blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP0639971

EP0639971 - THERAPEUTIC COMBINATIONS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.07.2000
Database last updated on 11.09.2024
Most recent event   Tooltip21.07.2000No opposition filed within time limitpublished on 06.09.2000 [2000/36]
Applicant(s)For all designated states
THE WELLCOME FOUNDATION LIMITED
Glaxo Wellcome House, Berkeley Avenue Greenford
Middlesex UB6 0NN / GB
[N/P]
Former [1997/42]For all designated states
THE WELLCOME FOUNDATION LIMITED
Glaxo Wellcome House, Berkeley Avenue
Greenford, Middlesex UB6 0NN / GB
Former [1995/09]For all designated states
THE WELLCOME FOUNDATION LIMITED
Unicorn House 160 Euston Road
London NW1 2BP / GB
Inventor(s)01 / LARDER, Brendan, Alexander Langley Court
Beckenham
Kent BR3 3BS / GB
02 / SYMONS, Sharon, Dawn Langley Court
Beckenham
Kent BR3 3BS / GB
[1995/09]
Representative(s)Garrett, Michael, et al
Glaxo Wellcome plc, Glaxo Wellcome House, Berkeley Avenue Greenford
Middlesex UB6 0NN / GB
[N/P]
Former [1995/09]Garrett, Michael, et al
The Wellcome Foundation Limited Group Patents and Agreements Langley Court
Beckenham Kent BR3 3BS / GB
Application number, filing date93910190.313.05.1993
[1995/09]
WO1993GB00980
Priority number, dateGB1992001025613.05.1992         Original published format: GB 9210256
GB1993000701302.04.1993         Original published format: GB 9307013
[1995/19]
Former [1995/09]GB1992001025613.05.1992
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO9323021
Date:25.11.1993
[1993/28]
Type: A1 Application with search report 
No.:EP0639971
Date:01.03.1995
Language:EN
The application published by WIPO in one of the EPO official languages on 25.11.1993 takes the place of the publication of the European patent application.
[1995/09]
Type: B1 Patent specification 
No.:EP0639971
Date:22.09.1999
Language:EN
[1999/38]
Search report(s)International search report - published on:EP03.03.1994
ClassificationIPC:A61K31/00, A61K31/55, A61K31/44, A61K31/505
[1995/09]
CPC:
A61K31/70 (EP); A61K31/00 (EP); A61K31/44 (EP);
A61K31/4439 (EP); A61K31/495 (EP); A61K31/496 (EP);
A61K31/505 (EP); A61K31/513 (EP); A61K31/517 (EP);
A61K31/55 (EP); A61K31/5513 (EP); A61K31/5517 (EP);
A61K31/7068 (EP) (-)
C-Set:
A61K31/4439, A61K2300/00 (EP);
A61K31/496, A61K2300/00 (EP);
A61K31/513, A61K2300/00 (EP);
A61K31/517, A61K2300/00 (EP);
A61K31/5513, A61K2300/00 (EP);
A61K31/5517, A61K2300/00 (EP);
A61K31/7068, A61K2300/00 (EP);
A61K31/70, A61K2300/00 (EP);
A61K31/70, A61K31/44 (EP);
A61K31/70, A61K31/495 (EP);
A61K31/70, A61K31/505 (EP);
A61K31/70, A61K31/55 (EP)
(-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1995/09]
TitleGerman:THERAPEUTISCHE KOMBINATIONEN[1995/09]
English:THERAPEUTIC COMBINATIONS[1995/09]
French:COMBINAISONS THERAPEUTIQUES[1995/09]
Entry into regional phase03.11.1994National basic fee paid 
03.11.1994Designation fee(s) paid 
03.11.1994Examination fee paid 
Examination procedure07.12.1993Request for preliminary examination filed
International Preliminary Examining Authority: EP
03.11.1994Examination requested  [1995/09]
02.12.1996Despatch of a communication from the examining division (Time limit: M06)
30.05.1997Reply to a communication from the examining division
15.12.1997Despatch of a communication from the examining division (Time limit: M04)
17.04.1998Reply to a communication from the examining division
04.08.1998Despatch of communication of intention to grant (Approval: No)
02.02.1999Despatch of communication of intention to grant (Approval: later approval)
25.03.1999Communication of intention to grant the patent
16.06.1999Fee for grant paid
16.06.1999Fee for publishing/printing paid
Opposition(s)24.06.2000No opposition filed within time limit [2000/36]
Fees paidRenewal fee
04.03.1995Renewal fee patent year 03
09.05.1996Renewal fee patent year 04
12.05.1997Renewal fee patent year 05
11.05.1998Renewal fee patent year 06
12.05.1999Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]EP0291633  (WELLCOME FOUND [GB]);
 [A]EP0336466  (JANSSEN PHARMACEUTICA NV [BE]);
 [A]EP0384522  (JANSSEN PHARMACEUTICA NV [BE]);
 [X]WO9109849  (UPJOHN CO [US]);
 [X]EP0462800  (MERCK & CO INC [US]);
 [A]WO9200979  (JANSSEN PHARMACEUTICA NV [BE]);
 [XP]WO9214743  (UNIV EMORY [US]);
 [XP]EP0513917  (GLAXO GROUP LTD [GB]);
 [XP]EP0530994  (MERCK & CO INC [US]);
 [X]EP0382526  (IAF BIOCHEM INT [CA])
 [X]  - MOL.PHARMACOL. vol. 41, no. 3, March 1992, pages 446 - 451 J.W.MELLORS ET AL. 'IN VITRO SELECTION AND MOLECULAR CHARACTERIZATION...'
 [X]  - ANTIMICROB.AGENTS CHEMOTHER. vol. 35, no. 2, February 1991, pages 305 - 308 D.RICHMAN ET AL. 'BI-RG-587 IS ACTIVE AGAINST ZIDOVUDINE-RESISTANT HUMAN IMMUNODEFICIENCY VIRUS...'
 [X]  - PROC.NATL.ACAD.SCI.USA vol. 88, August 1991, pages 6863 - 6867 M.E.GOLDMAN ET AL. 'PYTIDINONE DERIVATIVES...'
 [X]  - PROC.NATL.ACAD.SCI.USA vol. 88, no. 21, 1 November 1991, pages 9878 - 9882 C.-K. SHIH ET AL. 'CHIMERIC HUMAN IMMUNODEFICIENY...'
 [X]  - PROC.NATL.ACAD.SCI.USA vol. 88, October 1991, pages 8806 - 8810 D.L.ROMERO ET AL. 'NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS...'
 [X]  - PROC.NATL.ACAD.SCI.USA vol. 88, March 1991, pages 2356 - 2360 M.BABA ET AL. 'POTENT AND SELECTIVE INHIBITION...'
 [X]  - BEHRING INST.MITT. vol. 89, July 1991, pages 74 - 80 L.BIESERT ET AL. 'BIOCHEMICAL AND GENETICAL ANALYSIS...'
 [X]  - J.VIROL. vol. 65, no. 9, September 1991, pages 4887 - 4892 J.H.NUNBERG 'VIRAL RESISTANCE...'
 [X]  - ANTIVIRAL RES. vol. 17, no. SUP, March 1992, page 46 R.W.BUCKHEIT ET AL. 'COMBINATIONS OF AZT AND ANALOGS OF TIBO ACT SYNERGISTICALLY TO INHIBIT HIV-1 INFECTION IN VIVO.'
 [X]  - ANTIMICROB.AGENTS CHEMOTHER. vol. 36, no. 12, December 1992, pages 2664 - 2669 B.A.LARDER '3'-AZIDO-3'-DEOXYTHYMIDINE RESISTANCE...'
 [XP]  - VIROLOGY vol. 188, no. 2, June 1992, pages 900 - 904 K.DE VREESE ET AL. 'RESISTANCE OF HUMAN IMMUNODEFICIENCY VIRUS...'
 [A]  - NATURE vol. 343, 1 February 1990, pages 470 - 474 R.PAUWELS ET AL. 'POTENT AND SELECTIVE INHIBITION...' cited in the application
 [X]  - AIDS RES.HUM.RETROVIRUSES vol. 8, no. 2, February 1992, pages 119 - 134 E.DE CLERCQ 'HIV INHIBITORS TARGETED AT THE REVERSE TRANSCRIPTASE'
 [X]  - PROC.NATL.ACAD.SCI.USA vol. 88, no. 24, 15 December 1991, pages 11241 - 11245 D.RICHMAN ET AL. 'HUMAN UMMUNODEFICIENCY VIRUS TYPE 1 MUTANTS..'
 [XP]  - MOL.PHARMACOL. vol. 43, no. 1, January 1993, pages 11 - 16 J.W.MELLORS ET AL. 'A SINGLE CONSERVATIVE AMINO ACID SUBSTITUTION...'
 [A]  - SCIENCE vol. 253, 27 September 1991, pages 1557 - 1559 M.H.ST.CLAIR ET AL. 'RESISTANCE TO DDI AND SENSITIVITY TO AZT...'
Examination   - LARDER ET AL: "Potential Mechanism for sustained antiretroviral potency of AZT/3TC combination therapy.". Science 1995,,,vol. 269, no., pages 696 to 699
    - NIJHUIS ET AL: "Lamivudine Resistant Human Immunodeficiency Virus. ", J. INFECT.DIS. 1997,,,vol. 176, no.,pages 398 to 405
    - JOHNSON ET AL: "Drug Resistance, viral load and SI phenotype in NUCA 3002", ANTIVIRAL THERAPY 1996, vol. 1, no. 1, pp. 36-37
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.