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Extract from the Register of European Patents

EP About this file: EP4430071

EP4430071 - TRANSTHYRETIN (TTR) MONOMER BINDING ANTIBODIES [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  15.08.2024
Database last updated on 09.04.2026
FormerThe international publication has been made
Status updated on  19.05.2023
Most recent event   Tooltip16.12.2025Supplementary search reportpublished on 14.01.2026  [2026/03]
Applicant(s)For all designated states
Adrx, Inc.
515 Marin Street
Suite 314
Thousand Oaks, CA 91360 / US
[2024/38]
Inventor(s)01 / LEIBLY, David, James
Thousands Oaks, CA 91360 / US
02 / LAY, Anna, Rose
Thousands Oaks, CA 91360 / US
03 / APOSTOL, Marcin, Izydor
Thousands Oaks, CA 91360 / US
04 / KAROW, Margaret, Lee
Thousands oaks, CA 91360 / US
05 / MULLEN, Tracey, Elizabeth
Canton, MA 02021 / US
06 / SOUDERS, Colby, Amsden
Canton, MA 02021 / US
 [2024/38]
Representative(s)D Young & Co LLP
3 Noble Street
London EC2V 7BQ / GB
[2024/38]
Application number, filing date22893908.814.11.2022
[2024/38]
WO2022US79810
Priority number, dateUS202163278925P12.11.2021         Original published format: US 202163278925 P
[2024/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2023086989
Date:19.05.2023
Language:EN
[2023/20]
Type: A1 Application with search report 
No.:EP4430071
Date:18.09.2024
Language:EN
The application published by WIPO in one of the EPO official languages on 19.05.2023 takes the place of the publication of the European patent application.
[2024/38]
Search report(s)International search report - published on:US19.05.2023
(Supplementary) European search report - dispatched on:EP15.12.2025
ClassificationIPC:C07K16/18, C07K7/06, A61K38/00, A61P25/28, G01N33/68
[2025/43]
CPC:
A61P25/28 (EP); C07K16/18 (EP,US); G01N33/6854 (EP);
G01N33/6893 (US); G01N33/6896 (EP); C07K2317/24 (EP,US);
C07K2317/56 (EP); C07K2317/565 (EP); C07K2317/76 (EP);
C07K2317/92 (EP,US); G01N2470/04 (US); G01N2500/04 (EP) (-)
Former IPC [2024/38]C07K16/18, C07K7/06, A61K38/00, A61P25/28
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   ME,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2024/38]
TitleGerman:TRANSTHYRETIN (TTR)-MONOMERBINDENDE ANTIKÖRPER[2024/38]
English:TRANSTHYRETIN (TTR) MONOMER BINDING ANTIBODIES[2024/38]
French:ANTICORPS SE LIANT AU MONOMÈRE DE LA TRANSTHYRÉTINE (TTR)[2024/38]
Entry into regional phase15.05.2024National basic fee paid 
15.05.2024Search fee paid 
15.05.2024Designation fee(s) paid 
15.05.2024Examination fee paid 
Examination procedure15.05.2024Examination requested  [2024/38]
19.12.2024Amendment by applicant (claims and/or description)
Fees paidRenewal fee
11.10.2024Renewal fee patent year 03
16.10.2025Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XI] US2014056904  (CHAKRABARTTY AVIJIT et al.) [X] 1,8-13,16 * the whole document *[I] 1-16
 [XI] US2016251418  (LIU YUE et al.) [X] 1-2,8-13,16 * the whole document *[I] 1-16
 [A] WO2021097360  (UNIV TENNESSEE RES FOUND et al.) [A] 1-16 * the whole document *
 [A] US2021246226  (BAUM ALINA et al.) [A] 1-16 * the whole document *
 [XI]   MICHALON AUBIN ET AL: "A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells", NATURE COMMUNICATIONS, vol. 12, no. 1, 25 May 2021 (2021-05-25), UK, XP093308096, ISSN: 2041-1723, Retrieved from the Internet DOI: 10.1038/s41467-021-23274-x [X] 1,8-13,16 * the whole document *[I] 1-16

DOI:   http://dx.doi.org/10.1038/s41467-021-23274-x
 [IX]   HIGAKI JEFFREY N. ET AL: "Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin", AMYLOID, vol. 23, no. 2, 16 March 2016 (2016-03-16), GB, pages 86 - 97, XP093308087, ISSN: 1350-6129, Retrieved from the Internet DOI: 10.3109/13506129.2016.1148025 [I] 1-16 * the whole document *[X] 1,8-13,16

DOI:   http://dx.doi.org/10.3109/13506129.2016.1148025
 [A]   SEKIJIMA YOSHIKI ET AL: "Serum transthyretin monomer in patients with familial amyloid polyneuropathy", AMYLOID, 1 January 2001 (2001-01-01), pages 257 - 262, XP093308022, Retrieved from the Internet DOI: 10.3109/13506120108993822 [A] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.3109/13506120108993822
 [IX]   HOSOI AKIHIKO ET AL: "Novel Antibody for the Treatment of Transthyretin Amyloidosis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 291, no. 48, 1 November 2016 (2016-11-01), US, pages 25096 - 25105, XP093308108, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.738138 [I] 1-16 * the whole document *[X] 1,8-13,16

DOI:   http://dx.doi.org/10.1074/jbc.M116.738138
 [A]   XU JOHN L ET AL: "Diversity in the CDR3 region of VH is sufficient for most antibody specificities", IMMUNITY, CELL PRESS, AMSTERDAM, NL, vol. 13, no. 1, 1 July 2000 (2000-07-01), pages 37 - 45, XP009147376, ISSN: 1074-7613, [retrieved on 20000905], DOI: 10.1016/S1074-7613(00)00006-6 [A] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.1016/S1074-7613(00)00006-6
International search[XA] US2016355576  (GRIMM JAN et al.) [X] 1-4 * para [0001]; [0016]; [0032]; [0037]; [0209]; [0238] *[A] 6-7
 [A] US2019040138  (XIA YU et al.) [A] 6-7 * para [0006]; claim 1; SEQ ID NO: 17; SEQ ID NO: 18; SEQ ID NO: 19 *
 [A] US2018125920  (CASHMAN NEIL R et al.) [A] 6-7 * para [0059]; SEQ ID NO: 53; SEQ ID NO: 60 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.