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EP0478545
European procedure
Extract from the Register of European Patents
EP About this file: EP0478545
| EP0478545 - 1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 09.06.2000 Database last updated on 31.08.2024 | Most recent event Tooltip | 09.06.2000 | No opposition filed within time limit | published on 26.07.2000 [2000/30] | Applicant(s) | For all designated states SRI International 333 Ravenswood Avenue Menlo Park California 94025-3493 / US | [N/P] |
| Former [1995/34] | For all designated states SRI INTERNATIONAL 333 Ravenswood Avenue Menlo Park, California 94025-3493 / US | ||
| Former [1992/15] | For all designated states SRI INTERNATIONAL 333 Ravenswood Avenue Menlo Park, California 94025 / US | Inventor(s) | 01 /
LEE, William, W. 991 N. California Avenue Palo Alto, CA 94303 / US | 02 /
BROWN, J., Martin 2010 Abryan Way Redwood City California 94061 / US | 03 /
GRANGE, Edward, W. 3480 Waverly Street Palo Alto, CA 94306 / US | 04 /
MARTINEZ, Abelardo, P. 1111 Beaumont Drive San Jose, CA 95129 / US | 05 /
TRACY, Michael 1910 Menalto Avenue Menlo Park, CA 94025 / US | 06 /
POLLART, Daniel, J. 855 Arbor Road Menlo Park, CA 94025 / US | [1992/27] |
| Former [1992/15] | 01 /
LEE, William, W. 991 N. California Avenue Palo Alto, CA 94303 / US | ||
| 02 /
BROWN, J., Martin 33 Peter Coutts Circle Stanford, CA 94305 / US | |||
| 03 /
GRANGE, Edward, W. 3480 Waverly Street Palo Alto, CA 94306 / US | |||
| 04 /
MARTINEZ, Abelardo, P. 1111 Beaumont Drive San Jose, CA 95129 / US | |||
| 05 /
TRACY, Michael 1910 Menalto Avenue Menlo Park, CA 94025 / US | |||
| 06 /
POLLART, Daniel, J. 855 Arbor Road Menlo Park, CA 94025 / US | Representative(s) | Goldin, Douglas Michael, et al J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5JJ / GB | [N/P] |
| Former [1992/15] | Goldin, Douglas Michael, et al J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX / GB | Application number, filing date | 89911346.8 | 18.09.1989 | [1992/15] | WO1989US04112 | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO9104028 | Date: | 04.04.1991 | Language: | EN | [1991/08] | Type: | A1 Application with search report | No.: | EP0478545 | Date: | 08.04.1992 | Language: | EN | The application published by WIPO in one of the EPO official languages on 04.04.1991 takes the place of the publication of the European patent application. | [1992/15] | Type: | B1 Patent specification | No.: | EP0478545 | Date: | 11.08.1999 | Language: | EN | [1999/32] | Search report(s) | International search report - published on: | US | 04.04.1991 | (Supplementary) European search report - dispatched on: | EP | 18.06.1992 | Classification | IPC: | A61K31/53 | [1992/15] | CPC: |
C07D253/10 (EP);
A61K31/53 (EP);
A61K31/535 (EP);
A61P35/00 (EP)
| Designated contracting states | AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE [1992/15] | Title | German: | 1,2,4-BENZOTRIAZINOXIDE ALS FUNKEMPFINDLICHE UND SELEKTIVE ZYTOTOXISCHE MITTEL | [1992/15] | English: | 1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS | [1992/15] | French: | OXYDES DE 1,2,4-BENZOTRIAZINE A TITRE DE RADIOSENSIBILISATEURS ET D'AGENTS CYTOTOXIQUES SELECTIFS | [1992/15] | Entry into regional phase | 21.01.1992 | National basic fee paid | 21.01.1992 | Search fee paid | 21.01.1992 | Designation fee(s) paid | 21.01.1992 | Examination fee paid | Examination procedure | 16.04.1991 | Request for preliminary examination filed International Preliminary Examining Authority: DE | 21.01.1992 | Examination requested [1992/15] | 10.05.1993 | Despatch of a communication from the examining division (Time limit: M06) | 28.12.1993 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 03.03.1994 | Reply to a communication from the examining division | 29.04.1994 | Despatch of a communication from the examining division (Time limit: M08) | 20.12.1994 | Reply to a communication from the examining division | 24.02.1995 | Despatch of a communication from the examining division (Time limit: M04) | 03.07.1995 | Reply to a communication from the examining division | 02.08.1995 | Despatch of a communication from the examining division (Time limit: M06) | 26.01.1996 | Reply to a communication from the examining division | 29.08.1996 | Despatch of a communication from the examining division (Time limit: M04) | 17.12.1996 | Reply to a communication from the examining division | 30.01.1997 | Despatch of a communication from the examining division (Time limit: M04) | 22.05.1997 | Reply to a communication from the examining division | 08.07.1998 | Despatch of communication of intention to grant (Approval: No) | 08.01.1999 | Despatch of communication of intention to grant (Approval: later approval) | 21.01.1999 | Communication of intention to grant the patent | 20.04.1999 | Fee for grant paid | 20.04.1999 | Fee for publishing/printing paid | Opposition(s) | 12.05.2000 | No opposition filed within time limit [2000/30] | Request for further processing for: | 03.03.1994 | Request for further processing filed | 03.03.1994 | Full payment received (date of receipt of payment) Request granted | 22.03.1994 | Decision despatched | Fees paid | Renewal fee | 21.01.1992 | Renewal fee patent year 03 | 24.12.1992 | Renewal fee patent year 04 | 16.09.1993 | Renewal fee patent year 05 | 08.09.1994 | Renewal fee patent year 06 | 08.09.1995 | Renewal fee patent year 07 | 12.09.1996 | Renewal fee patent year 08 | 10.09.1997 | Renewal fee patent year 09 | 09.09.1998 | Renewal fee patent year 10 | Penalty fee | Additional fee for renewal fee | 30.09.1992 | 04 M06 Fee paid on 24.12.1992 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A]US3079390 (JAMES JIU, et al); | [X]DE2404375 (CIBA GEIGY AG); | [XD]US3991189 (SENG FLORIN, et al); | [X]US4027022 (SENG FLORIN, et al); | [A]US4091098 (LUMMA JR WILLIAM C); | [X]WO8802366 (STANFORD RES INST INT [US]); | [E]WO8908647 (STANFORD RES INST INT [US]) | [ ] - TETRAHEDRON, vol. 38, no. 12, 1982, pages 1793-1796, Pergamon Press Ltd., GB; R.H. ATALLAH et al.: "Oxides of 3-methyl-1,2,4-benzotriazine" | [ ] - RADIOTHERAPY AND ONCOLOGY, vol. 18, no. 3, 1988, pages 209-218, Elsevier Science Publishers B.V.; E.M. ZEMAN et al.: "Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233" | [ ] - BIOCHEMICAL PHARMACOLOGY, vol. 35, no. 19, October 1, 1986, pages 3417-3420; K.R. LADEROUTE et al.: "Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide" | [ ] - PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARACH, 18th annual meeting, May 24-27, 1989, San Francisco, Ca. US, vol. 30, March 1989, page 575, no. 2290; M. TRACY et al.: "Structure-activity relationships of 1,2,4-benzotriazine 1,4-di-N-oxides, a new class of bioreductive drugs with tumor specificity" | [ ] - INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol. 16, no. 4, April 1989, pages 977-981; E.M. ZEMAN et al.: "Structure-activity relationships for benzotriazine di-N-oxides" | [ ] - 35TH ANN. MEETING OF RADIATION RES. SOC. and 7TH ANN. MEETING OF NORTH AMER. HYPERTHERMIA GROUP, February 21-26, 1987, Atlanta, US, 1986, page 114, no. Fd-4; J.M. BROWN et al.: "Benzotriazine-N-oxides: A new class of bioreductive cytotoxic agents" | International search | [A]US3980779 (LEY KURT, et al); | [A]US3991189 (SENG FLORIN, et al); | [A]US4001410 (LEY KURT, et al); | [A]US4022022 (MARIETTA WALTER EDWIN) | Examination | - INT. J. RADIATION ONCOLOGY, BIOL. PHYS., vol. 12, no. 7, 1986, pages 1239-1242, Pergamon Journals Ltd., US; E.M. ZEMAN et al.: "SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells" | by applicant | US3079390 | DE2404375 | US3868371 | US3957799 | US3980779 | US3991189 | US4001410 | US4027022 | US4289771 | US4371540 | WO8802366 | WO8908647 | - ASQUITH ET AL., RADIATION RES, (1974), vol. 60, pages 108 - 118 | - HALL ET AL., BRIT J CANCER, (1978), vol. 37, pages 567 - 569 | - BROWN ET AL., RADIATION RES, (1980), vol. 82, pages 171 - 190 | - M. BROWN ET AL., "Bioreductive cytotoxic activity of 3-amino substituted 1,2,4-benzotriazine-1,4-dioxide is mentioned", IN 35TH ANN. MEETING OF RADIATION RES. SOC. AND 7TH. ANN. MEETING OF NORTH AM. HYPERTHERMIA GROUP, (19870221), page 114 | - E.W. ZEMAN; M. TRACY ET AL., "3-amino-1,2,4-benzotriazine-1,4-dioxide and analogues thereof with a view to better understanding its mechanism", INT. J. RADIATION ONCOLOGY BIOL. PHYS., (198904), vol. 16, no. 4, pages 977 - 981 | - E.W. ZEMAN ET AL., "3-amino-1,2,4-benzotriazine-1,4-dioxide and analogues thereof with a view to better understanding its mechanism", PROCEEDINGS OF THE AM. ASSOCIATION FOR CANCER RES. 18TH. ANN. MEETING, (19890330), page 575 | - K.R. LADEROUTE ET AL., "3-amino-1,2,4-benzotriazine-1,4-dioxide as a hypoxic cell toxic agent and investigates the major reduction products of this compound", BIOCHEMICAL PHARMACOLOGY, (19861001), vol. 35, no. 19, pages 3417 - 3420 | - E.M. ZEMAN ET AL., "a further study of 3-amino-1,2,4-benzotriazine-1,4-dioxide in the selective killing of hypoxic mammalian cells in vitro", RADIOTHERAPY AND ONCOLOGY, (1988), vol. 12, no. 7, pages 209 - 218 | - E.M. ZEMAN ET AL., "a further study on 3-amino-1,2,4-benzotriazine-1,4-dioxide as a bioreductive agent with selective toxicity with hypoxic mammalian cells", INT. J. RADIATION ONCOLOGY BIOL. PHYS., (1986), vol. 12, no. 7, pages 1239 - 1242 | - R.H. ATALLAH ET AL., "the preparation of 3-methyl-1,2,4-benzotriazineoxides", TETRAHEDRON, (1982), vol. 38, no. 12, pages 1793 - 1796 | - ROBBINS ET AL., J CHEM SOC, (1957), page 3186 | - MASON ET AL., J CHEM SOC B, (1970), page 911 | - ADAMS, G.E., Cancer: A Comprehensive Treatise, PLENUM, (1977), vol. 6, pages 181 - 223 | - FUJITA ET AL., J. AMER. CHEM. SOC., (1964), vol. 86, page 5175 | US19850730761 | US19850788762 |