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Extract from the Register of European Patents

EP About this file: EP4240341

EP4240341 - HICA FOR USE IN PROPHYLAXIS AND/OR TREATMENT OF A DISEASE OR CONDITION INVOLVING DEGRADATION OF CARTILAGE AND/OR DISRUPTION OF CARTILAGE HOMEOSTASIS AND/OR INTEGRITY [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  11.08.2023
Database last updated on 16.07.2024
FormerThe international publication has been made
Status updated on  13.05.2022
Formerunknown
Status updated on  01.12.2021
Most recent event   Tooltip12.01.2024Change: Validation statespublished on 14.02.2024  [2024/07]
12.01.2024Change - extension statespublished on 14.02.2024  [2024/07]
Applicant(s)For all designated states
SALARUSTA OY
Ville Vallgrenin Tie 8 B
02600 Espoo / FI
[2023/37]
Inventor(s)01 / SORSA, Timo
00200 Helsinki / FI
02 / TERVAHARTIALA, Taina
01730 Vantaa / FI
03 / KARILA, Tuomo
01680 Vantaa / FI
04 / COHEN, Beniamin
02600 Espoo / FI
 [2023/37]
Representative(s)Papula Oy
P.O. Box 981
00101 Helsinki / FI
[2023/37]
Application number, filing date21810648.205.11.2021
[2023/37]
WO2021FI50750
Priority number, dateFI2020000612406.11.2020         Original published format: FI 20206124
[2023/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022096789
Date:12.05.2022
Language:EN
[2022/19]
Type: A1 Application with search report 
No.:EP4240341
Date:13.09.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 12.05.2022 takes the place of the publication of the European patent application.
[2023/37]
Search report(s)International search report - published on:EP12.05.2022
ClassificationIPC:A61K31/19, A61P19/02
[2023/37]
CPC:
A61K31/19 (EP,FI,US); A61P19/02 (EP,FI); C07C59/01 (FI)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/37]
TitleGerman:HICA ZUR VERWENDUNG BEI DER PROPHYLAXE UND/ODER BEHANDLUNG EINER ERKRANKUNG ODER EINES LEIDENS MIT ABBAU VON KNORPEL UND/ODER UNTERBRECHUNG VON KNORPELHOMÖOSTASE UND/ODER INTEGRITÄT[2023/37]
English:HICA FOR USE IN PROPHYLAXIS AND/OR TREATMENT OF A DISEASE OR CONDITION INVOLVING DEGRADATION OF CARTILAGE AND/OR DISRUPTION OF CARTILAGE HOMEOSTASIS AND/OR INTEGRITY[2023/37]
French:HICA DESTINÉ À ÊTRE UTILISÉ DANS LA PROPHYLAXIE ET/OU LE TRAITEMENT D'UNE MALADIE OU D'UN ÉTAT PATHOLOGIQUE IMPLIQUANT LA DÉGRADATION DU CARTILAGE ET/OU LA RUPTURE DE L'HOMÉOSTASIE ET/OU DE L'INTÉGRITÉ DU CARTILAGE[2023/37]
Entry into regional phase05.06.2023National basic fee paid 
05.06.2023Designation fee(s) paid 
05.06.2023Examination fee paid 
Examination procedure05.09.2022Request for preliminary examination filed
International Preliminary Examining Authority: EP
05.06.2023Amendment by applicant (claims and/or description)
05.06.2023Examination requested  [2023/37]
05.06.2023Date on which the examining division has become responsible
Fees paidRenewal fee
15.11.2023Renewal fee patent year 03
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[Y]  - CHARLES H. LANG ET AL, "Chronic -hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy", AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM., US, (20130801), vol. 305, no. 3, doi:10.1152/ajpendo.00618.2012, ISSN 0193-1849, pages E416 - E428, XP055691993 [Y] 1-14 * See the abstract *

DOI:   http://dx.doi.org/10.1152/ajpendo.00618.2012
 [Y]  - NISHIZAKI K ET AL, "PP284-SUN: Effect of Supplementation with a Combination of [beta]-Hydroxy [beta]-Methylbutyrate, L-Arginine, and L-Glutamine on Quadriceps Muscle Strength in Patients with Osteoarthritis Following Total Knee Arth", CLINICAL NUTRITION, (201409), vol. 33, doi:10.1016/S0261-5614(14)50325-1, ISSN 0261-5614, XP029070559 [Y] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0261-5614(14)50325-1
 [T]  - ALWAY STEPHEN E ET AL, "[beta]-Hydroxy-[beta]-methylbutyrate (HMB) enhances the proliferation of satellite cells in fast muscles of aged rats during recovery from disuse atrophy", EXPERIMENTAL GERONTOLOGY,, (20130901), vol. 48, no. 9, doi:10.1016/J.EXGER.2013.06.005, ISSN 1873-6815, pages 973 - 984, XP002792976 [T] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.exger.2013.06.005
by applicant   - "CAS", Database accession no. 498-36-2
    - ANDERSON, D. D.S. CHUBINSKAYAF. GUILAKJ. A. MARTINT. R. OEGEMAS. A. OLSONJ. A. BUCKWALTER, "Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention", J Orthop Res, (20110000), vol. 29, no. 6, doi:10.1002/jor.21359, pages 802 - 809, XP055086449

DOI:   http://dx.doi.org/10.1002/jor.21359
    - BARRETO, G.A. SOININENP. YLINENJ. SANDELINY. T. KONTTINEND. C. NORDSTROMK. K. EKLUND, "Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis", Arthritis Res Ther, (20150000), vol. 17, page 379
    - BERENBAUM, F., "Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis", Osteoarthritis Cartilage, (20130000), vol. 21, no. 1, pages 16 - 21
    - CHOCKALINGAM, P.W. SUNM. RIVERA-BERMUDEZW. ZENGD. DUFIELDS. LARSSONL. S. LOHMANDERC. FLANNERYS. GLASSONK. GEORGIADIS, "Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor", Osteoarthritis and cartilage, (20110000), vol. 19, no. 3, doi:10.1016/j.joca.2010.12.004, pages 315 - 323, XP028152877

DOI:   http://dx.doi.org/10.1016/j.joca.2010.12.004
    - CHOI, E. Y.E. CHAVAKISM. A. CZABANKAH. F. LANGERL. FRAEMOHSM. ECONOMOPOULOUR. K. KUNDUA. ORLANDIY. Y. ZHENGD. A. PRIETO, "Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment", Science, (20080000), vol. 322, no. 5904, doi:10.1126/science.1165218, pages 1101 - 1104, XP055165830

DOI:   http://dx.doi.org/10.1126/science.1165218
    - CHU, Q.M. LOPEZK. HAYASHIM. IONESCUR. C. BILLINGHURSTK. A. JOHNSONA. R. POOLEM. D. MARKEL, "Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog", Osteoarthritis Cartilage, (20020000), vol. 10, no. 8, pages 662 - 669
    - CREAMER, P.M. C. HOCHBERG, "Osteoarthritis", Lancet, (19970000), vol. 350, no. 9076, doi:10.1016/S0140-6736(97)07226-7, pages 503 - 508, XP005106870

DOI:   http://dx.doi.org/10.1016/S0140-6736(97)07226-7
    - DEBERG, M.A. LABASSES. CHRISTGAUP. CLOOSD. BANG HENRIKSENJ. P. CHAPELLEB. ZEGELSJ. Y. REGINSTERY. HENROTIN, "New serum biochemical markers (Coll 2-1 and Coll 2-1 N02) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis", Osteoarthritis Cartilage, (20050000), vol. 13, no. 3, doi:10.1016/j.joca.2004.12.002, pages 258 - 265, XP004757510

DOI:   http://dx.doi.org/10.1016/j.joca.2004.12.002
    - DOUGADOS, M., "Evaluation of disease progression during nonsteroidal antiinflammatory drug treatment: imaging by arthroscopy", Osteoarthritis Cartilage, (19990000), vol. 7, no. 3, pages 345 - 347
    - DOUGADOS, M., "The role of anti-inflammatory drugs in the treatment of osteoarthritis: a European viewpoint", Clin Exp Rheumatol, (20010000), vol. 19, pages 9 - 14
    - ESKAN, M. A.R. JOTWANIT. ABEJ. CHMELARJ. H. LIMS. LIANGP. A. CIEROJ. L. KRAUSSF. LIM. RAUNER, "The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss", Nat Immunol, (20120000), vol. 13, no. 5, doi:10.1038/ni.2260, pages 465 - 473, XP055672883

DOI:   http://dx.doi.org/10.1038/ni.2260
    - FELSON, D. T., "Osteoarthritis: priorities for osteoarthritis research: much to be done", Nat Rev Rheumatol, (20140000), vol. 10, no. 8, pages 447 - 448
    - FEX, E.K. EBERHARDTT. SAXNE, "Tissue-derived macromolecules and markers of inflammation in serum in early rheumatoid arthritis: relationship to development of joint destruction in hands and feet", Br J Rheumatol, (19970000), vol. 36, no. 11, pages 1161 - 1165
    - FLANNERY, C. R.C. B. LITTLEC. E. HUGHESB. CATERSON, "Expression of ADAMTS homologues in articular cartilage", Biochemical and biophysical research communications, (19990000), vol. 260, no. 2, doi:10.1006/bbrc.1999.0909, pages 318 - 322, XP002943448

DOI:   http://dx.doi.org/10.1006/bbrc.1999.0909
    - FOSANG, A. J.K. LASTV. KNAUPERG. MURPHYP. J. NEAME, "Degradation of cartilage aggrecan by collagenase-3 (MMP-13", FEBS letters, (19960000), vol. 380, no. 1-2, pages 17 - 20
    - GARNERO, P.J. C. ROUSSEAUP. D. DELMAS, "Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases", Arthritis Rheum, (20000000), vol. 43, no. 5, doi:10.1002/1529-0131(200005)43:5<953::AID-ANR1>3.0.CO;2-Q, pages 953 - 968, XP002340001

DOI:   http://dx.doi.org/10.1002/1529-0131(200005)43:5<953::AID-ANR1>3.0.CO;2-Q
    - GEORGES, C.H. VIGNERONX. AYRALV. LISTRATP. RAVAUDM. DOUGADOSM. SHARIFP. DIEPPET. SAXNE, "Serum biologic markers as predictors of disease progression in osteoarthritis of the knee", Arthritis Rheum, (19970000), vol. 40, no. 3, pages 590 - 591
    - GLASSON, S. S.R. ASKEWB. SHEPPARDB. CARITOT. BLANCHETH.-L. MAC. R. FLANNERYD. PELUSOK. KANKIZ. YANG, "Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis", Nature, (20050000), vol. 434, no. 7033, doi:10.1038/nature03369, page 644, XP003003284

DOI:   http://dx.doi.org/10.1038/nature03369
    - GOLDBERG, R. L.J. P. HUFFM. E. LENZP. GLICKMANR. KATZE. J. THONAR, "Elevated plasma levels of hyaluronate in patients with osteoarthritis and rheumatoid arthritis", Arthritis Rheum, (19910000), vol. 34, no. 7, pages 799 - 807
    - GUILAK, F.R. J. NIMSA. DICKSC.-L. WUI. MEULENBELT, "Osteoarthritis as a disease of the cartilage pericellular matrix", Matrix Biology, (20180000), vol. 71, pages 40 - 50
    - HANEMAAIJER, R.H. VISSERY. T. KONTTINENP. KOOLWIJKJ. H. VERHEIJEN, "A novel and simple immunocapture assay for determination of gelatinase-B (MMP-9) activities in biological fluids: saliva from patients with Sjogren's syndrome contain increased latent and active gelatinase-B levels", Matrix Biol, (19980000), vol. 17, no. 8-9, pages 657 - 665
    - HONORATI, M. C.M. BOVARAL. CATTINIA. PIACENTINIA. FACCHINI, "Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis", Osteoarthritis Cartilage, (20020000), vol. 10, no. 10, pages 799 - 807
    - HOU, W. S.Z. LIR. E. GORDONK. CHANM. J. KLEINR. LEVYM. KEYSSERG. KEYSZERD. BROMME, "Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation", Am J Pathol, (20010000), vol. 159, no. 6, pages 2167 - 2177
    - HUANG, Z.C. DINGT. LIS. P. YU, "Current status and future prospects for disease modification in osteoarthritis", Rheumatology (Oxford, (20180000), vol. 57, pages iv108 - iv123
    - HUNTER, D. J.J. LIM. LAVALLEYD. C. BAUERM. NEVITTJ. DEGROOTR. POOLED. EYREA. GUERMAZID. GALE, "Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study", Arthritis Res Ther, (20070000), vol. 9, no. 5, page R108, XP021041146
    - JAHN, S.J. KLEIN, "Lubrication of articular cartilage", Physics Today, (20180000), vol. 71, no. 4, pages 48 - 54
    - KARSDAL, M. A.S. H. MADSENC. CHRISTIANSENK. HENRIKSENA. J. FOSANGB. C. SONDERGAARD, "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity", Arthritis Res Ther, (20080000), vol. 10, no. 3, page R63, XP021041230
    - KOJIMA, T.F. MWALET. YASUDAC. GIRARDA. R. POOLES. LAVERTY, "Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis", Arthritis Rheum, (20010000), vol. 44, no. 1, doi:10.1002/1529-0131(200101)44:1<120::AID-ANR16>3.0.CO;2-X, pages 120 - 127, XP003023406

DOI:   http://dx.doi.org/10.1002/1529-0131(200101)44:1<120::AID-ANR16>3.0.CO;2-X
    - KRUEGER, R. C., JR.T. A. FIELDSJ. T. HILDRETHN. B. SCHWARTZ, "Chick cartilage chondroitin sulfate proteoglycan core protein. I. Generation and characterization of peptides and specificity for glycosaminoglycan attachment", J Biol Chem, (19900000), vol. 265, no. 20, pages 12075 - 12087
    - LARSSON, S.L. LOHMANDERA. STRUGLICS, "An ARGS-aggrecan assay for analysis in blood and synovial fluid", Osteoarthritis and cartilage, (20140000), vol. 22, no. 2, pages 242 - 249
    - MALEMUD, C. J., "Pharmacologic Interventions for Preventing Chondrocyte Apoptosis in Rheumatoid Arthritis and Osteoarthritis", Drug Discovery: Concepts to Market, (20180000), vol. 45, page 77
    - MALEMUD, C. J., "Inhibition of MMPs and ADAM/ADAMTS", Biochem Pharmacol, (20190000), vol. 165, pages 33 - 40
    - MALFAIT, A.M. TORTORELLA, "The ''elusive DMOAD'': Aggrecanase inhibition from laboratory to clinic.", Clin Exp Rheumatol, (20190000), vol. 37, pages 130 - 134
    - MANICOURT, D. H.M. AZRIAL. MINDEHOLME. J. THONARJ. P. DEVOGELAER, "Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis", Arthritis Rheum, (20060000), vol. 54, no. 10, pages 3205 - 3211
    - YOSHIHARA, Y.H. NAKAMURAK. OBATAH. YAMADAT. HAYAKAWAK. FUJIKAWAY. OKADA, "Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis", Ann Rheum Dis, (20000000), vol. 59, no. 6, doi:10.1136/ard.59.6.455, pages 455 - 461, XP009024011

DOI:   http://dx.doi.org/10.1136/ard.59.6.455
    - MAZIERES, B.P. GARNEROA. GUEGUENM. ABBALL. BERDAHM. LEQUESNEM. NGUYENJ. P. SALLESE. VIGNONM. DOUGADOS, "Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort", Ann Rheum Dis, (20060000), vol. 65, no. 3, doi:10.1136/ard.2005.037275, pages 354 - 359, XP055206082

DOI:   http://dx.doi.org/10.1136/ard.2005.037275
    - MOHAN, V.D. TALMI-FRANKV. ARKADASHN. PAPOI. SAGI, "Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine", Metalloproteinases in Medicine, (20160000), vol. 3, doi:10.2147/MNM.S65143, page 31, XP009507093

DOI:   http://dx.doi.org/10.2147/MNM.S65143
    - MULLAN, R. H., C. MATTHEWS, B. BRESNIHAN, O. FITZGERALD, L. KING, A. R. POOLE, U. FEARON AND D. J. VEALE, "Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy", Arthritis Rheum, (20070000), vol. 56, no. 9, pages 2919 - 2928
    - NAGASE, H.M. KASHIWAGI, "Aggrecanases and cartilage matrix degradation", Arthritis Res Ther, (20030000), vol. 5, no. 2, doi:10.1186/ar630, page 94, XP009081422

DOI:   http://dx.doi.org/10.1186/ar630
    - PELLETIER, J. P., J. MARTEL-PELLETIER AND S. B. ABRAMSON, "Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets", Arthritis Rheum, (20010000), vol. 44, no. 6, doi:10.1002/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F, pages 1237 - 1247, XP055336395

DOI:   http://dx.doi.org/10.1002/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F
    - ROACH, H. I., N. YAMADA, K. S. CHEUNG, S. TILLEY, N. M. CLARKE, R. O. OREFFO, S. KOKUBUN AND F. BRONNER, "Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions", Arthritis Rheum, (20050000), vol. 52, no. 10, doi:10.1002/art.21300, pages 3110 - 3124, XP055012590

DOI:   http://dx.doi.org/10.1002/art.21300
    - SCHMINKE, B.S. TRAUTMANNB. MAIN. MIOSGES. BLASCHKE, "Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage", Eur J Immunol, (20160000), vol. 46, no. 2, pages 440 - 445
    - SHARIF, M.E. GEORGEL. SHEPSTONEW. KNUDSONE. J. THONARJ. CUSHNAGHANP. DIEPPE, "Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee", Arthritis Rheum, (19950000), vol. 38, no. 6, pages 760 - 767
    - SHIOMI, T.V. LEMAITREJ. D'ARMIENTOY. OKADA, "Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases", Pathol Int, (20100000), vol. 60, no. 7, pages 477 - 496
    - SINGH, P.K. B. MARCUM. B. GOLDRINGM. OTERO, "Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy", Annals of the New York Academy of Sciences, (20190000), vol. 1442, no. 1, pages 17 - 34
    - SORSA, T., T. SALO, E. KOIVUNEN, J. TYYNELA, Y. T. KONTTINEN, U. BERGMANN, A. TUUTTILA, E. NIEMI, O. TERONEN AND P. HEIKKILA, "Activation of type IV procollagenases by human tumor-associated trypsin-2", Journal of Biological Chemistry, (19970000), vol. 272, no. 34, pages 21067 - 21074
    - TERVAHARTIALA, T.T. INGMANT. SORSAY. DINGP. KANGASPUNTAY. T. KONTTINEN, "Proteolytic enzymes as indicators of periodontal health in gingival crevicular fluid of patients with Sjogren's syndrome", Eur J Oral Sci, (19950000), vol. 103, no. 1, pages 11 - 16
    - TROEBERG, L.H. NAGASE, "Proteases involved in cartilage matrix degradation in osteoarthritis", Biochim Biophys Acta, (20120000), vol. 1824, no. 1, doi:10.1016/j.bbapap.2011.06.020, pages 133 - 145, XP028336051

DOI:   http://dx.doi.org/10.1016/j.bbapap.2011.06.020
    - WANG, M.E. R. SAMPSONH. JINJ. LIQ. H. KEH. J. IMD. CHEN, "MMP13 is a critical target gene during the progression of osteoarthritis", Arthritis Res Ther, (20130000), vol. 15, no. 1, doi:10.1186/ar4133, page R5, XP021140545

DOI:   http://dx.doi.org/10.1186/ar4133
    - WANG, Z.T. BOYKOM. C. TRANM. LARUSSAN. BHATIAV. RASHIDIM. T. LONGAKERG. P. YANG, "DEL1 protects against chondrocyte apoptosis through integrin binding", J Surg Res, (20180500), vol. 231, pages 1 - 9
    - WANG, Z.M. C. TRANN. J. BHATIAA. W. HSINGC. CHENM. F. LARUSSAE. FATTAKHOVV. RASHIDIK. Y. JANGK. J. CHOO, "Dell Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis", PLoS One, (20160000), vol. 11, no. 8, page e0160684
    - WELLS, A. F.L. KLARESKOGS. LINDBLADT. C. LAURENT, "Correlation between increased hyaluronan localized in arthritic synovium and the presence of proliferating cells. A role for macrophage-derived factors", Arthritis Rheum, (19920000), vol. 35, no. 4, pages 391 - 396
    - VERSTAPPEN, S. M.A. R. POOLEM. IONESCUL. E. KINGM. ABRAHAMOWICZD. M. HOFMANJ. W. BIJLSMAF. P. LAFEBER, "Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis", Arthritis Res Ther, (20060000), vol. 8, no. 1, page R31, XP021011714
    - VINCENTI, M. P.C. E. BRINCKERHOFF, "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors", Arthritis Res, (20020000), vol. 4, no. 3, doi:10.1186/ar401, pages 157 - 164, XP007900025

DOI:   http://dx.doi.org/10.1186/ar401
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