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Extract from the Register of European Patents

EP About this file: EP0545999

EP0545999 - Process for the preparation of biologically active IGF-1 using IGF-1 having an amino-terminal extension [Right-click to bookmark this link]
Former [1993/24]BIOLOGICALLY ACTIVE COMPOUND, A PROCESS FOR THE PREPARATION THEREOF AND USE OF THE SAME
[1997/23]
StatusNo opposition filed within time limit
Status updated on  09.04.1998
Database last updated on 13.11.2024
Most recent event   Tooltip07.12.2007Lapse of the patent in a contracting state
Updated state(s): LU		published on 09.01.2008  [2008/02]
Applicant(s)For all designated states
NOVO NORDISK A/S
Novo Allé
2880 Bagsværd / DK
[N/P]
Former [1993/24]For all designated states
NOVO NORDISK A/S
Novo Allé
DK-2880 Bagsvaerd / DK
Inventor(s)01 / SKRIVER, Lars
Elles park 24
DK-2950 Vedb k / DK
02 / HEJNAS, Kim, Ry
Lyngholmsvej 1
DK-2800 Lyngby / DK
03 / DALBOGE, Henrik
Ligusterv nget 63
DK-2830 Virum / DK
[1993/24]
Representative(s)Nilausen, Kim, et al
c/o Novo Nordisk A/S
Novo Allé
2880 Bagsvaerd / DK
[N/P]
Former [1993/24]Nilausen, Kim, et al
c/o Novo Nordisk A/S Novo Allé
DK-2880 Bagsvaerd / DK
Application number, filing date91915251.216.08.1991
[1993/24]
WO1991DK00231
Priority number, dateDK1990000198920.08.1990         Original published format: DK 198990
DK1990000249716.10.1990         Original published format: DK 249790
[1993/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9203477
Date:05.03.1992
Language:EN
[1992/06]
Type: A1 Application with search report 
No.:EP0545999
Date:16.06.1993
Language:EN
The application published by WIPO in one of the EPO official languages on 05.03.1992 takes the place of the publication of the European patent application.
[1993/24]
Type: B1 Patent specification 
No.:EP0545999
Date:04.06.1997
Language:EN
[1997/23]
Search report(s)International search report - published on:SE05.03.1992
ClassificationIPC:C12N15/18, C07K14/65, C12N15/62, C12P21/06, C07K1/107
[1997/23]
CPC:
C07K14/65 (EP,US)
Former IPC [1993/24]C07K13/00, C12N15/18, C12N15/62, C12P21/06, C07K3/08
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IT,   LI,   LU,   NL,   SE [1993/24]
TitleGerman:Prozess für die Herstellung von biologisch aktivem IGF-1 durch Verwendung von amino-terminal verlängertem IGF-1[1997/23]
English:Process for the preparation of biologically active IGF-1 using IGF-1 having an amino-terminal extension[1997/23]
French:Procédé de préparation d l'IGF-1 biologiquement actif à partir d'un IGF-1 ayant une extension amino-terminale[1997/23]
Former [1993/24]BIOLOGISCH AKTIVE KOMPONENTEN, EIN PROZESS FÜR IHRE HERSTELLUNG UND IHRE VERWENDUNG
Former [1993/24]BIOLOGICALLY ACTIVE COMPOUND, A PROCESS FOR THE PREPARATION THEREOF AND USE OF THE SAME
Former [1993/24]COMPOSE BIOLOGIQUEMENT ACTIF, PROCEDE DE PREPARATION ET UTILISATION DE CELUI-CI
Entry into regional phase05.02.1993National basic fee paid 
05.02.1993Designation fee(s) paid 
05.02.1993Examination fee paid 
Examination procedure11.02.1992Request for preliminary examination filed
International Preliminary Examining Authority: DE
05.02.1993Examination requested  [1993/24]
29.10.1993Despatch of a communication from the examining division (Time limit: M06)
13.06.1994Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
18.07.1994Reply to a communication from the examining division
30.05.1995Despatch of a communication from the examining division (Time limit: M04)
30.09.1995Reply to a communication from the examining division
13.06.1996Despatch of communication of intention to grant (Approval: No)
26.11.1996Despatch of communication of intention to grant (Approval: later approval)
09.12.1996Communication of intention to grant the patent
19.03.1997Fee for grant paid
19.03.1997Fee for publishing/printing paid
Opposition(s)05.03.1998No opposition filed within time limit [1998/22]
Request for further processing for:18.07.1994Request for further processing filed
18.07.1994Full payment received (date of receipt of payment)
Request granted
01.08.1994Decision despatched
Fees paidRenewal fee
22.05.1993Renewal fee patent year 03
23.06.1994Renewal fee patent year 04
31.08.1995Renewal fee patent year 05
02.09.1996Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
ES04.06.1997
FR04.06.1997
GR04.06.1997
IT04.06.1997
LI04.06.1997
NL04.06.1997
LU16.08.1997
GB04.09.1997
SE04.09.1997
DE05.09.1997
[2004/38]
Former [2004/35]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
ES04.06.1997
FR04.06.1997
GR04.06.1997
IT04.06.1997
LI04.06.1997
NL04.06.1997
LU31.08.1997
GB04.09.1997
SE04.09.1997
DE05.09.1997
Former [2003/07]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
ES04.06.1997
GR04.06.1997
IT04.06.1997
LI04.06.1997
NL04.06.1997
LU31.08.1997
GB04.09.1997
SE04.09.1997
DE05.09.1997
FR31.10.1997
Former [2002/25]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
ES04.06.1997
GR04.06.1997
IT04.06.1997
LI04.06.1997
LU31.08.1997
GB04.09.1997
SE04.09.1997
DE05.09.1997
FR31.10.1997
Former [2000/05]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
GR04.06.1997
IT04.06.1997
LI04.06.1997
LU31.08.1997
GB04.09.1997
SE04.09.1997
DE05.09.1997
FR31.10.1997
Former [1999/42]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
IT04.06.1997
LI04.06.1997
GB04.09.1997
SE04.09.1997
DE05.09.1997
FR31.10.1997
Former [1998/30]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
LI04.06.1997
GB04.09.1997
SE04.09.1997
DE05.09.1997
FR31.10.1997
Former [1998/19]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
LI04.06.1997
SE04.09.1997
DE05.09.1997
FR31.10.1997
Former [1998/15]AT04.06.1997
BE04.06.1997
CH04.06.1997
DK04.06.1997
LI04.06.1997
SE04.09.1997
DE05.09.1997
Former [1998/12]AT04.06.1997
BE04.06.1997
CH04.06.1997
LI04.06.1997
SE04.09.1997
DE05.09.1997
Former [1998/10]AT04.06.1997
BE04.06.1997
CH04.06.1997
LI04.06.1997
DE05.09.1997
Former [1998/04]AT04.06.1997
CH04.06.1997
LI04.06.1997
DE05.09.1997
Former [1998/03]AT04.06.1997
DE05.09.1997
Former [1998/02]AT04.06.1997
Cited inInternational search[A]EP0219874  (BOEHRINGER MANNHEIM GMBH [DE]);
 [A]WO8702985  (BEATRICE CO INC [US]);
 [X]WO8810299  (NORDISK GENTOFTE [DK]);
 [A]EP0312358  (PITMAN MOORE INC [US])
by applicantWO8810299
    - RINDERKNECHT,E.; HUMBEL, R.E., J. BIOL. CHEM., (1978), vol. 253, pages 2769 - 2773
    - ZAPF,J. ET AL., CURR. TOPICS IN CELL REG., (1981), vol. 19, pages 257 - 309
    - HUMBEL,R.E., HORMONAL PROTEINS AND PEPTIDES, (1984), vol. 12, pages 56 - 69
    - VAN WYK,J.J., HORMONAL PROTEINS AND PEPTIDES, (1984), vol. 12, pages 81 - 125
    - HUMBEL,R.E., J. BIOL. CHEM., (1978), vol. 253, pages 2769 - 76
    - RINDERKNECHT,E.; HUMBEL,R.E., J. BIOL. CHEM, (1978), vol. 253, pages 2769 - 73
    - HOLLY,J.M.P.; WASS,J.A.H., J. ENDOCRINOL, (1989), vol. 122, pages 611 - 618
    - OOI,G.T.; HERRINGTON,A.C., J. ENDOCRINOL., (1988), vol. 118, pages 7 - 18
    - SALMON,W.D.JR.; DAUGHADAY,W.H., J. LAB. CLIN. MED., (1957), vol. 49, pages 825 - 836
    - FROESCH ET AL., ANN. REV. PHYIOL., (1985), vol. 47, pages 443 - 467
    - KATO ET AL., EUR. J. BIOCHEM., (1983), vol. 129, pages 685 - 690
    - STILES ET AL., P.N.A.S., USA, (1979), vol. 76, pages 1279 - 1283
    - O KEEFE ET AL., MOL. CELL. ENDOCRINOL., (1983), vol. 31, pages 167 - 186
    - GILLERFORS ET AL., J. BIOL. CHEM., (1989), vol. 264, pages 2748 - 53
    - SAMUELSSON, E. ET AL., BIOTECHNOLOGY, (1991), vol. 9, pages 363 - 366
    - DALBOEGE, H. ET AL., FEBS LETT., (1989), vol. 246, no. 1,2, pages 89 - 93
    - DALBOGE ET AL., BIOTECHNOL, (1987), vol. 5, page 161 FF
    - DALBOGE ET AL., GENE, (1989), vol. 79, pages 325 - 332
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.