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Extract from the Register of European Patents

EP About this file: EP4039681

EP4039681 - N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  10.02.2023
Database last updated on 12.07.2024
FormerThe application has been published
Status updated on  08.07.2022
Most recent event   Tooltip02.10.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
Kalvista Pharmaceuticals Limited
Porton Science Park
Bybrook Road
Porton Down, Salisbury SP4 0BF
Wiltshire / GB
[2022/32]
Inventor(s)01 / DAVIE, Rebecca Louise
Wiltshire, SP4 0BF / GB
02 / EDWARDS, Hannah Joy
Wiltshire, SP4 0BF / GB
03 / EVANS, David Michael
Wiltshire, SP4 0BF / GB
04 / HODGSON, Simon Teanby
Bedforshire, MK45 2NR / GB
 [2022/32]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2022/32]
Application number, filing date21215491.826.11.2015
[2022/32]
Priority number, dateGB2014002108327.11.2014         Original published format: GB 201421083
[2022/32]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP4039681
Date:10.08.2022
Language:EN
[2022/32]
Search report(s)(Supplementary) European search report - dispatched on:EP01.07.2022
ClassificationIPC:C07D401/14, C07D413/14, A61K31/415, A61K31/454, A61K31/4709, A61K31/497, A61K31/506, C07D231/14, C07D401/06, C07D401/10, C07D403/10, C07D409/14
[2022/32]
CPC:
A61K31/4439 (EP,IL,KR,US); C07D413/14 (EP,CN,IL,KR,RU,US); C07D401/10 (EP,CN,IL,KR,RU,US);
C07D401/14 (EP,CN,IL,RU,US); A61K31/415 (RU); A61K31/445 (IL,US);
A61K31/454 (RU); A61K31/4709 (RU); A61K31/496 (EP,IL,US);
A61K31/497 (RU); A61K31/506 (RU); A61P19/02 (RU);
A61P27/02 (RU); A61P29/00 (RU); A61P3/10 (RU);
A61P43/00 (EP,IL,RU,US); A61P7/02 (RU); A61P7/10 (RU);
A61P9/00 (US); A61P9/02 (RU); A61P9/10 (RU);
C07D231/14 (EP,CN,IL,KR,RU,US); C07D401/06 (EP,CN,IL,RU,US); C07D403/10 (EP,CN,IL,KR,RU,US);
C07D409/14 (EP,CN,IL,KR,RU,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/11]
Former [2022/32]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
Extension statesBA09.02.2023
ME09.02.2023
Validation statesMA09.02.2023
MD09.02.2023
TitleGerman:N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMID-VERBINDUNGEN ALS PLASMA-KALLIKREIN-INHIBITOREN[2022/32]
English:N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS[2022/32]
French:COMPOSÉS DE N-((HÉT)ARYLMÉTHYL)HÉTÉROARYLE-CARBOXAMIDES EN TANT QU'INHIBITEURS DE LA KALLICRÉINE PLASMATIQUE[2022/32]
Examination procedure09.02.2023Examination requested  [2023/11]
09.02.2023Date on which the examining division has become responsible
03.03.2023Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
11.05.2023Amendment by applicant (claims and/or description)
Parent application(s)   TooltipEP15804210.1  / EP3224256
EP19176610.4  / EP3556752
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
11.05.2023Request for further processing filed
11.05.2023Full payment received (date of receipt of payment)
Request granted
22.05.2023Decision despatched
Fees paidRenewal fee
13.01.2022Renewal fee patent year 03
13.01.2022Renewal fee patent year 04
13.01.2022Renewal fee patent year 05
13.01.2022Renewal fee patent year 06
13.01.2022Renewal fee patent year 07
13.10.2022Renewal fee patent year 08
29.09.2023Renewal fee patent year 09
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Documents cited:Search[X]WO2005049578  (SMITHKLINE BEECHAM CORP [US], et al) [X] 1-5,11-15 * Formula (I); Intermediate 107; Example 46;; claim - *;
 [X]WO2007113289  (GLAXO GROUP LTD [GB], et al) [X] 1,2,5,6,11-15 * Formula (I); Compounds D68, E36, D70; page 26; claim - *;
 [YD]WO2012017020  (NOVARTIS AG [CH], et al) [YD] 1-15 * Formula (I); page 58; example 79; claim - *;
 [YD]WO2013111108  (NOVARTIS AG [CH]) [YD] 1-15 * Formula (I); page 26; example -; claim -; compounds 15, 16, 27 *;
 [YD]WO2014108679  (KALVISTA PHARMACEUTICALS LTD [GB]) [YD] 1-15 * Formula (I);; examples 25, 55, 56, 84, 124, 132-133; claim 22 *;
 [XPI]WO2014188211  (KALVISTA PHARMACEUTICALS LTD [GB]) [XP] 1-3,5-9,11-15 * Formula (I);; example -; claim - * [I] 1-15;
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 [X]  - Chemical catalogue: AKos Consulting and Solutions GmbH, "2-Thiophenecarboxamide, 4-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-N-[(1-ethyl-2- pyrrolidinyl)methyl]-5-(4-morpholinyl)", REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20090122), Database accession no. 1094996-93-6, XP055244198 [X] 1-4,7 * the whole document *
 [X]  - Chemical catalogue: Ukrorgsyntez Ltd, "1H-Pyrazole-4-carboxamide, N-[[4-[[(2-amino-2-oxoethyl)amino]carbonyl]phenyl]methyl]-3-(4- methylphenyl)-1-[(4-methylphenyl)methyl]-", REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20120803), Database accession no. 1386189-59-8, XP055244204 [X] 1-3,5,6 * the whole document *
 [X]  - Chemical Catalogue: Ambinter, "1H-Pyrazole-4-carboxamide,N-[[4-(acetylamino)phenyl]methyl]-3-(4-methylphenyl)-1-[(4-methylphenyl)methyl]-", REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20090802), Database accession no. 1171693-25-6, XP055244636 [X] 1-3,5,6 * the whole document *
 [X]  - Registry, "Chemical Catalog extract", Registry, (20140328), pages 1 - 3, URL: www.stnext.org, (20201111), XP055749595 [X] 1-9 * the whole document *
 [X]  - Anonymous, "Benzoic acid, 4-[[[(1-[(3-chlorophenyl) methyl]-3-methyl-1H-pyrazol-4yl]carbonyl]amino]methyl]-2-methoxy-", REGISTRY, Chemical Abstracts, (20140324), Database accession no. 1572751-33-7, URL: STN, XP055933991 [X] 1-9 * the whole document *
by applicantWO9204371
 US5187157
 WO9429335
 WO9507921
 WO03076458
 EP1426364
 WO2005123680
 WO2008016883
 WO2008049595
 WO2010142801
 EP2281885
 WO2011118672
 WO2012004678
 WO2012009009
 WO2012017020
 WO2013111107
 WO2013111108
 WO2014108679
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.