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Extract from the Register of European Patents

EP About this file: EP0550580

EP0550580 - URACIL REDUCTASE INACTIVATOR [Right-click to bookmark this link]
Former [1993/28]URACIL REDUCTASE INACTIVATORS
[1999/10]
StatusNo opposition filed within time limit
Status updated on  12.01.2001
Database last updated on 25.09.2024
Most recent event   Tooltip12.01.2001No opposition filed within time limitpublished on 28.02.2001 [2001/09]
Applicant(s)For all designated states
THE WELLCOME FOUNDATION LIMITED
Glaxo Wellcome House, Berkeley Avenue Greenford
Middlesex UB6 0NN / GB
[N/P]
Former [1997/42]For all designated states
THE WELLCOME FOUNDATION LIMITED
Glaxo Wellcome House, Berkeley Avenue
Greenford, Middlesex UB6 0NN / GB
Former [1993/28]For all designated states
THE WELLCOME FOUNDATION LIMITED
Unicorn House 160 Euston Road
London NW1 2BP / GB
Inventor(s)01 / SPECTOR, Thomas
Route 7, PO Box 59
Durham, NC 27707 / US
02 / PORTER, David, John, Timothy
8512 Sawyer Drive
Raleigh, NC 27613 / US
03 / RAHIM, Saad, George Langley Court
Beckenham
Kent BR3 3BS / GB
[1993/28]
Representative(s)Filler, Wendy Anne, et al
GlaxoSmithKline
Corporate Intellectual Property (CN9.25.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
[N/P]
Former [1997/42]Filler, Wendy Anne, Dr., et al
Glaxo Wellcome plc Glaxo Wellcome House, Berkeley Avenue
Greenford, Middlesex UB6 0NN / GB
Former [1993/28]Chapman, Paul William, et al
The Wellcome Foundation Limited, Langley Court
Beckenham, Kent BR3 3BS / GB
Application number, filing date91917260.125.09.1991
[1993/28]
WO1991GB01650
Priority number, dateGB1990002093026.09.1990         Original published format: GB 9020930
[1993/28]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9204901
Date:02.04.1992
Language:EN
[1992/08]
Type: A1 Application with search report 
No.:EP0550580
Date:14.07.1993
Language:EN
The application published by WIPO in one of the EPO official languages on 02.04.1992 takes the place of the publication of the European patent application.
[1993/28]
Type: B1 Patent specification 
No.:EP0550580
Date:15.03.2000
Language:EN
[2000/11]
Search report(s)International search report - published on:EP02.04.1992
ClassificationIPC:A61K31/505, A61K31/70, C07D239/54
[1993/28]
CPC:
A61K31/70 (EP,US); A61K31/505 (EP,US); A61K31/513 (EP,US);
A61K31/7072 (EP,US); A61K45/06 (EP,US); A61K9/0031 (EP,US);
A61K9/1623 (EP,US); A61K9/1635 (EP,US); A61K9/1652 (EP,US);
A61K9/2018 (EP,US); A61K9/2054 (EP,US); A61K9/48 (EP,US);
A61P35/00 (EP); C07D239/54 (EP,US); C07H19/06 (EP,US) (-)
C-Set:
A61K31/505, A61K2300/00 (US,EP);
A61K31/505, A61K31/505 (US,EP);
A61K31/7072, A61K2300/00 (US,EP);
A61K31/7072, A61K31/7072, A61K31/505 (EP,US)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IT,   LI,   LU,   NL,   SE [1993/28]
TitleGerman:URACIL-REDUCTASE-INAKTIVATOR[1999/10]
English:URACIL REDUCTASE INACTIVATOR[1999/10]
French:INACTIVATEUR DE REDUCTASE URACILE[1999/10]
Former [1993/28]URACIL-REDUCTASE-INAKTIVATOREN
Former [1993/28]URACIL REDUCTASE INACTIVATORS
Former [1993/28]INACTIVATEURS DE REDUCTASE URACILE
Entry into regional phase12.03.1993National basic fee paid 
12.03.1993Designation fee(s) paid 
12.03.1993Examination fee paid 
Examination procedure01.04.1992Request for preliminary examination filed
International Preliminary Examining Authority: DE
12.03.1993Examination requested  [1993/28]
20.04.1995Despatch of a communication from the examining division (Time limit: M06)
18.10.1995Reply to a communication from the examining division
19.02.1997Despatch of a communication from the examining division (Time limit: M06)
18.08.1997Reply to a communication from the examining division
24.03.1998Despatch of a communication from the examining division (Time limit: M06)
17.09.1998Reply to a communication from the examining division
10.03.1999Despatch of communication of intention to grant (Approval: Yes)
18.08.1999Communication of intention to grant the patent
13.10.1999Fee for grant paid
13.10.1999Fee for publishing/printing paid
Divisional application(s)EP99202472.9  / EP0985415
Opposition(s)16.12.2000No opposition filed within time limit [2001/09]
Fees paidRenewal fee
28.06.1993Renewal fee patent year 03
11.07.1994Renewal fee patent year 04
10.07.1995Renewal fee patent year 05
12.09.1996Renewal fee patent year 06
10.09.1997Renewal fee patent year 07
09.09.1998Renewal fee patent year 08
13.09.1999Renewal fee patent year 09
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Cited inInternational search[X]US4719214  (SHEALY Y FULMER [US], et al);
 [X]EP0272065  (WELLCOME FOUND [GB]);
 [X]US4863927  (TOLMAN RICHARD L [US], et al);
 [X]EP0356166  (WELLCOME FOUND [GB]);
 [X]EP0371139  (MITSUBISHI CHEM IND [JP]);
 [XP]EP0409575  (UNIV BIRMINGHAM [GB])
 [X]  - Chemical Abstracts, volume 107, no. 21, 23 November 1987, (Columbus, Ohio, US), Tatsumi, Kunihiko et al : "Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts ", see page 28, abstract 190461z, & Jpn.J.Cancer Res.(GANN) 1987, 78( 7), 748- 75
 [X]  - Chemical Abstracts, volume 104, no. 3, 20 January 1986, (Columbus, Ohio, US), Tuchman, Mendel et al : "Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. ", see page 28, abstract 14633m, & Cancer Res. 1985, 45(11), 5553-555
 [X]  - NUCLEIC ACIDS RESEARCH, Vol. 3, No. 10, 1976 P.J. Barr et al: "Incorporation of 5-substituted uracil derivatives into nucleic acids. Part IV. The synthesis of 5-ethynyluracil. ",
 [X]  - CANCER RESEARCH, Vol. 46, 1986 Claude Desgranges et al: "Effect of (E)-5-(2-Bromovinyl)uracil on the Catabolism and Antitumor Activity of 5-Fluorouracil in Rats and Leukemic Mice ",
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.