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Extract from the Register of European Patents

EP About this file: EP4344703

EP4344703 - METHODS OF USING PYRUVATE KINASE ACTIVATORS [Right-click to bookmark this link]
StatusThe application has been published
Status updated on  01.03.2024
Database last updated on 24.08.2024
Most recent event   Tooltip28.06.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Agios Pharmaceuticals, Inc.
88 Sidney Street
Cambridge, MA 02139 / US
[2024/14]
Inventor(s)01 / AGRESTA, Samuel, V.
Lexington, MA / US
02 / CHEN, Yue
Quincy, MA / US
03 / COHEN, Marvin Barry
Newtown, PA / US
04 / DANG, Leonard Luan C.
Boston, MA / US
05 / KUNG, Charles
Arlington, MA / US
06 / MERICA, Elizabeth A.
Boston, MA / US
07 / SILVER, Bruce Alan
Dunkirk, MD / US
08 / YANG, Hua
Acton, MA / US
 [2024/14]
Representative(s)Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
[2024/14]
Application number, filing date23196616.910.06.2016
[2024/14]
Priority number, dateUS201562174216P11.06.2015         Original published format: US 201562174216 P
[2024/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP4344703
Date:03.04.2024
Language:EN
[2024/14]
Search report(s)(Supplementary) European search report - dispatched on:EP05.03.2024
ClassificationIPC:A61K31/4709, A61K31/496, C07D215/36, A61P7/06, A61K9/00
[2024/14]
CPC:
A61K31/496 (EP,US); A61P7/06 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2024/14]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:VERFAHREN ZUR VERWENDUNG VON PYRUVATKINASEAKTIVATOREN[2024/14]
English:METHODS OF USING PYRUVATE KINASE ACTIVATORS[2024/14]
French:PROCÉDÉS D'UTILISATION D'ACTIVATEURS DE LA PYRUVATE KINASE[2024/14]
Parent application(s)   TooltipEP16808374.9  / EP3307271
Fees paidRenewal fee
11.09.2023Renewal fee patent year 03
11.09.2023Renewal fee patent year 04
11.09.2023Renewal fee patent year 05
11.09.2023Renewal fee patent year 06
11.09.2023Renewal fee patent year 07
11.09.2023Renewal fee patent year 08
27.06.2024Renewal fee patent year 09
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO2012151451  (AGIOS PHARMACEUTICALS INC [US], et al) [Y] 1-12 * page 1, line 5 - page 3, paragraph 1 * * page 4, paragraph 3 - page 4, paragraph 1 * * page 23, paragraph last - page 25, paragraph first * * claims 1-30 * * figure 1/79 *;
 [Y]US2014155408  (SU SHIN-SAN MICHAEL [US]) [Y] 1-12 * page 2, paragraph 9 * * page 2, paragraph 14 - paragraph 16 * * page 44, paragraph 194 *;
 [A]US2014323467  (SALITURO FRANCESCO G [US], et al) [A] 1-12 * page 1, paragraph 24 * * page 2, paragraph 30 * * page 8, paragraph 156 * * page 16, paragraph 235 * * page 17, paragraph 240 * * page 229, paragraph 1324 *;
 [Y]  - KUNG CHARLES ET AL, "AG-348 Activation of Pyruvate Kinase in Vivo Enhances Red Cell Glycolysis in Mice", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (20141201), XP002787328 [Y] 1-12 * abstract *
 [Y]  - YANG HUA ET AL, "Phase I Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (201412), Database accession no. PREV201500280858, XP002787329 [Y] 1-12 * abstract *
 [A]  - DIMITRIOS ANASTASIOU, "Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Correspondence: performed in vivo pharmacology and ADME studies wrote the paper with significant input from Y", NAT CHEM BIOL., (20121001), vol. 8, no. 10, pages 839 - 847, XP055333200 [A] 1-12 * the whole document *
by applicantUS8785450
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