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EP4299736
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EP About this file: EP4299736
| EP4299736 - HYDROLASES AND USES THEREOF [Right-click to bookmark this link] | Status | Examination is in progress Status updated on 22.08.2025 Database last updated on 21.03.2026 | |
| Former | Request for examination was made Status updated on 27.09.2024 | ||
| Former | The application has been published Status updated on 01.12.2023 | Most recent event Tooltip | 18.03.2026 | New entry: Renewal fee paid | Applicant(s) | For all designated states Vilnius University Universiteto st. 3 01513 Vilnius / LT | [2024/01] | Inventor(s) | 01 /
Meskys, Rolandas Vilnius / LT | 02 /
Urbeliene, Nina Vilnius / LT | 03 /
Tauraite, Daiva Vilnius / LT | 04 /
Tiskus, Matas Vilnius / LT | 05 /
Preitakaite, Viktorija Vilnius / LT | [2024/01] | Representative(s) | Petniunaite, Jurga AAA Law A. Gostauto 40B 03163 Vilnius / LT | [2024/01] | Application number, filing date | 23168045.5 | 14.04.2023 | [2024/01] | Priority number, date | LT20220000514 | 15.04.2022 Original published format: LT 2022514 | [2024/01] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP4299736 | Date: | 03.01.2024 | Language: | EN | [2024/01] | Type: | A3 Search report | No.: | EP4299736 | Date: | 20.03.2024 | Language: | EN | [2024/12] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 15.02.2024 | Classification | IPC: | C12N9/78, A61K38/50 | [2024/01] | CPC: |
C12N9/78 (EP);
C12Y305/04005 (EP);
A61K38/00 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2024/44] |
| Former [2024/01] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Extension states | BA | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | HYDROLASEN UND VERWENDUNGEN DAVON | [2024/01] | English: | HYDROLASES AND USES THEREOF | [2024/01] | French: | HYDROLASES ET LEURS UTILISATIONS | [2024/01] | Examination procedure | 19.09.2024 | Examination requested [2024/44] | 19.09.2024 | Date on which the examining division has become responsible | 20.09.2024 | Amendment by applicant (claims and/or description) | 21.08.2025 | Despatch of a communication from the examining division (Time limit: M05) | 21.01.2026 | Reply to a communication from the examining division | Fees paid | Renewal fee | 23.04.2025 | Renewal fee patent year 03 | 16.03.2026 | Renewal fee patent year 04 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [I] ANONYMOUS: "Cytidine deaminase (UniProt entry: A0A1F9ZPJ8_9FIRM)", 7 April 2021 (2021-04-07), pages 1 - 2, XP093100358, Retrieved from the Internet | [I] ANONYMOUS: "Cytidine deaminase (UniProt entry: A0A3C1U8R5_9FIRM)", 2 June 2021 (2021-06-02), pages 1 - 2, XP093100360, Retrieved from the Internet | [A] ANONYMOUS: "Cytidine deaminase (UniProt entry: A0A412G6B7_9FIRM)", 7 April 2021 (2021-04-07), pages 1 - 2, XP093100361, Retrieved from the Internet | [A] STANISLAUSKIENE RUTA ET AL: "YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine derivatives", SCIENTIFIC REPORTS, vol. 10, no. 1, 21 January 2020 (2020-01-21), XP093100207, DOI: 10.1038/s41598-020-57664-w DOI: http://dx.doi.org/10.1038/s41598-020-57664-w | [A] URBELIENE NINA ET AL: "A Rapid Method for the Selection of Amidohydrolases from Metagenomic Libraries by Applying Synthetic Nucleosides and a Uridine Auxotrophic Host", CATALYSTS, vol. 10, no. 4, 21 April 2020 (2020-04-21), pages 445, XP093100231, DOI: 10.3390/catal10040445 DOI: http://dx.doi.org/10.3390/catal10040445 | [PX] URBELIENE NINA ET AL: "Cytidine deaminases catalyze the conversion of N(S,O)4-substituted pyrimidine nucleosides", SCIENCE ADVANCES, VOLUME 9, ISSUE 5, 3 February 2023 (2023-02-03), pages 1 - 14, XP093073374, Retrieved from the Internet DOI: http://dx.doi.org/10.1126/sciadv.ade4361 | [PX] URBELIENE NINA ET AL: "Supplementary Materials for: Cytidine deaminases catalyze the conversion of N ( S , O ) 4 -substituted pyrimidine nucleosides", SCIENCE ADVANCES, vol. 9, no. 5, 3 February 2023 (2023-02-03), pages 1 - 47, XP093100372, DOI: 10.1126/sciadv.ade4361 DOI: http://dx.doi.org/10.1126/sciadv.ade4361 | [PXI] ANONYMOUS: "Uncultured bacterium clone CDA_F14 cytidine deaminase (cdd) and EraGTPase genes, complete cds (GenBank: OM350122.1)", 27 December 2022 (2022-12-27), pages 1 - 2, XP093101440, Retrieved from the Internet | by applicant | US10035983 | WO2009143048 | US8349318 | WO0047725 | WO2005049845 | WO2006103452 | WO2015075475 | WO9512678 | US2008206221 | WO9945126 | EP0415731 | US2001035983 | WO2009148048 | CLARK, J.L.HOLLECKER, L.MASON, J.C.STUYVER, L.J.THARNISH, P.M.LOSTIA, S.MCBRAYER, T.R.SCHINAZI, R.F.WATANABE, K.A.OTTO, M.J. ET AL: "Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication", J. MED. CHEM., vol. 48, 2005, pages 5504 - 5508, XP002415215, DOI: 10.1021/jm0502788 DOI: http://dx.doi.org/10.1021/jm0502788 | COHEN, R.M.WOLFENDEN, R.: "Cytidine Deaminase from Escherichia coli PURIFICATION, PROPERTIES, AND INHIBITION BY THE POTENTIAL TRANSITION STATE ANALOG 3,4,5,6-TETRAHYDROURIDINE", J. BIOL. CHEM., vol. 246, 1971, pages 7561 - 7565 | GAO, Y.ZHANG, P.WU, L.MATSUURA, T.MENG, J.: "Synthesis of Uridine Derivatives Containing Amino Acid Residues", SYNTH. COMMUN., vol. 33, no. 15, 2003, pages 2635 - 2641 | GOBLE, A.M.FAN, H.SALI, A.RAUSHEL, F.M.: "Discovery of a Cytokinin Deaminase", ACS CHEM. BIOL., vol. 6, 2011, pages 1036 - 1040 | GONG, Y.CHEN, L.ZHANG, W.SALTER, R.: "Transglycosylation in the Modification and Isotope Labeling of Pyrimidine Nucleosides", ORG. LETT., vol. 22, no. 14, 2020, pages 5577 - 5581 | JAKUBOVSKA, J.TAURAITE, D.BIRSTONAS, L.MESKYS, R., NUCLEIC ACIDS RES., vol. 46, 2018, pages 5911 - 5923 | JANSEN RSROSING HSCHELLENS JHBEIJNEN JH: "Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?", FUNDAM CLIN PHARMACOL., vol. 25, no. 2, April 2011 (2011-04-01), pages 172 - 85, XP071692028, DOI: 10.1111/j.1472-8206.2010.00823.x DOI: http://dx.doi.org/10.1111/j.1472-8206.2010.00823.x | KALETA, Z.MAKOWSKI, B. T.SOOS, T.DEMBINSKI, R.: "Thionation Using Fluorous Lawesson's Reagent", ORG. LETT., vol. 8, no. 8, 2006, pages 1625 - 1628 | KRASZEWSKI A.DELORT A.M.TREOULE R.: "cSynthesis of N4-mono- and dialkyl-2'-deoxycytidines and their insertion into an oligonucleotide", TETRAHEDRON LETT, vol. 27, 1986, pages 861 - 864 | LIU, J.LIU, J.ZHAO, D.MA, N.LUAN, Y.: "Highly enhanced leukemia therapy and oral bioavailability from a novel amphiphilic prodrug of cytarabine", RSC ADV., vol. 6, 2016, pages 35991 - 35999 | MALEKSHAH, O.M.CHEN, X.NOMANI, A. ET AL.: "Enzyme/Prodrug Systems for Cancer Gene Therapy", CURR PHARMACOL REP, vol. 2, 2016, pages 299 - 308 | MILECKI, J.NOWAK, J.SKALSKI, B.FRANZEN, S.: "5-Fluoro-4-thiouridine phosphoramidite: New synthon for introducing photoaffinity label into oligodeoxynucleotides", BIOORG. MED. CHEM., vol. 19, 2011, pages 6098 - 6106, XP028299604, DOI: 10.1016/j.bmc.2011.08.035 DOI: http://dx.doi.org/10.1016/j.bmc.2011.08.035 | MURAKAMI, Y.KIMURA, Y.KAWAHARA, A.MITSUYASU, S.MIYAKE, H.TOHYAMA, K.ENDO, Y.YOSHIDA, N.IMAMURA, Y.WATARI, K. ET AL.: "The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes", ONCOTARGET, vol. 10, 2019, pages 2270 - 2281 | NOWAK, I.,ROBINS, M.J.: "Hydrothermal Deamidation of 4-N-Acylcytosine Nucleoside Derivatives:Efficient Synthesis of Uracil Nucleoside Esters", ORG. LETT., vol. 7, 2005, pages 4903 - 4905 | SHELTON, J.LU, X.HOLLENBAUGH, J.A.CHO, J.H.AMBLARD, F.SCHINAZI, R.F.: "Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs", CHEM. REV., vol. 116, 2016, pages 14379 - 14455, XP055568917, DOI: 10.1021/acs.chemrev.6b00209 DOI: http://dx.doi.org/10.1021/acs.chemrev.6b00209 | THOMPSON, J.D.HIGGINS, D.G.GIBSON, T.J.: "CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice", NUCLEIC ACIDS RES., vol. 22, no. 22, 11 November 1994 (1994-11-11), pages 4673 - 80, XP002956304 | URBELIENE, N. ET AL.: "A Rapid Method for the Selection of Amidohydrolases from Metagenomic Libraries by Applying Synthetic Nucleosides and a Uridine Auxotrophic Host", CATALYSTS, vol. 10, no. 445, 2020 | URBELIENE, N.KUTANOVAS, S.ME''SKIENE, R.GASPARAVIIT, R.TAURAITE, D.KOPLNAIT, M.MESKYS, R.: "Application of the uridine auxotrophic host and synthetic nucleosides for a rapid selection of hydrolases from metagenomic libraries", MICROB. BIOTECHNOL., vol. 12, 2019, pages 148 - 160 | WALKO, C.M.LINDLEY, C.: "Capecitabine: A review", CLIN. THER., vol. 27, 2005, pages 23 - 44, XP004778946, DOI: 10.1016/j.clinthera.2005.01.005 DOI: http://dx.doi.org/10.1016/j.clinthera.2005.01.005 | WENSKA, G.TARAS-GOSLINSKA, K.LAMPARSKA-KUPSIK, K.SKALSKI, B.GDANIEC, M.GDANIEC, Z.: "Photochemical transformations of 5-halogeno-4-thiouridines", J. CHEM. SOC., PERKIN TRANS., vol. 1, 2002, pages 53 - 57 |