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Extract from the Register of European Patents

EP About this file: EP0528011

EP0528011 - CD4-GAMMA2 AND CD4-IgG2 CHIMERAS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  24.10.2003
Database last updated on 24.08.2024
Most recent event   Tooltip24.10.2003Application deemed to be withdrawnpublished on 10.12.2003  [2003/50]
Applicant(s)For all designated states
PROGENICS PHARMACEUTICALS, INC.
Old Saw Mill River Road P.O. Box 549
Tarrytown, NY 10591 / US
[N/P]
Former [1993/08]For all designated states
PROGENICS PHARMACEUTICALS, INC.
Old Saw Mill River Road P.O. Box 549
Tarrytown, NY 10591 / US
Inventor(s)01 / BEAUDRY, Gary, A.
109 Inwood Avenue
Upper Montclair, NJ 07043 / US
02 / MADDON, Paul, J.
60 Haven Avenue Apt. 25C
New York, NY 10032 / US
[1993/08]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[N/P]
Former [1993/08]VOSSIUS & PARTNER
Postfach 86 07 67
D-81634 München / DE
Application number, filing date92907272.610.02.1992
[1993/08]
WO1992US01143
Priority number, dateUS1991065368408.02.1991         Original published format: US 653684
[1993/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9213947
Date:20.08.1992
Language:EN
[1992/22]
Type: A1 Application with search report 
No.:EP0528011
Date:24.02.1993
Language:EN
The application published by WIPO in one of the EPO official languages on 20.08.1992 takes the place of the publication of the European patent application.
[1993/08]
Search report(s)International search report - published on:US20.08.1992
(Supplementary) European search report - dispatched on:EP11.05.1993
ClassificationIPC:C12N15/62, C07K13/00, A61K39/00, G01N33/533, G01N33/534
[1993/24]
CPC:
C07K14/70514 (EP,US); A61K47/6875 (EP,US); C07K16/00 (EP,US);
A61K38/00 (EP,US); C07K2319/00 (EP,US); C07K2319/30 (EP,US)
Former IPC [1993/08]C12N15/00, A61K39/00, C07K13/00
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IT,   LI,   LU,   MC,   NL,   SE [1993/08]
TitleGerman:CD4-GAMMA2 UND CD4-IGG2 CHIMÄREN[1993/08]
English:CD4-GAMMA2 AND CD4-IgG2 CHIMERAS[1993/08]
French:CHIMERES DE CD4-GAMMA2 ET DE CD4-IgG2[1993/08]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase09.11.1992National basic fee paid 
09.11.1992Search fee paid 
09.11.1992Designation fee(s) paid 
22.02.1993Examination fee paid 
Examination procedure22.02.1993Examination requested  [1993/16]
12.12.1996Despatch of a communication from the examining division (Time limit: M04)
22.04.1997Reply to a communication from the examining division
11.07.1997Despatch of a communication from the examining division (Time limit: M06)
21.01.1998Reply to a communication from the examining division
11.08.1998Despatch of a communication from the examining division (Time limit: M06)
04.06.1999Reply to a communication from the examining division
30.07.2002Despatch of a communication from the examining division (Time limit: M06)
10.02.2003Reply to a communication from the examining division
27.03.2003Despatch of a communication from the examining division (Time limit: M02)
07.06.2003Application deemed to be withdrawn, date of legal effect  [2003/50]
11.07.2003Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2003/50]
Divisional application(s)EP03012917.5  / EP1340769
Request for further processing for:04.06.1999Request for further processing filed
04.06.1999Full payment received (date of receipt of payment)
Request granted
21.06.1999Decision despatched
Fees paidRenewal fee
17.01.1994Renewal fee patent year 03
19.01.1995Renewal fee patent year 04
16.01.1996Renewal fee patent year 05
15.01.1997Renewal fee patent year 06
20.05.1998Renewal fee patent year 07
15.01.1999Renewal fee patent year 08
19.01.2000Renewal fee patent year 09
19.01.2001Renewal fee patent year 10
21.01.2002Renewal fee patent year 11
20.01.2003Renewal fee patent year 12
Penalty fee
Additional fee for renewal fee
28.02.199807   M06   Fee paid on   20.05.1998
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Documents cited:Search[E]WO9213559  (PROGENICS PHARM INC [US])
 [X]  - BIOCHEMISTRY. vol. 29, no. 42, 23 October 1990, EASTON, PA US pages 9885 - 9891 Chamow SM;Peers DH;Byrn RA;Mulkerrin MG;Harris RJ;Wang WC;Bjorkman PJ;Capon DJ;Ashkenazi A; 'Enzymatic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments.'
 [X]  - DNA AND CELL BIOLOGY vol. 9, no. 5, June 1990, NEW YORK US pages 347 - 353 Zettlmeissl G;Gregersen JP;Duport JM;Mehdi S;Reiner G;Seed B; 'Expression and characterization of human CD4:immunoglobulin fusion proteins.'
International search[Y]US4664911  (UHR JONATHAN W [US], et al);
 [Y]WO8902922  (GENENTECH INC [US]);
 [Y]WO8906690  (GEN HOSPITAL CORP [US]);
 [Y]WO9001035  (US COMMERCE [US]);
 [Y]JPH02107393  (ASAHI CHEMICAL IND);
 [Y]WO9100360  (MEDAREX INC [US])
 [YP]  - Science, Volume 254, issued 22 November 1991, I. PASTAN et al., "Recombinant Toxins for Cancer Treatment", pages 1173-1177, see entire document.
 [Y]  - J. Biological Chemistry, Volume 264, No. 26, issued 15 September 1989, I. PASTAN et al., "Pseudomonas exotoxin: chimeric toxins", pages 15157-15160, see especially page 15159, paragraphs 2-3.
 [Y]  - Science, Volume 242, issued 25 November 1988, M.A. TILL et al., "HIV-Infected cells are killed by rCD4-Ricin A Chain", pages 1166-1168, see especially Abstract.
 [Y]  - Proc. Nat. Acad. Sci. US, Volume 81, issued November 1984, S.L. MORRISON et al., "Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains", pages 6851-6855, see entire article.
 [Y]  - Nature, Volume 339, issued 04 May 1989, A. TRAUNECKER et al., "Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules", pages 68-70, see entire article, especially Abstract.
 [Y]  - Nature, Volume 344, issued 12 April 1990, R.A. BYRN et al., "Biological properties of a CD4 immunoadhesin", pages 667-670, see entire article, especially page 667, 1st paragraph following Abstract.
 [Y]  - Nature, Volume 337, issued 09 February 1989, D.J. CAPON et al., "Designing CD4 immunoadhesins for AIDS therapy", pages 525-531, see especially paragraph bridging pages 525-526, last paragraph of column 1, page 530.
 [Y]  - Cancer Research, Volume 45, issued May 1985, J.L. MURRAY et al., "Radioimaging in malignant melanoma with 111In-labelled monoclonal antibody 96.5", pages 2376-2381, see entire document.
 [Y]  - DNA and Cell Biology, Volume 9, No. 5, issued 1990, G. ZEITMEISSL et al., "Expression and characterization of human CD4: immunoglobulin fusion proteins", pages 347-353, see entire article.
 [X]  - Microbiol. Immunol., Volume 180, No. 4, issued 1991, CHOWDHURY et al., "Evaluation of anti-human immunodeficiency virus effect of recombinant CD4-immunoglobulin in-vitro a good candidate for AIDS treatment", pages 183-192, see Abstract No. 92129982.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.