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Extract from the Register of European Patents

EP About this file: EP0383759

EP0383759 - N6 SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS [Right-click to bookmark this link]
Former [1990/35]N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS
[1998/37]
StatusNo opposition filed within time limit
Status updated on  16.07.1999
Database last updated on 16.11.2024
Most recent event   Tooltip06.08.2004Lapse of the patent in a contracting state
New state(s): LU		published on 22.09.2004  [2004/39]
Applicant(s)For all designated states
Discovery Therapeutics, Inc.
2028 Dabney Road - Suite E 17 Richmond
Virginia 23230-3311 / US
[N/P]
Former [1998/17]For all designated states
Discovery Therapeutics, Inc.
2028 Dabney Road - Suite E 17
Richmond, Virginia 23230-3311 / US
Former [1990/35]For all designated states
Whitby Research Incorporated
1001 Health Sciences Road West
Irvine, CA 92715 / US
Inventor(s)01 / OLSSON, Ray, Andrew
1000 West Horatio, No. 215
Tampa, FL 33606 / US
[1990/35]
Representative(s)Kraus, Walter, et al
Patentanwälte Kraus, Weisert & Partner Thomas-Wimmer-Ring 15
80539 München / DE
[N/P]
Former [1990/35]Kraus, Walter, Dr., et al
Patentanwälte Kraus, Weisert & Partner Thomas-Wimmer-Ring 15
D-80539 München / DE
Application number, filing date88904349.325.04.1988
[1990/35]
WO1988US01405
Priority number, dateUS1987004238324.04.1987         Original published format: US 42383
[1990/35]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO8808303
Date:03.11.1988
Language:EN
[1988/24]
Type: A1 Application with search report 
No.:EP0383759
Date:29.08.1990
Language:EN
The application published by WIPO in one of the EPO official languages on 03.11.1988 takes the place of the publication of the European patent application.
[1990/35]
Type: B1 Patent specification 
No.:EP0383759
Date:09.09.1998
Language:EN
[1998/37]
Search report(s)International search report - published on:US03.11.1988
(Supplementary) European search report - dispatched on:EP28.01.1993
ClassificationIPC:C07D473/34, A61K31/52
[1993/11]
CPC:
C07D473/34 (EP,KR); A61P9/00 (EP)
Former IPC [1990/35]A61K31/52, C07D473/34
Designated contracting statesAT,   BE,   CH,   DE,   FR,   GB,   IT,   LI,   LU,   NL,   SE [1990/35]
TitleGerman:N6 SUBSTITUIERTE 9-METHYLADENINE: EINE NEUE KLASSE VON ADENOSIN RECEPTOR ANTAGONISTEN[1998/37]
English:N6 SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS[1998/37]
French:METHYLADENINES-9 SUBSTITUEES EN N6 : UNE NOUVELLE CATEGORIE D'ANTAGONISTES RECEPTEURS D'ADENOSINE[1998/37]
Former [1990/35]N-6 SUBSTITUIERTE 9-METHYLADENINE: EINE NEUE KLASSE VON ADENOSIN RECEPTOR ANTAGONISTEN
Former [1990/35]N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS
Former [1990/35]METHYLADENINES 9 SUBSTITUEES EN N?6 : UNE NOUVELLE CATEGORIE D'ANTAGONISTES RECEPTEURS D'ADENOSINE
Entry into regional phase08.06.1989National basic fee paid 
08.06.1989Search fee paid 
08.06.1989Designation fee(s) paid 
08.06.1989Examination fee paid 
Examination procedure10.11.1988Request for preliminary examination filed
International Preliminary Examining Authority: DE
08.06.1989Examination requested  [1990/35]
25.10.1994Despatch of a communication from the examining division (Time limit: M04)
23.02.1995Reply to a communication from the examining division
22.11.1995Despatch of a communication from the examining division (Time limit: M06)
03.05.1996Reply to a communication from the examining division
01.09.1997Despatch of communication of intention to grant (Approval: Yes)
12.03.1998Communication of intention to grant the patent
10.06.1998Fee for grant paid
10.06.1998Fee for publishing/printing paid
Opposition(s)10.06.1999No opposition filed within time limit [1999/35]
Fees paidRenewal fee
12.03.1990Renewal fee patent year 03
25.03.1991Renewal fee patent year 04
16.03.1992Renewal fee patent year 05
23.03.1993Renewal fee patent year 06
18.03.1994Renewal fee patent year 07
24.03.1995Renewal fee patent year 08
25.03.1996Renewal fee patent year 09
24.03.1997Renewal fee patent year 10
26.03.1998Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT09.09.1998
BE09.09.1998
CH09.09.1998
LI09.09.1998
NL09.09.1998
SE09.12.1998
LU25.04.1999
[2004/39]
Former [2003/07]AT09.09.1998
BE09.09.1998
CH09.09.1998
LI09.09.1998
NL09.09.1998
SE09.12.1998
Former [1999/34]AT09.09.1998
BE09.09.1998
CH09.09.1998
LI09.09.1998
SE09.12.1998
Former [1999/32]BE09.09.1998
CH09.09.1998
LI09.09.1998
SE09.12.1998
Former [1999/27]BE09.09.1998
CH09.09.1998
LI09.09.1998
Former [1999/22]CH09.09.1998
LI09.09.1998
Documents cited:Search   [ ] - THE JOURNAL OF ORGANIC CHEMISTRY vol. 48, no. 6, 25 March 1983, pages 854 - 855 NICO J. KOS ET. AL. 'Anion Formation and Ring Opening of 9-Substituted Purines in Liquid Ammonia Containing Potassium Amide.'
    [ ] - CHEMICAL ABSTRACTS, vol. 103, no. 3, 22 July 1985, Columbus, Ohio, US; abstract no. 22353q, page 554 ;column 1 ;
International search[X]JPS45758B  ;
 [X]CA657337  (SHELL OIL CO);
 [X]GB953897  (SHELL INT RESEARCH);
 [X]GB2041359  (ICI LTD)
 [XP]  - UKENA D. ET AL, "N6-Substituted 9-Methyladenines: A New Class of Adenosine Receptor Antagonists", CHEMICAL ABSTRACTS, (19870817), vol. 107, no. 7, Database accession no. 51396U
    [ ] - FEBS LETT., (1987), vol. 215, no. 2, pages 203 - 208
 [X]  - Journal of the American Chemical Society, Vol. 79, No. 2, issued 20 January 1957, (ROBINS, et al.) "Potential Purine Antagonists. IV. Synthesis of Some 9-Methyl-6-Substituted-Purines", pages 490-494, see pages 490-494.
 [X]  - Journal of the American Chemical Society, Vol. 79, No. 19, issued 05 October 1957, (MONTGOMERY, et al.), "Synthesis of Potential Anticancer Agents, IX. 9-Ethyl-6-Substituted-Purines", pages 5238-5242. see all pages.
 [X]  - Journal of Organic Chemistry, Vol. 28, No. 8, issued August 1963, (MYERS, et al.), "Alkylation of the Purine Nucleus by Means of Quaternary Ammonium Compounds. I. Tetraalkylammonium Hydroxidees", pages 2087-2089.
 [X]  - CHEMICAL ABSTRACTS, Vol. 53, No. 15, issued 10 August 1959, (H.E. SKIPPER, et al. ), "Structure-Activity Relations and Cross-Resistance Observed on Evaluation of a Series of Purine Analogs against Experimental Neoplasms", Abstract No. 14344i-14345b, Cancer Research 19, 425-37 (1959).
 [X]  - CHEMICAL ABSTRACTS, Vol. 56, No. 9, issued 30 April, 1962, (ERNST CARSTENS, et al,), "6,9-Disubstituted Purine Derivatives", Abstract No. 10167i-10168d, Ger. (East) 21,223 (Cl. 12p.) Appl. May 29, 1958.
 [X]  - CHEMICAL ABSTRACTS, Vol. 68, No. 23, issued 03 June 1968, (O.N. KULAEVA, et al,), "The Effect Produced by Variations in the Structure of Cytokinins on their Physiological Activity", Abstract No. 104032g, Dokl. Akad. Nauk, SSSR 178(5), 1204-(1968) (Russ).
 [X]  - CHEMICAL ABSTRACTS, Vol. 70, No. 1, issued 06 Jan. 1969, (M.F. PETROVA, et al.), Synthesis of Potentially Antiblastic Substances Related to 5-Hydroxytryptamine (Serotonin), Abstract No. 4056r.
 [X]  - CHEMICAL ABSTRACTS, Vol. 78, No. 13, issued 02 April 1973, (KAMIYA, et al.), "4-(9H-Purin-6-yl) Amino-4-Deoxy-D-Erthyronate Esters, Abstract No. 84764y, Japan 72 45,757(Cl.C07d,A61k), 17 Nov. 1972, Appl. 70 26092, 28 Mar. 1979; 3pp.
 [X]  - CHEMICAL ABSTRACTS, Vol. 79, No. 19, issued 12 Nov. 1973, (J. E. FOX et al.), "Effect of Substituents at the 9-Position on Cytokinin Activity, Abstract No. 112299s, Phytochemistry 1973, 12(7), 1531-3 (Eng.).
 [X]  - CHEMICAL ABSTRACTS, Vol. 87, No. 25, issued 19 Dec. 1977, (T. HASHIZUME, et al.), Abstract No. 195316j, "Synthesis and Biological Activity of some New 6-Benzylamino-9-Alkvlpurines," Plant Growth Subst., Proc. Int. Conf., 8th 1973 (pub. 1974) 462-7 (Eng.)
ExaminationJPS45758B
    - TETRAHEDRON vol. 28, no. 3, February 1972, GREAT BRITAIN T. ITAYA ET. AL. '*Purines-6*'
    - CARDIOVASCULAR RESEARCH,1993,27,129-133
    - 5th AMER. COLL. OF CARDIOL.,43rd ANNUAL SCI. SESSION,1994
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.