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Extract from the Register of European Patents

EP About this file: EP4288520

EP4288520 - USE OF 3D POROUS STRUCTURE FOR PLATELET PRODUCTION [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  10.11.2023
Database last updated on 13.07.2024
FormerThe international publication has been made
Status updated on  12.08.2022
Formerunknown
Status updated on  07.03.2022
Most recent event   Tooltip12.04.2024Change: Validation statespublished on 15.05.2024  [2024/20]
12.04.2024Change - extension statespublished on 15.05.2024  [2024/20]
Applicant(s)For all designated states
HemostOD SA
EPFL Innovation Park, Batiment M
Rue des Jordils 1A
1025 Saint-Sulpice / CH
[2023/50]
Inventor(s)01 / DAHAN, Elodie
1015 Lausanne / CH
02 / CLAUDEL, Sophie
1015 Lausanne / CH
03 / HUMBERT, Magali
1015 Lausanne / CH
 [2023/50]
Representative(s)DTS Patent- und Rechtsanwälte PartmbB
Brienner Straße 1
80333 München / DE
[N/P]
Former [2023/50]DTS Patent- und Rechtsanwälte Schnekenbühl und Partner mbB
Brienner Straße 1
80333 München / DE
Application number, filing date22706019.108.02.2022
[2023/50]
WO2022EP52946
Priority number, dateEP2021015588708.02.2021         Original published format: EP 21155887
[2023/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022167676
Date:11.08.2022
Language:EN
[2022/32]
Type: A1 Application with search report 
No.:EP4288520
Date:13.12.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 11.08.2022 takes the place of the publication of the European patent application.
[2023/50]
Search report(s)International search report - published on:EP11.08.2022
ClassificationIPC:C12M3/04, C12M1/26
[2023/50]
CPC:
C12M33/14 (EP,US); C12N5/0644 (US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/50]
TitleGerman:VERWENDUNG EINER PORÖSEN 3D-STRUKTUR ZUR HERSTELLUNG VON BLUTPLÄTTCHEN[2023/50]
English:USE OF 3D POROUS STRUCTURE FOR PLATELET PRODUCTION[2023/50]
French:UTILISATION D'UNE STRUCTURE POREUSE 3D POUR LA PRODUCTION DE PLAQUETTES[2023/50]
Entry into regional phase28.07.2023National basic fee paid 
28.07.2023Designation fee(s) paid 
28.07.2023Examination fee paid 
Examination procedure28.07.2023Examination requested  [2023/50]
28.07.2023Date on which the examining division has become responsible
25.02.2024Amendment by applicant (claims and/or description)
Fees paidRenewal fee
23.02.2024Renewal fee patent year 03
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Cited inInternational search[A]WO2017047492  (MEGAKARYON CORP [JP]) [A] 1-21* paragraph [0021] *;
 [A]WO2017061528  (NAT UNIV CORP NAGOYA UNIV [JP], et al) [A] 1-21 * figures 5,6; claim 1 *;
 [XI]EP3238759  (FENWAL INC [US]) [X] 1-6,9,11,14,18 * paragraphs [0024] , [0049]; figures 2,3; claims 1,6 * [I] 7,8,10,12,13,15-17,19-21;
 [A]CN109967016  (NANJING JIANGNING HOSPITAL) [A] 1-21 * claim 1 *
by applicantWO2012129109
 WO2014107240
 WO2015075030
 WO2015153451
 WO2016180918
 WO2017044149
 WO2018165308
 WO2020018950
 US2021130781
    - LEFRAN AIS et al., "The lung is a site of platelet biogenesis and a reservoir for hematopoietic progenitors", Nature, (20170406), vol. 544, no. 7648, pages 105 - 109
    - PALLOTTA et al., "Three-Dimensional System for the In Vitro Study of Megakaryocytes and Functional Platelet Production Using Silk-Based Vascular Tubes", Tissue Engineering: Part C Methods, (20110000), vol. 17, no. 12, doi:10.1089/ten.tec.2011.0134, pages 1223 - 32, XP055108904

DOI:   http://dx.doi.org/10.1089/ten.tec.2011.0134
    - DI BUDUO et al., "Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies", Blood, (20150000), vol. 125, no. 14, pages 2254 - 2264
    - DI BUDUO et al., "Modular flow chamber for engineering bone marrow architecture and function", Biomaterials, (20170000), vol. 146, pages 60 - 71
    - DI BUDUO et al., "Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients", eLife, (20210000), vol. 10, page e58775
    - TOZZI et al., "Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production", Biomaterials, (20180000), vol. 178, pages 122 - 133
    - AVANZI MP et al., "A novel bioreactor and culture method drives high yields of platelets from stem cells", Transfusion, (20160000), vol. 56, no. 1, pages 170 - 178
    - SHEPHERD JH et al., "Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: enhancing production and purity", Biomaterials, (20180000), vol. 182, pages 135 - 144
    - NAKAGAWA et al., "Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes", Experimental Hematology, (20130000), vol. 41, no. 8, doi:10.1016/j.exphem.2013.04.007, pages 742 - 748, XP055109130

DOI:   http://dx.doi.org/10.1016/j.exphem.2013.04.007
    - THON et al., "Platelet bioreactor-on-a-chip", Blood, (20140000), vol. 124, doi:10.1182/blood-2014-05-574913, pages 1857 - 1867, XP055375808

DOI:   http://dx.doi.org/10.1182/blood-2014-05-574913
    - ITO et al., "Turbulence activates platelet biogenesis to enable clinical scale ex vivo production", Cell, (20180000), vol. 174, no. 3, doi:10.1016/j.cell.2018.06.011, pages 636 - 648, XP055567213

DOI:   http://dx.doi.org/10.1016/j.cell.2018.06.011
    - DUNOIS-LARDE et al., "Exposure of human megakaryocytes to high shear rates accelerates platelet production", Blood, (20090827), vol. 114, no. 9, doi:10.1182/blood-2009-03-209205, pages 1875 - 83, XP002563898

DOI:   http://dx.doi.org/10.1182/blood-2009-03-209205
    - BLIN et al., "Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics", Scientific Reports, (20160000), vol. 6, page 21700
    - KUMON et al., "On-Chip Platelet Production Using Three Dimensional Microchannel", 2018 IEEE Micro Electro Mechanical Systems (MEMS, (20180000), doi:10.1109/MEMSYS.2018.8346498, pages 121 - 124, XP033335572

DOI:   http://dx.doi.org/10.1109/MEMSYS.2018.8346498
    - ASHFORD et al., "Standard terminology for platelet additive solutions", The International Journal of Transfusion Medicine, (20100000), vol. 98, pages 577 - 578
    - POIRAULT-CHASSAC et al., "Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation", Blood, (20100000), vol. 116, no. 25, doi:10.1182/blood-2010-05-285957, page 5670, XP055501227

DOI:   http://dx.doi.org/10.1182/blood-2010-05-285957
 EP20210155887
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