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Extract from the Register of European Patents

EP About this file: EP4146201

EP4146201 - TREATMENT OF PROLIFERATIVE DISEASES OF THE CNS [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  10.02.2023
Database last updated on 11.09.2024
FormerThe international publication has been made
Status updated on  12.11.2021
Most recent event   Tooltip02.08.2024Change - applicantpublished on 04.09.2024  [2024/36]
Applicant(s)For all designated states
Aucentra Therapeutics Pty Ltd
43/7 Liberman Close
Adelaide, SA 5000 / AU
[2024/36]
Former [2023/11]For all designated states
Aucentra Therapeutics Pty Ltd
C/- Bentleys Pty Ltd.
Level 5
63 Pirie Street
Adelaide SA 5000 / AU
Inventor(s)01 / WANG, Shudong
Adelaide, South Australia 5000 / AU
 [2023/11]
Representative(s)Gill Jennings & Every LLP
The Broadgate Tower
20 Primrose Street
London EC2A 2ES / GB
[2023/11]
Application number, filing date21799549.705.05.2021
[2023/11]
WO2021AU00036
Priority number, dateAU2020090143506.05.2020         Original published format: AU 2020901435
[2023/11]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021222967
Date:11.11.2021
Language:EN
[2021/45]
Type: A1 Application with search report 
No.:EP4146201
Date:15.03.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 11.11.2021 takes the place of the publication of the European patent application.
[2023/11]
Search report(s)International search report - published on:AU11.11.2021
(Supplementary) European search report - dispatched on:EP20.03.2024
ClassificationIPC:A61K31/427, A61K31/506, C07D417/14, A61P35/00, A61K31/495, A61K45/06
[2024/16]
CPC:
A61P35/00 (EP,AU,US); A61K31/506 (EP,AU,US); A61K31/4184 (AU,US);
A61K31/436 (AU); A61K31/439 (US); A61K31/4439 (AU,US);
A61K31/495 (EP,AU,US); A61K45/06 (EP); A61P25/00 (US);
A61P35/02 (AU); A61K2300/00 (AU) (-)
C-Set:
A61K31/4184, A61K2300/00 (AU);
A61K31/436, A61K2300/00 (AU);
A61K31/4439, A61K2300/00 (AU);
A61K31/495, A61K2300/00 (AU,EP);
A61K31/506, A61K2300/00 (AU,EP)
(-)
Former IPC [2023/11]A61K31/427, A61K31/506, C07D417/14, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/11]
TitleGerman:BEHANDLUNG PROLIFERATIVER ERKRANKUNGEN DES ZNS[2023/11]
English:TREATMENT OF PROLIFERATIVE DISEASES OF THE CNS[2023/11]
French:TRAITEMENT DE MALADIES PROLIFÉRATIVES DU SNC[2023/11]
Entry into regional phase14.10.2022National basic fee paid 
14.10.2022Search fee paid 
14.10.2022Designation fee(s) paid 
14.10.2022Examination fee paid 
Examination procedure14.10.2022Examination requested  [2023/11]
Fees paidRenewal fee
06.04.2023Renewal fee patent year 03
01.03.2024Renewal fee patent year 04
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Cited inInternational search[X]WO2017020065  (UNIV SOUTH AUSTRALIA [AU]) [X] 1-15 * [0011]; [0065]-[0071]; [00213]; tables 1-2, 4 *;
 [A]  - Solomon Tadesse; Laychiluh Bantie; Khamis Tomusange; Mingfeng Yu; Saiful Islam; Nataliya Bykovska; Benjamin Noll; Ge Zhu; Peng Li; Frankie Lam; Malika Kumarasiri; Robert Milne; Shudong Wang, "Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin‐dependent kinases 4 and 6 as anticancer agents", BRITISH JOURNAL OF PHARMACOLOGY, Wiley-Blackwell, UK, UK , (20180508), vol. 175, no. 12, doi:10.1111/bph.13974, ISSN 0007-1188, pages 2399 - 2413, XP071172417 [A] 1-15 * Tables 1-2; figure 3 *

DOI:   http://dx.doi.org/10.1111/bph.13974
 [A]  - Tadesse Solomon, Yu Mingfeng, Mekonnen Laychiluh B., Lam Frankie, Islam Saiful, Tomusange Khamis, Rahaman Muhammed H., Noll Benjamin, Basnet Sunita K. C., Teo Theodosia, Albrecht Hugo, Milne Robert, Wang Shudong, "Highly Potent, Selective, and Orally Bioavailable 4-Thiazol- N -(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation", Journal of Medicinal Chemistry, American Chemical Society, US, US , (20170309), vol. 60, no. 5, doi:10.1021/acs.jmedchem.6b01670, ISSN 0022-2623, pages 1892 - 1915, XP055870680 [A] 1-15 * Abstract; scheme 3; tables 1, 3 *

DOI:   http://dx.doi.org/10.1021/acs.jmedchem.6b01670
 [A]  - Cao Yingxiao, Li Xin, Kong Shiqi, Shang Shuling, Qi Yanhui, "CDK4/6 inhibition suppresses tumour growth and enhances the effect of temozolomide in glioma cells", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, RO , (20200501), vol. 24, no. 9, doi:10.1111/jcmm.15156, ISSN 1582-1838, pages 5135 - 5145, XP055870678 [A] 1-15 * . Whole document; in particular: abstract; page 5139, col. 1, para. 3 - col. 2, para. 2. *

DOI:   http://dx.doi.org/10.1111/jcmm.15156
 [A]  - Bing Li, Hua He, Bang-Bao Tao, Zhen-Yu Zhao, Guo-Han Hu, Chun Luo, Ju-Xiang Chen, Xue-Hua Ding, Ping Sheng, Yan Dong, Ling Zhang, Yi-Cheng Lu, "Knockdown of CDK6 enhances glioma sensitivity to chemotherapy", Oncology Reports, Athens, (20120000), vol. 28, no. 3, doi:10.3892/or.2012.1884, ISSN 1021-335X, pages 909 - 914, XP009532085 [A] 1-15 * Whole document; in particular: abstract; figure 4. *

DOI:   http://dx.doi.org/10.3892/or.2012.1884
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.