blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP0454146

EP0454146 - Cytotoxic bicyclo 7.3.1 tridec-4-ene-2,6-diyne compounds and process for the preparation thereof [Right-click to bookmark this link]
Former [1991/44]Cytotoxic bicyclo[7.3.1] tridec-4-ene-2,6-diyne compounds and process for the preparation thereof
[2007/46]
StatusThe application has been refused
Status updated on  23.11.1995
Database last updated on 02.11.2024
Most recent event   Tooltip12.10.2007Change - English titlepublished on 14.11.2007  [2007/46]
Applicant(s)For all designated states
Bristol-Myers Squibb Company
Route 206 and Province Line Road
Princeton, NJ 08543 / US
[N/P]
Former [1991/44]For all designated states
Bristol-Myers Squibb Company
345 Park Avenue
New York, N.Y. 10154 / US
Inventor(s)01 / Kadow, John F.
126 Metacomet Drive
Meriden, Connecticut 06450 / US
[1991/44]
Representative(s)Kinzebach, Werner, et al
Reitstötter, Kinzebach & Partner Patentanwälte Postfach 86 06 49
81633 München / DE
[N/P]
Former [1991/44]Kinzebach, Werner, Dr., et al
Patentanwälte Reitstötter, Kinzebach und Partner Postfach 86 06 49
D-81633 München / DE
Application number, filing date91106789.026.04.1991
[1991/44]
Priority number, dateUS1990062150330.11.1990         Original published format: US 621503
US1990051538727.04.1990         Original published format: US 515387
[1991/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP0454146
Date:30.10.1991
Language:EN
[1991/44]
Search report(s)(Supplementary) European search report - dispatched on:EP24.07.1991
ClassificationIPC:C07C49/733, C07F15/06, C07C321/20, C07F7/18, A61K31/12
[1991/44]
CPC:
C07F15/06 (EP); C07C325/02 (KR); A61P35/00 (EP);
C07C323/22 (EP); C07C45/673 (EP); C07C49/733 (EP);
C07F7/1804 (EP); C07C2602/48 (EP) (-)
C-Set:
C07C45/673, C07C49/733 (EP)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IT,   LI,   LU,   NL,   SE [1991/44]
TitleGerman:Zitotoxische Bicyclo (7.3.1) Tridec-4-En 2,6-Diynverbindungen und Verfahren zu ihrer Herstellung[1991/44]
English:Cytotoxic bicyclo 7.3.1 tridec-4-ene-2,6-diyne compounds and process for the preparation thereof[2007/46]
French:Composés bicyclo (7.3.1) tridec-4-ène 2,6-diyne cytotoxiques et procédé pour leur préparation[1991/44]
Former [1991/44]Cytotoxic bicyclo[7.3.1] tridec-4-ene-2,6-diyne compounds and process for the preparation thereof
File destroyed:03.03.2001
Examination procedure29.04.1992Examination requested  [1992/27]
21.04.1994Despatch of a communication from the examining division (Time limit: M04)
31.08.1994Reply to a communication from the examining division
14.09.1994Despatch of a communication from the examining division (Time limit: M02)
20.09.1994Reply to a communication from the examining division
09.12.1994Despatch of communication of intention to grant (Approval: )
17.05.1995Despatch of communication that the application is refused, reason: formalities examination [1996/02]
27.05.1995Application refused, date of legal effect [1996/02]
Fees paidRenewal fee
13.04.1993Renewal fee patent year 03
11.04.1994Renewal fee patent year 04
04.04.1995Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[AD]  - JOURNAL OF ORGANIC CHEMISTRY. vol. 55, no. 6, 16 March 1990, EASTON US pages 1709 - 1711; PHILIP MAGNUS ET AL.: "STUDIES ON THE SYNTHESIS OF THE ANTITUMOR AGENTS ESPERAMICIN A1/CALICHEAMICIN GAMMA 1: STEREOSPECIFIC SYNTHESIS ...."
 [A]  - TETRAHEDRON LETTERS. vol. 30, no. 15, March 1989, OXFORD GB pages 1905 - 1906; PHILIP MAGNUS ET AL.: "SYNTHETIC STUDIES ON THE ESPERAMICIN/CALICHEAMICIN ANTITUMOR ANTIBIOTICS. CONJUGATE ADDITION OF THIOL TO INITIATE 1,4-DIYL FORMATION"
 [AD]  - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. vol. 110, no. 20, 28 September 1988, GASTON, PA US pages 6921 - 6923; PHILIP MAGNUS ET AL.: "SYNTHESIS OF A REMARKABLY STABLE BICYCLO[7.3.1ÜDIYNENE ESPERAMICIN A1/CALICHEAMICIN GAMMA SYSTEM. STRUCTURAL REQUIREMENTS FOR FACILE FORMATION OF A 1,4-DIYL"
 [AD]  - TETRAHEDRON LETTERS. vol. 30, no. 7, February 1989, OXFORD GB pages 851 - 854; KIYOSHI TOMIOKA ET AL.: "SYNTHESIS OF THE CORE ENEDIYNE STRUCTURE OF ESPERAMICIN-CALICHEMICIN CLASS OF ANTITUMOR ANTIBIOTICS"
 [AD]  - TETRAHEDRON LETTERS. vol. 30, no. 28, July 1989, OXFORD GB pages 3637 - 3640; PHILIP MAGNUS ET AL.: "SYNTHETIC STUDIES ON THE ESPERAMICIN/CALICHEAMICIN ANTITUMOR ANTIBIOTICS.SELENIUM DIOXIDE OXIDATION OF A BRIDGEHEAD TRIALKYLSILYL ENOL ETHER"
 [AD]  - TETRAHEDRON LETTERS. vol. 29, no. 34, August 1988, OXFORD GB pages 4217 - 4220; ANDREW S. KENDE ET AL.: "SYNTHESIS OF A CALICHEAMICIN DEOXYAGLYCONE MODEL BY AN INTRAMOLECULAR ACETYLIDE CYCLIZATION "
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.