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EP4241840
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EP About this file: EP4241840
| EP4241840 - METHODS FOR TREATING CHOLESTASIS [Right-click to bookmark this link] | Status | Examination is in progress Status updated on 14.02.2025 Database last updated on 09.04.2026 | |
| Former | Request for examination was made Status updated on 17.05.2024 | ||
| Former | The application has been published Status updated on 11.08.2023 | Most recent event Tooltip | 19.03.2026 | New entry: Reply to examination report | Applicant(s) | For all designated states Mirum Pharmaceuticals, Inc. 989 E Hillsdale Blvd., Suite 300 Foster City, CA 94404 / US | [2024/29] |
| Former [2023/37] | For all designated states Mirum Pharmaceuticals, Inc. 950 Tower Lane, Suite 1050 Foster City, CA 94404 / US | Inventor(s) | 01 /
JAECKLIN, Thomas 2800 Delemont / CH | 02 /
DORENBAUM, Alejandro Mill Valley, 94941 / US | [2023/37] | Representative(s) | Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | [2023/37] | Application number, filing date | 23184125.5 | 12.02.2020 | [2023/37] | Priority number, date | US201962804523P | 12.02.2019 Original published format: US 201962804523 P | US201962863904P | 20.06.2019 Original published format: US 201962863904 P | US201962908431P | 30.09.2019 Original published format: US 201962908431 P | US201962932015P | 07.11.2019 Original published format: US 201962932015 P | [2023/37] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP4241840 | Date: | 13.09.2023 | Language: | EN | [2023/37] | Type: | A3 Search report | No.: | EP4241840 | Date: | 22.11.2023 | Language: | EN | [2023/47] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 24.10.2023 | Classification | IPC: | A61K31/4995, A61P1/16, A61P17/04 | [2023/47] | CPC: |
A61P17/04 (EP,IL,US);
A61K31/4995 (EP,IL,KR,US);
A61K31/554 (IL,KR,US);
A61K31/7042 (EP,IL,KR,US);
A61K38/05 (EP);
A61K38/10 (IL);
A61P1/16 (EP,IL,KR,US);
C12N15/11 (IL);
C12N15/113 (IL);
C12Q1/6883 (KR);
G01N33/6893 (US);
C12Q2600/106 (KR);
|
| Former IPC [2023/37] | A61P17/04 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2024/25] |
| Former [2023/37] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Title | German: | VERFAHREN ZUR BEHANDLUNG VON CHOLESTASE | [2023/37] | English: | METHODS FOR TREATING CHOLESTASIS | [2023/37] | French: | PROCÉDÉS DE TRAITEMENT DE LA CHOLESTASE | [2023/37] | Examination procedure | 13.05.2024 | Amendment by applicant (claims and/or description) | 13.05.2024 | Examination requested [2024/25] | 13.05.2024 | Date on which the examining division has become responsible | 14.02.2025 | Despatch of a communication from the examining division (Time limit: M04) | 16.06.2025 | Reply to a communication from the examining division | 17.11.2025 | Despatch of a communication from the examining division (Time limit: M04) | 17.03.2026 | Reply to a communication from the examining division | Parent application(s) Tooltip | EP20756138.2 / EP3924490 | Fees paid | Renewal fee | 07.07.2023 | Renewal fee patent year 03 | 07.07.2023 | Renewal fee patent year 04 | 26.02.2024 | Renewal fee patent year 05 | 18.02.2025 | Renewal fee patent year 06 | 19.02.2026 | Renewal fee patent year 07 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [XIY] THOMPSON RICHARD: "Oral Abstracts (Abstracts 1-263)", vol. 66, no. S1, 1 October 2017 (2017-10-01), US, pages 1 - 148, XP093090080, ISSN: 0270-9139, Retrieved from the Internet DOI: http://dx.doi.org/10.1002/hep.29500 | [XIY] THOMPSON RICHARD J ET AL: "Phase 2 open-label efficacy and safety study of the apical sodium-dependent bile acid transporter inhibitor maralixibat in children with progressive familial intrahepatic cholestasis: 48-week interim efficacy analysis", 24 October 2017 (2017-10-24), pages 1 - 18, XP093090535, Retrieved from the Internet | [PXI] MIRUM PHARMACEUTICALS: "Mirum Pharmaceuticals Presents New Data Demonstrating Durable Improvements in Clinical Outcome Measures in Patients with PFIC2 and Alagille Syndrome Treated with Maralixibat", 15 April 2019 (2019-04-15), XP055892012, Retrieved from the Internet | [Y] MALATACK JEFFREY ET AL: "Case RepoRt A Drug Regimen for Progressive Familial Cholestasis Type 2", PEDIATRICS, 1 January 2018 (2018-01-01), pages 1 - 5, XP055975631, Retrieved from the Internet DOI: http://dx.doi.org/doi:10.1542/peds.2016-3877 | [PY] ANONYMOUS: "Study Record Versions History of Changes for Study: NCT04185363 An Extension Study of Maralixibat in Patients With Progressive Familial Intrahepatic Cholestasis (PFIC)", CLINICAL TRIALS.GOV, 6 December 2019 (2019-12-06), clinical trials, pages 1 - 9, XP055977607, Retrieved from the Internet | [PY] ANONYMOUS: "Study Record Versions History of Changes for Study: NCT04168385 MRX-800: A Long-Term Safety Study of Maralixibat in the Treatment of Cholestatic Liver Disease in Subjects Who Previously Participated in a Maralixibat Study (MERGE)", CLINICALTRIALS.GOV, 22 January 2020 (2020-01-22), pages 1 - 9, XP055977617, Retrieved from the Internet | Examination | ANONYMOUS: "Study Record Versions Contacts/Locations and Study Status Study Status and Study Identification Contacts/Locations and Study Status History of Changes for Study: NCT02160782 Safety and Efficacy Study of LUM001 With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS) (ICONIC)", 19 September 2018 (2018-09-19), XP055892127, Retrieved from the Internet | by applicant | EP1810689 | US6458851 | US7413536 | US7514421 | US2002147184 | US2003119809 | US2003149010 | US2004014806 | US2004092500 | US2004180861 | US2004180860 | US2005031651 | US2006069080 | US2006199797 | US2006241121 | US2007065428 | US2007066644 | US2007161578 | US2007197628 | US2007203183 | US2007254952 | US2008070888 | US2008070892 | US2008070889 | US2008070984 | US2008089858 | US2008096921 | US2008161400 | US2008167356 | US2008194598 | US2008255202 | US2008261990 | WO0250027 | WO2005046797 | WO2006017257 | WO2006105913 | WO2006105912 | WO2006116499 | WO2006117076 | WO2006121861 | WO2006122186 | WO2006124713 | WO2007050628 | WO2007101531 | WO2007134862 | WO2007140934 | WO2007140894 | WO2008028590 | WO2008033431 | WO2008033464 | WO2008031501 | WO2008031500 | WO2008033465 | WO2008034534 | WO2008039829 | WO2008064788 | WO2008064789 | WO2008088836 | WO2008104306 | WO2008124505 | WO2008130616 | WO9316055 | WO9418183 | WO9418184 | WO9605188 | WO9608484 | WO9616051 | WO9733882 | WO9838182 | WO9935135 | WO9840375 | WO9964409 | WO9964410 | WO0001687 | WO0047568 | WO0061568 | DE19825804 | WO0038725 | WO0038726 | WO0038727 | WO0038728 | WO0166533 | WO0250051 | EP0864582 | WO9424087 | WO9807749 | WO9856757 | WO9932478 | WO0020392 | WO0020393 | WO0020410 | WO0020437 | WO0134570 | WO0035889 | WO0168637 | WO0168096 | WO0208211 | WO03020710 | WO03022825 | WO03022830 | WO03022861 | JPH1072371 | US5910494 | US5723458 | US5817652 | US5663165 | US5998400 | US6465451 | US5994391 | US6107494 | US6387924 | US6784201 | US6875877 | US6740663 | US6852753 | US5070103 | US6114322 | US6020330 | US7179792 | EP0251315 | EP0417725 | EP0489423 | EP0549967 | EP0573848 | EP0624593 | EP0624594 | EP0624595 | EP0869121 | EP1070703 | WO2004005247 | EP0597107 | WO9308155 | US3383281 | US3308020 | US3769399 | US3846541 | US3974272 | US4172120 | US4252790 | US4340585 | US4814354 | US4874744 | US4895723 | US5695749 | US6066 | US336 | US4647459 | EP0190826 | US5275823 | DRUGS OF THE FUTURE, vol. 24, 1999, pages 425 - 430 | JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5837 - 5852 | CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 997 - 1016 | BYRNE ET AL.: "Missense Mutations and Single Nucleotide Polymorphisms in ABCB11 Impair Bile Salt Export Pump Processing and Function or Disrupt Pre-Messanger RNA Splicing", HEPATOLOGY, vol. 49, 2009, pages 553 - 567 | "Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING COMPANY | HOOVER, JOHN E: "Remington's Pharmaceutical Sciences", 2000, MACK PUBLISHING CO | "Pharmaceutical Dosage Forms", 1980, MARCEL DECKER | "Pharmaceutical Dosage Forms and Drug Delivery Systems", 1999, LIPPINCOTT WILLIAMS & WILKINS | "Handbook of Pharmaceutical Excipients", 2003, PHARMACEUTICAL PRESS |