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Extract from the Register of European Patents

EP About this file: EP4117645

EP4117645 - COMBINATIONS OF BETA-LACTAM COMPOUNDS, PROBENECID, AND VALPROIC ACID AND USES THEREOF [Right-click to bookmark this link]
StatusGrant of patent is intended
Status updated on  21.01.2026
Database last updated on 09.04.2026
FormerExamination is in progress
Status updated on  30.05.2024
FormerRequest for examination was made
Status updated on  16.12.2022
FormerThe international publication has been made
Status updated on  17.09.2021
Formerunknown
Status updated on  23.03.2021
Most recent event   Tooltip25.03.2026New entry: Renewal fee paid 
Applicant(s)For all designated states
Iterum Therapeutics International Limited
Block 2 Floor 3 Harcourt Centre
Harcourt Street
Dublin, 2 / IE
[2023/03]
Inventor(s)01 / DUNNE, Michael
30 Cromwell Place
Old Saybrook, Connecticut 06475 / US
 [2023/03]
Representative(s)Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB
Ganghoferstraße 68 B
80339 München / DE
[N/P]
Former [2023/03]Cooley (UK) LLP
22 Bishopsgate
London EC2N 4BQ / GB
Application number, filing date21711548.411.03.2021
[2023/03]
WO2021EP56210
Priority number, dateUS202062987963P11.03.2020         Original published format: US 202062987963 P
[2023/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021180857
Date:16.09.2021
Language:EN
[2021/37]
Type: A1 Application with search report 
No.:EP4117645
Date:18.01.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 16.09.2021 takes the place of the publication of the European patent application.
[2023/03]
Search report(s)International search report - published on:EP16.09.2021
ClassificationIPC:A61K31/19, A61K31/245, A61K31/431, A61P31/04, A61P25/08
[2023/03]
CPC:
A61P31/04 (EP); A61K31/19 (EP,KR,US); A61K31/431 (EP,KR,US);
A61K31/18 (US); A61K31/195 (KR); A61K31/245 (EP);
A61K9/0019 (US); A61K9/0053 (US); A61K9/2086 (US);
A61K9/209 (KR); A61P25/08 (EP,KR); A61P25/14 (KR);
A61P25/18 (KR); A61K2300/00 (KR) (-)
C-Set:
A61K31/19, A61K2300/00 (EP);
A61K31/245, A61K2300/00 (EP);
A61K31/431, A61K2300/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/03]
TitleGerman:KOMBINATIONEN AUS BETA-LACTAM-VERBINDUNGEN, PROBENECID UND VALPROINSÄURE UND VERWENDUNGEN DAVON[2023/03]
English:COMBINATIONS OF BETA-LACTAM COMPOUNDS, PROBENECID, AND VALPROIC ACID AND USES THEREOF[2023/03]
French:ASSOCIATIONS DE COMPOSÉS DE BÊTA-LACTAME, DE PROBÉNÉCIDE ET D'ACIDE VALPROÏQUE ET LEURS UTILISATIONS[2023/03]
Entry into regional phase11.10.2022National basic fee paid 
11.10.2022Designation fee(s) paid 
11.10.2022Examination fee paid 
Examination procedure11.10.2022Examination requested  [2023/03]
11.10.2022Date on which the examining division has become responsible
02.05.2023Amendment by applicant (claims and/or description)
29.05.2024Despatch of a communication from the examining division (Time limit: M04)
17.09.2024Reply to a communication from the examining division
22.01.2026Communication of intention to grant the patent
Fees paidRenewal fee
27.03.2023Renewal fee patent year 03
02.04.2024Renewal fee patent year 04
26.02.2025Renewal fee patent year 05
23.03.2026Renewal fee patent year 06
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A] US2019374516  (DUNNE MICHAEL et al.)
 [I]   MIN KYU PARK ET AL: "Reduced Valproic Acid Serum Concentrations Due to Drug Interactions With Carbapenem Antibiotics: Overview of 6 Cases", THERAPEUTIC DRUG MONITORING, 1 October 2012 (2012-10-01), Hagerstown, MD, pages 599 - 603, XP055806656, Retrieved from the Internet [retrieved on 20210521], DOI: 10.1097/FTD.0b013e318260f7b3

DOI:   http://dx.doi.org/10.1097/FTD.0b013e318260f7b3
 [A]   AL-QUTEIMAT OSAMA ET AL: "Valproate Interaction With Carbapenems: Review and Recommendations", HOSPITAL PHARMACY, vol. 55, no. 3, 22 February 2019 (2019-02-22), pages 182 - 188, XP055806520, Retrieved from the Internet DOI: 10.1177/0018578719831974

DOI:   http://dx.doi.org/doi: 10.1177/0018578719831974
by applicantUS4522811
 US5763263
   RALPH G. DACEYMERLE A. SANDE, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 6, 1974, pages 437 - 441
   DOMINY ET AL., SCI. ADV., vol. 5, 2019, pages eaau3333
   LOIS M. EDNIEPETER C. APPELBAUM, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 53, 2009, pages 2163 - 2170
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   CAHNINGOLD, J. CHEM. SOC., vol. 1951, pages 612
   CAHN ET AL., EXPERIENTIA, vol. 12, 1956, pages 81
   CAHN, J. CHEM. EDUC., vol. 41, 1964, pages 116
   PATANILAVOIE, CHEM. REV., vol. 96, 1996, pages 3147 - 3176
   SMITH, M. B.MARCH, J.: "March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", 2001, JOHN WILEY & SONS
   GREENE, T.W.WUTS, P.G. M.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
   R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
   L. FIESERM. FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
   "Remington: the Science and Practice of Pharmacy", 1995, MACK PUBLISHING CO.
   AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 2005, JOHN WILEY AND SONS, INC.
   SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2000, COLD SPRING HARBOR PRESS
   FINGL ET AL., THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, 1975
   "Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
   MANDELL ET AL.: "Principles and Practice of Infectious Diseases", 2014, SAUNDERS PUBLISHING
   DEVLIN: "High Throughput Screening", 1998, MARCEL DEKKER
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.