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Extract from the Register of European Patents

EP About this file: EP0440709

EP0440709 - THROMBOLYTIC AGENTS WITH MODIFIED KRINGLE DOMAINS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.03.1996
Database last updated on 06.07.2024
Most recent event   Tooltip29.03.1996No opposition filed within time limitpublished on 15.05.1996 [1996/20]
Applicant(s)For all designated states
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Juliana van Stolberglaan 148
2595 CL Den Haag / NL
[N/P]
Former [1991/33]For all designated states
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Juliana van Stolberglaan 148
NL-2595 CL The Hague / NL
Inventor(s)01 / HATZENBUHLER, Nicole, T.
2776 Bronson Circle
Kalamazoo, MI 49008 / US
02 / MAROTTI, Keith, R.
2707 Lomond Drive
Kalamazoo, MI 49008 / US
03 / REHBERG, Edward, F.
3801 Winchell P 301
Kalamazoo, MI 49008 / US
04 / VERHEIJEN, Johan, H.
Verdistraat 14
NL-2651 VB Berkel en Rodenrijs / NL
[1991/33]
Representative(s)Smulders, Theodorus A.H.J., et al
Vereenigde Postbus 87930
2508 DH Den Haag / NL
[N/P]
Former [1991/33]Smulders, Theodorus A.H.J., Ir., et al
Vereenigde Octrooibureaux Nieuwe Parklaan 97
NL-2587 BN 's-Gravenhage / NL
Application number, filing date89912186.704.10.1989
[1991/33]
WO1989US04247
Priority number, dateUS1988026367327.10.1988         Original published format: US 263673
[1991/33]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9004635
Date:03.05.1990
Language:EN
[1990/10]
Type: A1 Application with search report 
No.:EP0440709
Date:14.08.1991
Language:EN
The application published by WIPO in one of the EPO official languages on 03.05.1990 takes the place of the publication of the European patent application.
[1991/33]
Type: B1 Patent specification 
No.:EP0440709
Date:24.05.1995
Language:EN
[1995/21]
Search report(s)International search report - published on:EP03.05.1990
ClassificationIPC:C12N9/72
[1995/21]
CPC:
C12N9/6456 (EP,US); A61P7/02 (EP); A61K38/00 (EP,US)
Former IPC [1991/33]C12N9/64, C12N9/72, C12N15/58
Designated contracting statesAT,   BE,   CH,   DE,   FR,   GB,   IT,   LI,   LU,   NL,   SE [1991/33]
TitleGerman:TROMBOLYTISCHER WIRKSTOFF MIT MODIFIKATION DER DOMÄNE DER KRINGLE[1991/33]
English:THROMBOLYTIC AGENTS WITH MODIFIED KRINGLE DOMAINS[1991/33]
French:AGENTS THROMBOLYTIQUES A DOMAINES KRINGLE MODIFIES[1991/33]
Entry into regional phase26.04.1991National basic fee paid 
26.04.1991Designation fee(s) paid 
26.04.1991Examination fee paid 
Examination procedure02.01.1990Request for preliminary examination filed
International Preliminary Examining Authority: DE
26.04.1991Examination requested  [1991/33]
21.03.1994Despatch of a communication from the examining division (Time limit: M04)
07.04.1994Reply to a communication from the examining division
06.09.1994Despatch of communication of intention to grant (Approval: Yes)
30.11.1994Communication of intention to grant the patent
02.03.1995Fee for grant paid
02.03.1995Fee for publishing/printing paid
Opposition(s)27.02.1996No opposition filed within time limit [1996/20]
Fees paidRenewal fee
31.10.1991Renewal fee patent year 03
30.10.1992Renewal fee patent year 04
02.11.1993Renewal fee patent year 05
31.10.1994Renewal fee patent year 06
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Cited inInternational search[Y]WO8703906  (UPJOHN CO [US]);
 [Y]EP0234051  (STICHTING CENTRAAL LAB [NL]);
 [Y]EP0241208  (BEECHAM GROUP PLC [GB]);
 [Y]EP0273774  (CETUS CORP [US]);
 [Y]EP0277313  (CIBA GEIGY AG [CH])
 [Y]  - Chemical Abstracts, volume 110, no. 13, 27 March 1989, (Columbus, Ohio, US), Lijnen, H.R. et al : "Characterization of a chimeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type plasminogen activator (amino acids 173 through 262) between residues Asp and Ser of urokinase-type plasminogen activator", see page 17, abstract 107601p, & Thromb .Res. 1988, 52( 5), 431- 41.
 [Y]  - Proc.Natl.Acad.Sci., Vol. 83, 1986 (USA) Anton-Jan van Zonneveld et al: "Autonomous functions of structural domains on human tissue-type plasminogen activator ", see page 4670 - page 4674, see page 1 the abstract and page 4673, right column.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.