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Extract from the Register of European Patents

EP About this file: EP4082557

EP4082557 - PEPTIDES AND METHODS OF TRANSPLANTATION AND RESTORATIVE ORGAN FUNCTION [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  01.12.2023
Database last updated on 08.10.2024
FormerThe application has been published
Status updated on  30.09.2022
Most recent event   Tooltip01.12.2023Application deemed to be withdrawnpublished on 03.01.2024  [2024/01]
Applicant(s)For all designated states
Bioincept LLC
1697 Lark Lane
Cherry Hill, NJ 08003 / US
[2022/44]
Inventor(s)01 / BARNEA, Eytan, R.
New York, NY 10016 / US
 [2022/44]
Representative(s)Heath, Abigail, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[2022/44]
Application number, filing date22164880.117.07.2018
[2022/44]
Priority number, dateUS201762533636P17.07.2017         Original published format: US 201762533636 P
[2022/44]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP4082557
Date:02.11.2022
Language:EN
[2022/44]
Type: A3 Search report 
No.:EP4082557
Date:25.01.2023
Language:EN
[2023/04]
Search report(s)(Supplementary) European search report - dispatched on:EP22.12.2022
ClassificationIPC:A61K38/10, C07K14/72, C07K14/47, A61K9/00, A61K31/573, A61K38/02, A61K38/17, A61K38/21, A61K45/06, A61K47/02
[2022/44]
CPC:
A61K38/1709 (EP,US); A61K31/573 (EP); A61K38/02 (EP);
A61K38/1793 (EP); A61K38/21 (EP); A61K45/06 (EP,US);
A61K47/02 (EP); A61K9/0019 (EP); A61L27/3604 (US);
A61P37/00 (US) (-)
C-Set:
A61K31/573, A61K2300/00 (EP);
A61K38/02, A61K2300/00 (EP);
A61K38/1709, A61K2300/00 (EP);
A61K38/1793, A61K2300/00 (EP);
A61K38/21, A61K2300/00 (EP)
(-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/44]
TitleGerman:PEPTIDE UND VERFAHREN ZUR TRANSPLANTATION UND FÜR RESTAURATIVE ORGANFUNKTION[2022/44]
English:PEPTIDES AND METHODS OF TRANSPLANTATION AND RESTORATIVE ORGAN FUNCTION[2022/44]
French:PEPTIDES ET PROCÉDÉS DE TRANSPLANTATION ET RESTAURATION DE LA FONCTION DES ORGANES[2022/44]
Examination procedure26.07.2023Application deemed to be withdrawn, date of legal effect  [2024/01]
17.08.2023Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2024/01]
Parent application(s)   TooltipEP18835689.3  / EP3655010
Fees paidRenewal fee
28.03.2022Renewal fee patent year 03
28.03.2022Renewal fee patent year 04
21.07.2022Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
31.07.202306   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XI]US2015125886  (BARNEA EYTAN R [US]) [X] 1-3 * paragraph [0104] * [I] 6;
 [A]US2015232418  (SCHLECHTINGEN GEORG [DE], et al) [A] 1-3,6 * claims 1-32 *;
 [A]WO2016030901  (TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES LTD [IL]) [A] 1-3,6 * claims 1-14 *;
 [X]WO2016044493  (BIOINCEPT LLC [US]) [X] 1-3,6 * claims 50-69 *;
 [A]WO2017079430  (BIOINCEPT LLC [US]) [A] 1-3,6 * claims 1-32 *;
 [XA]  - AZAR YEHUDITH ET AL, "PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model)", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, KLUGE CARDEN JENNINGS PUBLISHING, CHARLOTTESVILLE, VA, US, (20121221), vol. 19, no. 4, doi:10.1016/J.BBMT.2012.12.011, ISSN 1083-8791, pages 519 - 528, XP028992634 [X] 1-3 * abstract * *Introduction* * page 520, column 1 * [A] 6

DOI:   http://dx.doi.org/10.1016/j.bbmt.2012.12.011
 [XA]  - LOLA WEISS ET AL, "Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice", ENDOCRINE, SPRINGER US, BOSTON, (20110322), vol. 40, no. 1, doi:10.1007/S12020-011-9438-5, ISSN 1559-0100, pages 41 - 54, XP019933707 [X] 1-3 * abstract * [A] 6

DOI:   http://dx.doi.org/10.1007/s12020-011-9438-5
 [A]  - EYTAN R BARNEA ET AL, "PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-[alpha]2[beta]3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, BIOMED CENTRAL LTD, GB, (20120712), vol. 10, no. 1, doi:10.1186/1477-7827-10-50, ISSN 1477-7827, page 50, XP021116082 [A] 1-3,6 * abstract *

DOI:   http://dx.doi.org/10.1186/1477-7827-10-50
 [XP]  - FEICHTINGER MICHAEL ET AL, "Allogeneic ovarian transplantation using immunomodulator preimplantation factor (PIF) as monotherapy restored ovarian function in olive baboon", JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, PLENUM PUBLISHING, US, vol. 35, no. 1, doi:10.1007/S10815-017-1051-Y, ISSN 1058-0468, (20171111), pages 81 - 89, (20171111), XP036398020 [XP] 1-3,6 * the whole document *

DOI:   http://dx.doi.org/10.1007/s10815-017-1051-y
 [AP]  - HAKAM MIYA SOUKAINA ET AL, "Preimplantation Factor (PIF) Promotes HLA-G, -E, -F, -C Expression in JEG-3 Choriocarcinoma Cells and Endogenous Progesterone Activity", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, CH, vol. 43, no. 6, doi:10.1159/000484378, ISSN 1015-8987, (20171027), pages 2277 - 2296, URL: https://www.karger.com/Article/Pdf/484378, XP055959065 [AP] 1-3,6 * the whole document *

DOI:   http://dx.doi.org/10.1159/000484378
by applicantWO2012166559
 WO2013050615
 WO2013050616
 WO2013123267
 WO2013172954
 WO2014071241
 WO2014138429
 US2015094457
    - BORNSTEIN, S.R., "Predisposing factors for adrenal insufficiency", N Engl J Med, (20090000), vol. 360, no. 22, pages 2328 - 39
    - S. M. BERGE et al., "Pharmaceutical Salts", J Pharm Sci, (19770000), vol. 66, doi:10.1002/jps.2600660104, pages 1 - 19, XP002675560

DOI:   http://dx.doi.org/10.1002/jps.2600660104
    - "Vitro Selection of Unnatural Cyclic Peptide Libraries via mRNA Display", MA, Z.HARTMAN, M.C., Ribosome Display and Related Technologies: Methods and Protocols, Springer, (20120000), vol. In Vitro Selection of Unnatural Cyclic Peptide Libraries via mRNA Display, pages 367 - 390
    - RIPKA & RICH, Chern. Bioi., (19980000), vol. 2, pages 441 - 452
    - HRUBY et al., Curr. Op.Chem. Bioi., (19970000), vol. 1, pages 114 - 119
    - HRUBYBAISE, Curr.Med. Chern., (20000000), vol. 9, pages 945 - 970
    - RIPKA & RICH, Bioi., (19980000), vol. 2, pages 441 - 452
    - ZARNANI AH et al., "Microenvironment of the feto-maternal interface protects the semiallogenic fetus through its immunomodulatory activity on dendritic cells", Fertil Steril, (20080000), vol. 90, doi:10.1016/j.fertnstert.2007.01.102, pages 781 - 788, XP025474374

DOI:   http://dx.doi.org/10.1016/j.fertnstert.2007.01.102
    - PAIDAS MJ et al., "Pregnancy and Multiple Sclerosis (MS): A Beneficial Association. Possible therapeutic application of embryo-specific Pre-implantation Factor (PIF", Am J Reprod Immunol, (20120000), vol. 68, doi:10.1111/j.1600-0897.2012.01170.x, pages 456 - 464, XP055547063

DOI:   http://dx.doi.org/10.1111/j.1600-0897.2012.01170.x
    - BARNEA ER et al., "Reproduction and autoimmune disease: important translational implications from embryomaternal interaction", Immunotherapy, (20130000), vol. 5, pages 769 - 780
    - TINCANI A et al., "Pregnancy, lupus and antiphospholipid syndrome (Hughes syndrome", Lupus, (20060000), vol. 15, pages 156 - 160
    - THELLIN O, "Tolerance to the foeto-placental 'graft': ten ways to support a child for nine months. ", Immunol, (20000000), vol. 12, doi:10.1016/S0952-7915(00)00170-9, pages 731 - 737, XP004257750

DOI:   http://dx.doi.org/10.1016/S0952-7915(00)00170-9
    - BEAGLEY KWGOCKEL CM, "Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone", FEMS Immunol Med Microbiol, (20030000), vol. 38, pages 13 - 22
    - "Signaling between Embryo and Mother in Early Pregnancy: Basis for Development of Tolerance", BARNEA ER, Recurrent Pregnancy Loss - Causes, Controversies, and Treatment, CRC, (20140000), pages 17 - 28
    - GENBACEV O et al., "Establishment of human trophoblast progenitor cell lines from the chorion", Stem Cells, (20110000), vol. 29, pages 1427 - 1436
    - HANNA J, "Decidual NK cells regulate key developmental processes at the human fetal-maternal interface", Nat Med, (20060000), vol. 12, pages 1065 - 1074
    - GREGORI S, "HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal Niche", Frontiers in immunology, (20150000), vol. 6, page 128
    - LYNGE NILSSON L et al., "Controlling the Immunological Crosstalk during Conception and Pregnancy: HLA-G in Reproduction", Frontiers in immunology, (20140000), vol. 5, page 198
    - MOFFETT ALOKE C, "Immunology of placentation in eutherian mammals", Nat Rev Immunol, (20060000), vol. 6, pages 584 - 594
    - BARNEA ER, "The Effect of Progesterone upon First Trimester Trophoblastic Cell Differentiation and Human Chorionic Gonadotropin Secretion", Hum Reprod, (19910000), vol. 6, pages 905 - 909
    - YIE SM, "Progesterone regulates HLA-G gene expression through a novel progesterone response element", Hum Reprod, (20060000), vol. 21, pages 2538 - 2544
    - JABEEN A et al., "Quantified colocalization reveals heterotypic histocompatibility class I antigen associations on trophoblast cell membranes: relevance for human pregnancy", Biol Reprod, (20130000), vol. 89, page 94
    - SHAIKLY V et al., "Cell bio-imaging reveals co-expression of HLA-G and HLA-E in human preimplantation embryos", Reprod Biomed Online, (20100000), vol. 20, doi:10.1016/j.rbmo.2009.11.008, pages 223 - 233, XP026930746

DOI:   http://dx.doi.org/10.1016/j.rbmo.2009.11.008
    - SPENCER PS et al., "Key cellular components and interactive histocompatibility molecules regulating tolerance to the fetal allograft", Am J Reprod Immunol, (20120000), vol. 68, pages 95 - 99
    - BARNEA ER et al., "Progesterone, Estradiol, and Alpha-Human Chorionic Gonadotropin Secretion in Patients with Ectopic Pregnancy", J Clin Endocrinol Metab, (19860000), vol. 62, pages 529 - 531
    - MOREL Y et al., "Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis", Ann Endocrinol (Paris, (20160000), vol. 77, pages 82 - 89
    - BARNEA ER, "Applying Embryo-Derived Immune Tolerance to the Treatment of Immune Disorders", Annals of the New York Academy of Sciences, (20070000), vol. 1110, pages 602 - 618
    - BARNEA, E.R., "Insight into early pregnancy events: the emerging role of the embryo", Am J Reprod Immunol, (20040000), vol. 51, no. 5, pages 319 - 322, XP008123722
    - THAN NG, "Embryo-Placento-Maternal Interaction and Biomarkers: From Diagnosis to Therapy - A Workshop Report", Trophoblast Research, (20070000), vol. 21, pages S1 - S4
    - STAMATKIN, C.W. et al., "Preimplantation Factor (PIF) correlates with early mammalian embryo development-bovine and murine models", Reprod Biol Endocrinol, (20110000), vol. 9, doi:10.1186/1477-7827-9-63, page 63, XP021100711

DOI:   http://dx.doi.org/10.1186/1477-7827-9-63
    - STAMATKIN, C.W. et al., "Preimplantation factor negates embryo toxicity and promotes embryo development in culture", Reprod Biomed Online, (20110000), vol. 23, no. 4, doi:10.1016/j.rbmo.2011.06.009, pages 517 - 524, XP028307535

DOI:   http://dx.doi.org/10.1016/j.rbmo.2011.06.009
    - RAMU, S. et al., "Preimplantation factor (PIF) detection in maternal circulation in early pregnancy correlates with live birth (bovine model", Reprod Biol Endocrinol, (20130000), vol. 11, doi:10.1186/1477-7827-11-105, page 105, XP021168194

DOI:   http://dx.doi.org/10.1186/1477-7827-11-105
    - ROUSSEV, R.G. et al., "Preimplantation factor inhibits circulating natural killer cell cytotoxicity and reduces CD69 expression: implications for recurrent pregnancy loss therapy", Reprod Biomed Online, (20130000), vol. 26, no. 1, doi:10.1016/j.rbmo.2012.09.017, pages 79 - 87, XP028962467

DOI:   http://dx.doi.org/10.1016/j.rbmo.2012.09.017
    - BARNEA ER, "Insight into Preimplantation Factor (PIF*) mechanism for embryo protection and development: target oxidative stress and protein misfolding (PDI and HSP) through essential RIKP binding site", PLoS One, (20140000), vol. 9, page e100263
    - PAIDAS, M.J. et al., "A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells", Am J Obstet Gynecol, (20100000), vol. 202, no. 5, doi:10.1016/j.ajog.2010.03.024, pages 459,451 - 458, XP055382503

DOI:   http://dx.doi.org/10.1016/j.ajog.2010.03.024
    - BARNEA, E.R., "Preimplantation factor (PIF) promoting role in embryo implantation: increases endometrial integrin-alpha2beta3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua", Reprod Biol Endocrinol, (20120000), vol. 10, doi:10.1186/1477-7827-10-50, page 50, XP021116082

DOI:   http://dx.doi.org/10.1186/1477-7827-10-50
    - DUZYJ, C.M., "Preimplantation Factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor", Journal of Neurodevelopmental Disorders, (20140000), vol. 6, no. 1, doi:10.1186/1866-1955-6-36, page 36, XP021198147

DOI:   http://dx.doi.org/10.1186/1866-1955-6-36
    - BARNEA, E.R. et al., "Preimplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells", Am J Obstet Gynecol, (20120000), vol. 207, no. 4, doi:10.1016/j.ajog.2012.07.017, pages 313,311 - 311, XP055535314

DOI:   http://dx.doi.org/10.1016/j.ajog.2012.07.017
    - BARNEA ER, "Blocks mitogen-activated PBMCs proliferation, promotes TH2/TH1 bias, independent of Ca(2+)", Immunobiology, (20150000), vol. 220, doi:10.1016/j.imbio.2015.01.010, pages 865 - 875, XP029236985

DOI:   http://dx.doi.org/10.1016/j.imbio.2015.01.010
    - BARNEA, E.R. et al., "Preimplantation factor (PIF*) regulates systemic immunity and targets protective regulatory and cytoskeleton proteins", Immunobiology, (20160000), vol. 221, no. 7, doi:10.1016/j.imbio.2016.02.004, pages 778 - 793, XP029536120

DOI:   http://dx.doi.org/10.1016/j.imbio.2016.02.004
    - CHEN, Y.C. et al., "Preimplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids", Thromb Haemost, (20160000), vol. 115, no. 5, pages 1010 - 24
    - AZAR, Y. et al., "Preimplantation factor reduces graft-versus-host disease by regulating immune response and lowering oxidative stress (murine model", Biol Blood Marrow Transplant, (20130000), vol. 19, no. 4, doi:10.1016/j.bbmt.2012.12.011, pages 519 - 528, XP028992634

DOI:   http://dx.doi.org/10.1016/j.bbmt.2012.12.011
    - SHAINER R et al., "Preimplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies", Oncotarget, (20160913), vol. 7, no. 37, doi:10.18632/oncotarget.10635, pages 58975 - 58994, XP055443934

DOI:   http://dx.doi.org/10.18632/oncotarget.10635
    - WEISS, L. et al., "Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice", Endocrine, (20110000), vol. 40, no. 1, pages 41 - 54
    - WEISS, L. et al., "Preimplantation factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model", J Neurol Sci, (20120000), vol. 312, no. 1-2, pages 146 - 157
    - SHAINER, R. et al., "Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation", Conference Papers in Medicine, (20130000), vol. 2013, doi:10.1155/2013/718031, pages 1 - 8, XP055334794

DOI:   http://dx.doi.org/10.1155/2013/718031
    - MUELLER M et al., "Preimplantation factor promotes neuroprotection by targeting microRNA let-7", Proc Natl Acad Sci U S A, (20140000), vol. 111, doi:10.1073/pnas.1411674111, pages 13882 - 13887, XP055572291

DOI:   http://dx.doi.org/10.1073/pnas.1411674111
    - MUELLER M et al., Cell death and differentiation, (20150000), vol. 22, pages 2078 - 2086
    - MOINDJIE H et al., "Preimplantation factor (PIF) promotes human trophoblast invasion", Biol Reprod, (20140000), vol. 91, page 118
    - DUZYJ CM et al., "Preimplantation factor promotes first trimester trophoblast invasion", Am J Obstet Gynecol, (20100000), vol. 203, XP027313989
    - TILLBURGS, T, "Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes", Proc Natl Acad Sci USA., (20150609), vol. 112, no. 23, pages 7219 - 24
    - MOINDJIE H et al., "Preimplantation Factor is an anti-apoptotic effector in human trophoblasts involving p53 signaling pathway", Cell Death & Disease, (20160000), vol. 7, no. 12, doi:10.1038/cddis.2016.382, page e2504, XP055575068

DOI:   http://dx.doi.org/10.1038/cddis.2016.382
    - LIU Z, "The Roles of p38 MAPK and ERK1/2 in Coplanar Polychlorinated Biphenyls-Induced Apoptosis of Human Extravillous Cytotrophoblast-Derived Transformed Cells", Cell Physiol Biochem., (20150000), vol. 36, no. 6, pages 2418 - 32
    - SHAIKLY VR et al., J Immunol, (20080000), vol. 180, pages 4330 - 4337
    - MENIER C et al., "Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules", Hum Immunol, (20030000), vol. 64, doi:10.1016/S0198-8859(02)00821-2, pages 315 - 326, XP055365555

DOI:   http://dx.doi.org/10.1016/S0198-8859(02)00821-2
    - PALMISANO GL et al., "HLA-E surface expression is independent of the availability of HLA class I signal sequence-derived peptides in human tumor cell lines", Hum Immunol, (20050000), vol. 66, doi:10.1016/j.humimm.2004.10.006, pages 1 - 12, XP004695137

DOI:   http://dx.doi.org/10.1016/j.humimm.2004.10.006
    - ZHAO L, "Reassessment of HLA-G isoform specificity of MEM-G/9 and 4H84 monoclonal antibodies", Antigens, (20120000), vol. 80, pages 231 - 238
    - COOPER JC et al., "An impaired breeding phenotype in mice with a genetic deletion of beta-2 microglobulin and diminished MHC class I expression: role in reproductive fitness", Biol Reprod, (20070000), vol. 77, doi:10.1095/biolreprod.106.057125, pages 274 - 279, XP055489229

DOI:   http://dx.doi.org/10.1095/biolreprod.106.057125
    - CHERRY RJ et al., "Detection of dimers of dimers of human leukocyte antigen (HLA)-DR on the surface of living cells by single-particle fluorescence imaging", The Journal of cell biology, (19980000), vol. 140, doi:10.1083/jcb.140.1.71, pages 71 - 79, XP002185514

DOI:   http://dx.doi.org/10.1083/jcb.140.1.71
    - SASSE JGALLAGHER SR, "Staining proteins in gels", Curr Protoc Immunol, (20040000), vol. 8
    - SASSE JGALLAGHER SR, "Staining proteins in gels", Curr Protoc Mol Biol, (20030000), vol. 10
    - LIPTON MS, PASA-TOLIC L, "Mass spectrometry of proteins and peptides: methods and protocols. Preface", Mol Biol, (20090000), vol. 492
    - PADLIYA NDWOOD TD, "Improved peptide mass fingerprinting matches via optimized sample preparation in MALDI mass spectrometry", Anal Chim Acta, (20080000), vol. 627, doi:10.1016/j.aca.2008.05.059, pages 162 - 168, XP025408752

DOI:   http://dx.doi.org/10.1016/j.aca.2008.05.059
    - MURTHI P et al., Placenta, (20120000), vol. 33, pages 741 - 744
    - HIBY SE et al., "Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2", J Clin Invest, (20100000), vol. 120, pages 4102 - 4110
    - LEE N, "HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences", J Immunol, (19980000), vol. 160, pages 4951 - 4960, XP055042201
    - LEE N et al., "HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A", Proc Natl Acad Sci U S A, (19980000), vol. 95, doi:10.1073/pnas.95.9.5199, pages 5199 - 5204, XP002374950

DOI:   http://dx.doi.org/10.1073/pnas.95.9.5199
    - HIBY SE et al., "Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success", J Exp Med, (20040000), vol. 200, pages 957 - 965
    - FAN M et al., "Rac1/I3-Catenin Signalling Pathway Contributes to Trophoblast Cell Invasion by Targeting Snail and MMP9", Cell Physiol Biochem., (20160000), vol. 38, no. 4, pages 1319 - 32
    - LI H et al., "Differential Proteomic Analysis of Syncytiotrophoblast Extracellular Vesicles from Early-Onset Severe Preeclampsia, using 8-Plex iTRAQ Labeling Coupled with 2D Nano LC-MS/MS", Cell Physiol Biochem., (20150000), vol. 36, no. 3, pages 1116 - 30
    - HUANG QT et al., "Activation of PAR-1/NADPH oxidase/ROS signaling pathways is crucial for the thrombin-induced sFlt-1 production in extravillous trophoblasts: possible involvement in the pathogenesis of preeclampsia", Cell Physiol Biochem., (20150000), vol. 35, no. 4, pages 1654 - 62
    - BHATTACHARYYA S, "Antibodies to hCG inhibit progesterone production from human syncytiotrophoblast cells", Placenta, (19920000), vol. 13, doi:10.1016/0143-4004(92)90028-R, pages 135 - 139, XP023038076

DOI:   http://dx.doi.org/10.1016/0143-4004(92)90028-R
    - SOMERSET DA et al., "Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset", Immunology, (20040000), vol. 112, doi:10.1111/j.1365-2567.2004.01869.x, pages 38 - 43, XP071274950

DOI:   http://dx.doi.org/10.1111/j.1365-2567.2004.01869.x
    - ZIPFEL PFSKERKA C, "Complement regulators and inhibitory proteins", Nat Rev Immunol, (20090000), vol. 9, pages 729 - 740
    - GRANOT I, "Endometrial inflammation and effect on implantation improvement and pregnancy outcome", Reproduction, (20120000), vol. 144, pages 661 - 668
    - CHALLIS JR et al., "Inflammation and pregnancy", Reprod Sci, (20090000), vol. 16, pages 206 - 215
    - CHAOUAT G et al., "The emerging role of IL-10 in pregnancy", Am J Reprod Immunol, (19960000), vol. 35, pages 325 - 329
    - MOREAU P et al., "IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes", Int Immunol, (19990000), vol. 11, pages 803 - 811
    - RIZZO R et al., "The HLA-G genotype is associated with IL-10 levels in activated PBMCs", Immunogenetics, (20050000), vol. 57, doi:10.1007/s00251-005-0788-0, pages 172 - 181, XP019331647

DOI:   http://dx.doi.org/10.1007/s00251-005-0788-0
    - ANDREWS, P.A., "Summary of the British Transplantation Society/Renal Association UK Guidelines for Living Donor Kidney Transplantation", Transplantation, (20120000), vol. 93, no. 7, pages 666 - 673
    - MARTIN, P. et al., "Evaluation for Liver Transplantation in Adults: 2013 Practice Guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation", Hepatology, (20140000), vol. 59, no. 3, pages 1144 - 1165
    - WAGNER, M. et al., "Mycophenolic acid versus azathioprine as primary immunosuppression for kidney transplant recipients", Cochrane Database Syst Rev, (20150000), no. 12, page CD007746
    - BAMGBOLA, O., "Metabolic consequences of modern immunosuppressive agents in solid organ transplantation", Ther Adv Endocrinol Metab, (20160000), vol. 7, no. 3, pages 110 - 27
    - BALYURA, M. et al., "Transplantation of bovine adrenocortical cells encapsulated in alginate", Proc Natl Acad Sci U S A, (20150000), vol. 112, no. 8, pages 2527 - 32
    - BARNEA, E.R., "New York Academy of Sciences Applying Embryo-Derived Immune Tolerance to the Treatment of Immune Disorders ", New York Academy of Sciences, (20070000), vol. 1110, pages 602 - 618
    - Reprod Biol Endocrinol, (20120000), vol. 10, page 50
    - BARNEA, E.R., "Insight into Preimplantation Factor (PIF*) mechanism for embryo protection and development: target oxidative stress and protein misfolding (PDI and HSP) through essential RIPK binding site", PLoS One, (20140000), vol. 9, no. 7, doi:10.1371/journal.pone.0100263, page e100263, XP055439126

DOI:   http://dx.doi.org/10.1371/journal.pone.0100263
    - GOODALE, L.F. et al., "Preimplantation Factor (PIF) protects cultured embryos against oxidative stress: relevance for recurrent pregnancy loss (RPL) therapy", Oncotarget, (20170000), pages 1 - 14
    - BARNEA, E.R., " PIF direct immune regulation: Blocks mitogen-activated PBMCs proliferation, promotes TH2/TH1 bias, independent of Ca(2+)", Immunobiology, (20150000), vol. 220, no. 7, doi:10.1016/j.imbio.2015.01.010, pages 865 - 75, XP029236985

DOI:   http://dx.doi.org/10.1016/j.imbio.2015.01.010
    - WANG, B., "ATXN1 L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition", Cell Rep, (20170000), vol. 18, no. 6, pages 1543 - 1557
    - LI, D. et al., "Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17", Mol Cell Biol, (20070000), vol. 27, no. 19, pages 6669 - 85
    - WALCZAK, E.M., G.D. HAMMER, "Regulation of the adrenocortical stem cell niche: implications for disease", Rev Endocrinol, (20150000), vol. 11, no. 1, pages 14 - 28
    - HANUKOGLU, I. et al., "Isolation of a cDNA for adrenodoxin reductase (ferredoxin-NADP+ reductase). Implications for mitochondrial cytochrome P-450 systems", Eur J Biochem, (19870000), vol. 169, no. 3, pages 449 - 55
    - SHINOZAKI, K. et al., "Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation", Gene Ther, (19990000), vol. 6, no. 5, doi:10.1038/sj.gt.3300881, pages 816 - 22, XP037771571

DOI:   http://dx.doi.org/10.1038/sj.gt.3300881
    - DINANT, S. et al., "IL-10 attenuates hepatic I/R injury and promotes hepatocyte proliferation", J Surg Res, (20070000), vol. 141, no. 2, doi:10.1016/j.jss.2006.09.018, pages 176 - 82, XP022329099

DOI:   http://dx.doi.org/10.1016/j.jss.2006.09.018
    - HEINE, G., "Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts", Eur J Immunol, (20140000), vol. 44, no. 6, pages 1615 - 21
    - MUELLER, M. et al., "Preimplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling", Cell Death Differ, (20150000), vol. 22, no. 12, doi:10.1038/cdd.2015.55, pages 2078 - 86, XP055546850

DOI:   http://dx.doi.org/10.1038/cdd.2015.55
    - MUELLER, M. et al., "Preimplantation factor promotes neuroprotection by targeting microRNA let-7", Proc Natl Acad Sci USA, (20140000), vol. 111, no. 38, doi:10.1073/pnas.1411674111, pages 13882 - 7, XP055572291

DOI:   http://dx.doi.org/10.1073/pnas.1411674111
    - LEE, J.H. et al., "Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression", Arthritis Rheum, (20050000), vol. 52, no. 8, pages 2386 - 95
    - DONNEZ, J. et al., "Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation", Fertil Steril, (20130000), vol. 99, no. 6, doi:10.1016/j.fertnstert.2013.03.030, pages 1503 - 13, XP028591436

DOI:   http://dx.doi.org/10.1016/j.fertnstert.2013.03.030
    - SCOTT, J.R. et al., "Pregnancy after tubo-ovarian transplantation", Obstet Gynecol, (19870000), vol. 70, no. 2, pages 229 - 34
    - Hum Reprod, (19930000), vol. 8, no. 6, pages 929 - 31
    - KIM, S.S. et al., "The future of human ovarian cryopreservation and transplantation: fertility and beyond", Fertil Steril, (20010000), vol. 75, no. 6, pages 1049 - 56
    - DENTON, M.D. et al., "Sayegh, Immunosuppressive strategies in transplantation", Lancet, (19990000), vol. 353, no. 9158, pages 1083 - 91
    - MHATRE, P. et al., "Ovarian transplant: a new frontier", Transplant Proc, (20050000), vol. 37, no. 2, doi:10.1016/j.transproceed.2004.11.083, pages 1396 - 8, XP022309821

DOI:   http://dx.doi.org/10.1016/j.transproceed.2004.11.083
    - MHATRE, P., J. MHATRE, "Orthotopic ovarian transplant--review and three surgical techniques", Transplant, (20060000), vol. 10, no. 7, pages 782 - 7
    - SILBER, S.J. et al., "Ovarian transplantation between monozygotic twins discordant for premature ovarian failure", N Engl J Med, (20050000), vol. 353, no. 1, pages 58 - 63
    - DONNEZ, J. et al., "Allograft of ovarian cortex between two genetically non-identical sisters: case report", Hum Reprod, (20070000), vol. 22, no. 10, pages 2653 - 9
    - SILBER, S.J.R.G. GOSDEN, "Ovarian transplantation in a series of monozygotic twins discordant for ovarian failure", N Engl J Med, (20070000), vol. 356, no. 13, pages 1382 - 4
    - MUELLER, M. et al., "Preimplantation factor promotes neuroprotection by targeting microRNA let-7", Proc Natl Acad, (20140000), vol. 111, no. 38, doi:10.1073/pnas.1411674111, pages 13882 - 7, XP055572291

DOI:   http://dx.doi.org/10.1073/pnas.1411674111
    - BARNEA, E.R. et al., "Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult", Pharmacol Ther, (20150000), vol. 156, doi:10.1016/j.pharmthera.2015.10.008, pages 10 - 25, XP029320057

DOI:   http://dx.doi.org/10.1016/j.pharmthera.2015.10.008
    - ENSKOG, A. et al., "Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation", Hum Reprod, (20100000), vol. 25, no. 8, pages 1980 - 720
    - BAUER, C, "The baboon (Papio sp.) as a model for female reproduction studies", Contraception, (20150000), vol. 92, no. 2, pages 120 - 3
    - DONNEZ, J. et al., "Livebirth after orthotopic transplantation of cryopreserved ovarian tissue", Lancet, (20040000), vol. 364, no. 9443, doi:10.1016/S0140-6736(04)17222-X, pages 1405 - 10, XP005106738

DOI:   http://dx.doi.org/10.1016/S0140-6736(04)17222-X
    - DONNEZ, J.M.M. DOLMANS, "Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice", J Assist Reprod Genet, (20150000), vol. 32, no. 8, doi:10.1007/s10815-015-0544-9, pages 1167 - 70, XP035533332

DOI:   http://dx.doi.org/10.1007/s10815-015-0544-9
    - BRANNSTROM, M. et al., "Livebirth after uterus transplantation", Lancet, (20150000), vol. 385, no. 9968, pages 607 - 16
    - JOHANNESSON, L. et al., "Uterus transplantation trial: 1-year outcome", Fertil Steril, (20150000), vol. 103, no. 1, pages 199 - 204
    - YIN, H. et al., "Transplantation of intact rat gonads using vascular anastomosis: effects of cryopreservation, ischaemia and genotype", Hum Reprod, (20030000), vol. 18, no. 6, pages 1165 - 72
    - GOSDEN, R.G, "Survival of ovarian allografts in an experimental animal model", Pediatr Transplant, (20070000), vol. 11, no. 6, pages 628 - 33
    - MERAZ, M.M. et al., "Restoration of endocrine function and fertility with orthotopic tubal-ovarian allotransplant as the anatomical-functional unit in rabbits", J Invest Surg, (20080000), vol. 21, no. 6, pages 348 - 59
    - LIN, Y.H. et al., "Evaluating the effects of immunosuppression by in-vivo bioluminescence imaging after allotransplantation of ovarian grafts", Reprod Biomed Online, (20110000), vol. 22, no. 2, doi:10.1016/j.rbmo.2010.10.010, pages 220 - 7, XP028131850

DOI:   http://dx.doi.org/10.1016/j.rbmo.2010.10.010
    - CHEN, C.H. et al., "Tracking the rejection and survival of mouse ovarian iso- and allografts in vivo with bioluminescent imaging", Reproduction, (20100000), vol. 140, no. 1, pages 105 - 12
    - ROBERTSON, J.A, "Ethical issues in ovarian transplantation and donation", Fertil Steril, (20000000), vol. 73, no. 3, pages 443 - 6
    - LOPEZ-CABRERA, M. et al., "Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors", J Exp Med, (19930000), vol. 178, no. 2, pages 537 - 47
    - SCHOWENGERDT, K.O. et al., "Increased expression of the lymphocyte early activation marker CD69 in peripheral blood correlates with histologic evidence of cardiac allograft rejection", Transplantation, (20000000), vol. 69, no. 10, pages 2102 - 7
    - POSSELT, A.M. et al., "CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients", Transplantation, (20030000), vol. 76, no. 1, doi:10.1097/01.TP.0000073614.29680.A8, pages 190 - 5, XP009102959

DOI:   http://dx.doi.org/10.1097/01.TP.0000073614.29680.A8
    - MACLARAN, K.N. PANAY, "Premature ovarian failure", J Fam Plann Reprod Health Care, (20110000), vol. 37, no. 1, pages 35 - 42
    - VAN DER SCHOUW, Y.T. et al., "Age at menopause as a risk factor for cardiovascular mortality", Lancet, (19960000), vol. 347, no. 9003, doi:10.1016/S0140-6736(96)90075-6, pages 714 - 8, XP085558685

DOI:   http://dx.doi.org/10.1016/S0140-6736(96)90075-6
    - ROCCA, W.A. et al., "Survival patterns after oophorectomy in premenopausal women: a population-based cohort study", Lancet Oncol, (20060000), vol. 7, no. 10, doi:10.1016/S1470-2045(06)70869-5, pages 821 - 8, XP028057690

DOI:   http://dx.doi.org/10.1016/S1470-2045(06)70869-5
    - POPAT, V.B. et al., "Bone mineral density in estrogen-deficient young women", J Clin Endocrinol Metab, (20090000), vol. 94, no. 7, pages 2277 - 83
    - SCHMIDT, P.J., "Depression in women with spontaneous 46, XX primary ovarian insufficiency", Endocrinol Metab, (20110000), vol. 96, no. 2, pages E278 - 87
    - QUIGLEY, C.A. et al., "Effects of low-dose estrogen replacement during childhood on pubertal development and gonadotropin concentrations in patients with Turner syndrome: results of a randomized, double-blind, placebo-controlled clinical trial", J Clin Endocrinol Metab, (20140000), vol. 99, no. 9, pages E1754 - 64
    - POIROT, C. et al., "Induction of puberty by autograft of cryopreserved ovarian tissue", Lancet, (20120000), vol. 379, no. 9815, page 588
    - ERNST, E. et al., "Case report: stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue", Eur J Cancer, (20130000), vol. 49, no. 4, pages 911 - 4
    - KIM, S.S, "Assessment of long term endocrine function after transplantation of frozen-thawed human ovarian tissue to the heterotopic site: 10 year longitudinal follow-up study", J Assist Reprod Genet, (20120000), vol. 29, no. 6, pages 489 - 93
    - JENSEN, A.K., "Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark", Hum Reprod, (20150000), vol. 30, no. 12, pages 2838 - 45
    - COMMITTEE, I.P. et al., "Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer", J Assist Reprod Genet, (20120000), vol. 29, no. 6, doi:10.1007/s10815-012-9786-y, pages 465 - 8, XP035068181

DOI:   http://dx.doi.org/10.1007/s10815-012-9786-y
    - IMBERT, R. et al., "Safety and usefulness of cryopreservation of ovarian tissue to preserve fertility: a 12-year retrospective analysis", Hum Reprod, (20140000), vol. 29, no. 9, pages 1931 - 40
    - KHAN, Z. et al., "Unilateral oophorectomy results in compensatory follicular recruitment in the remaining ovary at time of ovarian stimulation for in vitro fertilization", Fertil Steril, (20140000), vol. 101, no. 3, doi:10.1016/j.fertnstert.2013.11.019, pages 722 - 7, XP028616225

DOI:   http://dx.doi.org/10.1016/j.fertnstert.2013.11.019
    - BJELLAND, E.K., "Is unilateral oophorectomy associated with age at menopause? A population study (the HUNT2 Survey)", Hum Reprod, (20140000), vol. 29, no. 4, pages 835 - 41
    - STEVENS, V.C, "Some reproductive studies in the baboon", Hum Reprod Update, (19970000), vol. 3, no. 6, pages 533 - 40
    - D'HOOGHE, T., "The Baboon as a Nonhuman Primate Model for the Study of Human Reproduction", Gynecol Obstet Invest., (20030000), pages 1 - 60
    - AMORIM, C.A. et al., "Successful vitrification and autografting of baboon (Papio anubis) ovarian tissue", Hum Reprod, (20130000), vol. 28, no. 8, pages 2146 - 56
    - JOHANNESSON, L. et al., "Preclinical report on allogeneic uterus transplantation in non-human primates", Hum Reprod, (20130000), vol. 28, no. 1, pages 189 - 98
    - NYACHIEO, A., "Ovarian tissue cryopreservation by vitrification in olive baboons (papio anubis): a pilot study", Gynecol Obstet Invest, (20130000), vol. 75, no. 3, pages 157 - 62
    - TODO, S. et al., "Renal transplantation in baboons under FK 506", Surgery, (19890000), vol. 106, no. 2, pages 444 - 50
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