Extract from the Register of European Patents

EP About this file: EP4659818

EP4659818 - TREATMENT METHOD AND PRODUCT FOR UTERINE FIBROIDS USING PURIFIED COLLAGENASE [Right-click to bookmark this link]
StatusThe application has been published
Status updated on  07.11.2025
Database last updated on 08.04.2026
Most recent event   Tooltip13.03.2026New entry: Renewal fee paid 
Applicant(s)For all designated states
Endo Biologics Limited
First Floor, Minerva House
Simmonscourt Road
Ballsbridge
Dublin 4, D04H9P8 / IE
For all designated states
Duke University
2138 Campus Drive
Durham, North Carolina 27708 / US
[2025/51]
Former [2025/50]For all designated states
BioSpecifics Technologies Corporation
35 Wilbur Street
Lynbrook, NY 11563 / US
For all designated states
Duke University
2138 Campus Drive
Durham, North Carolina 27708 / US
Inventor(s)01 / LEPPERT, Phyllis Carolyn
Durham, 27705 / US
02 / WEGMAN, Thomas L
New York, 11566 / US
 [2025/50]
Representative(s)Abel & Imray LLP
Westpoint Building
James Street West
Bath BA1 2DA / GB
[2025/50]
Application number, filing date25180240.114.03.2014
[2025/50]
Priority number, dateUS201361790070P15.03.2013         Original published format: US 201361790070 P
[2025/50]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP4659818
Date:10.12.2025
Language:EN
[2025/50]
Type: A3 Search report 
No.:EP4659818
Date:04.03.2026
Language:EN
[2026/10]
Search report(s)(Supplementary) European search report - dispatched on:EP30.01.2026
ClassificationIPC:A61K38/48, A61P35/00, A61K9/00, A61K38/43, A61K45/06, A61P15/00, A61P43/00
[2026/10]
CPC:
A61K38/4886 (EP,US); A61K9/48 (US); A61K38/43 (EP,US);
A61K45/06 (EP,US); A61K9/0019 (EP,US); A61K9/0034 (EP,US);
A61K9/1075 (US); A61P15/00 (EP); A61P35/00 (EP);
A61P43/00 (EP); C12Y304/24003 (EP,US) (-)
C-Set:
A61K38/4886, A61K2300/00 (EP,US)
Former IPC [2025/50]A61P43/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2025/50]
TitleGerman:BEHANDLUNGSVERFAHREN UND MITTEL FÜR GEBÄRMUTTERFIBROIDEN UNTER VERWENDUNG GEREINIGTER KOLLAGENASE[2025/50]
English:TREATMENT METHOD AND PRODUCT FOR UTERINE FIBROIDS USING PURIFIED COLLAGENASE[2025/50]
French:PROCÉDÉ ET PRODUIT DE TRAITEMENT DE FIBROMES UTÉRINS À L'AIDE DE COLLAGÉNASE PURIFIÉE[2025/50]
Parent application(s)   TooltipEP14721664.2  / EP2968484
EP20201646.5  / EP3834840
Fees paidRenewal fee
31.07.2025Renewal fee patent year 03
31.07.2025Renewal fee patent year 04
31.07.2025Renewal fee patent year 05
31.07.2025Renewal fee patent year 06
31.07.2025Renewal fee patent year 07
31.07.2025Renewal fee patent year 08
31.07.2025Renewal fee patent year 09
31.07.2025Renewal fee patent year 10
31.07.2025Renewal fee patent year 11
31.07.2025Renewal fee patent year 12
12.03.2026Renewal fee patent year 13
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Documents cited:Search[XY] WO2006121968  (BOSTON SCIENT SCIMED INC et al.)
 [Y] WO2012031245  (UNIV NORTH CAROLINA et al.)
 [XY]   F. L. JAVES ET AL: "TREATMENT OF UTERINE FIBROIDS WITH HIGHLY PURIFIED CLOSTRIDIAL COLLAGENASE", FERTILITY AND STERILITY, vol. 98, no. 3, 25 August 2012 (2012-08-25), pages S232, XP055127058, DOI: 10.4137/CMT.S3331

DOI:   http://dx.doi.org/10.4137/CMT.S3331
 [Y]   DARLENE K. TAYLOR ET AL: "Treatment for uterine fibroids: Searching for effective drug therapies", DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES, vol. 9, no. 1, 10 August 2012 (2012-08-10), pages e41 - e49, XP055127057, ISSN: 1740-6773, DOI: 10.1016/j.ddstr.2012.06.001

DOI:   http://dx.doi.org/10.1016/j.ddstr.2012.06.001
 [XI]   DARLENE TAYLOR ET AL: "Putting the Moose on the Table: Understanding the Molecular Biology of Uterine Fibroids and Development of Non-invasion Treatments", 28 October 2012 (2012-10-28), XP055257658, Retrieved from the Internet [retrieved on 20160311]
   DARLENE K. TAYLOR ET AL: "Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management", F1000RESEARCH, 6 July 2015 (2015-07-06), XP055257667, DOI: 10.12688/f1000research.6189.1

DOI:   http://dx.doi.org/10.12688/f1000research.6189.1
 [Y]   TAYLOR D K ET AL: "Temperature-responsive biocompatible copolymers incorporating hyperbranched polyglycerols for adjustable functionality", JOURNAL OF FUNCTIONAL BIOMATERIALS, M D P I AG, CH, vol. 2, 1 January 2011 (2011-01-01), pages 173 - 194, XP009165596, ISSN: 2079-4983, [retrieved on 20110823]

DOI:   http://dx.doi.org/10.3390/jfb2030173
by applicantUS7811560
 US2010086971
 US6565530
 US6544227
 US10083003
   FENG LLEIKIN S ET AL., XXIIND MEETING OF THE FEDERATION OF EUROPEAN CONNECTIVE TISSUE SOCIETIES (FECTS, 3 July 2010 (2010-07-03)
   LEPPERT ET AL.: "A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays", AM J OBSTET GYN, vol. 95, 2006, pages 415 - 20, XP005587597, DOI: 10.1016/j.ajog.2005.12.059

DOI:   http://dx.doi.org/10.1016/j.ajog.2005.12.059
   HINZGABBIANI, CURRENT OPINIONS IN BIOTECHNOLOGY, vol. 14, 2003, pages 38 - 46
   CATHERINO, GENES, CHROMOSOMES & CANCER, vol. 40, 2004, pages 204 - 217
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