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EP4288529
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| EP4288529 - SYNTHETIC DEGRADER SYSTEM FOR TARGETED PROTEIN DEGRADATION [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 19.07.2024 Database last updated on 19.07.2024 | |
| Former | Request for examination was made Status updated on 10.11.2023 | ||
| Former | The international publication has been made Status updated on 12.08.2022 | ||
| Former | unknown Status updated on 26.03.2022 | Most recent event Tooltip | 19.07.2024 | Application deemed to be withdrawn | published on 21.08.2024 [2024/34] | Applicant(s) | For all designated states Outpace Bio, Inc. 500 Fairview Ave N. Suite 560 Seattle, WA 98109 / US | [2023/50] | Inventor(s) | 01 /
MOFFETT, Howell Seattle, Washington 98102 / US | 02 /
NGUYEN, Duy San Francisco, California 94080 / US | 03 /
LANGAN, Robert Seattle, Washington 98122 / US | 04 /
BOYKEN, Scott Seattle, Washington 98125 / US | 05 /
LAJOIE, Marc Seattle, Washington 98125 / US | 06 /
FOIGHT, Glenna Houston, Texas 77004 / US | [2023/50] | Representative(s) | Cooley (UK) LLP 22 Bishopsgate London EC2N 4BQ / GB | [2023/50] | Application number, filing date | 22710773.7 | 02.02.2022 | [2023/50] | WO2022US14998 | Priority number, date | US202163144895P | 02.02.2021 Original published format: US 202163144895 P | US202163248516P | 26.09.2021 Original published format: US 202163248516 P | [2023/50] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2022169913 | Date: | 11.08.2022 | Language: | EN | [2022/32] | Type: | A2 Application without search report | No.: | EP4288529 | Date: | 13.12.2023 | Language: | EN | The application published by WIPO in one of the EPO official languages on 11.08.2022 takes the place of the publication of the European patent application. | [2023/50] | Search report(s) | International search report - published on: | EP | 29.09.2022 | Classification | IPC: | C12N9/10, C12N15/52, C12N15/62, A61P35/00, C07K14/705, C07K14/725 | [2023/50] | CPC: |
C12N9/104 (EP);
A61P35/00 (EP);
C07K14/705 (EP);
C07K14/7051 (EP);
C12N15/62 (EP);
C12Y203/02 (EP);
C07K14/70521 (EP);
C07K2319/00 (EP);
C07K2319/01 (EP);
C07K2319/81 (EP)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2023/50] | Title | German: | SYNTHETISCHES ABBAUSYSTEM FÜR GEZIELTEN PROTEINABBAU | [2023/50] | English: | SYNTHETIC DEGRADER SYSTEM FOR TARGETED PROTEIN DEGRADATION | [2023/50] | French: | SYSTÈME DE DÉGRADATION SYNTHÉTIQUE POUR LA DÉGRADATION CIBLÉE DE PROTÉINES | [2023/50] | Entry into regional phase | 25.08.2023 | National basic fee paid | 25.08.2023 | Designation fee(s) paid | 25.08.2023 | Examination fee paid | Examination procedure | 25.08.2023 | Examination requested [2023/50] | 25.08.2023 | Date on which the examining division has become responsible | 23.03.2024 | Application deemed to be withdrawn, date of legal effect [2024/34] | 23.03.2024 | Loss of particular rights, legal effect: Claims | 16.04.2024 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time [2024/34] | 16.04.2024 | Despatch of communication of loss of particular rights: Claims {1} | Fees paid | Renewal fee | 26.02.2024 | Renewal fee patent year 03 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [A]WO2020093043 (CHEN ZIBO [US], et al) [A] 1-143 * Whole document, especially the claims *; | [XI] - DENG WEN ET AL, "Tunable light and drug induced depletion of target proteins", NATURE COMMUNICATIONS, (20200116), vol. 11, no. 1, doi:10.1038/s41467-019-14160-8, XP055933138 [X] 1,2,5,7,9,20,21,82-84,106,108,117-119,121 * Whole document, especially figure 1, and page 2, right column, top paragraph. * [I] 3,4,6,8,10-19,22-81,85-105,107,109-116,120,122-143 DOI: http://dx.doi.org/10.1038/s41467-019-14160-8 | [ ] - Deng Wen ET AL, "Supplementary information Tunable light and drug induced depletion of target proteins", Nature communications, (20200116), pages 1 - 24, URL: https://static-content.springer.com/esm/art:10.1038/s41467-019-14160-8/MediaObjects/41467_2019_14160_MOESM1_ESM.pdf, (20220620), XP055933148 [ ] * whole document, especially figure 1a, b * | [A] - EMMANUEL CAUSSINUS ET AL, "Fluorescent fusion protein knockout mediated by anti-GFP nanobody", NATURE STRUCTURAL & MOLECULAR BIOLOGY, New York, (20120101), vol. 19, no. 1, doi:10.1038/nsmb.2180, ISSN 1545-9993, pages 117 - 121, XP055613880 [A] 1-143 * whole document, especially figure 1. * DOI: http://dx.doi.org/10.1038/nsmb.2180 | [A] - CHEN ZIBO ET AL, "Programmable design of orthogonal protein heterodimers", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 565, no. 7737, doi:10.1038/S41586-018-0802-Y, ISSN 0028-0836, (20181219), pages 106 - 111, (20181219), XP036664328 [A] 1-143 * the whole document * DOI: http://dx.doi.org/10.1038/s41586-018-0802-y | [A] - MICHAEL ZENGERLE ET AL, "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4", ACS CHEMICAL BIOLOGY, (20150821), vol. 10, no. 8, doi:10.1021/acschembio.5b00216, ISSN 1554-8929, pages 1770 - 1777, XP055333869 [A] 1-143 * the whole document * DOI: http://dx.doi.org/10.1021/acschembio.5b00216 | [A] - FOIGHT GLENNA WINK ET AL, "Multi-input chemical control of protein dimerization for programming graded cellular responses", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 37, no. 10, doi:10.1038/S41587-019-0242-8, ISSN 1087-0156, (20190909), pages 1209 - 1216, (20190909), XP036897234 [A] 1-143 * the whole document * DOI: http://dx.doi.org/10.1038/s41587-019-0242-8 | [A] - SCHNEEKLOTH A R ET AL, "Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 22, doi:10.1016/J.BMCL.2008.07.114, ISSN 0960-894X, (20081115), pages 5904 - 5908, (20080731), XP025627166 [A] 1-143 * the whole document * DOI: http://dx.doi.org/10.1016/j.bmcl.2008.07.114 | [A] - Baltz Morgan R ET AL, "Design and functional characterization of synthetic E3 ubiquitin ligases for targeted protein depletion: Selective protein knockout using engineered ubiquibodies", Current protocols in chemical biology, doi:10.1002/cpch.37, (20180301), pages 72 - 90, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062852/pdf/nihms920139.pdf, (20220511), XP055920080 [A] 1-143 * abstract * DOI: http://dx.doi.org/10.1002/cpch.37 | [A] - ALYSE D. PORTNOFF ET AL, "Ubiquibodies, Synthetic E3 Ubiquitin Ligases Endowed with Unnatural Substrate Specificity for Targeted Protein Silencing", JOURNAL OF BIOLOGICAL CHEMISTRY, (20140128), vol. 289, no. 11, doi:10.1074/jbc.M113.544825, ISSN 0021-9258, pages 7844 - 7855, XP055198417 [A] 1-143 * abstract * DOI: http://dx.doi.org/10.1074/jbc.M113.544825 | [A] - BUCKLEY DENNIS L ET AL, "HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins", ACS CHEMICAL BIOLOGY, ACS PUBLICATIONS, USA, (20150821), vol. 10, no. 8, ISSN 1554-8937, pages 1831 - 1837, XP002762672 [A] 1-143 * the whole document * | [A] - NAYAK DIGANT ET AL, "Structure of LNX1:Ubc13 ~ Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1", JOURNAL OF MOLECULAR BIOLOGY, United Kingdom, (20180401), vol. 430, no. 8, doi:10.1016/j.jmb.2018.02.016, ISSN 0022-2836, pages 1173 - 1188, XP055933104 [A] 1-143 * the whole document * DOI: http://dx.doi.org/10.1016/j.jmb.2018.02.016 | by applicant | US2014242701 | WO2020117778 | - European Bioinformatics Institute (EBI, URL: ebi.ac.uk/Tools/psa | - U.S. government's National Center for Biotechnology Information BLAST, URL: blast.ncbi.nlm.nih.gov | - THOMPSON, K.E., ACS Synth. 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