Extract from the Register of European Patents

EP About this file: EP4705439

EP4705439 - GENETICALLY MODIFIED YEAST WITH DECREASED ERYTHRITOL PRODUCTION [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  06.02.2026
Database last updated on 09.04.2026
FormerThe international publication has been made
Status updated on  09.11.2024
Formerunknown
Status updated on  06.06.2024
Most recent event   Tooltip06.02.2026Publication in section I.1 EP Bulletinpublished on 11.03.2026  [2026/11]
06.02.2026The date on which the examining division becomes responsible, has been established 
06.02.2026Request for examination filedpublished on 11.03.2026  [2026/11]
Applicant(s)For all designated states
Cargill, Incorporated
15407 McGinty Road West
Wayzata, Minnesota 55391 / US
[2026/11]
Inventor(s)01 / LIAO, Hans H.
Plymouth, Minnesota 55447 / US
02 / LIES, Douglas Paul
Wayzata, Minnesota 55391 / US
03 / POOR, Catherine Bradshaw
Wayzata, Minnesota 55391 / US
 [2026/11]
Representative(s)Cargill IP Department
Cargill R&D Centre Europe BV
Bedrijvenlaan 9
2800 Mechelen / BE
[2026/11]
Application number, filing date24729485.302.05.2024
[2026/11]
WO2024US27357
Priority number, dateUS202363499989P04.05.2023         Original published format: US 202363499989 P
[2026/11]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2024229192
Date:07.11.2024
Language:EN
[2024/45]
Type: A1 Application with search report 
No.:EP4705439
Date:11.03.2026
Language:EN
The application published by WIPO in one of the EPO official languages on 07.11.2024 takes the place of the publication of the European patent application.
[2026/11]
Search report(s)International search report - published on:EP07.11.2024
ClassificationIPC:C12N9/04, C12P7/18, C12R1/645
[2026/11]
CPC:
C12N9/0006 (EP); C12P7/18 (EP); C12Y101/01021 (EP);
C12R2001/645 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   ME,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2026/11]
Extension statesBANot yet paid
Validation statesGENot yet paid
KHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:GENETISCH MODIFIZIERTE HEFE MIT VERMINDERTER ERYTHRITOLPRODUKTION[2026/11]
English:GENETICALLY MODIFIED YEAST WITH DECREASED ERYTHRITOL PRODUCTION[2026/11]
French:LEVURE GÉNÉTIQUEMENT MODIFIÉE À PRODUCTION D'ÉRYTHRITOL RÉDUITE[2026/11]
Entry into regional phase10.11.2025National basic fee paid 
10.11.2025Designation fee(s) paid 
10.11.2025Examination fee paid 
Examination procedure10.11.2025Amendment by applicant (claims and/or description)
10.11.2025Examination requested  [2026/11]
10.11.2025Date on which the examining division has become responsible
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Cited inInternational search[A] WO2013096693  (XYLECO INC et al.)
 [A] EP1221478  (NAT FOOD RES et al.)
 [I]   SZCZEPANCZYK MATEUSZ ET AL: "The Overexpression of YALI0B07117g Results in Enhanced Erythritol Synthesis from Glycerol by the Yeast Yarrowia lipolytica", MOLECULES, vol. 26, no. 24, 13 December 2021 (2021-12-13), CH, pages 7549, XP093200835, ISSN: 1420-3049, DOI: 10.3390/molecules26247549
 [I]   CHENG HUILING ET AL: "Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering", MICROBIAL CELL FACTORIES, vol. 17, no. 1, 29 August 2018 (2018-08-29), XP093200875, ISSN: 1475-2859, Retrieved from the Internet DOI: 10.1186/s12934-018-0982-z

DOI:   http://dx.doi.org/10.1186/s12934-018-0982-z
 [A]   DESHPANDE MANDAR S. ET AL: "Erythritol production from sugar based feedstocks by Moniliella pollinis using lysate of recycled cells as nutrients source", PROCESS BIOCHEMISTRY, vol. 112, 1 January 2022 (2022-01-01), GB, pages 45 - 52, XP093200722, ISSN: 1359-5113, DOI: 10.1016/j.procbio.2021.11.020
 [A]   DATABASE Geneseq [online] 5 March 2009 (2009-03-05), "Ustilago maydis 521 protein, SEQ ID 9980.", XP093201162, retrieved from EBI accession no. GSP:AUZ41206 Database accession no. AUZ41206
by applicantUS6440712
 US63364363
 US63364370
 US63364375
 US198262633643
 US63364359
 US198062633643
   GEISER ET AL.: "Prospecting the biodiversity of the fungal family Ustilaginacceae for the production of value-added chemicals", FUNGAL BIOL BIOTECHNOL, vol. 1, no. 2, 2014
   FELDBRUGGE ET AL.: "The biotechnological use and potential of plant pathogenic smut fungi", APPL MICROBIOL BIOTECHNOL, vol. 97, no. 8, 2013, pages 3253 - 65, XP035329647, DOI: 10.1007/s00253-013-4777-1

DOI:   http://dx.doi.org/10.1007/s00253-013-4777-1
   GUEVARRA ET AL.: "Accumulation of itaconic, 2-hydroxyparaconic, itatartaric, and malic acids by strains of the genus Ustilago", AGRIC. BIOL. CHEM., vol. 54, no. 9, 1990, pages 2353 - 2358, XP055196196, DOI: 10.1271/bbb1961.54.2353

DOI:   http://dx.doi.org/10.1271/bbb1961.54.2353
   MOON ET AL.: "Biotechnological production of erythritol and its applications", APPL MICROBIOL BIOTECHNOL, vol. 86, 2010, pages 1017 - 1025, XP019800001
   TIWARI, S. ET AL.: "Nectar yeast community of tropical flowering plants and assessment of their osmotolerance and xylitol-producing potential", CURRENT MICROBIOLOGY, vol. 79, 2022, pages 28
   LI ET AL.: "Methods for genetic transformation of filamentous fungi", MICROB CELL FACT, vol. 16, 2017, pages 168
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