Extract from the Register of European Patents

EP About this file: EP4056546

EP4056546 - ALIPHATIC 18F-RADIOLABELING OF A TETRAZINE PRECURSOR [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  21.07.2023
Database last updated on 14.03.2026
FormerThe application has been published
Status updated on  12.08.2022
Most recent event   Tooltip21.07.2023Application deemed to be withdrawnpublished on 23.08.2023  [2023/34]
Applicant(s)For all designated states
University of Copenhagen
Nørregade 10
1165 Copenhagen K / DK
For all designated states
Rigshospitalet
Blegdamsvej 9
2100 Copenhagen Ø / DK
[2022/37]
Inventor(s)01 / HERTH, Matthias Manfred
21121 Malmö / DK
02 / KJÆR, Andreas
2000 Frederiksberg / DK
03 / JØRGENSEN, Jesper Tranekjær
1165 Copenhagen / DK
04 / BATTISTI, Umberto Maria
1165 Copenhagen / DK
05 / BRATTEBY, Klas Erik
1165 Copenhagen / DK
 [2022/37]
Representative(s)Budde Schou A/S
Dronningens Tvaergade 30
1302 Copenhagen K / DK
[2022/37]
Application number, filing date21162064.611.03.2021
[2022/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP4056546
Date:14.09.2022
Language:EN
[2022/37]
Search report(s)(Supplementary) European search report - dispatched on:EP08.09.2021
ClassificationIPC:C07B59/00, A61K47/68, A61K51/04
[2022/37]
CPC:
A61K51/0461 (EP); A61K47/6851 (EP); A61K47/6897 (EP);
C07B59/002 (EP); C07D401/14 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/37]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:ALIPHATISCHE 18F-RADIOAKTIVE MARKIERUNG EINES TETRAZINVORLÄUFERS[2022/37]
English:ALIPHATIC 18F-RADIOLABELING OF A TETRAZINE PRECURSOR[2022/37]
French:RADIOMARQUAGE 18F ALIPHATIQUE D'UN PRÉCURSEUR DE TÉTRAZINE[2022/37]
Examination procedure15.03.2023Application deemed to be withdrawn, date of legal effect  [2023/34]
05.04.2023Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2023/34]
Fees paidPenalty fee
Additional fee for renewal fee
31.03.202303   M06   Not yet paid
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Documents cited:Search[A] WO2020239687  (RIGSHOSPITALET et al.)
 [X]   ZIBO LI ET AL: "Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, vol. 46, no. 42, 14 November 2010 (2010-11-14), pages 8043 - 8045, XP002629675, ISSN: 1359-7345, [retrieved on 20100922], DOI: 10.1039/C0CC03078C

DOI:   http://dx.doi.org/10.1039/c0cc03078c
 [X]   EHRET FABIAN ET AL: "Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 137, no. 28, 22 July 2015 (2015-07-22), pages 8876 - 8879, XP055836153, ISSN: 0002-7863, DOI: 10.1021/jacs.5b03371

DOI:   http://dx.doi.org/10.1021/jacs.5b03371
 [X]   EHRET FABIAN ET AL: "Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes Supporting Information", J. AM. CHEM. SOC., vol. 137, 1 January 2015 (2015-01-01), pages S1 - S28, XP055836157, Retrieved from the Internet
 [A]   E. JOHANNA L. STEN ET AL: "Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2019, no. 8, 28 February 2019 (2019-02-28), DE, pages 1722 - 1725, XP055740981, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801457

DOI:   http://dx.doi.org/10.1002/ejoc.201801457
 [A]   DENK CHRISTOPH ET AL: "Development of a 18 F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 36, 1 September 2014 (2014-09-01), DE, pages 9655 - 9659, XP055836227, ISSN: 1433-7851, DOI: 10.1002/anie.201404277

DOI:   http://dx.doi.org/10.1002/anie.201404277
by applicantWO2012012612
   ORIT JACOBSON ET AL., BIOCONJUGATE CHEM, vol. 26, 2015, pages 1 - 18
   STEFAN VERHOOG ET AL.: "Chemical communications", 2019, article "Ring opening of epoxides with [18F]FeF species to produce [18F]fluorohydrin PET imaging agents"
   OUTI KEINANEN ET AL., ACS MED. CHEM. LETT., vol. 7, 2016, pages 62 - 66
   STEEN, J.JORGENSEN, J. T.CHRISTOPH, D.BATTISTI, U. M.N RREGAARD, K.EDEM, P.BRATTEBY, K.SHALGUNOV, V.MARTIN, W.SVATUNEK, D.: "Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine", TOOLS IN PRETARGETED IN VIVO CHEMISTRY, 24 December 2020 (2020-12-24)
   BORJESSON, P. K.JAUW, Y. W.DE BREE, R.ROOS, J. C.CASTELIJNS, J. A.LEEMANS, C. R.VAN DONGEN, G. A.BOELLAARD, R.: "Radiation dosimetry of Zr-labeled chimeric monoclonal antibody U36 as used for immuno-PET in head and neck cancer patients", J NUCL MED, vol. 50, 2009, pages 1828 - 36
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