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Extract from the Register of European Patents

EP About this file: EP4121523

EP4121523 - SINGLE CELL WORKFLOW FOR WHOLE GENOME AMPLIFICATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.03.2026
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  04.04.2025
FormerGrant of patent is intended
Status updated on  20.11.2024
FormerExamination is in progress
Status updated on  18.10.2024
FormerRequest for examination was made
Status updated on  23.12.2022
FormerThe international publication has been made
Status updated on  08.06.2022
Most recent event   Tooltip13.03.2026No opposition filed within time limitpublished on 15.04.2026 [2026/16]
Applicant(s)For all designated states
Mission Bio, Inc.
400 E Jamie Ct, Suite 100
South San Francisco, California 94080 / US
[2023/04]
Inventor(s)01 / DHINGRA, Dalia
c/o MISSION BIO, INC. 400 E Jamie Ct, Suite 100
South San Francisco, CA 94080 / US
02 / RUFF, David
c/o MISSION BIO, INC. 400 E Jamie Ct, Suite 100
South San Francisco, CA 94080 / US
 [2023/04]
Representative(s)Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
[2023/04]
Application number, filing date21772292.519.03.2021
[2023/04]
WO2021US23145
Priority number, dateUS202062992772P20.03.2020         Original published format: US 202062992772 P
[2023/04]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021188889
Date:23.09.2021
Language:EN
[2021/38]
Type: A1 Application with search report 
No.:EP4121523
Date:25.01.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 23.09.2021 takes the place of the publication of the European patent application.
[2023/04]
Type: B1 Patent specification 
No.:EP4121523
Date:07.05.2025
Language:EN
[2025/19]
Search report(s)International search report - published on:US23.09.2021
(Supplementary) European search report - dispatched on:EP16.01.2024
ClassificationIPC:C12N9/12, C12N15/10, C12Q1/6806, C12Q1/6869
[2023/04]
CPC:
C12N9/22 (EP); C12Q1/6869 (EP,US); B01L3/502761 (US);
B01L7/52 (US); C12N15/1065 (US); C12N15/1093 (EP);
C12Q1/6806 (EP,US); B01L2200/0647 (US); B01L2200/0673 (US);
B01L2300/18 (US); C12Q1/6844 (US); C12Q2600/16 (US) (-)
C-Set:
C12N15/1093, C12Q2525/191, C12Q2531/113, C12Q2535/122, C12Q2563/157 (EP);
C12Q1/6806, C12Q2521/537, C12Q2525/191, C12Q2527/101, C12Q2531/113, C12Q2535/122, C12Q2563/157 (EP);
C12Q1/6806, C12Q2521/537, C12Q2527/101, C12Q2535/122, C12Q2537/149, C12Q2563/159, C12Q2563/179 (EP);
C12Q1/6869, C12Q2525/191, C12Q2527/101, C12Q2531/113, C12Q2563/157 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/04]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:EINZELZELLENARBEITSABLAUF FÜR GESAMTGENOMAMPLIFIKATION[2023/04]
English:SINGLE CELL WORKFLOW FOR WHOLE GENOME AMPLIFICATION[2023/04]
French:FLUX DE TRAVAIL UNICELLULAIRE POUR L'AMPLIFICATION DU GÉNOME ENTIER[2023/04]
Entry into regional phase11.10.2022National basic fee paid 
11.10.2022Search fee paid 
11.10.2022Designation fee(s) paid 
11.10.2022Examination fee paid 
Examination procedure11.10.2022Examination requested  [2023/04]
26.07.2024Amendment by applicant (claims and/or description)
26.07.2024Date on which the examining division has become responsible
16.10.2024Despatch of a communication from the examining division (Time limit: M04)
17.10.2024Reply to a communication from the examining division
21.11.2024Communication of intention to grant the patent
11.03.2025Fee for grant paid
11.03.2025Fee for publishing/printing paid
11.03.2025Receipt of the translation of the claim(s)
Opposition(s)10.02.2026No opposition filed within time limit [2026/16]
Fees paidRenewal fee
27.03.2023Renewal fee patent year 03
27.03.2024Renewal fee patent year 04
27.03.2025Renewal fee patent year 05
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT07.05.2025
BG07.05.2025
CZ07.05.2025
DK07.05.2025
EE07.05.2025
ES07.05.2025
FI07.05.2025
HR07.05.2025
IT07.05.2025
LV07.05.2025
NL07.05.2025
PL07.05.2025
SK07.05.2025
SM07.05.2025
NO07.08.2025
RS07.08.2025
GR08.08.2025
IS07.09.2025
PT08.09.2025
[2026/10]
Former [2026/09]AT07.05.2025
BG07.05.2025
CZ07.05.2025
DK07.05.2025
ES07.05.2025
FI07.05.2025
HR07.05.2025
LV07.05.2025
NL07.05.2025
PL07.05.2025
SM07.05.2025
NO07.08.2025
RS07.08.2025
GR08.08.2025
IS07.09.2025
PT08.09.2025
Former [2026/08]AT07.05.2025
BG07.05.2025
DK07.05.2025
ES07.05.2025
FI07.05.2025
HR07.05.2025
LV07.05.2025
NL07.05.2025
PL07.05.2025
SM07.05.2025
NO07.08.2025
RS07.08.2025
GR08.08.2025
IS07.09.2025
PT08.09.2025
Former [2025/49]AT07.05.2025
BG07.05.2025
ES07.05.2025
FI07.05.2025
HR07.05.2025
LV07.05.2025
NL07.05.2025
PL07.05.2025
NO07.08.2025
RS07.08.2025
GR08.08.2025
IS07.09.2025
PT08.09.2025
Former [2025/48]AT07.05.2025
BG07.05.2025
ES07.05.2025
FI07.05.2025
HR07.05.2025
NL07.05.2025
PL07.05.2025
NO07.08.2025
RS07.08.2025
GR08.08.2025
PT08.09.2025
Former [2025/47]BG07.05.2025
ES07.05.2025
FI07.05.2025
NL07.05.2025
PL07.05.2025
NO07.08.2025
GR08.08.2025
PT08.09.2025
Former [2025/46]ES07.05.2025
FI07.05.2025
PT08.09.2025
Documents cited:Search[X] WO2018226708  (UNIV OREGON HEALTH & SCIENCE et al.) [X] 15 * figure 1 *
 [X] WO2019204229  (ILLUMINA INC et al.) [X] 15 * figure 11; examples 1, 3; claims 1,9 *
International search[XY] WO2019222688  (ILLUMINA INC et al.) [X] 107-112 * entire document *[Y] 6
 [X] US2018023119  (ADEY ANDREW C et al.) [X] 113, 114 * entire document *
 [Y] WO2018119301  (UNIV CALIFORNIA et al.) [Y] 16, 9, 35-37, 53-58, 61,87-89 * entire document *
 [Y] WO2018218226  (10X GENOMICS INC et al.) [Y] 1-6, 9, 35-37, 53-58, 61,87-89 * entire document *
 [A] WO2019222657  (UNIV JOHNS HOPKINS et al.) [A] 1-6, 9, 35-37, 53-58, 61,87-89, 107-114 * entire document *
 [A] WO2019033062  (METABIOTECH CORP et al.) [A] 1-6, 9, 35-37, 53-58, 61,87-89, 107-114 * entire document *
by applicantWO2018226708
 WO2019204229
 WO0028082
 US7405281
 US2016016444
 US2015232942
 US6210891
 US6258568
 US6833246
 US7115400
 US6969488
 US5912148
 US6130073
 US7169560
 US7282337
 US7482120
 US7501245
 US6818395
 US6911345
 US2009026082
 US2009127589
 US2010301398
 US2010197507
 US2010188073
 US2010137143
 US2020051663
 US2020026480
 US2020026482
 US2018216160
 US2020232011
   AUSUBEL ET AL.: "Current Protocols In Molecular Biology", 1993, JOHN WILEY & SONS
   ALTSCHUL ET AL., NUC. ACIDS RES., vol. 25, 1977, pages 3389 - 3402
   SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
   NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
   VOELKERDING ET AL., CLINICAL CHEM., vol. 55, 2009, pages 641 - 658
   MACLEAN ET AL., NATURE REV. MICROBIOL., vol. 7, pages 287 - 296
   MARGULIES ET AL., NATURE, vol. 437, 2005, pages 376 - 380
   ADDITIONAL DETAILS FOR ION TORRENT TECHNOLOGY IS FOUND IN SCIENCE, vol. 327, no. 5970, 2010, pages 1190
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.