EP4227321 - ANTIBODIES TARGETING THE B-CELL RECEPTOR OF CHRONIC LYMPHOCYTIC LEUKEMIA AND USES THEREOF [Right-click to bookmark this link] | |||
Former [2023/33] | ANTIBODIES TARGETING THE B-CELL RECEPTOR OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) FOR USE IN TREATMENT OF CLL | ||
[2023/35] | Status | Examination is in progress Status updated on 06.10.2023 Database last updated on 12.12.2024 | |
Former | Request for examination was made Status updated on 14.07.2023 | Most recent event Tooltip | 22.11.2024 | Stay | published on 25.12.2024 [2024/52] | Applicant(s) | For all designated states SinABioSolution GmbH Klaus-Groth-Strasse 8 14050 Berlin / DE | [2024/13] |
Former [2024/01] | For all designated states AVA Lifescience GmbH Norsinger Strasse 30 79189 Bad Krozingen / DE | ||
Former [2023/33] | For all designated states AVA Lifescience GmbH Ferdinand-Porsche Strasse 5/1 79211 Denzlingen / DE | Inventor(s) | 01 /
DÜHREN-VON MINDEN, Marcus 79379 Müllheim / DE | [2023/33] | Representative(s) | ETL IP Patent- und Rechtsanwaltsgesellschaft mbH Clayallee 343 14169 Berlin / DE | [N/P] |
Former [2023/33] | Cacace, Sabrina Rosella Immentalstraße 38 79104 Freiburg / DE | Application number, filing date | 22156205.1 | 10.02.2022 | [2023/33] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP4227321 | Date: | 16.08.2023 | Language: | EN | [2023/33] | Type: | A8 Corrected patent application | No.: | EP4227321 | Date: | 27.09.2023 | [2023/39] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 19.07.2022 | Classification | IPC: | C07K16/30, A61K39/395, A61P35/02 | [2023/33] | CPC: |
C07K16/3061 (EP);
C07K16/2803 (KR,US);
A61K39/39566 (EP);
A61P35/00 (US);
A61P35/02 (EP,KR);
A61K2039/505 (EP,KR);
A61K2039/545 (KR);
C07K2317/24 (KR,US);
C07K2317/56 (EP);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2024/13] |
Former [2023/33] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | ANTIKÖRPER GEGEN DEN B-ZELL REZEPTOR CHRONISCHER LYMPHATISCHER LEUKÄMIE UND VERWENDUNGEN DAVON | [2023/35] | English: | ANTIBODIES TARGETING THE B-CELL RECEPTOR OF CHRONIC LYMPHOCYTIC LEUKEMIA AND USES THEREOF | [2023/35] | French: | ANTICORPS CONTRE LE RECEPTEUR DES CELLULES B DE LA LEUCEMIE LYMPHOIDE CHRONIQUE ET LEUR UTILISATION | [2023/35] |
Former [2023/33] | ANTIKÖRPER GEGEN DEN B-ZELL REZEPTOR CHRONISCHER LYMPHATISCHER LEUKÄMIE (CLL) ZUR VERWENDUNG BEI DER BEHANDLUNG VON CLL | ||
Former [2023/33] | ANTIBODIES TARGETING THE B-CELL RECEPTOR OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) FOR USE IN TREATMENT OF CLL | ||
Former [2023/33] | ANTICORPS CONTRE LE RECEPTEUR DES CELLULES B DE LA LEUCEMIE LYMPHOIDE CHRONIQUE (LLC) UTILISÉES DANS LE TRAITEMENT DE LLC | Examination procedure | 16.02.2022 | Examination requested [2023/33] | 19.07.2022 | Date on which the examining division has become responsible | 05.10.2023 | Despatch of a communication from the examining division (Time limit: M06) | 08.05.2024 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 08.07.2024 | Reply to a communication from the examining division | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 08.07.2024 | Request for further processing filed | 08.07.2024 | Full payment received (date of receipt of payment) Request granted | 16.07.2024 | Decision despatched | Fees paid | Renewal fee | 28.02.2024 | Renewal fee patent year 03 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Stay/Interruption | 14.11.2024 | Stay of proceedings | [2024/52] | Documents cited: | Search | [AD]WO2019008129 (AVA LIFESCIENCE GMBH [DE]) [AD] 1-13 * example 1 * * sequences 9, 10 * * claims 15,16 *; | [A]WO2020127827 (AVA LIFESCIENCE GMBH [DE]) [A] 1-13 * example 1 * * sequences 5, 6 *; | [A]WO2020221466 (AVA LIFESCIENCE GMBH [DE]) [A] 1-13 * example 1 * * sequences 9, 10 * * claims 7, 8 *; | [AD] - MAITY PALASH C. ET AL, "IGLV3-21 * 01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 8, doi:10.1073/pnas.1913810117, ISSN 0027-8424, (20200211), pages 4320 - 4327, URL: https://www.pnas.org/doi/full/10.1073/pnas.1913810117, XP055939305 [AD] 1-13 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.1913810117 | [ ] - MAITY PALASH C. ET AL, "IGLV3-21 * 01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling - supporting information", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 8, doi:10.1073/pnas.1913810117, ISSN 0027-8424, (20200211), pages 4320 - 4327, URL: https://www.pnas.org/doi/full/10.1073/pnas.1913810117, XP055939309 [ ] * table on p.4 suppl. info. * DOI: http://dx.doi.org/10.1073/pnas.1913810117 | [A] - PATEL KRISH ET AL, "Current and future treatment strategies in chronic lymphocytic leukemia", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 14, no. 1, doi:10.1186/s13045-021-01054-w, (20210426), URL: https://link.springer.com/article/10.1186/s13045-021-01054-w/fulltext.html, XP055939369 [A] 1-13 * the whole document * DOI: http://dx.doi.org/10.1186/s13045-021-01054-w | [A] - JAMES TORCHIA ET AL, "Targeting lymphoma with precision using semisynthetic anti-idiotype peptibodies", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20160425), vol. 113, no. 19, doi:10.1073/pnas.1603335113, ISSN 0027-8424, pages 5376 - 5381, XP055565565 [A] 1-13 DOI: http://dx.doi.org/10.1073/pnas.1603335113 | [A] - MACARRÓN PALACIOS ARTURO ET AL, "Specific Targeting of Lymphoma Cells Using Semisynthetic Anti-Idiotype Shark Antibodies", FRONTIERS IN IMMUNOLOGY, Lausanne, CH, (20201126), vol. 11, doi:10.3389/fimmu.2020.560244, ISSN 1664-3224, XP055880182 [A] 1-13 DOI: http://dx.doi.org/10.3389/fimmu.2020.560244 | [T] - SAWALHA YAZEED ET AL, "Novel treatments in B cell non-Hodgkin's lymphomas", BMJ, doi:10.1136/bmj-2020-063439, (20220420), page e063439, URL: https://www.bmj.com/content/377/bmj-2020-063439, XP055939610 DOI: http://dx.doi.org/10.1136/bmj-2020-063439 | by applicant | WO9951642 | US6194551 | WO2019008129 | - ROZ-MAN CMONTSERRAT E, "Chronic lymphocytic leukemia", N Engl J Med, (19950000), vol. 333, pages 1052 - 1057 | - KIPPS TJSTEVENSON FKWU CJCROCE CMPACKHAM GWIERDA WG et al., "Chronic lymphocytic leukemia", Nat Rev Dis Primers, (20170000), vol. 3, pages 1 - 12 | - BURGER JACHIORAZZI N., "B cell receptor signaling in chronic lymphocytic leukemia", Trends Immunol, (20130000), vol. 34, pages 592 - 601 | - FLASWINKEL, H.RETH, M., "Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor", EMBO J., (19940000), vol. 13, pages 83 - 89 | - STEVENSON FKKRYSOV SDAVIES AJSTEELE AJ, "Packham G. B-cell receptor signaling in chronic lymphocytic leukemia", Blood, (20110000), vol. 118, pages 4313 - 4320 | - CASOLA SOTIPOBY KIALIMZHANOV M et al., "B cell receptor signal strength determines B cell fate", Nat Immunol, (20040000), vol. 5, doi:10.1038/ni1036, pages 317 - 27, XP055106262 DOI: http://dx.doi.org/10.1038/ni1036 | - DUHREN-VON MINDEN M et al., "Chronic lymphocytic leukemia is driven by antigen-independent cell-autonomous signalling", Nature, (20120000), vol. 489, pages 309 - 313 | - GOBESSI SLAURENTI LLONGO PGCARSETTI LBERNO VSICA S et al., "Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells", Leukemia, (20090000), vol. 23, pages 686 - 697 | - RINGSHAUSEN ISCHNELLER FBOGNER CHIPP SDUYSTER JPESCHEL C et al., "Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase C delta", Blood, (20020000), vol. 100, pages 3741 - 3748 | - PLATE JM, "P13-kinase regulates survival of chronic lymphocytic leukemia B- cells by preventing caspase 8 activation", Leuk Lymphoma, (20040000), vol. 45, pages 1519 - 1529 | - SAINZ-PEREZ AGARY-GOUY HPORTIER ADAVI FMERLE-BERAL HGALANAUD P et al., "High Mda-7 expression promotes malignant cell survival and p38 MAP kinase activation in chronic lymphocytic leukemia", Leukemia, (20060000), vol. 20, doi:10.1038/sj.leu.2404073, pages 498 - 504, XP002469144 DOI: http://dx.doi.org/10.1038/sj.leu.2404073 | - LOEDER S et al., "A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia", Cancer Res., (20090000), vol. 69, pages 8977 - 8986 | - PETLICKOVSKI ALAURENTI LLI XMARIETTI SCHIUSOLO PSICA SLEONE GEFREMOV DG., "Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells", Blood, (20050000), vol. 105, pages 4820 - 4827 | - STAMATOPOULOS KBELESSI CMORENO C et al., "Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenic implications and clinical correlations", Blood, (20070000), vol. 109, no. 1, doi:10.1182/blood-2006-03-012948, pages 259 - 270, XP055547143 DOI: http://dx.doi.org/10.1182/blood-2006-03-012948 | - AGATHANGELIDIS A. et al., "Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: A molecular classification with implications for targeted therapies", Blood, (20120000), vol. 119, pages 4467 - 4475 | - MINICI, C. et al., "Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukemia", Nature Comm., (20170000), vol. 8, page 15746 | - STAMATOPOULOS BSMITH TCROMPOT E et al., "The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study", Clin Cancer Res, (20180000), vol. 24, no. 20, pages 5048 - 5057 | - NADEU FROYO RCLOT G et al., "IGLV3-21 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics", Blood, (20210000), vol. 137, no. 21, doi:10.1182/blood.2020008311, pages 2935 - 2946, XP086581473 DOI: http://dx.doi.org/10.1182/blood.2020008311 | - HOELLENRIEGEL JMEADOWS SASIVINA M et al., "The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia", Blood, (20110000), vol. 118, doi:10.1182/blood-2011-05-352492, pages 3603 - 3612, XP002676784 DOI: http://dx.doi.org/10.1182/blood-2011-05-352492 | - HERMANN SEGORDON ALHERTLEIN E et al., "Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765", Blood, (20110000), vol. 117, doi:10.1182/blood-2011-01-328484, pages 6287 - 6296, XP008177912 DOI: http://dx.doi.org/10.1182/blood-2011-01-328484 | - MAITY PCBILAL MKONING MT et al., "IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signalling", PNAS, (20200000), vol. 117, no. 8, pages 4320 - 4327 | - CHOTHIALESK, J Mol Biol, (19870000), vol. 196, pages 901 - 917 | - LEFRANC et al., "IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig super-family V-like domains", Dev. Comp. Immunol., (20030000), vol. 27, pages 55 - 77 | - GAZZANO-SAN-TORO et al., J. Immunol. Methods, (19960000), vol. 202, page 163 | - KHORANA et al., J. Mol. Biol., (19710000), vol. 72, pages 209 - 217 | - DUHREN VON MINDEN et al., Nature, (20120000), vol. 489, pages 309 - 313 | - QI J et al., "An IgG1-like bispecific antibody targeting CD52 and CD20 for the treatment of B-cell malignancies", Methods, (20190000), vol. 154, pages 70 - 76 |