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EP0607413
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EP About this file: EP0607413
| EP0607413 - SIDE CHAIN DERIVATIZED 15-OXYGENATED STEROLS, METHODS OF USING THEM AND A PROCESS FOR PREPARING THEM [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 30.01.1998 Database last updated on 02.11.2024 | Most recent event Tooltip | 30.01.1998 | Application deemed to be withdrawn | published on 18.03.1998 [1998/12] | Applicant(s) | For all designated states WILLIAM MARSH RICE UNIVERSITY P.O. Box 2666 Houston Texas 77001 / US | [N/P] |
| Former [1994/30] | For all designated states WILLIAM MARSH RICE UNIVERSITY P.O. Box 2666 Houston Texas 77001 / US | Inventor(s) | 01 /
SCHROEPFER, George J., Jr. 1400 Hermann Drive 9G Houston, TX 77004 / US | 02 /
HERZ, Josef E. 8421 Hearth Drive, Apt. 24 Houston, TX 77054 / US | 03 /
SWAMINATHAN, Shankar 10225 Bissonnet, 1205 Houston, TX 77036 / US | 04 /
WILSON, William K. 6506 Newcastle Drive Bellaire, TX 77401 / US | [1994/30] | Representative(s) | Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstrasse 4 80802 München / DE | [N/P] |
| Former [1994/30] | Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Maximilianstrasse 58 D-80538 München / DE | Application number, filing date | 93918559.1 | 03.08.1993 | [1994/30] | WO1993US07230 | Priority number, date | US19920923423 | 03.08.1992 Original published format: US 923423 | [1994/30] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO9403177 | Date: | 17.02.1994 | [1994/05] | Type: | A1 Application with search report | No.: | EP0607413 | Date: | 27.07.1994 | Language: | EN | The application published by WIPO in one of the EPO official languages on 17.02.1994 takes the place of the publication of the European patent application. | [1994/30] | Search report(s) | International search report - published on: | EP | 09.06.1994 | Classification | IPC: | A61K31/575, C07J41/00, C07J9/00, C07J31/00 | [1994/30] | CPC: |
C07J9/005 (EP,US);
A61K31/575 (EP,US);
A61P3/06 (EP);
A61P43/00 (EP);
C07J31/006 (EP,US);
C07J41/0055 (EP,US);
C07J9/00 (EP,US)
(-)
| Designated contracting states | AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [1994/30] | Title | German: | SEITENKETTE-MODIFIZIERTEN 15-OXYGENIERTEN STEROLE, VERFAHREN ZUR DEREN VERWENDUNG UND VERFAHREN ZUR HERSTELLUNG | [1994/30] | English: | SIDE CHAIN DERIVATIZED 15-OXYGENATED STEROLS, METHODS OF USING THEM AND A PROCESS FOR PREPARING THEM | [1994/30] | French: | STEROLS OXYGENES EN POSITION 15 ET DERIVES AU NIVEAU DE LA CHAINE LATERALE, ET PROCEDES D'UTILISATION ET DE PREPARATION | [1994/30] | Entry into regional phase | 22.04.1994 | National basic fee paid | 22.04.1994 | Designation fee(s) paid | 12.08.1994 | Examination fee paid | Examination procedure | 12.08.1994 | Examination requested [1994/41] | 13.05.1997 | Despatch of a communication from the examining division (Time limit: M04) | 24.09.1997 | Application deemed to be withdrawn, date of legal effect [1998/12] | 22.10.1997 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [1998/12] | Fees paid | Renewal fee | 18.08.1995 | Renewal fee patent year 03 | 19.08.1996 | Renewal fee patent year 04 | Penalty fee | Additional fee for renewal fee | 31.08.1997 | 05 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [XD]US4202891 (KANDUTSCH ANDREW A [US], et al) [XD] 1-20,33-37* column 3, line 22 - line 27 * | [X] - R.E.DOLLE ET AL., "Synthesis of Zymosterol, Fecosterol, and Related Biosynthetic Sterol Intermediates", J.AM.CHEM.SOC., (1989), vol. 111, no. 1, pages 278 - 284 [X] 1-20,33-37 * see Scheme 2, compound 26, and page 282, right column, first paragraph * | [X] - J.E.HERZ ET AL., "Inhibitors of sterol biosynthesis. Synthesis and spectral properties of 3-beta-hydroxy-24-dimethylamino-5-alpha-chol-8(14)-en-15-one and its effects on HMG-CoA reductase activity in CHO-K1 cells", CHEM.PHYS.LIPIDS, (199111), vol. 60, no. 1, pages 61 - 69 [X] 1-20,33-37 * see page 61, abstract, page 62, Fig. 2, compounds VI and VII, page 65, left column, second paragraph - page 66, right column, second paragraph * * see page 66, right column, last paragraph - page 67, right column, last paragraph - page 68, second paragraph * | [X] - G.J.SCHROEPFER ET AL., "ENZYMATIC FORMETION AND CHEMICAL SYNTHESIS OF AN ACTIVE METABOLITE OF 3-BETA-HYDROXY-5-ALPHA-CHOLEST-8(14)-EN-15-ONE, A POTENT REGULATOR OF CHOLESTEROL METABOLISM", BIOCHEM. BIOPHYS. RES. COMMUN., (19880229), vol. 151, no. 1, pages 130 - 136 [X] 1-20,33-37 * see summary, page 132, Figure 2, compound II, page 135, last paragraph * | [X] - H.-S- KIM ET AL., "Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3-beta,26-dihydroxy-5-alpha-cholest-8(14)-en-15-one, a metabolite of 3-beta-hydroxy-5-alpha-cholest-8(14)-en-15-one", J.LIPID RES., (198902), vol. 30, no. 2, pages 247 - 261 [X] 1-20,33-37 * see abstract, Fig. 1, compound II, page 252, left column, first paragraph, page 255, Fig. 3, pages 257-259 * | [X] - S.SWAMINATHAN ET AL., "Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of (25R)-5-alpha-cholest-8(14)-ene-3-beta,15-beta,26-triol, a potential metabolite of 3-beta-hydroxy-5-alpha-cholest-8(14)-en-15-one and its effects on 3-hydroxy-3-methylglutaryl-coenzyme A reductase in CHO-K1 cells", CHEM.PHYS.LIPIDS, (199205), vol. 61, no. 3, pages 235 - 242 [X] 1-20,33-37 * see abstract, page 236, Figure 1, compounds II and III, page 238, left column, second paragraph, right column, page 241, left column * | [X] - J.ST.PYREK ET AL., "Inhibitors of Sterol Synthesis", J.BIOL.CHEM., (19890315), vol. 264, no. 8, pages 4536 - 4543 [X] 1-20,33-37 * see page 4538, Figure 4, compounds IIa, IVa, IVd, Va and VIa, page 4541, last paragraph * | [X] - J.ST.PYREK ET AL., "Inhibitors of sterol synthesis. Characterization of trimethylsilyl dienol ethers of 3-beta-hydroxy-5-alpha-cholest-8(14)-en-15-one. Applications in the analysis of mitochondrial metabolites of the 15-ketosterol by gas chromatography - mass spectrometry", J.LIPID RES., (199108), vol. 32, no. 8, pages 1371 - 1380 [X] 1-20,33-37 * page 1371 * | [X] - S.SWAMINATHAN ET AL., "Inhibitors of Sterol Synthesis. 3-beta,25-Dihydroxy-5-alpha-cholest-5(14)-en-15-one, an Active Metabolite of 3-beta-Hydroxy-5-alpha-cholest-8(14)-en-15-one", J.MED.CHEM., (19920221), vol. 35, no. 4, pages 793 - 795 [X] 1-20,33-37 * see the whole document, especially page 794, Figure 1, compounds 2, 5 and 6 * | [X] - J.E.HERZ ET AL., "Inhibitors of Sterol Synthesis. An Efficient and Specific Side Chain Oxidation of 3-beta-Hydroxy-5-alpha-cholest-8(14)-en-15-one. Facile Access to its Metabolites and Analogs.", TETRAHEDRON LETT., (1991), vol. 32, no. 32, pages 3923 - 3926 [X] 1-20,33-37 * the whole document * | [XP] - A.U.SIDDIQUI ET AL., "Inhibitors of sterol synthesis...", CHEM.PHYS.LIPIDS, (199211), vol. 63, no. 1-2, pages 77 - 90 [XP] 1-20,33-37 * the whole document * | [XP] - S.SWAMINATHAN ET AL., "Inhibitors of sterol synthesis...", J.LIPID RES., (199210), vol. 33, no. 10, pages 1503 - 1515 [XP] 1-20,33-37 * the whole document * | [X] - W.K.WILSON ET AL., "Inhibitors of sterol synthesis...", J.LIPID RES., (199107), vol. 32, no. 7, pages 1215 - 1227 [X] 1-20,33-37 * the whole document * | [X] - H.-S- KIM ET AL., "Inhibitors of sterol synthesis...", CHEM.PHYS.LIPIDS, (199207), vol. 62, no. 1, pages 55 - 67 [X] 1-20,33-37 * the whole document * |