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Extract from the Register of European Patents

EP About this file: EP0692029

EP0692029 - GENETICALLY ENGINEERED GLUTAMINASE AND ITS USE IN THERAPY [Right-click to bookmark this link]
Former [1996/03]GENETICALLY ENGINEERED GLUTAMINASE AND ITS USE IN ANTIVIRAL AND ANTICANCER THERAPY
[2006/44]
StatusNo opposition filed within time limit
Status updated on  14.03.2008
Database last updated on 31.08.2024
Most recent event   Tooltip18.04.2008Lapse of the patent in a contracting state
New state(s): GR
published on 21.05.2008  [2008/21]
Applicant(s)For all designated states
ME MEDICAL ENZYMES AG
Frohburgweg 7
CH-6340 Baar / CH
[2007/19]
Former [1996/03]For all designated states
ME MEDICAL ENZYMES AG
Frohburgweg 7
CH-6340 Baar / CH
Inventor(s)01 / ROBERTS, Joseph
6 Sunturf Circle
Columbia, SC 29223 / US
02 / MacALLISTER, Thomas W.
308 E. Meadow Court
Columbia, SC 29210 / US
03 / SETHURAMAN, Natarajan
1340 Long Creek Drive 713
Columbia, SC 29210 / US
04 / FREEMAN, Abbie G.
1538 Lonsford Road
Columbia, SC 29206 / US
[1996/03]
Representative(s)Wright, Simon Mark, et al
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
[N/P]
Former [2001/21]Wright, Simon Mark, et al
J.A. Kemp & Co. 14 South Square Gray's Inn
London WC1R 5LX / GB
Former [2001/03]Tombling, Adrian George, et al
Withers & Rogers Goldings House 2 Hays Lane
London SE1 2HW / GB
Former [1996/03]Dean, John Paul, et al
Withers & Rogers 4 Dyer's Buildings Holborn
London EC1N 2JT / GB
Application number, filing date93900818.104.12.1992
[1996/03]
WO1992US10421
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9413817
Date:23.06.1994
Language:EN
[1994/14]
Type: A1 Application with search report 
No.:EP0692029
Date:17.01.1996
Language:EN
The application published by WIPO in one of the EPO official languages on 23.06.1994 takes the place of the publication of the European patent application.
[1996/03]
Type: B1 Patent specification 
No.:EP0692029
Date:09.05.2007
Language:EN
[2007/19]
Search report(s)International search report - published on:EP23.06.1994
ClassificationIPC:C12N15/55, C12N9/80, A61K47/48, A61K48/00, C12N1/21
[2006/44]
CPC:
C12N9/82 (EP,US); A61K47/6815 (EP,US); A61K47/6865 (EP,US);
A61K47/6899 (EP,US); A61P31/12 (EP); A61P35/00 (EP);
B82Y5/00 (EP,US); C07K16/3053 (EP,US); C07K19/00 (EP,US);
C12N9/80 (EP,US); C12Y305/01038 (EP,US); A61K38/00 (EP,US);
A61K48/00 (EP,US); C07K2317/73 (EP,US); C07K2319/00 (EP,US) (-)
Former IPC [1996/03]C12N15/55, A61K37/54, C12N9/80, C07K13/00, A61K47/48, A61K48/00, A61K9/127, C12N1/21
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1996/03]
TitleGerman:GENTECHNOLOGISCH HERGESTELLTE GLUTAMINASE UND IHRE VERWENDUNG IN THERAPIE[2006/44]
English:GENETICALLY ENGINEERED GLUTAMINASE AND ITS USE IN THERAPY[2006/44]
French:GLUTAMINASE PRODUITE PAR GÉNIE GÉNETIQUE ET SON UTILISATION EN THÉRAPIE[2006/44]
Former [1996/03]GENETECHNOLOGISCH HERGESTELLTE GLUTAMINASE UND IHRE VERWENDUNG IN ANTIVIRALER UND ANTIKREBSTHERAPIE
Former [1996/03]GENETICALLY ENGINEERED GLUTAMINASE AND ITS USE IN ANTIVIRAL AND ANTICANCER THERAPY
Former [1996/03]GLUTAMINASE PRODUITE PAR GENIE GENETIQUE ET SON UTILISATION EN THERAPIE ANTIVIRALE ET ANTICANCEREUSE
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase28.04.1995National basic fee paid 
28.04.1995Designation fee(s) paid 
28.04.1995Examination fee paid 
Examination procedure09.06.1994Request for preliminary examination filed
International Preliminary Examining Authority: EP
28.04.1995Examination requested  [1996/03]
26.04.1996Despatch of a communication from the examining division (Time limit: M06)
05.12.1996Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
11.02.1997Reply to a communication from the examining division
04.06.1998Despatch of a communication from the examining division (Time limit: M06)
14.12.1998Reply to a communication from the examining division
10.11.1999Despatch of a communication from the examining division (Time limit: M06)
18.05.2000Reply to a communication from the examining division
08.02.2001Despatch of a communication from the examining division (Time limit: M08)
16.10.2001Reply to a communication from the examining division
19.02.2002Despatch of a communication from the examining division (Time limit: M06)
23.08.2002Reply to a communication from the examining division
04.02.2004Despatch of a communication from the examining division (Time limit: M07)
14.09.2004Reply to a communication from the examining division
17.11.2006Communication of intention to grant the patent
15.03.2007Fee for grant paid
15.03.2007Fee for publishing/printing paid
Divisional application(s)EP07009229.1  / EP1854876
Opposition(s)12.02.2008No opposition filed within time limit [2008/16]
Request for further processing for:11.02.1997Request for further processing filed
11.02.1997Full payment received (date of receipt of payment)
Request granted
25.02.1997Decision despatched
Fees paidRenewal fee
27.05.1995Renewal fee patent year 03
07.12.1995Renewal fee patent year 04
09.12.1996Renewal fee patent year 05
05.12.1997Renewal fee patent year 06
21.12.1998Renewal fee patent year 07
06.12.1999Renewal fee patent year 08
07.12.2000Renewal fee patent year 09
07.12.2001Renewal fee patent year 10
28.11.2002Renewal fee patent year 11
18.12.2003Renewal fee patent year 12
07.12.2004Renewal fee patent year 13
13.12.2005Renewal fee patent year 14
12.12.2006Renewal fee patent year 15
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Lapses during opposition  TooltipDK09.05.2007
GR10.08.2007
PT09.10.2007
[2008/21]
Former [2008/12]DK09.05.2007
PT09.10.2007
Former [2008/08]DK09.05.2007
Cited inInternational search[Y]CA1168150  (UNIV ALBERTA [CA]);
 [Y]US4762707  (JANSEN FRANZ [FR], et al)
 [A]  - Roberts, et al., "Inhibition of mouse retroviral disease by bioactive glutaminase-asparaginase", J. Gen. Virol., 72:299-305 (1991).
 [AO]  - Ollenschl{ger, et al., "Intestinal Glutamine Metabolism of Patients with HIV-Infection", Clinical Nutrition, 9:48-49 (1990).
 [AO]  - Roberts, et al., "Glutaminase has potent antiretroviral activity in vivo", Abstract, Proc. Am. Assoc. Cancer Res., 30:454 (1989).
 [Y]  - Schmer, et al., "Kinetics of Uptake and Activity in Mouse Liver of Glutaminase Coupled to Desialated Orosomucoid", Biochimica et Biophysica Acta, 538:397-405 (1978).
 [A]  - Shapiro, et al., "Isolation, Characterization, and in Vitro Expression of a cDNA That Encodes the Kidney Isoenzyme of the Mitochondrial Glutaminase", J. Biol. Chem., 266:18792-18796 (1991).
 [X]  - Roberts, et al., "Biologic and Antineoplastic Effects of Enzyme-Mediated In Vivo Depletion of L-Glutamine, L-Tryptophan, and L-Histidine", Cancer Treatment Reports, 63:1045-1054 (1979).
 [A]  - Wu, et al., "Receptor-mediated Gene Delivery in Vivo", J. Biol. Chem., 266:14338-14342 (1991).
 [A]  - Nicolau, et al., "Liposomes as Carriers for in Vivo Gene Transfer and Expression", Meth. Enzymol., 149:157-176 (1987).
Examination   - J. GEN. VIROL. vol. 72, no. 2, February 1991, COLCHESTER, UK pages 299 - 305 J. ROBERTS & W.G. MCGREGOR 'Inhibition of mouse retroviral disease by bioactive glutaminase-asparaginase' cited in the application
    - CLIN. NUTR. (EDINB.) vol. 9, no. 1, February 1990, EDINBURGH, UK pages 48 - 49 G. OLLENSCHL[GER ET AL. 'Intestinal Glutamine Metabolism of Patients with HIV-Infection'
    - PROC. AM. ASSOC. CANCER RES. ANNU. MEET.; ABSTR.NO. 1806 vol. 30, no. 0, 1989, page 454 J. ROBERTS & W.G. MCGREGOR 'Glutaminase has potent entiretroviral activity in vivo'
    - BIOCHIMICA ET BIOPHYSICA ACTA vol. 538, 1978, AMSTERDAM, NL pages 397 - 405 G. SCHMER ET AL. 'KINETICS OF UPTAKE AND ACTIVITY IN MOUSE LIVER OF GLUTAMINASE COUPLED TO DESIALATED OROSOMUCOID'
    - JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS) vol. 266, no. 28, 5 October 1991, BALTIMORE, MD US pages 18792 - 18796 R.A. SHAPIRO ET AL. 'Isolation, Characterization, and in Vitro Expression of a cDNA That Encodes the Kidney Isoenzyme of the Mitochondrial Glutaminase'
    - CANCER TREATMENT REPORTS vol. 63, no. 6, June 1979, BETHESDA, MD, USA pages 1045 - 1054 J. ROBERTS ET AL. 'Biologic and Antineoplastic Effects of Enzyme-Mediated In Vivo Depletion of L-Glutamine, L-Tryptophan, and L-histidine' cited in the application
    - JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS) vol. 266, no. 22, 5 August 1991, BALTIMORE, MD US pages 14338 - 14342 G.Y. WU ET AL. 'Receptor-mediated Gene Delivery in Vivo' cited in the application
    - METHODS IN ENZYMOLOGY, VOL. 149, PART B 1987, NEW YORK, US pages 157 - 176 C. NICOLAU ET AL. 'Liposomes as Carriers for in Vivo Gene Transfer and Expression' cited in the application
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.