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EP0233031
European procedure
Extract from the Register of European Patents
EP About this file: EP0233031
| EP0233031 - Methylthioribose analogues, their preparation and use as medicinal agents and biocides [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 10.02.1994 Database last updated on 09.04.2026 | Most recent event Tooltip | 07.03.1997 | Lapse of the patent in a contracting state | published on 23.04.1997 [1997/17] | Applicant(s) | For all designated states STATE OF OREGON BY AND THROUGH OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OREGON HEALTH SC. UNIV. AND OREGON STATE UNIV. 3181 S.W. Sam Jackson Park Road Portland Oregon 97201 / US | [N/P] |
| Former [1987/34] | For all designated states STATE OF OREGON BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND OREGON STATE UNIVERSITY, 3181 S.W. Sam Jackson Park Road Portland, Oregon 97201 / US | Inventor(s) | 01 /
Risco, Michael K. 19355 S.W. 65th Street Tualatin Oregon 97202 / US | 02 /
Fitchen, John H. 6920 S.E. 28th Avenue Portland Oregon 97202 / US | 03 /
Ferro, Adolph J. 1112 N.W. Charlemagne Corvallis Oregon 97330 / US | [1987/34] | Representative(s) | Sheard, Andrew Gregory, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | [N/P] |
| Former [1992/42] | Sheard, Andrew Gregory, et al Kilburn & Strode 30, John Street London WC1N 2DD / GB | ||
| Former [1991/17] | Thompson, Clive Beresford SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD / GB | ||
| Former [1987/34] | Sheard, Andrew Gregory Kilburn & Strode 30, John Street London WC1N 2DD / GB | Application number, filing date | 87300871.8 | 30.01.1987 | [1987/34] | Priority number, date | US19860823929 | 30.01.1986 Original published format: US 823929 | [1987/34] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP0233031 | Date: | 19.08.1987 | Language: | EN | [1987/34] | Type: | A3 Search report | No.: | EP0233031 | Date: | 05.04.1989 | Language: | EN | [1989/14] | Type: | B1 Patent specification | No.: | EP0233031 | Date: | 07.04.1993 | Language: | EN | [1993/14] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 15.02.1989 | Classification | IPC: | C07H5/02, C07H15/14, A61K31/70, // C07H19/06 | [1987/34] | CPC: |
C07H5/02 (EP);
A61P31/04 (EP);
A61P33/02 (EP);
C07H15/14 (EP);
C07H19/06 (EP)
| Designated contracting states | AT, BE, CH, DE, ES, FR, GB, GR, IT, LI, LU, NL, SE [1987/34] | Title | German: | Analoge der Methylthioribose, ihre Herstellung sowie medizinische und biozide Verwendung | [1987/34] | English: | Methylthioribose analogues, their preparation and use as medicinal agents and biocides | [1987/34] | French: | Analogues de méthylthioribose, leur préparation et emploi comme agents à activité médicinale et biocide | [1987/34] | Examination procedure | 25.09.1989 | Examination requested [1989/47] | 11.02.1991 | Despatch of a communication from the examining division (Time limit: M04) | 11.06.1991 | Reply to a communication from the examining division | 29.01.1992 | Despatch of a communication from the examining division (Time limit: M02) | 21.02.1992 | Reply to a communication from the examining division | 06.04.1992 | Despatch of communication of intention to grant (Approval: Yes) | 06.08.1992 | Communication of intention to grant the patent | 30.09.1992 | Fee for grant paid | 30.09.1992 | Fee for publishing/printing paid | Opposition(s) | 08.01.1994 | No opposition filed within time limit [1994/13] | Fees paid | Renewal fee | 31.01.1989 | Renewal fee patent year 03 | 17.01.1990 | Renewal fee patent year 04 | 29.01.1991 | Renewal fee patent year 05 | 30.12.1991 | Renewal fee patent year 06 | 21.01.1993 | Renewal fee patent year 07 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X] CABOHYDRATE RESEARCH, vol. 99, no. 1, January 1982, pages 23-31, Elsevier Scientific Publishing Co., Amsterdam, NL; W.L. DILLS, Jr. et al.: "2,5-anhydro-1-deoxy-d-lyxitol, 2,5-anhydro-1-deoxy-d-mannitol, and 2,5-anhydro-1-deoxy-d-talitol. Synthesis and enzymic studies" | [X] CHEMICAL ABSTRACTS, vol. 102, no. 3, 21st January 1985, page 20, no. 17155b, Columbus, Ohio, US; L. NOVOTNY et al.: "Structure-intestinal transport and structure-metabolism correlations of some potential cancerostatic pyrimidine nucleosides in isolated rat jejunum", & CANCER CHEMOTHER. PHARMACOL. 1984, 13(3), 195-9; & Eleventh Collective Index, volumes 96-105, 1982-1986, formulas C5H8O2-C8H7T; & Beta-d-ribofuranose,5-chloro-5-deoxy | [X] TETRAHEDRON LETTERS, vol. 26, no. 24, 1985, pages 2885-2888, Pergamon Press Ltd, GB; Y. TAMARU et al.: "Iodoetherification of 4-penten-1,3-diols: Stereoselective synthesis of cis 2-iodomethyl-3-hydroxytetrahydrofurans" | [X] CHEMICAL ABSTRACTS, vol. 101, no. 7, 13th August 1984, page 648, no. 55396t, Columbus, Ohio, US; R. WEN et al.: "Methyleneindolines, indolenines and indoleniniums. XVII. Rearrangement of deethyltabersonine in acetic acid", & HETEROCYCLES 1984, 22(5), 1061-5 | [X] TETRAHEDRON LETTERS, vol. 21, 1980, pages 3051-3054, Pergamon Press Ltd, GB; J.-P. BATS et al.: "Transposition des oxirannes-ethanols par l'intermdiaire d'alcoxyetains. Influence de la configuration de l'oxiranne" | [X] TETRAHEDRON LETTERS, vol. 22, no. 45, 1981, pages 4503-4506, Pergamon Press Ltd, GB; S. DAVID et al.: "A case of oligomerization on attempted chlorination of an alpha-hydroxy acetal with the triphenylphosphine tetrachloromethane reagent" [X] | [X] CHEMICAL ABSTRACTS, vol. 95, no. 21, 23rd November 1981, page 214, no. 182436p, Columbus, Ohio, US; S.K. SHAPIRO et al.: "5-methylthioribose as a precursor of the carbon chain of methionine", & BIOCHEM. BIOPHYS. RES. COMMUN. 1981, 102(1), 302-7 [X] | [X] CHEMICAL ABSTRACTS, vol. 80, no. 11, 18th March 1974, page 151, no. 57296g, Columbus, Ohio, US; H.T. SCHROEDER et al.: "Biological production of 5-methylthioribose.", & CAN. J. MICROBIOL. 1973, 19(11), 1347-54 [X] | Examination | Kushad et al, Plant Physiology, 1985, 79(2), 525-9, discloses ethylthioribose (ETR), isopropylthioribose (iPTR) and isobutylthioribose (iBTR) as inhibitors of MTR-kinase present in tomatoes | Methods in enzymology, 1983, 94, 361-364, discloses that ETR, PTR, i-PTR, BTR and iBTR are substrates of MTR-kinase isolated from E.aerogenes | Biochem. Pharmacol., 1980, 29(13), 1963-5, discloses that iBTR is a metabolite of isobutylthioadenosine | Biochimica et Biophysica Acta, 1976, 438, 487-494, discloses PTR and ETR as products of an MTA nucleosidase | J. Med. Chem, 1974, 17(11), 1197-207, discloses ETR as an intermediate |