-
EP4067496
European procedure
Extract from the Register of European Patents
EP Citations: EP4067496
| Cited in | Search | Type: | Patent literature | Publication No.: | WO2013079953
[E] (KYMAB LTD et al.) | Type: | Patent literature | Publication No.: | US2004018626
[A] (MURPHY ANDREW J et al.) | Type: | Patent literature | Publication No.: | WO2011004192
[A] (GENOME RES LTD et al.) | Type: | Patent literature | Publication No.: | WO2011158009
[AP] (KYMAB LTD et al.) | Type: | Non-patent literature | Publication information: | [XA] CHOI I ET AL: "Characterization and comparative genomic analysis of intronless Adams with testicular gene expression", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 83, no. 4, 1 April 2004 (2004-04-01), pages 636 - 646, XP004495995, ISSN: 0888-7543, DOI: 10.1016/J.YGENO.2003.10.001 | DOI: | http://dx.doi.org/10.1016/j.ygeno.2003.10.001 | Type: | Non-patent literature | Publication information: | [XA] EDWARDS D R ET AL: "The ADAM metalloproteinases", MOLECULAR ASPECTS OF MEDICINE, PERGAMON PRESS, OXFORD, GB, vol. 29, no. 5, 1 October 2009 (2009-10-01), pages 258 - 289, XP025473840, ISSN: 0098-2997, [retrieved on 20080815], DOI: 10.1016/J.MAM.2008.08.001 | DOI: | http://dx.doi.org/10.1016/j.mam.2008.08.001 | Type: | Non-patent literature | Publication information: | [XA] FEATHERSTONE KAREN ET AL: "The Mouse Immunoglobulin Heavy Chain V-D Intergenic Sequence Contains Insulators That May Regulate Ordered V(D)J Recombination", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 13, March 2010 (2010-03-01), pages 9327 - 9338, XP002677428, ISSN: 0021-9258 | DOI: | http://dx.doi.org/10.1074/JBC.M109.098251 | Type: | Non-patent literature | Publication information: | [XA] HAN CECIL ET AL: "Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.", BIOLOGY OF REPRODUCTION MAY 2009 LNKD- PUBMED:19129510, vol. 80, no. 5, May 2009 (2009-05-01), pages 1001 - 1008, XP002677427, ISSN: 0006-3363 | DOI: | http://dx.doi.org/10.1095/BIOLREPROD.108.073700 | Type: | Non-patent literature | Publication information: | [AD] LONBERG NILS: "Human antibodies from transgenic animals", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 9, 1 September 2005 (2005-09-01), pages 1117 - 1125, XP002442149, ISSN: 1087-0156, DOI: 10.1038/NBT1135 | DOI: | http://dx.doi.org/10.1038/nbt1135 | Type: | Non-patent literature | Publication information: | [T] ANDREW MURPHY: "BAC-based Modifications of the Mouse Genome: The Big and the Backward", SLIDE PRESENTATION, WELLCOME TRUST ADVANCED COURSE: GENETIC MANIPULATION OF ES CELLS; OCTOBER 26 - NOVEMBER 3, 2009; HINXTON, UK,, 3 November 2009 (2009-11-03), pages 1 - 58, XP002752689 | Cited in | by applicant | Type: | Patent literature | Publication No.: | US6586251
| Type: | Patent literature | Publication No.: | US6596541
| Type: | Patent literature | Publication No.: | US7105348
| Type: | Patent literature | Publication No.: | US7473557
| Type: | Patent literature | Publication No.: | US2007280945
| Type: | Patent literature | Publication No.: | US7659842
| Type: | Patent literature | Publication No.: | US7576259
| Type: | Patent literature | Publication No.: | US7294754
| Type: | Non-patent literature | Publication information: | WATERSTON ET AL.: "Initial sequencing and comparative analysis of the mouse genome", NATURE, vol. 420, 2002, pages 520 - 562, XP002270594, DOI: 10.1038/nature01262 | DOI: | http://dx.doi.org/10.1038/nature01262 | Type: | Non-patent literature | Publication information: | THROMB HAEMOST, vol. 95, pages 341 - 347 | Type: | Non-patent literature | Publication information: | HOMANICS ET AL.: "Production and characterization of murine models of classic and intermediate maple syrup urine disease", BMC MED GENET, vol. 7, 2006, pages 33, XP021015829, DOI: 10.1186/1471-2350-7-33 | DOI: | http://dx.doi.org/10.1186/1471-2350-7-33 | Type: | Non-patent literature | Publication information: | JAMSAI ET AL.: "A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia", GENOMICS, vol. 88, no. 3, 2006, pages 309 - 15 | Type: | Non-patent literature | Publication information: | PAN: "Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function:human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice", MOL IMMUNOL, vol. 43, 2006, pages 1741 - 1750 | Type: | Non-patent literature | Publication information: | ALT ET AL.: "Immunoglobulin genes in transgenic mice", TRENDS GENET, vol. 1, 1985, pages 231 - 236, XP025943164, DOI: 10.1016/0168-9525(85)90089-7 | DOI: | http://dx.doi.org/10.1016/0168-9525(85)90089-7 | Type: | Non-patent literature | Publication information: | GREEN ET AL.: "Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs", NAT GENET, vol. 7, 1994, pages 13 - 21, XP037115612, DOI: 10.1038/ng0594-13 | DOI: | http://dx.doi.org/10.1038/ng0594-13 | Type: | Non-patent literature | Publication information: | LONBERG ET AL.: "Antigen-specific human antibodies from mice comprising four distinct genetic modifications", NATURE, vol. 368, 1994, pages 856 - 859, XP002626115, DOI: 10.1038/368856a0 | DOI: | http://dx.doi.org/10.1038/368856a0 | Type: | Non-patent literature | Publication information: | JAKOBOVITS ET AL.: "From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice", NAT BIOTECHNOL, vol. 25, 2007, pages 1134 - 1143, XP002556637, DOI: 10.1038/nbt1337 | DOI: | http://dx.doi.org/10.1038/nbt1337 | Type: | Non-patent literature | Publication information: | TOMIZUKA ET AL.: "Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies", PNAS USA, vol. 97, 2000, pages 722 - 727, XP002949329, DOI: 10.1073/pnas.97.2.722 | DOI: | http://dx.doi.org/10.1073/pnas.97.2.722 | Type: | Non-patent literature | Publication information: | GIBSON ET AL.: "Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer", CLIN COLORECTAL CANCER, vol. 6, 2006, pages 29 - 31 | Type: | Non-patent literature | Publication information: | JAKOBOVITSKIM ET AL.: "Clinical efficacy of zanolimumab (HuMax-CD4): two Phase II studies in refractory cutaneous T-cell lymphoma", BLOOD, vol. 109, no. 11, 2007, pages 4655 - 62 | Type: | Non-patent literature | Publication information: | LONBERG: "Human antibodies from transgenic animals", NAT BIOTECHNOL, vol. 23, 2005, pages 1117 - 1125, XP055545019, DOI: 10.1038/nbt1135 | DOI: | http://dx.doi.org/10.1038/nbt1135 | Type: | Non-patent literature | Publication information: | MAKER: "Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase l/ll study", ANN SURG ONCOL, vol. 12, 2005, pages 1005 - 1016, XP019369612 | Type: | Non-patent literature | Publication information: | MCCLUNG ET AL.: "Denosumab in postmenopausal women with low bone mineral density", NEW ENGL J MED, vol. 354, 2006, pages 821 - 831, XP002511209, DOI: 10.1056/NEJMoa044459 | DOI: | http://dx.doi.org/10.1056/NEJMoa044459 | Type: | Non-patent literature | Publication information: | GARRETT ET AL.: "Chromatin architecture near a potential 3' end of the IgH locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites", MOL CELL BIOL, vol. 25, 2005, pages 1511 - 1525, XP055628379, DOI: 10.1128/MCB.25.4.1511-1525.2005 | DOI: | http://dx.doi.org/10.1128/MCB.25.4.1511-1525.2005 | Type: | Non-patent literature | Publication information: | MANIS ET AL.: "Elucidation of a downstream boundary of the 3' IgH regulatory region", MOL LMMUNOL, vol. 39, 2003, pages 753 - 760 | Type: | Non-patent literature | Publication information: | PAWLITZKY ET AL.: "Identification of a candidate regulatory element within the 5' flanking region of the mouse IgH locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A", J IMMUNOL, vol. 176, 2006, pages 6839 - 6851, XP055197563, DOI: 10.4049/jimmunol.176.11.6839 | DOI: | http://dx.doi.org/10.4049/jimmunol.176.11.6839 | Type: | Non-patent literature | Publication information: | HOMBACH ET AL.: "Molecular components of the B-cell antigen receptor complex of the IgM class", NATURE, vol. 343, 1990, pages 760 - 762, XP001179842, DOI: 10.1038/343760a0 | DOI: | http://dx.doi.org/10.1038/343760a0 | Type: | Non-patent literature | Publication information: | J IMMUNOL, vol. 169, pages 1859 - 1868 | Type: | Non-patent literature | Publication information: | BRAMBELL ET AL.: "A Theoretical Model of Gamma-Globulin Catabolism", NATURE, vol. 203, 1964, pages 1352 - 1354 | Type: | Non-patent literature | Publication information: | JUNGHANSANDERSON: "The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor", PNAS USA, vol. 93, 1996, pages 5512 - 5516 | Type: | Non-patent literature | Publication information: | RAOHJELM ET AL.: "Antibody-mediated regulation of the immune response", SCAND J IMMUNOL, vol. 64, 2002, pages 177 - 184 | Type: | Non-patent literature | Publication information: | NIMMERJAHNRAVETCH: "Fc-receptors as regulators of immunity", ADV IMMUNOL, vol. 96, 2007, pages 179 - 204 | Type: | Non-patent literature | Publication information: | BUCHHOLZ ET AL.: "Improved properties of FLP recombinase evolved by cycling mutagenesis", NAT BIOTECHNOL, vol. 16, 1998, pages 657 - 662, XP000775868, DOI: 10.1038/nbt0798-657 | DOI: | http://dx.doi.org/10.1038/nbt0798-657 | Type: | Non-patent literature | Publication information: | ZAMBROWICZ ET AL., PNAS USA, vol. 94, 1997, pages 3789 - 3794 | Type: | Non-patent literature | Publication information: | MICHAEL ET AL., MECH. DEV., vol. 85, 1999, pages 35 - 47 | Type: | Non-patent literature | Publication information: | WALLACE ET AL., NUCLEIC ACIDS RES., vol. 28, 2000, pages 1455 - 1464 | Type: | Non-patent literature | Publication information: | VALENZUELAZHANG: "A new logic for DNA engineering using recombination in Escherichia coli", NAT GENET, vol. 20, 1998, pages 123 - 128 | Type: | Non-patent literature | Publication information: | SCHWARTZCANTOR: "Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis", CELL, vol. 37, 1984, pages 67 - 75 | Type: | Non-patent literature | Publication information: | EMBO J, vol. 2, pages 1373 - 1378 | Type: | Non-patent literature | Publication information: | MORTENSEN ET AL.: "Production of homozygous mutant ES cells with a single targeting construct", MOL CELL BIOL, vol. 12, 1992, pages 2391 - 2395 | Type: | Non-patent literature | Publication information: | MCLEOD ET AL.: "Identification of the crossover site during FLP-mediated recombination in the Saccharomyces cerevisiae plasmid 2 microns circle", MOL CELL BIOL, vol. 20, 1986, pages 3357 - 3367 | Type: | Non-patent literature | Publication information: | WEICHHOLD ET AL.: "The human immunoglobulin kappa locus consists of two copies that are organized in opposite polarity", GENOMICS, vol. 16, 1993, pages 503 - 511, XP024796526, DOI: 10.1006/geno.1993.1217 | DOI: | http://dx.doi.org/10.1006/geno.1993.1217 | Type: | Non-patent literature | Publication information: | SCHAIBLE: "The immunoglobulin kappa locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals", HUM GENET, vol. 91, 1993, pages 261 - 267 | Type: | Non-patent literature | Publication information: | MATSUDA: "The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus", J EXP MED, vol. 188, 1998, pages 2151 - 2162, XP001008659, DOI: 10.1084/jem.188.11.2151 | DOI: | http://dx.doi.org/10.1084/jem.188.11.2151 | Type: | Non-patent literature | Publication information: | BRUGGEMANN ET AL.: "A repertoire of monoclonal antibodies with human heavy chains from transgenic mice", PNAS, vol. 86, 1989, pages 6709 - 6713, XP000068417, DOI: 10.1073/pnas.86.17.6709 | DOI: | http://dx.doi.org/10.1073/pnas.86.17.6709 | Type: | Non-patent literature | Publication information: | GREENTUAILLON ET AL.: "Human immunoglobulin heavy-chain minilocus recombination in transgenic mice: gene-segment use in mu and gamma transcripts", PNAS USA, vol. 90, 1993, pages 3720 - 3724 | Type: | Non-patent literature | Publication information: | J IMMUNOL METHODS, vol. 244, pages 217 - 225 | Type: | Non-patent literature | Publication information: | BROCHET ET AL.: "IMGTN-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis", NUCLEIC ACIDS RES, vol. 36, 2008, pages W503 - 508 | Type: | Non-patent literature | Publication information: | CHEN ET AL.: "RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development", PNAS USA, vol. 90, 1993, pages 4528 - 4532, XP055531002, DOI: 10.1073/pnas.90.10.4528 | DOI: | http://dx.doi.org/10.1073/pnas.90.10.4528 | Type: | Non-patent literature | Publication information: | FEENEY: "Factors that influence formation of B cell repertoire", IMMUNOL RES, vol. 21, 2000, pages 195 - 202 | Type: | Non-patent literature | Publication information: | HARLOWLANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS | Type: | Non-patent literature | Publication information: | LIEPETROPOULOS: "Advances in quantitative PCR technology: 5'nuclease assays", CURR OPIN BIOTECHNOL, vol. 9, no. 1, 1998, pages 43 - 48, XP002909587, DOI: 10.1016/S0958-1669(98)80082-7 | DOI: | http://dx.doi.org/10.1016/S0958-1669(98)80082-7 | Type: | Non-patent literature | Publication information: | RODRIGUEZ ET AL.: "High-efficiency deleter mice show that FLPe is an alternative to Cre-/oxP", NATURE GENETICS, vol. 25, 2000, pages 139 - 140, XP003034016, DOI: 10.1038/75973 | DOI: | http://dx.doi.org/10.1038/75973 |