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EP0676964
European procedure
Extract from the Register of European Patents
EP About this file: EP0676964
| EP0676964 - NITROSYLATION OF ENZYME SH GROUPS AS A THERAPEUTIC MODALITY [Right-click to bookmark this link] | |||
| Former [1995/42] | NITROSYLATION OF PROTEIN SH GROUPS AND AMINO ACID RESIDUES AS A THERAPEUTIC MODALITY | ||
| [1999/46] | Status | No opposition filed within time limit Status updated on 30.11.2001 Database last updated on 16.07.2024 | Most recent event Tooltip | 30.11.2001 | No opposition filed within time limit | published on 16.01.2002 [2002/03] | Applicant(s) | For all designated states BRIGHAM AND WOMEN'S HOSPITAL 75 Francis Street Boston Massachusetts 02115 / US | [N/P] |
| Former [1995/42] | For all designated states BRIGHAM AND WOMEN'S HOSPITAL 75 Francis Street Boston, Massachusetts 02115 / US | Inventor(s) | 01 /
STAMLER, Jonathan 220 Marlborough Street, 1 Boston, MA 02116 / US | 02 /
LOSCALZO, Joseph 50 Pacella Drive Dedham, MA 02026 / US | 03 /
SIMON, Daniel 211 Dorset Street Waban, MA 02168 / US | 04 /
SINGEL, David 152 Park Avenue Extension Arlington, MA 02174 / US | [1995/42] | Representative(s) | Segeth, Wolfgang Patentanwälte Louis, Pöhlau, Lohrentz & Segeth Postfach 30 55 90014 Nürnberg / DE | [N/P] |
| Former [1995/42] | Segeth, Wolfgang Patentanwälte Louis, Pöhlau, Lohrentz & Segeth Postfach 30 55 D-90014 Nürnberg / DE | Application number, filing date | 92924388.9 | 13.11.1992 | [1995/42] | WO1992US09667 | Priority number, date | US19910791668 | 14.11.1991 Original published format: US 791668 | US19920943835 | 14.09.1992 Original published format: US 943835 | [1995/42] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO9309806 | Date: | 27.05.1993 | Language: | EN | [1993/13] | Type: | A1 Application with search report | No.: | EP0676964 | Date: | 18.10.1995 | Language: | EN | The application published by WIPO in one of the EPO official languages on 27.05.1993 takes the place of the publication of the European patent application. | [1995/42] | Type: | B1 Patent specification | No.: | EP0676964 | Date: | 24.01.2001 | Language: | EN | [2001/04] | Search report(s) | International search report - published on: | US | 27.05.1993 | (Supplementary) European search report - dispatched on: | EP | 10.08.1995 | Classification | IPC: | A61K38/43, A61K38/48, C12N9/70, A61K38/16, A61K38/00, C07K14/00, C07K2/00, C07K4/00, C07K16/00, C12N9/72, C12N9/64, A61K39/395 | [1999/46] | CPC: |
C12N9/6472 (EP,US);
A61P11/00 (EP);
A61P9/00 (EP);
C07K1/1077 (EP,US);
C07K14/3153 (EP,US);
C07K14/4702 (EP,US);
C07K14/76 (EP,US);
C07K14/765 (EP,US);
C07K14/805 (EP,US);
C07K16/00 (EP,US);
C12N9/6459 (EP,US);
C12Y304/21069 (EP,US);
A61K38/00 (EP,US)
(-)
|
| Former IPC [1995/42] | A61K37/48, A61K37/547, C12N9/70, A61K37/14, A61K37/00, C07K13/00, C07K15/00, C12N9/72, C12N9/64, A61K39/395 | Designated contracting states | CH, DE, DK, FR, GB, IT, LI, SE [1995/42] | Title | German: | DIE NITROSYLIERUNG VON ENZYM-SH GRUPPEN ALS EINE THERAPEUTISCHE MASSNAHME | [1999/46] | English: | NITROSYLATION OF ENZYME SH GROUPS AS A THERAPEUTIC MODALITY | [1999/46] | French: | NITROSATION DE GROUPES ENZYMATIQUES SH UTILISEE COMME MODALITE THERAPEUTIQUE | [1999/46] |
| Former [1995/42] | DIE NITROSYLIERUNG VON PROTEIN-SH GRUPPEN UND AMINOSÄURERESTEN ALS EINE THERAPEUTISCHE MASSNAHME | ||
| Former [1995/42] | NITROSYLATION OF PROTEIN SH GROUPS AND AMINO ACID RESIDUES AS A THERAPEUTIC MODALITY | ||
| Former [1995/42] | NITROSATION DE GROUPES PROTEIQUES SH ET DE RESTES D'ACIDES AMINES UTILISEE COMME MODALITE THERAPEUTIQUE | Entry into regional phase | 11.06.1994 | National basic fee paid | 11.06.1994 | Search fee paid | 11.06.1994 | Designation fee(s) paid | 11.06.1994 | Examination fee paid | Examination procedure | 03.06.1993 | Request for preliminary examination filed International Preliminary Examining Authority: US | 11.06.1994 | Examination requested [1995/42] | 04.08.1998 | Despatch of a communication from the examining division (Time limit: M06) | 09.02.1999 | Reply to a communication from the examining division | 11.03.1999 | Despatch of a communication from the examining division (Time limit: M02) | 15.05.1999 | Reply to a communication from the examining division | 28.05.1999 | Despatch of a communication from the examining division (Time limit: M02) | 04.08.1999 | Reply to a communication from the examining division | 27.10.1999 | Despatch of communication of intention to grant (Approval: Yes) | 05.05.2000 | Communication of intention to grant the patent | 28.07.2000 | Fee for grant paid | 28.07.2000 | Fee for publishing/printing paid | Divisional application(s) | EP00108906.9 / EP1025853 | EP00108907.7 / EP1023900 | EP00108908.5 / EP1023905 | Opposition(s) | 25.10.2001 | No opposition filed within time limit [2002/03] | Fees paid | Renewal fee | 07.10.1994 | Renewal fee patent year 03 | 25.08.1995 | Renewal fee patent year 04 | 28.10.1996 | Renewal fee patent year 05 | 29.10.1997 | Renewal fee patent year 06 | 30.10.1998 | Renewal fee patent year 07 | 25.11.1999 | Renewal fee patent year 08 | 13.11.2000 | Renewal fee patent year 09 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [POX] - J. STAMLER ET AL, "Exposure of sulphydryl-containing proteins to nitric oxide and endothelium-derived relaxing factor confers novel bioactivity and modulates their intrinsic functional properties", BIOLOGY OF NITRIC OXIDE, (1992), vol. 1, pages 20 - 23 [POX] 1-3,11-16 * PROC. INT. MEET., 2ND 1991. Edited by Moncada, S. Portland Press: London UK * | International search | [AY]US4900719 (MEANS GARY E [US], et al); | [AY]US5002964 (LOSCALZO JOSEPH [US]); | [AY]US5025001 (LOSCALZO JOSEPH [US], et al); | [APY]US5116861 (GOTO GIICHI [JP], et al) | [AY] - Journal of Clinical Investigation, Volume 76, issued August 1985, LOSCALZO et al., "N-Acetylcysteine Potentiates Inhibition of Platelet Aggregation by Nitroglycerin", pages 703-708, entire document. | [AY] - Molecular Pharmacology, Volume 23, issued 1983, MELLION et al., "Inhibition of Human Platelet Aggregation by S-Nitrothiols", pages 653-664, see entire document. | [AY] - Journal of Pharmacology and Experimental Therapeutics, Volume 218, issued 1981, IGNARRO et al., "Mechanism of Vascular Muscle Relaxation by Organic Nitrates, Nitrites, Nitroprusside and Nitric Oxide: Evidence for the Involvement of S-Nitrothiols as Active Intermediates", pages 739-749, see entire document. | [AY] - Circulation Research, Volume 65, No. 3, issued 1989, STAMLER et al., "N-Actylcysteine Potentiates Platelet Inhibition by Endothelium-Derived Relaxing Factor", pages 789-95, see entire document. | [A] - Molecular Pharmacology, Volume 38, issued 1990, FORSTERMANN et al., "Hormone-Induced Biosynthesis of Endothelium-Derived Relaxing Factor/Nitric Oxide-Like Material in N1E-115 Neuroblastoma Cells Requires Calcium and Calmodulin", pages 7-13 (1990), see entire document. | [A] - Circulation Research, Volume 65, No. 1, issued 1989, IGNARRO, "Biological Actions and Properties of Endothelium-Derived Nitric Oxide Formed and Released from Artery and Vein", pages 1-21, see entire document. | [AY] - Journal of Pharmacology and Experimental Therapeutics, Volume 249, No. 3, issued 1989, LOSCALZO et al., "S-Nitrosocaptopril I. Molecular Characterization and Effects on the Vasculature and on Platelets", pages 726-729, see entire document. | [Y] - New England Journal of Medicine, Volume 319, No. 14, issued 06 October 1988, LOSCALZO et al., "Tissue Plasminogen Activator", pages 925-931, see entire document. | [AY] - JAMA, Volume 265, No. 1, issued 2 January 1991, MAHLEY et al., "Genetic Defects in Lipoprotein Metabolism", pages 78-83, see entire document. | [AY] - Nature, Volume 345, issued 10 May 1990, MYERS et al., "Vasorelaxant Properties of the Endothelium-Derived Relaxing Factor More Closely Resemble S-Nitrosocysteine than Nitric Oxide", pages 161-163, see entire document. | [A] - European Journal of Pharmacology, Volume 161, issued 1989, BUGA et al., "Endothelium-Derived Nitric Oxide Relaxes Nonvascular Smooth Muscle", pages 61-72, see entire document. | [AY] - Drug Metabolism and Disposition, Volume 18, No. 1, issued 1990, CHONG et al., "Thiol-Mediated Catalysis of Nitroglycerin Degradation by Serum Proteins", pages 61-67, see entire document. | [A] - Biochemical and Biophysical Research Communications, Volume 151, No. 3, issued 30 March 1988, UMEMOTO et al., "Oxidation of the 2-Hydroxyamino Derivatives of 2-Amino-6-Methyl-Dipyrido(1,2-a:3',2'-d) Imidazole to its 2-Nitroso Form, an Ultimate Form Reacting with Hemoglobin Thiol Groups", pages 1326-1331, see entire | [PA] - Proceedings of the National Academy of Science, Volume 89, No. 1, issued 01 January 1992, STAMLER et al., "S-Nitrosylation of Proteins with Nitric Oxide: Synthesis and Characterization of Biologically Active Compounds", pages 444-448, entire document. | [PA] - Proceedings of the National Academy of Science, Volume 89, No. 16, issued 15 August 1992, STAMLER et al., "Nitric Oxide Circulates in Mammilian Plasma Primarily as an S-Nitroso Adduct of Serum Albumin", pages 7674-7677, entire document. | [PA] - Proceedings of the National Academy of Science, Volume 89, No. 17, issued 15 August 1992, STAMLER et al., "S-Nitrosylation of Tissue Type Plasminogen Activator Confers Vasodilatory and Antiplatelet Properties on the Enzyme", pages 8087-8091, entire document. |