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Extract from the Register of European Patents

EP About this file: EP4205764

EP4205764 - ANTI-TRUNCATED MUTANT CALR-CD3 BISPECIFIC ANTIBODY AND PHARMACEUTICAL COMPOSITION [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  02.06.2023
Database last updated on 12.07.2024
FormerThe international publication has been made
Status updated on  05.03.2022
Most recent event   Tooltip06.07.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Juntendo Educational Foundation
2-1-1, Hongo
Bunkyo-ku
Tokyo 113-8421 / JP
For all designated states
Meiji Seika Pharma Co., Ltd.
4-16, Kyobashi 2-chome, Chuo-ku
Tokyo 104-8002 / JP
[2023/27]
Inventor(s)01 / KOMATSU, Norio
Tokyo 113-8421 / JP
02 / ARAKI, Marito
Tokyo 113-8421 / JP
03 / KIHARA, Yoshihiko
Tokyo 113-8421 / JP
04 / ISHIDA, Yoji
Tokyo 104-8002 / JP
05 / KITAMURA, Koichi
Tokyo 104-8002 / JP
06 / FUKUSHIMA, Takayoshi
Odawara-shi, Kanagawa 250-0852 / JP
07 / YASUI, Kaori
Tokyo 104-8002 / JP
 [2023/27]
Representative(s)Plougmann Vingtoft a/s
Strandvejen 70
2900 Hellerup / DK
[2023/27]
Application number, filing date21861669.626.08.2021
[2023/27]
WO2021JP31355
Priority number, dateJP2020014355127.08.2020         Original published format: JP 2020143551
[2023/27]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022045247
Date:03.03.2022
Language:JA
[2022/09]
Type: A1 Application with search report 
No.:EP4205764
Date:05.07.2023
Language:EN
[2023/27]
Search report(s)International search report - published on:JP03.03.2022
ClassificationIPC:A61K39/395, A61P35/00, A61P35/02, C07K16/18, C07K16/28, C07K16/46, C12N15/13, A61K51/10, G01N33/53, G01N33/531
[2023/27]
CPC:
A61P35/00 (EP,IL,KR); A61K39/395 (IL); C07K16/18 (EP,IL,KR);
C07K16/28 (IL,US); A61K51/10 (IL); A61P35/02 (IL,KR);
C07K16/00 (IL); C07K16/2809 (EP,KR,US); C07K16/46 (IL);
G01N33/53 (IL); G01N33/531 (EP,IL,KR); G01N33/574 (KR);
G01N33/57426 (EP); G01N33/57492 (US); A61K2039/505 (KR);
C07K2317/24 (EP); C07K2317/30 (EP); C07K2317/31 (EP,KR,US);
C07K2317/52 (US); C07K2317/73 (EP,KR); C07K2317/92 (EP,KR,US);
G01N2333/4727 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/27]
Extension statesBA16.03.2023
ME16.03.2023
Validation statesKH16.03.2023
MA16.03.2023
MD16.03.2023
TN16.03.2023
TitleGerman:ANTI-TRUNKIERTER MUTANTER BISPEZIFISCHER CALR-CD3-ANTIKÖRPER UND PHARMAZEUTISCHE ZUSAMMENSETZUNG[2023/27]
English:ANTI-TRUNCATED MUTANT CALR-CD3 BISPECIFIC ANTIBODY AND PHARMACEUTICAL COMPOSITION[2023/27]
French:ANTICORPS BISPÉCIFIQUE CALR-CD3 MUTANT ANTI-TRONQUÉ ET COMPOSITION PHARMACEUTIQUE[2023/27]
Entry into regional phase01.03.2023Translation filed 
01.03.2023National basic fee paid 
01.03.2023Search fee paid 
01.03.2023Designation fee(s) paid 
01.03.2023Examination fee paid 
Examination procedure01.03.2023Amendment by applicant (claims and/or description)
01.03.2023Examination requested  [2023/27]
Fees paidRenewal fee
03.07.2023Renewal fee patent year 03
05.07.2024Renewal fee patent year 04
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Cited inInternational search[Y]JP2016537012  (CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH) [Y] 1-22 * claims, paragraph [0168], example 2 *;
 [Y]US2017269092  (KRALOVICS ROBERT [AT]) [Y] 1-22 * claims, example 1, tables *;
 [PY]WO2020175689  (JUNTENDO EDUCATIONAL FOUND [JP], et al) [PY] 1-22* claims, examples *;
 [Y]  - Izumi Kumagai , Ryutaro Asano, "Human bispecific antibody that recognizes lymphocytes and cancer cells", Drug Delivery System, (20080101), vol. 23, no. 5, doi:10.2745/dds.23.518, ISSN 0913-5006, pages 518 - 525, XP055108472 [Y] 1-22 * p. 521, fig. 3 *

DOI:   http://dx.doi.org/10.2745/dds.23.518
 [A]  - Vannucchi A M, Rotunno G, Bartalucci N, Raugei G, Carrai V, Balliu M, Mannarelli C, Pacilli A, Calabresi L, Fjerza R, Pieri , Bosi A, Manfredini R, Guglielmelli P, "Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value", Leukemia, London, (20140901), vol. 28, no. 9, doi:10.1038/leu.2014.100, ISSN 0887-6924, pages 1811 - 1818, XP002733584 [A] 1-22 * abstract, results, fig. 1a *

DOI:   http://dx.doi.org/10.1038/leu.2014.100
by applicantJPH0159878B
 WO9201047
 WO9203918
 WO9220791
 WO9306213
 WO9311236
 WO9312227
 WO9319172
 WO9402602
 WO9425585
 WO9501438
 WO9515388
 WO9634096
 WO9633735
 WO9954440
 WO2015036599
 JP2015110628
 WO2016087514
 JP2017137329
 JP2019022497
 WO2019178362
    - KLAMPFL TGISSLINGER HHARUTYUNYAN AS et al., "Somatic mutations of calreticulin in myeloproliferative neoplasms", The New England journal of medicine, (20130000), vol. 369, doi:10.1056/NEJMoa1311347, pages 2379 - 90, XP002733585

DOI:   http://dx.doi.org/10.1056/NEJMoa1311347
    - NANGALIA JMASSIE CEBAXTER EJ et al., "Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2", The New England journal of medicine, (20130000), vol. 369, doi:10.1056/NEJMoa1312542, pages 2391 - 405, XP055148137

DOI:   http://dx.doi.org/10.1056/NEJMoa1312542
    - ARAKI MYANG YMASUBUCHI N et al., "Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms", Blood, (20160000), vol. 127, pages 1307 - 16
    - ELF SABDELFATTAH NSCHEN E et al., "Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation", Cancer Discov, (20160000), vol. 6, doi:10.1158/2159-8290.CD-15-1434, pages 368 - 81, XP055527242

DOI:   http://dx.doi.org/10.1158/2159-8290.CD-15-1434
    - MARTY CPECQUET CNIVARTHI H et al., "Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis", Blood, (20160000), vol. 127, doi:10.1182/blood-2015-11-679571, pages 1317 - 24, XP055527263

DOI:   http://dx.doi.org/10.1182/blood-2015-11-679571
    - VAINCHENKER WKRALOVICS R, "Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms", Blood, (20170000), vol. 129, doi:10.1182/blood-2016-10-695940, pages 667 - 79, XP086677972

DOI:   http://dx.doi.org/10.1182/blood-2016-10-695940
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