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Extract from the Register of European Patents

EP About this file: EP4507676

EP4507676 - METAL-ORGANIC FRAMEWORKS AS SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  09.01.2026
Database last updated on 26.03.2026
FormerRequest for examination was made
Status updated on  17.01.2025
FormerThe international publication has been made
Status updated on  21.10.2023
Formerunknown
Status updated on  19.04.2023
Most recent event   Tooltip09.01.2026Application deemed to be withdrawnpublished on 11.02.2026  [2026/07]
Applicant(s)For all designated states
Julius-Maximilians-Universität Würzburg
Sanderring 2
97070 Würzburg / DE
[2025/08]
Inventor(s)01 / SCHELLER, Lena
97070 Wuerzburg / DE
02 / MEINEL, Lorenz
97082 Wuerzburg / DE
03 / LUEHMANN, Tessa
97070 Wuerzburg / DE
 [2025/08]
Representative(s)Kraus & Lederer PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
[2025/08]
Application number, filing date23716277.130.03.2023
[2025/08]
WO2023EP58309
Priority number, dateEP2022016838714.04.2022         Original published format: EP 22168387
[2025/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2023198471
Date:19.10.2023
Language:EN
[2023/42]
Type: A1 Application with search report 
No.:EP4507676
Date:19.02.2025
Language:EN
The application published by WIPO in one of the EPO official languages on 19.10.2023 takes the place of the publication of the European patent application.
[2025/08]
Search report(s)International search report - published on:EP19.10.2023
ClassificationIPC:A61K9/107, A61K9/00, A61K9/14, A61K9/20, A61K31/00
[2025/08]
CPC:
A61K9/1075 (EP,US); A61K47/24 (US); A61K31/538 (EP);
A61K9/0009 (EP); A61K9/145 (EP); A61K9/2095 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   ME,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2025/08]
TitleGerman:METALLORGANISCHE GERÜSTE ALS FESTE SELBSTMIKROEMULGIERENDE ARZNEIMITTELABGABESYSTEME[2025/08]
English:METAL-ORGANIC FRAMEWORKS AS SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS[2025/08]
French:STRUCTURES ORGANOMÉTALLIQUES EN TANT QUE SYSTÈMES D'ADMINISTRATION DE MÉDICAMENT AUTO-MICROÉMULSIFIANTS SOLIDES[2025/08]
Entry into regional phase01.08.2024National basic fee paid 
01.08.2024Designation fee(s) paid 
01.08.2024Examination fee paid 
Examination procedure01.08.2024Examination requested  [2025/08]
01.08.2024Date on which the examining division has become responsible
01.10.2025Application deemed to be withdrawn, date of legal effect  [2026/07]
16.10.2025Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2026/07]
Fees paidPenalty fee
Additional fee for renewal fee
31.03.202503   M06   Not yet paid
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A] WO2022007298  (SHENZHEN INST OF ADV TECH CAS et al.)
 [A]   WANG ZHANGJIE ET AL: "A Novel Drug Delivery System: the Encapsulation of Naringenin in Metal-Organic Frameworks into Liposomes", AAPS PHARMSCITECH, vol. 22, no. 2, 1 February 2021 (2021-02-01), XP037381590, DOI: 10.1208/S12249-021-01927-W

DOI:   http://dx.doi.org/10.1208/s12249-021-01927-w
 [A]   LIN KUN-YI ANDREW ET AL: "Efficient demulsification of oil-in-water emulsions using a zeolitic imidazolate framework: Adsorptive removal of oil droplets from water", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS,INC, US, vol. 478, 1 June 2016 (2016-06-01), pages 97 - 106, XP029628029, ISSN: 0021-9797, DOI: 10.1016/J.JCIS.2016.05.057

DOI:   http://dx.doi.org/10.1016/j.jcis.2016.05.057
 [A]   XUERUI CHEN ET AL: "Derivative of Epigallocatechin-3-gallatea Encapsulated in ZIF-8 with Polyethylene Glycol-Folic Acid Modification for Target and pH Responsive Drug Release in Anticancer Research", ACS BIOMATER. SCI. ENG,, vol. 2018, no. 4, 9 November 2018 (2018-11-09), pages 4183 - 4192, XP002804868, DOI: 10.1021/ACSBIOMATERIALS.8B00840

DOI:   http://dx.doi.org/10.1021/acsbiomaterials.8b00840
 [AD]   SANDER CAMILLA ET AL: "Porous magnesium aluminometasilicate tablets as carrier of a cyclosporine self-emulsifying formulation", AAPS PHARMSCITECH, SPRINGER NEW YORK LLC, US, vol. 10, no. 4, 1 January 2009 (2009-01-01), pages 1388 - 1395, XP008152886, ISSN: 1530-9932, Retrieved from the Internet DOI: 001: 1O.1208/S12249-009-934O-O

DOI:   http://dx.doi.org/001: 1O.1208/s12249-009-934O-O
by applicant  S. TALEGAONKARA. AZEEMF.J. AHMADR.K. KHARS.A. PATHANZ.I. KHAN: "Microemulsions: a novel approach to enhanced drug delivery", RECENT PAT DRUG DELIV FORMUL, vol. 2, 2008, pages 238 - 257, XP055808225, DOI: 10.2174/187221108786241679

DOI:   http://dx.doi.org/10.2174/187221108786241679
   C.J .H. PORTERW.N. CHARMAN: "In vitro assessment of oral lipid based formulations", ADVANCED DRUG DELIVERY REVIEWS, vol. 50, 2001, pages S127 - S147, XP002422521, DOI: 10.1016/S0169-409X(01)00182-X

DOI:   http://dx.doi.org/10.1016/S0169-409X(01)00182-X
   M.J. LAWRENCEG.D. REES: "Microemulsion-based media as novel drug delivery systems", ADVANCED DRUG DELIVERY REVIEWS, vol. 45, 2000, pages 89 - 121, XP055011623, DOI: 10.1016/S0169-409X(00)00103-4

DOI:   http://dx.doi.org/10.1016/S0169-409X(00)00103-4
   S. GIBAUDD. ATTIVI: "Microemulsions for oral administration and their therapeutic applications", EXPERT OPIN DRUG DELIV, vol. 9, 2012, pages 937 - 951
   C. SANDERP. HOLM: "Porous magnesium aluminometasilicate tablets as carrier of a cyclosporine self-emulsifying formulation", AAPS PHARMSCITECH, vol. 10, 2009, pages 1388 - 1395, XP008152886, DOI: 001: 1O.1208/s12249-009-934O-O

DOI:   http://dx.doi.org/001: 1O.1208/s12249-009-934O-O
   D.W. KIMJ.H. KANGD.H. OHC.S. YONGH.G. CHOI: "Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier", J MICROENCAPSUL, vol. 29, 2012, pages 323 - 330
   K. VITHANIA. GOYANESV. JANNINA.W. BASITS. GAISFORDB.J. BOYD: "A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics", PHARM RES, vol. 36, 2019, pages 102
   K. CERPNJAKA. ZVONARF. VRECERM. GASPERLIN: "Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen", DRUG DEV LND PHARM, vol. 41, 2015, pages 1548 - 1557
   D. K.; DAVISJ. L.ALLEN, I. C.MORRIS, A. J.GROVE, T. Z.: "Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle", CHEM COMMUN (CAMB, vol. 54, no. 55, 2018, pages 7617 - 7620, XP055966376, DOI: 10.1039/C8CC01601A

DOI:   http://dx.doi.org/10.1039/C8CC01601A
   LIN, W.HU, Q.YU, J.JIANG, K.YANG, Y.XIANG, S.CUI, Y.YANG, Y.WANG, Z.QIAN, G.: "Low Cytotoxic Metal-Organic Frameworks as Temperature-Responsive Drug Carriers", CHEMPLUSCHEM, vol. 81, no. 8, 2016, pages 804 - 810
   JIANG, K.ZHANG, L.HU, Q.ZHAO, D.XIA, T.LIN, W.YANG, Y.CUI, Y.YANG, Y.QIAN, G.: "Pressure controlled drug release in a Zr-cluster-based MOF", J MATER CHEM B, vol. 4, no. 39, 2016, pages 6398 - 6401
   LEI, B.WANG, M.JIANG, Z.QI, W.SU, R.HE, Z.: "Constructing Redox-Responsive Metal-Organic Framework Nanocarriers for Anticancer Drug Delivery", ACS APPLMATER INTERFACES, vol. 10, no. 19, 2018, pages 16698 - 16706, XP055966372, DOI: 10.1021/acsami.7b19693

DOI:   http://dx.doi.org/10.1021/acsami.7b19693
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.