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EP About this file: EP0504290

EP0504290 - INHIBITORS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 28.11.1997 Database last updated on 29.06.2024
Most recent event Tooltip	08.08.2008	Change - applicant	published on 10.09.2008 [2008/37]
Applicant(s)	For all designated states CHIRON CORPORATION 4560 Horton Street Emeryville CA 94608-2916 / US
	[2008/37]
Former [1993/15]	For all designated states CHIRON CORPORATION 4560 Horton Street, R440 Emeryville California 94608-2916 / US
Former [1992/39]	For all designated states PROTOS CORPORATION 4560 Horton Street Emeryville, CA 94608-2916 / US
Inventor(s)	01 / SANTI, Daniel, V. 211 Belgrave Avenue San Francisco, CA 94117 / US
	02 / MARLOWE, Charles, K. 765 8th Avenue San Francisco, CA 94118 / US
	[1992/39]
Representative(s)	Glawe, Delfs, Moll Partnerschaft mbB von Patent- und Rechtsanwälten Postfach 26 01 62 80058 München / DE
	[N/P]
Former [1992/39]	Glawe, Delfs, Moll & Partner Patentanwälte Postfach 26 01 62 D-80058 München / DE
Application number, filing date	91901399.5	07.12.1990
	[1992/39]
	WO1990US07218
Priority number, date	US19890447181	07.12.1989 Original published format: US 447181
	[1992/39]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9108668
	Date:	27.06.1991
	Language:	EN
	[1991/14]
	Type:	A1 Application with search report
	No.:	EP0504290
	Date:	23.09.1992
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 27.06.1991 takes the place of the publication of the European patent application.
	[1992/39]
	Type:	B1 Patent specification
	No.:	EP0504290
	Date:	22.01.1997
	Language:	EN
	[1997/04]
Search report(s)	International search report - published on:	US	27.06.1991
	(Supplementary) European search report - dispatched on:	EP	04.02.1993
Classification	IPC:	A01N43/66	[1992/39]
	CPC:	A61K31/53 (EP); A61P31/12 (EP); Y02A50/30 (EP)
	C-Set:	A61K31/53, A61K2300/00 (EP); A61K31/53, A61K31/18 (EP); A61K31/53, A61K31/505 (EP)
Designated contracting states	AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE [1992/39]
Title	German:	INHIBITOREN DER DIHYDROFOLATREDUKTASE VON PNEUMOCYSTIS CARINII	[1992/39]
	English:	INHIBITORS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE	[1992/39]
	French:	INHIBITEURS DE REDUCTASE DE DIHYDROFOLATE DE PNEUMOCYSTIS CARINII	[1992/39]
Entry into regional phase	26.05.1992	National basic fee paid
	26.05.1992	Search fee paid
	26.05.1992	Designation fee(s) paid
	26.05.1992	Examination fee paid
Examination procedure	05.07.1991	Request for preliminary examination filed International Preliminary Examining Authority: DE
	26.05.1992	Examination requested [1992/39]
	24.02.1995	Despatch of a communication from the examining division (Time limit: M06)
	05.09.1995	Reply to a communication from the examining division
	07.05.1996	Despatch of communication of intention to grant (Approval: Yes)
	10.07.1996	Communication of intention to grant the patent
	05.09.1996	Fee for grant paid
	05.09.1996	Fee for publishing/printing paid
Opposition(s)	23.10.1997	No opposition filed within time limit [1998/03]
Fees paid	Renewal fee
	18.12.1992	Renewal fee patent year 03
	24.11.1993	Renewal fee patent year 04
	30.11.1994	Renewal fee patent year 05
	27.11.1995	Renewal fee patent year 06
	22.11.1996	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X] - ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 33, no. 11, November 1989, pages 1860-1863, American Society for Microbiology; J.D. BERMAN et al.: "Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors"
		[Y] - ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 32, no. 4, April 1988, pages 430-433, American Society for Microbiology; J.A. KOVACS et al.: "Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate"
		[Y] - E. MUTSCHLER: "Arzneimittelwirkungen, Lehrbuch der Pharmakologie und Toxikologie", 5th edition, 1986, page 665, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, DE
		[Y] - E. MUTSCHLER: "Arzneimittelwirkungen, Lehrbuch der Pharmakologie und Toxikologie", 5th edition, 1986, pages 586-592, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, DE
		[A] - "The Merck Index", 10th edition, 1983, page 390, no. 2715, Merck & Co., Inc., Rahway, NJ, US
		[Y] - ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 266, no. 1, October 1988, pages 152-161, Academic Press, Inc.; M.G. KOEHLER et al.: "A molecular shape analysis and quantitative structure-activity relationship investigation of some triazine-antifolate inhibitors of Leishmania dihydrofolate reductase"
		[T] - THE JOURNAL OF INFECTION, vol. 22, no. 2, March 1991, pages 143-152, The British Society for the Study of Infection; A. GONZALEZ-RUIZ et al.: "Dapsone in low doses prevents Pneumocystis carinii pneumonia in the rat model"
	International search	[Y]US2823161 (LUX RUSSELL E, et al);
		[Y]US2836539 ;
		[Y]US2959519 (JOHN SPEZIALE ANGELO, et al);
		[Y]US3074947 ;
		[Y]US3123527 ;
		[Y]US3215600 (THOMPSON PAUL E, et al);
		[Y]US3959469 (KAY IAN TREVOR)
		[Y] - Avery's Drug Treatment, Principles and Practices of Clinical Pharmacology and Therapeutics 3rd Edition, TREVOR M SPEIGHT ed, William and Wilkins, Baltimore.
		[Y] - The Menck Manual of Diagnosis and Therapy 14th edition, ROBERT BERKOW ed, Menck Sharp and Dohme Research Laboratories, Rahway N.J. 1982.
	Examination	- E. MUTSCHLER: "Arzneimittelwirkungen, Lehrbuch der Pharmakologie und Toxikologie", 5th edition, 1986, page 665, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, DE
		- Toxikologie", 5th edition, 1986, pages 586-592, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, DE

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