Extract from the Register of European Patents

EP About this file: EP0555385

EP0555385 - AGENTS AND METHODS FOR BINDING TO ELAM-1 [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  27.08.1999
Database last updated on 28.03.2026
Most recent event   Tooltip27.08.1999Application deemed to be withdrawnpublished on 13.10.1999 [1999/41]
Applicant(s)For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
475 East Jefferson, Room 2354
Ann Arbor, Michigan 48109-1248 / US
[N/P]
Former [1993/33]For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
475 East Jefferson, Room 2354
Ann Arbor, Michigan 48109-1248 / US
Inventor(s)01 / LOWE, John, B.
3055 Whisperwood Drive, 383
Ann Arbor, MI 48105 / US
02 / MARKS, Rory, M.
2017 Ferdon Street
Ann Arbor, MI 48104 / US
03 / STOOLMAN, Lloyd, M.
5201 Birkdale
Ann Arbor, MI 48103 / US
[1993/33]
Representative(s)des Termes, Monique, et al
BREVALEX 3, rue du Docteur Lancereaux
75008 Paris / FR
[N/P]
Former [1993/33]Des Termes, Monique, et al
c/o Société de Protection des Inventions 25, rue de Ponthieu
F-75008 Paris / FR
Application number, filing date92900499.225.10.1991
[1993/33]
WO1991US07678
Priority number, dateUS1990060301825.10.1990         Original published format: US 603018
[1993/33]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9207572
Date:14.05.1992
Language:EN
[1992/11]
Type: A1 Application with search report 
No.:EP0555385
Date:18.08.1993
Language:EN
The application published by WIPO in one of the EPO official languages on 14.05.1992 takes the place of the publication of the European patent application.
[1993/33]
Search report(s)International search report - published on:US14.05.1992
(Supplementary) European search report - dispatched on:EP07.02.1996
ClassificationIPC:C07H3/06, C07H13/04, C07H15/04, A61K31/70, A61K48/00, A61K35/14, A61K49/00, C12N5/10, A61K9/127
[1996/12]
CPC:
C07H13/04 (EP); A61K38/45 (EP); A61K47/6425 (EP);
A61K47/6911 (EP); A61K49/0002 (EP); A61K49/0004 (EP);
A61K49/1812 (EP); A61K9/1271 (EP); A61P11/16 (EP);
A61P9/00 (EP); A61P9/10 (EP); C07H15/04 (EP);
A61K48/00 (EP) (-)
Former IPC [1995/35]C07H3/06, C07H13/04, C07H15/04, A61K31/70, A61K48/00, A61K35/14, A61K49/00, C12N5/10
Former IPC [1993/33]A61K31/73, C07H15/04, C07H5/06, C12N5/10
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IT,   LI,   LU,   NL,   SE [1993/33]
TitleGerman:SUBSTANZEN UND METHODEN ZUR BINDUNG AN ELAM-1[1993/33]
English:AGENTS AND METHODS FOR BINDING TO ELAM-1[1993/33]
French:AGENTS ET PROCEDES DE LIAISON A L'ELAM-1[1993/33]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase30.04.1993National basic fee paid 
30.04.1993Search fee paid 
30.04.1993Designation fee(s) paid 
30.04.1993Examination fee paid 
Examination procedure19.05.1992Request for preliminary examination filed
International Preliminary Examining Authority: DE
03.05.1993Examination requested  [1993/33]
24.03.1998Despatch of a communication from the examining division (Time limit: M06)
21.09.1998Reply to a communication from the examining division
06.10.1998Despatch of a communication from the examining division (Time limit: M06)
17.04.1999Application deemed to be withdrawn, date of legal effect  [1999/41]
17.05.1999Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [1999/41]
Fees paidRenewal fee
11.10.1993Renewal fee patent year 03
19.09.1994Renewal fee patent year 04
25.09.1995Renewal fee patent year 05
16.09.1996Renewal fee patent year 06
26.09.1997Renewal fee patent year 07
05.10.1998Renewal fee patent year 08
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Documents cited:Search[X]   M. M. PALCIC ET AL.: "Enzymic synthesis of oligosaccharides terminating in the tumor-associated sialyl-Lewis-a determinant.", CARBOHYDRATE RESEARCH, vol. 190, no. 1, 1 July 1989 (1989-07-01), AMSTERDAM NL, pages 1 - 11 [X] 1-3,12 * page 1 - page 7 *
 [X]   P. STANLEY AND P. H. ATKINSON: "The LEC11 chinese hamster ovary mutant synthesizes N-linked carbohydrates containing sialylated, fucosylated lactosamine units. Analysis by one and two-dimensional 1H NMR spectroscopy.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 23, 15 August 1988 (1988-08-15), MD US, pages 11374 - 11381 [X] 1-3,12 * page 11374 - page 11375 *
 [PX]   A. KAMEYAMA ET AL.: "Synthetic studies on sialoglycoconjugates 22: total synthesis of tumor associated ganglioside, sialyl Lewis X.", JOURNAL OF CARBOHYDRATE CHEMISTRY, vol. 10, no. 4, pages 549 - 560 [PX] 1-3,12 * page 551 - page 552 *
International search[X]   The Journal of Biological Chemistry, Vol. 259, No. 14, issued 25 July 1984, LAMBLIN et al., "Primary Structure Determination of Five Sialylated Oligosaccharides Derived from Bronchial Mucus Glycoproteins of Patients Suffering from Cystic Fibrosis", pages 9051-9058, see entire document. [X]
 [X]   Cancer Research, Vol. 44, issued November 1984, FUKUSHIMA et al., "Characterization of Sialosylated Lewis X as New Tumor-Associated Antigen", pages 5279-5285, see entire document. [X]
 [X]   European Journal of Biochemistry, Vol. 177, No. 2, issued November 1988, VAN HALBEEK et al., "Isolalation and Structural Characterization of Low-molecular-mass Monosialyl Oligosaccharides Derived from Respiratory-mucus Glycoproteins of a Patient Suffering from Bronchiectasis", pages 443-460, see entire document. [X]
 [X]   Chemistry and Physics of Lipids, Vol. 42, issued 1986, HAKOMORI, "Tumor-associated Glycolipid Antigens, Their Metabolism and Organization", pages 209-233, see entire document. [X]
 [XP]   Proceedings of the National Academy of Sciences, (USA), Vol. 88, issued February 1991, TIEMEYER et al., "Carbohydrate Ligands for Endothelial-leukocyte Adhesion Molecule 1", pages 1138-1142, see entire document. [XP]
 [XP]   Biochemical Society Transactions, Vol. 19, No. 3, issued August 1991, LOWE et al., "A Transfected Human Fucosyltransferase cDNA Determines Biosynthesis of Oligosaccharide Ligand(s) for Endothelial-leukocyte Adhesion Molecule 1", pages 649-653, see entire document. [XP]
 [XP]   The Journal of Biologica Chemistry, Vol. 266, No. 23, issued 15 August 1991, BERG et al., "A Carbohydrate Domain Common to both Sialyl Le A and Sialyl Le X is Recognized by the Endothelial Cell Leudocyte Adhesion Molecule ELAM-1", pages 14869-14872, see entire document. [XP]
 [AP]   The Journal of Cell Biology, Vol. 115, No. 2, issued October 1991, ZHOU et al., "The Selectin GMP-140 Binds to Sialylated, Fucosylated Lactosaminoglycans on both Myeloid and Nonmyeloid Cells", pages 557-564. [AP]
 [XP]   Cell, Vol. 63, issued 21 December 1990, GOELZ et al., "ELFT: A Gene that Directs the Expression of an ELAM-1 Ligand", pages 1349-1356, see entire document. [XP]
 [XP]   Science, Vol. 250, issued 23 November 1990, WALZ et al., "Recognition by ELAM-1 of the Sialyl-Le X Determinant on Myeloid and Tumor Cells", pages 1132-1135, see entire document. [XP]
 [XP]   Science, Vol. 250, issued 23 November 1990, PHILLIPS et al., "ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le X", pages 1130-1132, see entire document. [XP]
 [X]   Proceedings of the National Academy of Sciences (USA), Vol. 87, issued March 1990, HESSION et al., "Endothelial Leukocyte Adhesion Molecule 1: Direct Expressions Cloning and Functional Interactions", pages 1673-1677, see entire document. [X]
 [AP]   Biochemical and Biophysical Research Communications, Vol. 179, No. 2, issued 16 September 1991, TAKADA et al., "Adhesion of Human Cancer Cells to Vascular Endothelium Mediated by a Carbohydrate Antigen, Sialyl Lewis A", pages 713-719, see entire document. [AP]
 [T]   The Journal of Experimental Medicine, Vol. 174, issued December 1991, BERG et al., "The Cutaneous Lymphocyte Antigen In a Skin Lymphocyte Homing Receptor for the Vascular Lectin Endothelial Cell-Leukocyte Adhesion Molecule 1", pages 1461-1466, see entire document. [T]
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