955224 P
US202062993249P23.03.2020         Original published format: US 202062993249 P
[2022/45]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021138469
Date:08.07.2021
Language:EN
[2021/27]
Type: A1 Application with search report 
No.:EP4085141
Date:09.11.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 08.07.2021 takes the place of the publication of the European patent application.
[2022/45]
Search report(s)International search report - published on:US08.07.2021
(Supplementary) European search report - dispatched on:EP07.02.2024
ClassificationIPC:C12N15/85, C12N9/22, A61K38/46, C12N15/01, A61K38/00, A61K47/00
[2022/45]
CPC:
C12N9/1276 (EP,US); C12N15/90 (EP,US); C12N9/22 (EP,US);
C12Y301/01 (EP,US); C07K2319/00 (EP,US); C07K2319/80 (EP);
C12N2310/20 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/45]
TitleGerman:GENOMEDITIERUNG UNTER VERWENDUNG VON REVERSER TRANSKRIPTASE FÜR VOLLSTÄNDIG AKTIVE CRISPR-KOMPLEXE[2022/45]
English:GENOME EDITING USING REVERSE TRANSCRIPTASE ENABLED AND FULLY ACTIVE CRISPR COMPLEXES[2022/45]
French:ÉDITION DE GÉNOME À L'AIDE DE COMPLEXES CRISPR ACTIVÉS ET ENTIÈREMENT ACTIFS DE LA TRANSCRIPTASE INVERSE[2022/45]
Entry into regional phase07.07.2022National basic fee paid 
07.07.2022Search fee paid 
07.07.2022Designation fee(s) paid 
07.07.2022Examination fee paid 
Examination procedure07.07.2022Examination requested  [2022/45]
27.08.2024Amendment by applicant (claims and/or description)
27.08.2024Date on which the examining division has become responsible
Fees paidRenewal fee
27.12.2022Renewal fee patent year 03
27.12.2023Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XP]WO2020191153  (BROAD INST INC [US], et al) [XP] 1,2 * the whole document *;
 [XYI]  - ANZALONE ANDREW V ET AL, "Search-and-replace genome editing without double-strand breaks or donor DNA", NATURE,, (20191021), vol. 576, no. 7785, doi:10.1038/S41586-019-1711-4, pages 149 - 157, XP036953141 [X] 1,2 * the whole document * [Y] 3-5 [I] 3-14

DOI:   http://dx.doi.org/10.1038/s41586-019-1711-4
 [Y]  - LUKAS OESINGHAUS ET AL, "Switching the activity of Cas12a using guide RNA strand displacement circuits", NATURE COMMUNICATIONS, (20190507), vol. 10, no. 1, doi:10.1038/s41467-019-09953-w, XP055738806 [Y] 3-5 * the whole document *

DOI:   http://dx.doi.org/10.1038/s41467-019-09953-w
 [Y]  - SILVANA KONERMANN ET AL, "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", NATURE, (20150101), vol. 517, no. 7536, doi:10.1038/nature14136, pages 583 - 588, XP055585957 [Y] 3-5 * the whole document *

DOI:   http://dx.doi.org/10.1038/nature14136
International search[PX]WO2020191153  (BROAD INST INC [US], et al) [PX] 1-4, 17-20, 30-32* ; entire document *;
 [XY]  - Anzalone Andrew V.; Randolph Peyton B.; Davis Jessie R.; Sousa Alexander A.; Koblan Luke W.; Levy Jonathan M.; Chen Peter J.; Wilson Christopher; Newby Gregory A.; Raguram Aditya; Liu David R., "Search-and-replace genome editing without double-strand breaks or donor DNA", Nature, Macmillan Journals Ltd., etc., London, London, (20191021), vol. 576, no. 7785, doi:10.1038/s41586-019-1711-4, ISSN 0028-0836, pages 149 - 157, XP036953141 [X] 1-2, 17-18, 30 * ; especially abstract; pg 151, col 2, para 3; pg 153, col 1, para 2; pg 154, col 1, para 2; pg S17; Figure 1 * [Y] 3-4, 19-20, 31-32

DOI:   http://dx.doi.org/10.1038/s41586-019-1711-4
 [Y]  - Silvana Konermann, Mark D. Brigham, Alexandro E. Trevino, Julia Joung, Omar O. Abudayyeh, Clea Barcena, Patrick D. Hsu, Naomi Habib, Jonathan S. Gootenberg, Hiroshi Nishimasu, Osamu Nureki, Feng Zhang, "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", Nature, Macmillan Journals Ltd., etc., London, London, (20150101), vol. 517, no. 7536, doi:10.1038/nature14136, ISSN 0028-0836, pages 583 - 588, XP055585957 [Y] 3-4, 31-32 * ; especially pg 583, col 2, para 3 - pg 584, col 2, para 1; Figure 1 *

DOI:   http://dx.doi.org/10.1038/nature14136
 [Y]  - Alexis C. Komor, Zhao Kevin T., Packer Michael S., Gaudelli Nicole M., Waterbury Amanda L., Koblan Luke W., Kim Y. Bill, Badran Ahmed H., Liu David R., "Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity", Science Advances, (20170801), vol. 3, no. 8, doi:10.1126/sciadv.aao4774, page eaao4774, XP055453964 [Y] 19-20 * ; especially abstract; pg 2, col 1, para 1; pg 7, col 2, para 2 *

DOI:   http://dx.doi.org/10.1126/sciadv.aao4774
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.