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Extract from the Register of European Patents

EP About this file: EP0315650

EP0315650 - PURIFICATION OF RECOMBINANT INTERLEUKIN-1 [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.01.1994
Database last updated on 25.09.2024
Most recent event   Tooltip13.01.1994No opposition filed within time limitpublished on 02.03.1994 [1994/09]
Applicant(s)For all designated states
Immunex Corporation
51 University Street Seattle
Washington 98101 / US
[N/P]
Former [1989/20]For all designated states
IMMUNEX CORPORATION
51 University Street
Seattle Washington 98101 / US
Inventor(s)01 / KRONHEIM, Shirley R.
11526 36th Street, NE
Seattle, WA 98125 / US
[1993/10]
Former [1989/20]01 / KRONHEIM, Shirley, R.
11526 36th Street, NE
Seattle, WA 98125 / US
Representative(s)Sheard, Andrew Gregory, et al
Kilburn & Strode LLP
20 Red Lion Street
London WC1R 4PJ / GB
[N/P]
Former [1989/20]Sheard, Andrew Gregory, et al
Kilburn & Strode 30, John Street
London WC1N 2DD / GB
Application number, filing date87906498.827.08.1987
[1989/20]
WO1987US02140
Priority number, dateUS1986090842604.09.1986         Original published format: US 908426
[1989/20]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO8801624
Date:10.03.1988
Language:EN
[1988/06]
Type: A1 Application with search report 
No.:EP0315650
Date:17.05.1989
Language:EN
The application published by WIPO in one of the EPO official languages on 10.03.1988 takes the place of the publication of the European patent application.
[1989/20]
Type: B1 Patent specification 
No.:EP0315650
Date:10.03.1993
Language:EN
[1993/10]
Search report(s)International search report - published on:US10.03.1988
(Supplementary) European search report - dispatched on:EP28.12.1989
ClassificationIPC:C07K15/00, C07K3/20, C07K3/28, C12P21/00
[1989/20]
CPC:
C07K14/545 (EP,US); Y10S435/803 (EP,US)
Designated contracting statesAT,   BE,   CH,   DE,   FR,   GB,   IT,   LI,   LU,   NL,   SE [1989/20]
TitleGerman:REINIGUNG VON REKOMBINANTEM INTERLEUKIN-1[1989/20]
English:PURIFICATION OF RECOMBINANT INTERLEUKIN-1[1989/20]
French:PURIFICATION D'INTERLEUKINE-1 RECOMBINANTE[1989/20]
Entry into regional phase21.02.1989National basic fee paid 
21.02.1989Search fee paid 
21.02.1989Designation fee(s) paid 
21.02.1989Examination fee paid 
Examination procedure11.03.1988Request for preliminary examination filed
International Preliminary Examining Authority: AT
21.02.1989Examination requested  [1989/20]
05.06.1992Despatch of communication of intention to grant (Approval: Yes)
07.09.1992Communication of intention to grant the patent
25.09.1992Fee for grant paid
25.09.1992Fee for publishing/printing paid
Opposition(s)11.12.1993No opposition filed within time limit [1994/09]
Fees paidRenewal fee
14.08.1989Renewal fee patent year 03
18.08.1990Renewal fee patent year 04
08.08.1991Renewal fee patent year 05
10.08.1992Renewal fee patent year 06
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Documents cited:Search[X]EP0165654  (IMMUNEX CORP [US])
 [XP]  - BIOTECHNOLOGY, vol. 4, no. 12, December 1986, pages 1078-1082, New York, US; S.R. KRONHEIM et al.: "Purification and characterization of human interleukin-1 expressed in Escherichia coli"
International search[X]  - Nature, Vol. 315, issued June 1985, Cloning, Seqeunce and Expression of Two District Human Inter Leukin-1 Complementary DNAs," (March), pg. 641-47, (see pg. 644).
 [X]  - Journal of Immunology, Vol. 136, issued April 1986, Recombinant Human Interleukin 1 alpha -: Purification and Biological Characterization", (GUBLER), p 2492 (see pg. 2492-93).
 [X]  - Journal of Immunology, Vol. 136, issued May 1986, Purification to Homogeneity and NH2 - Terminal Amino Acid Sequence of a Novel Interleukin-1 Species Derived from a Human B-Cell Line", (RIMSKY), page 3304-10.
 [AP]  - Nucleic Acid Research, Vol. 14, issued October 1986, "Genomic Sequence for Human Prointerleukin 1 beta: Possible Evelution from a Reverse Transcribed Pro-Interleukin 1 alpha Gene", (CLARK) page 7897-14.
 [AP]  - Journal of Immunology, Vol. 137, issued December 1986, "Two Inter Leukin 1 Genes in the Mouse. Cloning and Expression of the cDNA for Murine Interleukin 1beta", (GRAY), pages 3644-48.
 [X]  - Biochemistry, Vol. 25, issued June 1986, Purification and Biochemical Characterization of Two Distinct Human Interleukins-1 from the Myelomonocytic THP-1 Cell Line", (MATSUSHIMA), pages 3424-29
 [A]  - Journal Experimental Medicine, Vol. 162, issued September 1985, "Amino Acid Sequence Analysis of Human Interleukin 1 (IL-1): Evidence for Biochemically Distinct Froms of IL-1, (CAMERON), pages 790-801
 [AP]  - Journal Chromatography, Vol. 387, issued January 1987, "Chromatofocusing of N-Terminally Processed Froms of Protein", (WINFIELD), pages 290-300.
 [X]  - Nucleic Acids Research, Vol. 14, issued April 1986, "Complete Nucleotide Sequence of the Gene for Human Interleukin 1 alpha", (FURUTANI), pages 3167-79.
Examination   - BIOTECHNOLOGY, vol. 4, no. 12, December 1986, New York, US; S.R. KRONHEIM et al.: "Purification and characterization of human interleukin-1 expressed in Escherichia coli", pages 1078-1082
    - NATURE, VOL. 315, JUNE 20, 1985; C.J. MARCH ET AL. "CLONING, SEQUENCE AND EXPRESSION OF TWO DISTINCT HUMAN INTER LEUKIN-1 COMPLEMENTARY DNAs", PAGES 641-647
    - JOURNAL OF IMMUNOLOGY, VOL. 136, APRIL 07, 1986; U. GUBLER ET AL. "RECOMBINANT HUMAN INTERLEUKIN 1 alpha: PURIFICATION AND BIOLOGICAL CHARACTERIZATION", PAGE 2492
    - JOURNAL OF IMMUNOLOGY, VOL. 136, MAY 01, 1986; L. RIMSKY ET AL. "PURIFICATION TO HOMOGENEOTY AND NH2-TERMAINAL AMINO ACID SEQUENCE OF A NOVEL INTERLEUKIN 1 SPECIES DERIVED FROM A HUMAN B-CELL LINE", PAGES 3304-3310
    - NUCLEIC ACID RESEARCH, VOL. 14, NO. 20, OCTOBER 1986; B.D. CLARK ET AL. "GENOMIC SEQUENCE FOR HUMAN PROINTERLEUKIN 1 BETA: POSSIBLE EVELUTION FROM A REVERSE TRANSCRIBED PROINTERLEUKIN 1 ALPHA GENE", PAGES 7897-7914
    - JOURNAL OF IMMUNOLOGY, VOL. 137, NO. 11, DECEMBER 01, 1986; P.W. GRAY ET AL. "TWO INTER LEUKIN 1 GENES IN THE MOUSE: CLONING AND EXPRESSION OF THE cDNA FOR MURINE INTERLEUKIN 1beta", PAGES 3644-3648
    - BIOCHEMISTRY, VOL. 25, NO. 17, JUNE 1986; K. MATSUSHIMA ET AL. "PURIFICATION AND BIOCHEMICAL CHARACTERISTICS OF TWO DISTINCT HUMAN INTERLEUKINS 1 FROM THE MYELOMONOCYTIC THP-1 CELL LINE", PAGES 3424-3429
    - JOURNAL CHROMATOGRAPHY, VOL. 387, JANUARY 30, 1987; P.T. WINGFIELD ET AL. "CHROMATOFOCUSING OF N-TERMINALLY PRCESSED FORMS OF PROTEINS", PAGES 290-300
    - NUCLEIC ACIDS RESEARCH, VOL. 14, NO. 8, APRIL 1986; Y. FURUTANI ET AL. "COMPLETE NUCLEOTIDE SEQUENCE OF THE GENE FOR HUMAN INTERLEUKING 1 ALPHA", PAGES 3167-3179
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