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EP4127723
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EP About this file: EP4127723
| EP4127723 - PROGNOSTIC MARKERS OF DISEASE RECURRENCE IN LIVER TRANSPLANT RECIPIENTS WITH HEPATOCELLULAR CARCINOMA [Right-click to bookmark this link] | Status | The patent has been granted Status updated on 09.05.2025 Database last updated on 28.03.2026 | |
| Former | Grant of patent is intended Status updated on 17.02.2025 | ||
| Former | Examination is in progress Status updated on 28.09.2023 | ||
| Former | Request for examination was made Status updated on 06.01.2023 | ||
| Former | The international publication has been made Status updated on 02.10.2021 | ||
| Former | unknown Status updated on 31.03.2021 | Most recent event Tooltip | 30.01.2026 | Lapse of the patent in a contracting state New state(s): PL, SK | published on 04.03.2026 [2026/10] | Applicant(s) | For all designated states Universiteit Gent Sint-Pietersnieuwstraat 25 9000 Gent / BE | [2025/12] |
| Former [2023/06] | For all designated states Universiteit Gent Technologiepark Zwijnaarde 914 9052 Gent / BE | Inventor(s) | 01 /
VERHELST, Xavier Rooberg 1 9860 Landskouter / BE | 02 /
VAN VLIERBERGHE, Hans Rooigemstraat 11 9750 Kruisem / BE | [2023/06] | Application number, filing date | 21713692.8 | 25.03.2021 | [2023/06] | WO2021EP57788 | Priority number, date | EP20200166316 | 27.03.2020 Original published format: EP 20166316 | [2023/06] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2021191372 | Date: | 30.09.2021 | Language: | EN | [2021/39] | Type: | A1 Application with search report | No.: | EP4127723 | Date: | 08.02.2023 | Language: | EN | The application published by WIPO in one of the EPO official languages on 30.09.2021 takes the place of the publication of the European patent application. | [2023/06] | Type: | B1 Patent specification | No.: | EP4127723 | Date: | 11.06.2025 | Language: | EN | [2025/24] | Search report(s) | International search report - published on: | EP | 30.09.2021 | Classification | IPC: | G01N33/574 | [2023/06] | CPC: |
G01N33/57525 (EP,US);
G01N2400/00 (EP);
G01N2400/12 (US);
G01N2440/38 (EP);
G01N2800/245 (EP);
G01N2800/52 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2023/06]
| Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | PROGNOSTISCHE KRANKHEITSMARKER IN LEBERTRANSPLANTATIONSEMPFÄNGERN MIT HEPATOZELLULÄREM KARZINOM | [2023/06] | English: | PROGNOSTIC MARKERS OF DISEASE RECURRENCE IN LIVER TRANSPLANT RECIPIENTS WITH HEPATOCELLULAR CARCINOMA | [2023/06] | French: | MARQUEURS DE PRONOSTIC DE LA RÉCURRENCE DE LA MALADIE CHEZ LES RECEVEURS DE GREFFE DE FOIE ATTEINTS D'UN CARCINOME HÉPATOCELLULAIRE | [2025/08] |
| Former [2023/06] | MARQUEURS DE PRONOSTIC DE RÉCIDIVE DE MALADIE CHEZ DES RECEVEURS DE GREFFE HÉPATIQUE ATTEINT D'UN CARCINOME HÉPATOCELLULAIRE | Entry into regional phase | 18.08.2022 | National basic fee paid | 18.08.2022 | Designation fee(s) paid | 18.08.2022 | Examination fee paid | Examination procedure | 18.08.2022 | Examination requested [2023/06] | 18.08.2022 | Date on which the examining division has become responsible | 02.05.2023 | Amendment by applicant (claims and/or description) | 27.09.2023 | Despatch of a communication from the examining division (Time limit: M04) | 20.11.2023 | Reply to a communication from the examining division | 18.02.2025 | Communication of intention to grant the patent | 05.05.2025 | Fee for grant paid | 05.05.2025 | Fee for publishing/printing paid | 05.05.2025 | Receipt of the translation of the claim(s) | Fees paid | Renewal fee | 23.03.2023 | Renewal fee patent year 03 | 27.03.2024 | Renewal fee patent year 04 | 26.03.2025 | Renewal fee patent year 05 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | CZ | 11.06.2025 | HR | 11.06.2025 | PL | 11.06.2025 | SK | 11.06.2025 | SM | 11.06.2025 | NO | 11.09.2025 | RS | 11.09.2025 | GR | 12.09.2025 | IS | 11.10.2025 | [2026/10] |
| Former [2026/09] | CZ | 11.06.2025 | |
| HR | 11.06.2025 | ||
| SM | 11.06.2025 | ||
| NO | 11.09.2025 | ||
| RS | 11.09.2025 | ||
| GR | 12.09.2025 | ||
| IS | 11.10.2025 | ||
| Former [2026/08] | HR | 11.06.2025 | |
| SM | 11.06.2025 | ||
| NO | 11.09.2025 | ||
| RS | 11.09.2025 | ||
| GR | 12.09.2025 | ||
| IS | 11.10.2025 | ||
| Former [2026/07] | HR | 11.06.2025 | |
| NO | 11.09.2025 | ||
| RS | 11.09.2025 | ||
| GR | 12.09.2025 | ||
| IS | 11.10.2025 | ||
| Former [2025/48] | HR | 11.06.2025 | |
| NO | 11.09.2025 | ||
| RS | 11.09.2025 | ||
| GR | 12.09.2025 | ||
| Former [2025/47] | NO | 11.09.2025 | |
| GR | 12.09.2025 | Cited in | International search | [A] DECAENS T ET AL: "Factors associated with tumor recurrence after liver transplantation for hepatocellular carcinoma: prospective cohort on 371 patients", JOURNAL OF HEPATOLOGY, vol. 66, no. 1, 2017, XP085011823, ISSN: 0168-8278, DOI: 10.1016/S0168-8278(17)30694-3 DOI: http://dx.doi.org/10.1016/S0168-8278(17)30694-3 | [A] VERHELST XAVIER ET AL: "Glycome Patterns of Perfusate in Livers Before Transplantation Associate With Primary Nonfunction", GASTROENTEROLOGY : OFFICIAL PUBLICATION OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION, WILLIAMS & WILKINS, US, vol. 154, no. 5, 6 January 2018 (2018-01-06), pages 1361 - 1368, XP085372513, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2017.12.027 DOI: http://dx.doi.org/10.1053/j.gastro.2017.12.027 | [A] LIU X-E ET AL: "N-Glycomic Changes in Hepatocellular Carcinoma Patients with Liver Cirrhosis Induced by Hepatitis B Virus", HEPATOLOGY, JOHN WILEY & SONS, INC, US, vol. 46, no. 5, 1 January 2007 (2007-01-01), pages 1426 - 1435, XP002494797, ISSN: 0270-9139, DOI: 10.1002/HEP.21855 DOI: http://dx.doi.org/10.1002/hep.21855 | [A] XAVIER VERHELST ET AL: "A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis", CLINICAL CANCER RESEARCH, vol. 23, no. 11, 16 December 2016 (2016-12-16), US, pages 2750 - 2758, XP055691101, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-16-1500 DOI: http://dx.doi.org/10.1158/1078-0432.CCR-16-1500 | by applicant | CALLEWAERT ET AL., NAT MED, vol. 10, 2004, pages 429 | LAROY, W.CONTRERAS, R.CALLEWAERT, N.: "Glycome mapping on DNA sequencing equipment", NAT. PROTOC., vol. 1, 2006, pages 397 - 405, XP001538561 | DUVOUX CROUDOT-THORAVAL FDECAENS TPESSIONE FBADRAN HPIARDI TFRANCOZ CCOMPAGNON PVANLEMMENS CDUMORTIER J: "Liver Transplantation French Study Group. Liver transplantation for hepatocellular carcinoma: a model including a-fetoprotein improves the performance of Milan criteria", GASTROENTEROLOGY, vol. 143, no. 4, October 2012 (2012-10-01), pages 986 - 94 | MIYAHARA ET AL.: "Alteration of N-glycan profiles in patients with chronic hepatitis and hepatocellular carcinoma", HEPATOLOGY RESEARCH, 2015, pages 986, XP055691066, DOI: 10.1111/hepr.12441 DOI: http://dx.doi.org/10.1111/hepr.12441 | MIYAHARA ET AL.: "Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib", HEPATOLOGY, 2014, pages 355 | KAMAYAMA ET AL.: "Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis", HEPATOLOGY, 2013, pages 2314 | CALLEWAERT, N. ET AL.: "Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics", NAT. MED., vol. 10, 2004, pages 429 - 34, XP055538395, DOI: 10.1038/nm1006 DOI: http://dx.doi.org/10.1038/nm1006 |