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Extract from the Register of European Patents

EP About this file: EP4344741

EP4344741 - AAV VECTORS TARGETED TO THE CENTRAL NERVOUS SYSTEM [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  28.02.2025
Database last updated on 08.04.2026
FormerThe application has been published
Status updated on  01.03.2024
Most recent event   Tooltip17.10.2025Change - applicantpublished on 19.11.2025  [2025/47]
Applicant(s)For all designated states
The University of North Carolina at Chapel Hill
136 East Rosemary Street, Suite 100
Chapel Hill, NC 27514 / US
[2025/47]
Former [2024/14]For all designated states
The University of North Carolina at Chapel Hill
100 Europa Drive, Suite 430
Chapel Hill, North Carolina 27517 / US
Inventor(s)01 / GRAY, Steven
Southlake, 76092 / US
02 / MCCOWN, Thomas
Carrboro, 27510 / US
 [2024/14]
Representative(s)Kransell & Wennborg KB
P.O. Box 27834
115 93 Stockholm / SE
[2024/14]
Application number, filing date23199459.120.11.2015
[2024/14]
Priority number, dateUS201462082897P21.11.2014         Original published format: US 201462082897 P
US201562218857P15.09.2015         Original published format: US 201562218857 P
[2024/14]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP4344741
Date:03.04.2024
Language:EN
[2024/14]
Type: A3 Search report 
No.:EP4344741
Date:28.08.2024
Language:EN
[2024/35]
Search report(s)(Supplementary) European search report - dispatched on:EP25.07.2024
ClassificationIPC:C12N15/34, C12N15/62, C12N5/10, C12N7/00, C07K19/00, C07K14/01, A61K31/7088, A61K35/76, A61K39/12, A61P25/00
[2024/35]
CPC:
A61K48/0058 (EP,IL,US); A61K31/7088 (IL,RU); A61K48/00 (KR);
A61K31/711 (EP,IL,RU,US); A61K35/76 (EP,IL,US); A61K9/0014 (IL,US);
A61P21/00 (EP,IL); A61P25/00 (EP,IL,KR); A61P7/00 (EP,IL);
C07K14/005 (EP,IL,KR,US); C12N15/62 (EP,IL,RU,US); C12N15/86 (EP,IL,KR,US);
C12N7/00 (EP,IL,US); C12N2750/14121 (EP,IL,US); C12N2750/14122 (EP,IL,KR,US);
C12N2750/14143 (EP,IL,KR,US); C12N2750/14145 (EP,IL,KR,US); C12N2750/14151 (EP,IL,US);
C12N2830/008 (EP,IL,KR,US) (-)
Former IPC [2024/14]A61P25/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2024/14]
TitleGerman:AUF DAS ZENTRALE NERVENSYSTEM GERICHTETE AAV-VEKTOREN[2024/14]
English:AAV VECTORS TARGETED TO THE CENTRAL NERVOUS SYSTEM[2024/14]
French:VECTEURS AAV CIBLANT LE SYSTÈME NERVEUX CENTRAL[2024/14]
Examination procedure24.02.2025Amendment by applicant (claims and/or description)
24.02.2025Examination requested  [2025/14]
24.02.2025Date on which the examining division has become responsible
Parent application(s)   TooltipEP15861347.1  / EP3221453
Fees paidRenewal fee
06.01.2024Renewal fee patent year 03
06.01.2024Renewal fee patent year 04
06.01.2024Renewal fee patent year 05
06.01.2024Renewal fee patent year 06
06.01.2024Renewal fee patent year 07
06.01.2024Renewal fee patent year 08
06.01.2024Renewal fee patent year 09
04.10.2024Renewal fee patent year 10
06.10.2025Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[I] WO2014052789  (UNIV NORTH CAROLINA et al.)
 [X] WO2011133890  (UNIV MASSACHUSETTS et al.)
 [A] US2013225666  (KASPAR BRIAN K et al.)
 [A] WO2007089632  (UNIV NORTH CAROLINA et al.)
 [I]   GRAY S J ET AL: "Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood-Brain Barrier (BBB)", MOLECULAR THERAPY, vol. 18, no. 3, 1 March 2010 (2010-03-01), pages 570 - 578, XP055086790, ISSN: 1525-0016, DOI: 10.1038/mt.2009.292

DOI:   http://dx.doi.org/10.1038/mt.2009.292
 [I]   GRAY S J: "Gene therapy and neurodevelopmental disorders", NEUROPHARMACOLOGY, vol. 68, 1 May 2013 (2013-05-01), pages 136 - 142, XP055099736, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2012.06.024

DOI:   http://dx.doi.org/10.1016/j.neuropharm.2012.06.024
 [I]   KOERBER J T ET AL: "Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 17, no. 12, 1 December 2009 (2009-12-01), US, pages 2088 - 2095, XP055468132, ISSN: 1525-0016, DOI: 10.1038/mt.2009.184

DOI:   http://dx.doi.org/10.1038/mt.2009.184
 [I]   MAGUIRE C A ET AL: "Directed evolution of adeno-associated virus for glioma cell transduction", JOURNAL OF NEURO-ONCOLOGY, KLUWER ACADEMIC PUBLISHERS, BO, vol. 96, no. 3, 19 July 2009 (2009-07-19), pages 337 - 347, XP019773413, ISSN: 1573-7373
 [A]   YANG B ET AL: "Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 22, no. 7, 1 July 2014 (2014-07-01), US, pages 1299 - 1309, XP055473055, ISSN: 1525-0016, DOI: 10.1038/mt.2014.68

DOI:   http://dx.doi.org/10.1038/mt.2014.68
 [A]   WU Z ET AL: "Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 80, no. 22, 1 November 2006 (2006-11-01), pages 11393 - 11397, XP002656650, ISSN: 0022-538X, DOI: 10.1128/JVI.01288-06

DOI:   http://dx.doi.org/10.1128/JVI.01288-06
 [A]   HUTSON T H ET AL: "Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector", GENE THERAPY, vol. 19, no. 1, 12 May 2011 (2011-05-12), GB, pages 49 - 60, XP055497367, ISSN: 0969-7128, DOI: 10.1038/gt.2011.71

DOI:   http://dx.doi.org/10.1038/gt.2011.71
by applicantUS201462082897
 US201562218857
 WO0028061
 WO9961601
 WO9811244
 US6156303
 US5478745
 WO0028004
 WO0192551
 US7465583
 US2003017131
 US2007026076
 US5877022
 US6013487
 US6083702
 US5869248
 US6653467
 US6727355
 US6653466
 US5354855
 US5023243
 US5149797
 WO0177350
 US5916563
 US5905040
 US5882652
 US5863541
 US4968603
 WO9005142
 US6040183
 US6093570
 WO0017377
 US5658785
 US4474893
 US4816567
 US4676980
 WO03095647
 WO2006021724
 US2006287259
 US2007059288
 US5399346
 WO0191803
 US7201898
 US4501729
 WO2012093784
 WO2009137006
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