| EP4056546 - ALIPHATIC 18F-RADIOLABELING OF A TETRAZINE PRECURSOR [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 21.07.2023 Database last updated on 14.03.2026 | |
| Former | The application has been published Status updated on 12.08.2022 | Most recent event Tooltip | 21.07.2023 | Application deemed to be withdrawn | published on 23.08.2023 [2023/34] | Applicant(s) | For all designated states University of Copenhagen Nørregade 10 1165 Copenhagen K / DK | For all designated states Rigshospitalet Blegdamsvej 9 2100 Copenhagen Ø / DK | [2022/37] | Inventor(s) | 01 /
HERTH, Matthias Manfred 21121 Malmö / DK | 02 /
KJÆR, Andreas 2000 Frederiksberg / DK | 03 /
JØRGENSEN, Jesper Tranekjær 1165 Copenhagen / DK | 04 /
BATTISTI, Umberto Maria 1165 Copenhagen / DK | 05 /
BRATTEBY, Klas Erik 1165 Copenhagen / DK | [2022/37] | Representative(s) | Budde Schou A/S Dronningens Tvaergade 30 1302 Copenhagen K / DK | [2022/37] | Application number, filing date | 21162064.6 | 11.03.2021 | [2022/37] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP4056546 | Date: | 14.09.2022 | Language: | EN | [2022/37] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 08.09.2021 | Classification | IPC: | C07B59/00, A61K47/68, A61K51/04 | [2022/37] | CPC: |
A61K51/0461 (EP);
A61K47/6851 (EP);
A61K47/6897 (EP);
C07B59/002 (EP);
C07D401/14 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/37] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | ALIPHATISCHE 18F-RADIOAKTIVE MARKIERUNG EINES TETRAZINVORLÄUFERS | [2022/37] | English: | ALIPHATIC 18F-RADIOLABELING OF A TETRAZINE PRECURSOR | [2022/37] | French: | RADIOMARQUAGE 18F ALIPHATIQUE D'UN PRÉCURSEUR DE TÉTRAZINE | [2022/37] | Examination procedure | 15.03.2023 | Application deemed to be withdrawn, date of legal effect [2023/34] | 05.04.2023 | Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time [2023/34] | Fees paid | Penalty fee | Additional fee for renewal fee | 31.03.2023 | 03   M06   Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A] WO2020239687 (RIGSHOSPITALET et al.) | [X] ZIBO LI ET AL: "Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, vol. 46, no. 42, 14 November 2010 (2010-11-14), pages 8043 - 8045, XP002629675, ISSN: 1359-7345, [retrieved on 20100922], DOI: 10.1039/C0CC03078C DOI: http://dx.doi.org/10.1039/c0cc03078c | [X] EHRET FABIAN ET AL: "Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 137, no. 28, 22 July 2015 (2015-07-22), pages 8876 - 8879, XP055836153, ISSN: 0002-7863, DOI: 10.1021/jacs.5b03371 DOI: http://dx.doi.org/10.1021/jacs.5b03371 | [X] EHRET FABIAN ET AL: "Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes Supporting Information", J. AM. CHEM. SOC., vol. 137, 1 January 2015 (2015-01-01), pages S1 - S28, XP055836157, Retrieved from the Internet | [A] E. JOHANNA L. STEN ET AL: "Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2019, no. 8, 28 February 2019 (2019-02-28), DE, pages 1722 - 1725, XP055740981, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801457 DOI: http://dx.doi.org/10.1002/ejoc.201801457 | [A] DENK CHRISTOPH ET AL: "Development of a 18 F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 36, 1 September 2014 (2014-09-01), DE, pages 9655 - 9659, XP055836227, ISSN: 1433-7851, DOI: 10.1002/anie.201404277 DOI: http://dx.doi.org/10.1002/anie.201404277 | by applicant | WO2012012612 | ORIT JACOBSON ET AL., BIOCONJUGATE CHEM, vol. 26, 2015, pages 1 - 18 | STEFAN VERHOOG ET AL.: "Chemical communications", 2019, article "Ring opening of epoxides with [18F]FeF species to produce [18F]fluorohydrin PET imaging agents" | OUTI KEINANEN ET AL., ACS MED. CHEM. LETT., vol. 7, 2016, pages 62 - 66 | STEEN, J.JORGENSEN, J. T.CHRISTOPH, D.BATTISTI, U. M.N RREGAARD, K.EDEM, P.BRATTEBY, K.SHALGUNOV, V.MARTIN, W.SVATUNEK, D.: "Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine", TOOLS IN PRETARGETED IN VIVO CHEMISTRY, 24 December 2020 (2020-12-24) | BORJESSON, P. K.JAUW, Y. W.DE BREE, R.ROOS, J. C.CASTELIJNS, J. A.LEEMANS, C. R.VAN DONGEN, G. A.BOELLAARD, R.: "Radiation dosimetry of Zr-labeled chimeric monoclonal antibody U36 as used for immuno-PET in head and neck cancer patients", J NUCL MED, vol. 50, 2009, pages 1828 - 36 |