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Extract from the Register of European Patents

EP About this file: EP0641208

EP0641208 - 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.06.2001
Database last updated on 28.06.2024
Most recent event   Tooltip26.12.2003Lapse of the patent in a contracting state
New state(s): GR		published on 11.02.2004  [2004/07]
Applicant(s)For all designated states
Merck & Co., Inc.
126, East Lincoln Avenue P.O. Box 2000 Rahway
New Jersey 07065-0900 / US
[N/P]
Former [2000/31]For all designated states
Merck & Co., Inc.
126, East Lincoln Avenue P.O. Box 2000
Rahway New Jersey 07065-0900 / US
Former [1995/10]For all designated states
MERCK & CO. INC.
126, East Lincoln Avenue P.O. Box 2000
Rahway New Jersey 07065-0900 / US
Inventor(s)01 / WITZEL, Bruce, E.
115 Scotch Plains Avenue
Westfield, NJ 07090 / US
02 / TOLMAN, Richard, L.
29 Upper Warren Way
Warren, NJ 07059 / US
[1995/10]
Representative(s)Thompson, John
Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road
Harlow, Essex CM20 2QR / GB
[N/P]
Former [1995/10]Thompson, John Dr.
Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road
Harlow, Essex CM20 2QR / GB
Application number, filing date93911333.817.05.1993
[1995/10]
WO1993US04634
Priority number, dateUS1992088664520.05.1992         Original published format: US 886645
[1995/10]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9323048
Date:25.11.1993
Language:EN
[1993/28]
Type: A1 Application with search report 
No.:EP0641208
Date:08.03.1995
Language:EN
The application published by WIPO in one of the EPO official languages on 25.11.1993 takes the place of the publication of the European patent application.
[1995/10]
Type: B1 Patent specification 
No.:EP0641208
Date:02.08.2000
Language:EN
[2000/31]
Search report(s)International search report - published on:US25.11.1993
(Supplementary) European search report - dispatched on:EP14.07.1995
ClassificationIPC:C07J73/00, A61K31/58
[1995/34]
CPC:
C07J73/005 (EP,US)
Former IPC [1995/10]A61K31/45, C07D221/02
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   NL,   PT,   SE [1995/10]
TitleGerman:4-AZASTEROIDE ALS 5-ALPHA-REDUKTASE[1995/10]
English:4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS[1995/10]
French:INHIBITEURS DE 5-$g(a)-REDUCTASE A BASE DE 4-AZASTEROIDES[1995/10]
Entry into regional phase20.12.1994National basic fee paid 
20.12.1994Search fee paid 
20.12.1994Designation fee(s) paid 
20.12.1994Examination fee paid 
Examination procedure07.12.1993Request for preliminary examination filed
International Preliminary Examining Authority: US
20.12.1994Examination requested  [1995/10]
08.04.1998Despatch of a communication from the examining division (Time limit: M06)
26.08.1998Reply to a communication from the examining division
10.03.1999Despatch of a communication from the examining division (Time limit: M04)
12.05.1999Reply to a communication from the examining division
10.08.1999Despatch of a communication from the examining division (Time limit: M04)
23.09.1999Reply to a communication from the examining division
28.10.1999Despatch of communication of intention to grant (Approval: Yes)
25.01.2000Communication of intention to grant the patent
04.05.2000Fee for grant paid
04.05.2000Fee for publishing/printing paid
Opposition(s)03.05.2001No opposition filed within time limit [2001/29]
Fees paidRenewal fee
31.05.1995Renewal fee patent year 03
31.05.1996Renewal fee patent year 04
02.06.1997Renewal fee patent year 05
02.06.1998Renewal fee patent year 06
31.05.1999Renewal fee patent year 07
31.05.2000Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT02.08.2000
BE02.08.2000
CH02.08.2000
GR02.08.2000
LI02.08.2000
NL02.08.2000
DK02.11.2000
PT02.11.2000
SE02.11.2000
[2004/07]
Former [2003/45]AT02.08.2000
BE02.08.2000
CH02.08.2000
LI02.08.2000
NL02.08.2000
DK02.11.2000
PT02.11.2000
SE02.11.2000
Former [2003/08]AT02.08.2000
BE02.08.2000
CH02.08.2000
LI02.08.2000
NL02.08.2000
PT02.11.2000
SE02.11.2000
Former [2002/02]AT02.08.2000
BE02.08.2000
CH02.08.2000
LI02.08.2000
PT02.11.2000
SE02.11.2000
Former [2001/27]AT02.08.2000
BE02.08.2000
PT02.11.2000
SE02.11.2000
Former [2001/22]AT02.08.2000
BE02.08.2000
PT02.11.2000
Former [2001/18]AT02.08.2000
PT02.11.2000
Former [2001/17]AT02.08.2000
Documents cited:Search[E]WO9323038  (MERCK & CO INC [US], et al) [E] 1-19 * the whole document *;
 [E]WO9323053  (ENDORECHERCHE INC [CA]) [E] 1-19 * page 27 - page 33; tables I, III * * page 63 *;
 [E]EP0572166  (MERCK & CO INC [US]) [E] 1-10* page 62 - page 115 *
International search[X]US4377584  (RASMUSSON GARY H, et al);
 [A]EP0200859  (ERBA FARMITALIA [IT], et al);
 [A]US4760071  (RASMUSSON GARY H [US], et al);
 [A]US4859681  (RASMUSSON GARY H [US], et al);
 [A]US5049562  (RASMUSSON GARY H [US], et al);
 [A]US5110939  (HOLT DENNIS A [US], et al);
 [XP]US5116983  (BHATTACHARYA APURBA [US], et al)
 [A]  - Jour. Clinical Endoc. and Metab., Vol. 74, 1992, DIANI et al., "Hair Growth Effects of Oran Administration of Fina Steride, a Steroids Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque", pages 345-350, see page 345, para. bridging, cols. 1-2, last 3 lines.
 [A]  - J. Org. Chem., Vol. 46, 1981, BACK, "Oxidation of Azasteroid Lactams and Alcohols with Benzeneselenic Anhydride", pages 1442-6.
 [A]  - Jour. Med. Chem., Vol. 27, 1984, RASMUSSON et al., "Azasteroids as Inhibitors of Rat Prostatic 52 Reductase", pages 1690-1701.
 [A]  - Jour. Med. Chem., Vol. 29, 1986, RASMUSSON et al., "A2A Steroids: Structure-Activity Relationship for Inhibition of 52 Reductase and of Androgen Receptor Binding", pages 2298-2315.
 [A]  - Jour. Organic Chem., Vol. 54, 1989, BACK et al., "Nchloro Azasteroids a Novel Class of Reactive Steroid Analogues. Preparation, Reaction with Thiols and Photochemical Conversion to Electrophilic N Acyl Imines", pages 1904-10.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.