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EP About this file: EP4162028

EP4162028 - METHODS FOR PRODUCING A (THREE DIMENSIONAL) NEURAL TISSUE [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  10.03.2023
Database last updated on 31.08.2024
FormerThe international publication has been made
Status updated on  17.12.2021
Formerunknown
Status updated on  07.07.2021
Most recent event   Tooltip02.04.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Technische Universiteit Eindhoven
Groene Loper 3
5612 AE Eindhoven / NL
[2023/15]
Inventor(s)01 / SABERI, Aref
5612 AE EINDHOVEN / NL
02 / KURNIAWAN, Nicholas Agung
5612 AE EINDHOVEN / NL
03 / BOUTEN, Carolina Victoria Catharina
5612 AE EINDHOVEN / NL
 [2023/15]
Representative(s)Algemeen Octrooi- en Merkenbureau B.V.
P.O. Box 645
5600 AP Eindhoven / NL
[2023/15]
Application number, filing date21734954.708.06.2021
[2023/15]
WO2021NL50363
Priority number, dateNL2020202578408.06.2020         Original published format: NL 2025784
[2023/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021251820
Date:16.12.2021
Language:EN
[2021/50]
Type: A1 Application with search report 
No.:EP4162028
Date:12.04.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 16.12.2021 takes the place of the publication of the European patent application.
[2023/15]
Search report(s)International search report - published on:EP16.12.2021
ClassificationIPC:C12N5/079
[2023/15]
CPC:
C12N5/0618 (EP); C12N5/0619 (US); C12N2501/115 (EP,US);
C12N2501/119 (EP,US); C12N2501/41 (EP); C12N2501/415 (EP);
C12N2506/00 (EP); C12N2506/45 (US); C12N2509/00 (US);
C12N2513/00 (US); C12N2533/90 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/15]
TitleGerman:VERFAHREN ZUR HERSTELLUNG EINES (DREIDIMENSIONALEN) NEURALEN GEWEBES[2023/15]
English:METHODS FOR PRODUCING A (THREE DIMENSIONAL) NEURAL TISSUE[2023/15]
French:PROCÉDÉS DE PRODUCTION D'UN TISSU NEURONAL (TRIDIMENSIONNEL)[2023/15]
Entry into regional phase22.12.2022National basic fee paid 
22.12.2022Designation fee(s) paid 
22.12.2022Examination fee paid 
Examination procedure22.12.2022Examination requested  [2023/15]
22.12.2022Date on which the examining division has become responsible
21.07.2023Amendment by applicant (claims and/or description)
Fees paidRenewal fee
27.06.2023Renewal fee patent year 03
31.03.2024Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]WO2015077648  (SLOAN KETTERING INST CANCER [US]) [X] 1-10,12,16-18 * example - *;
 [A]WO2017060884  (UNIVERSITÉ DU LUXEMBOURG [LU])[A] 1-18;
 [X]WO2017160234  (AGENCY SCIENCE TECH & RES [SG], et al) [X] 1-18 * paragraph [0157] - paragraph [0165]; example -; claim - *;
 [X]US2020087623  (KUMAMARU HIROMI [US], et al) [X] 1-10,12,16-18 * paragraph [0040] - paragraph [0045]; figure -; claim - *
by applicant   - QUADRATO, G. et al., "Cell diversity and network dynamics in photosensitive human brain organoids", Nature, (20170000), vol. 545, doi:10.1038/nature22047, pages 48 - 53, XP055476690

DOI:   http://dx.doi.org/10.1038/nature22047
    - GIANDOMENICO, S. L. et al., "Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output", Nat. Neurosci., (20190000), vol. 22, doi:10.1038/s41593-019-0350-2, pages 669 - 679, XP036928337

DOI:   http://dx.doi.org/10.1038/s41593-019-0350-2
    - BIREY, F., "Assembly of functionally integrated human forebrain spheroids", Nature, (20170000), vol. 545, doi:10.1038/nature22330, pages 54 - 59, XP055476749

DOI:   http://dx.doi.org/10.1038/nature22330
    - PA CA, A. M. et al., "Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture", Nat. Protoc., (20150000), vol. 12, doi:10.1038/nmeth.3415, pages 671 - 678, XP055477490

DOI:   http://dx.doi.org/10.1038/nmeth.3415
    - LANCASTER, M. A. et al., "Guided self-organization and cortical plate formation in human brain organoids", Nat. Biotechnol., (20170000), vol. 35, doi:10.1038/nbt.3906, pages 659 - 666, XP055468377

DOI:   http://dx.doi.org/10.1038/nbt.3906
    - LANCASTER, M. A.KNOBLICH, J. A., "Organogenesis in a dish: Modeling development and disease using organoid technologies", Science, (20140000), vol. 345, page 1247125
    - EIRAKU, M. et al., "Article Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals", Stem Cell, (20080000), vol. 3, doi:10.1016/j.stem.2008.09.002, pages 519 - 532, XP008141935

DOI:   http://dx.doi.org/10.1016/j.stem.2008.09.002
    - "Leading Process Dynamics During Neuronal Migration", VALDEOLMILLOS, M.MOYA, F., Cellular Migration and Formation of Neuronal Connections, Academic Press, (20130000), pages 245 - 260
    - OHTAKA-MARUYAMA, C. et al., "Synaptic transmission from subplate neurons controls radial migration of neocortical neurons", Science, (20180000), vol. 360, pages 313 - 317
    - ROBINSON, H. P. et al., "Periodic synchronized bursting and intracellular calcium transients elicited by low magnesium in cultured cortical neurons", J. Neurophysiol., (19930000), vol. 70, pages 1606 - 1616
    - EGUILUZ, V. M., CHIALVO, D. R., CECCHI, G. A., BALIKI, M., APKARIAN, A. V., "Scale-Free Brain Functional Networks", Phys. Rev. Lett., (20050000), vol. 94, page 018102
    - FELDT, S.BONIFAZI, P.COSSART, R., "Dissecting functional connectivity of neuronal microcircuits : experimental and theoretical insights", Trends Neurosci., (20110000), vol. 34, doi:10.1016/j.tins.2011.02.007, pages 225 - 236, XP028207844

DOI:   http://dx.doi.org/10.1016/j.tins.2011.02.007
    - BATISTA, C. A. S., BATISTA, A. M., PONTES, J. A. C. DE, VIANA, R. L., LOPES, S., "R. Chaotic phase synchronization in scale-free networks of bursting neurons", Phys. Rev. E, (20070000), vol. 76, page 016218
    - GRINSTEIN, G.LINSKER, R., "Synchronous neural activity in scale-free network models versus random network models", Proc. Natl. Acad. Sci., (20050000), vol. 102, pages 9948 - 9953
    - BARABASI, A.REKA, A., "Emergence of Scaling in Random Networks", Science, (19990000), vol. 286, pages 509 - 512
    - HE, B. J., "Scale-free brain activity: past, present and future", Trends Cogn Sci, (20150000), vol. 18, pages 480 - 487
    - MCINTOSH, A. R., "Towards a network theory of cognition", Neural Networks, (20000000), vol. 13, doi:10.1016/S0893-6080(00)00059-9, pages 861 - 870, XP004226349

DOI:   http://dx.doi.org/10.1016/S0893-6080(00)00059-9
    - COHEN, J. R.ESPOSITO, M. D., "The Segregation and Integration of Distinct Brain Networks and Their Relationship to Cognition", J. Neurosci., (20160000), vol. 36, pages 12083 - 12094
    - BLONDEL, V. D.GUILLAUME, J.LAMBIOTTE, R.LEFEBVRE, E., "Fast unfolding of communities in large networks", J. Stat. Mech. theory Exp., (20080000), vol. 10, page 10008
    - PEDERSEN, M.ZALESKY, A.OMIDVARNIA, A.JACKSON, G. D., "Multilayer network switching rate predicts brain performance", Proc. Natl. Acad. Sci., (20180000), vol. 115, pages 13376 - 13381
    - HEUVEL, M. P. VAN DENSTAM, C. J.KAHN, S.POL, H. E. H., "Efficiency of Functional Brain Networks and Intellectual Performance", J. Neurosci., (20090000), vol. 29, pages 7619 - 7624
    - FRUCHTERMAN, T. M. J.REINGOLD, E. M., "Graph Drawing by Force-directed Placement", Software-practice Exp., (19910000), vol. 21, doi:10.1002/spe.4380211102, pages 1129 - 1164, XP000276626

DOI:   http://dx.doi.org/10.1002/spe.4380211102
    - FISHER, R. S., "Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology", Zeitschrift fur Epileptol., (20170000), vol. 58, pages 522 - 530
    - JOHNSON, H. C.WALKER, E., "Intraventricular penicillin: a note of warning", J. Am. Med. Assoc., (19450000), vol. 127, pages 217 - 219
    - AVOLI, M.JEFFERYS, J. G. R., "Models of drug-induced epileptiform synchronization in vitro", J. Neurosci. Methods, (20160000), vol. 260, doi:10.1016/j.jneumeth.2015.10.006, pages 26 - 32, XP029406061

DOI:   http://dx.doi.org/10.1016/j.jneumeth.2015.10.006
    - "Electrophysiological and modeling insights toward the mechanism", Mol. Cell. Neurosci., (20140000), vol. 63, pages 72 - 82
    - TREIMAN, D. M., "GABAergic mechanisms in epilepsy", Epilepsia, (20010000), vol. 42, pages 8 - 12
    - KATZ, L. C., SHATZ, C. J., "Synaptic Activity and the ConstructKatz, LC; Shatz, CJion of Cortical Circuits", Science, (19960000), vol. 274, pages 1133 - 1138
    - ZHANG, L. I.POO, M. M., "Electrical activity of neural circuits", Nat. Neurosci., (20010000), vol. 4, pages 1207 - 1214
    - BHADURI, A., "Cell stress in cortical organoids impairs molecular subtype specification", Nature, (20200000), vol. 578, doi:10.1038/s41586-020-1962-0, pages 142 - 148, XP037008100

DOI:   http://dx.doi.org/10.1038/s41586-020-1962-0
    - SOLIMAN, M. A.ABOHARB, F.ZELTNER, N.STUDER, L., "Pluripotent stem cells in neuropsychiatric disorders", Mol. Psychiatry, (20170000), vol. 22, pages 1241 - 1249
    - NOBILI, A., "Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease Annalisa", Nat. Commun., (20170000), vol. 8, pages 1 - 14
    - LUBRINI, G.MARTIN-MONTES, A.DIEZ-ASCASO, O.DIEZ-TEJEDOR, E., "Brain disease, connectivity, plasticity and cognitive therapy: A neurological view of mental disorders", Neurologia, (20180000), vol. 33, pages 187 - 191
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