EP4085141 - GENOME EDITING USING REVERSE TRANSCRIPTASE ENABLED AND FULLY ACTIVE CRISPR COMPLEXES [Right-click to bookmark this link] | Status | Request for examination was made Status updated on 07.10.2022 Database last updated on 02.09.2024 | |
Former | The international publication has been made Status updated on 10.07.2021 | Most recent event Tooltip | 02.09.2024 | The date on which the examining division becomes responsible, has been established | 02.09.2024 | Amendment by applicant | Applicant(s) | For all designated states The Broad Institute, Inc. 415 Main Street Cambridge, MA 02142 / US | For all designated states MASSACHUSETTS INSTITUTE OF TECHNOLOGY 77 Massachusetts Avenue Cambridge, MA 02139 / US | [2022/45] | Inventor(s) | 01 /
ZHANG, Feng c/o 415 Main Street Cambridge, Massachusetts 02142 / US | 02 /
STRECKER, Jonathan c/o 415 Main Street Cambridge, Massachusetts 02142 / US | 03 /
LI, David c/o 77 Massachusetts Avenue Cambridge, Massachusetts 02139 / US | [2022/45] | Representative(s) | V.O. P.O. Box 87930 2508 DH Den Haag / NL | [2022/45] | Application number, filing date | 20911273.9 | 30.12.2020 | [2022/45] | WO2020US67535 | Priority number, date | US201962955224P | 30.12.2019 Original published format: US 201962955224 P | US202062993249P | 23.03.2020 Original published format: US 202062993249 P | [2022/45] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2021138469 | Date: | 08.07.2021 | Language: | EN | [2021/27] | Type: | A1 Application with search report | No.: | EP4085141 | Date: | 09.11.2022 | Language: | EN | The application published by WIPO in one of the EPO official languages on 08.07.2021 takes the place of the publication of the European patent application. | [2022/45] | Search report(s) | International search report - published on: | US | 08.07.2021 | (Supplementary) European search report - dispatched on: | EP | 07.02.2024 | Classification | IPC: | C12N15/85, C12N9/22, A61K38/46, C12N15/01, A61K38/00, A61K47/00 | [2022/45] | CPC: |
C12N9/1276 (EP,US);
C12N15/90 (EP,US);
C12N9/22 (EP,US);
C12Y301/01 (EP,US);
C07K2319/00 (EP,US);
C07K2319/80 (EP);
C12N2310/20 (EP,US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/45] | Title | German: | GENOMEDITIERUNG UNTER VERWENDUNG VON REVERSER TRANSKRIPTASE FÜR VOLLSTÄNDIG AKTIVE CRISPR-KOMPLEXE | [2022/45] | English: | GENOME EDITING USING REVERSE TRANSCRIPTASE ENABLED AND FULLY ACTIVE CRISPR COMPLEXES | [2022/45] | French: | ÉDITION DE GÉNOME À L'AIDE DE COMPLEXES CRISPR ACTIVÉS ET ENTIÈREMENT ACTIFS DE LA TRANSCRIPTASE INVERSE | [2022/45] | Entry into regional phase | 07.07.2022 | National basic fee paid | 07.07.2022 | Search fee paid | 07.07.2022 | Designation fee(s) paid | 07.07.2022 | Examination fee paid | Examination procedure | 07.07.2022 | Examination requested [2022/45] | 27.08.2024 | Amendment by applicant (claims and/or description) | 27.08.2024 | Date on which the examining division has become responsible | Fees paid | Renewal fee | 27.12.2022 | Renewal fee patent year 03 | 27.12.2023 | Renewal fee patent year 04 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [XP]WO2020191153 (BROAD INST INC [US], et al) [XP] 1,2 * the whole document *; | [XYI] - ANZALONE ANDREW V ET AL, "Search-and-replace genome editing without double-strand breaks or donor DNA", NATURE,, (20191021), vol. 576, no. 7785, doi:10.1038/S41586-019-1711-4, pages 149 - 157, XP036953141 [X] 1,2 * the whole document * [Y] 3-5 [I] 3-14 DOI: http://dx.doi.org/10.1038/s41586-019-1711-4 | [Y] - LUKAS OESINGHAUS ET AL, "Switching the activity of Cas12a using guide RNA strand displacement circuits", NATURE COMMUNICATIONS, (20190507), vol. 10, no. 1, doi:10.1038/s41467-019-09953-w, XP055738806 [Y] 3-5 * the whole document * DOI: http://dx.doi.org/10.1038/s41467-019-09953-w | [Y] - SILVANA KONERMANN ET AL, "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", NATURE, (20150101), vol. 517, no. 7536, doi:10.1038/nature14136, pages 583 - 588, XP055585957 [Y] 3-5 * the whole document * DOI: http://dx.doi.org/10.1038/nature14136 | International search | [PX]WO2020191153 (BROAD INST INC [US], et al) [PX] 1-4, 17-20, 30-32* ; entire document *; | [XY] - Anzalone Andrew V.; Randolph Peyton B.; Davis Jessie R.; Sousa Alexander A.; Koblan Luke W.; Levy Jonathan M.; Chen Peter J.; Wilson Christopher; Newby Gregory A.; Raguram Aditya; Liu David R., "Search-and-replace genome editing without double-strand breaks or donor DNA", Nature, Macmillan Journals Ltd., etc., London, London, (20191021), vol. 576, no. 7785, doi:10.1038/s41586-019-1711-4, ISSN 0028-0836, pages 149 - 157, XP036953141 [X] 1-2, 17-18, 30 * ; especially abstract; pg 151, col 2, para 3; pg 153, col 1, para 2; pg 154, col 1, para 2; pg S17; Figure 1 * [Y] 3-4, 19-20, 31-32 DOI: http://dx.doi.org/10.1038/s41586-019-1711-4 | [Y] - Silvana Konermann, Mark D. Brigham, Alexandro E. Trevino, Julia Joung, Omar O. Abudayyeh, Clea Barcena, Patrick D. Hsu, Naomi Habib, Jonathan S. Gootenberg, Hiroshi Nishimasu, Osamu Nureki, Feng Zhang, "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", Nature, Macmillan Journals Ltd., etc., London, London, (20150101), vol. 517, no. 7536, doi:10.1038/nature14136, ISSN 0028-0836, pages 583 - 588, XP055585957 [Y] 3-4, 31-32 * ; especially pg 583, col 2, para 3 - pg 584, col 2, para 1; Figure 1 * DOI: http://dx.doi.org/10.1038/nature14136 | [Y] - Alexis C. Komor, Zhao Kevin T., Packer Michael S., Gaudelli Nicole M., Waterbury Amanda L., Koblan Luke W., Kim Y. Bill, Badran Ahmed H., Liu David R., "Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity", Science Advances, (20170801), vol. 3, no. 8, doi:10.1126/sciadv.aao4774, page eaao4774, XP055453964 [Y] 19-20 * ; especially abstract; pg 2, col 1, para 1; pg 7, col 2, para 2 * DOI: http://dx.doi.org/10.1126/sciadv.aao4774 |