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Extract from the Register of European Patents

EP About this file: EP0659408

EP0659408 - Use of R(+)alpha-lipoic acid, R-(-)dihydrolipoic and metabolites for the treatment of diabetes mellitus and its resulting disorders [Right-click to bookmark this link]
Status	Patent revoked Status updated on 10.04.2009 Database last updated on 02.09.2024
Most recent event Tooltip	10.04.2009	Revocation of patent	published on 13.05.2009 [2009/20]
	10.04.2009	Lapse of the patent in a contracting state	published on 13.05.2009 [2009/20]
Applicant(s)	For all designated states Evonik Degussa GmbH Rellinghauser Straße 1-11 45128 Essen / DE
	[N/P]
Former [2009/14]	For all designated states Evonik Degussa GmbH Rellinghauser Strasse 1-11 45128 Essen / DE
Former [2007/47]	For all designated states Degussa GmbH Bennigsenplatz 1 40474 Düsseldorf / DE
Former [2002/13]	For all designated states VIATRIS GmbH & Co. KG Weismüllerstrasse 45 60314 Frankfurt am Main / DE
Former [2001/31]	For all designated states ASTA Medica Aktiengesellschaft An der Pikardie 10 01277 Dresden / DE
Former [1995/26]	For all designated states ASTA Medica Aktiengesellschaft An der Pikardie 10 D-01277 Dresden / DE
Inventor(s)	01 / Wessel, Dr. Klaus Homburger Landstrasse 46c D-60435 Frankfurt / DE
	02 / Borbe, Dr. Harald Im Borner Grund 87 D-55127 Mainz / DE
	03 / Ulrich, Dr. Heinz Bayernstrasse 2 D-63843 Niedernberg / DE
	04 / Hettche, Dr. Helmut Martinstrasse 23 D-63128 Dietzenbach / DE
	05 / Bisswanger, Prof. Dr. Hans Lindenstrasse 31 D-72411 Bodelshausen / DE
	06 / Packer, Prof. Dr. L. 64, Charles Hill Road Orinda, California 94563 / US
	07 / Klip, Prof. Amira 33, Harbour Square apt. 1620 Toronto M5G 1x8 / CA
	[1995/26]
Representative(s)	Godemeyer, Thomas, et al polypatent An den Gärten 7 51491 Overath / DE
	[N/P]
Former [2004/36]	Godemeyer, Thomas, Dr., et al Sternagel, Fleischer, Godemeyer & Partner Patentanwälte An den Gärten 7 51491 Overath / DE
Former [2001/23]	Wibbelmann, Jobst, Dr., Dipl.-Chem., et al Wuesthoff & Wuesthoff, Patent- und Rechtsanwälte, Schweigerstrasse 2 81541 München / DE
Application number, filing date	94120045.3	17.12.1994
	[1995/26]
Priority number, date	DE19934343593	21.12.1993 Original published format: DE 4343593
	[1995/26]
Filing language	DE
Procedural language	DE
Publication	Type:	A1 Application with search report
	No.:	EP0659408
	Date:	28.06.1995
	Language:	DE
	[1995/26]
	Type:	B1 Patent specification
	No.:	EP0659408
	Date:	01.08.2001
	Language:	DE
	[2001/31]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	24.04.1995
Classification	IPC:	A61K31/385	[1995/26]
	CPC:	A61K31/385 (EP,US); A61K31/19 (EP,US); A61K31/22 (EP,US); A61K31/355 (EP,US); A61P3/08 (EP); A61P3/10 (EP)
Designated contracting states	AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [1995/26]
Title	German:	Verwendung von R-(+)alpha-Liponsäure, R(-)-Dihydroliponsäure und Metabolite zur Behandlung von Diabetes mellitus sowie seiner Folgeerkrankungen	[2000/38]
	English:	Use of R(+)alpha-lipoic acid, R-(-)dihydrolipoic and metabolites for the treatment of diabetes mellitus and its resulting disorders	[1995/26]
	French:	Utilisation de R(+)alpha acide loique, R(-)-acide dihydrolipoique et leurs metabolites pour le traitement de diabète et ses désordres secondaires	[1995/26]
	Former [1995/26]	Verwendung von R-(+)alpha-Liponsäure, R(-)-Dihydroliponsäure und Metabolite zur Behandlung von Diabetes mellitus sowie seiner Folge-erkrankungen
Examination procedure	17.12.1994	Examination requested [1995/26]
	29.06.1998	Despatch of a communication from the examining division (Time limit: M08)
	05.02.1999	Reply to a communication from the examining division
	11.01.2001	Despatch of communication of intention to grant (Approval: Yes)
	08.02.2001	Communication of intention to grant the patent
	01.03.2001	Fee for grant paid
	01.03.2001	Fee for publishing/printing paid
Divisional application(s)	EP99102285.6 / EP0958816
Opposition(s)	Opponent(s)	01 29.04.2002 17.05.2002 ADMISSIBLE Dr. Gerhard Mann Chem.-pharm. Fabrik GmbH Brunsbütteler Damm 165-173 D-13581 Berlin / DE Opponent's representative Maiwald, Walter, et al, et al Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE
		[N/P]
	Former [2008/39]
	Opponent(s)	01 29.04.2002 17.05.2002 ADMISSIBLE Dr. Gerhard Mann Chem.-pharm. Fabrik GmbH Brunsbütteler Damm 165-173 D-13581 Berlin / DE Opponent's representative Maiwald, Walter, et al, et al Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE
	Former [2007/07]
	Opponent(s)	01 29.04.2002 17.05.2002 ADMISSIBLE Dr. Gerhard Mann Chem.-pharm. Fabrik GmbH Brunsbütteler Damm 165-173 D-13581 Berlin / DE Opponent's representative Maiwald, Walter, et al, et al Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 D-80335 München / DE
	Former [2002/26]
	Opponent(s)	01 29.04.2002 Dr. Gerhard Mann Chem.-pharm. Fabrik GmbH Brunsbütteler Damm 165-173 D-13581 Berlin / DE Opponent's representative Maiwald, Walter, Dr. Dipl.-Chem, et al, et al Maiwald Patentanwalds GmbH Achenstrasse 43 40237 Düsseldorf / DE
	05.06.2002	Invitation to proprietor to file observations on the notice of opposition
	03.02.2003	Reply of patent proprietor to notice(s) of opposition
	25.03.2004	Date of oral proceedings
	06.05.2004	Despatch of minutes of oral proceedings
	06.05.2004	Despatch of communication that the patent will be revoked
	06.11.2007	Legal effect of revocation of patent [2009/20]
Appeal following opposition	06.07.2004	Appeal received No. T0857/04
	13.09.2004	Statement of grounds filed
	06.11.2007	Result of appeal procedure: appeal of the proprietor was rejected
	06.11.2007	Date of oral proceedings
Fees paid	Renewal fee
	23.12.1996	Renewal fee patent year 03
	10.12.1997	Renewal fee patent year 04
	30.11.1998	Renewal fee patent year 05
	09.12.1999	Renewal fee patent year 06
	12.12.2000	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[PX] - T. KAWABATA ET AL, "Alpha-lipoate can protect against glycation of serum albumin, but not low density lipoprotein.", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 203, no. 1, pages 99 - 104, XP008036187 [PX] 4,5 * the whole document * DOI: http://dx.doi.org/10.1006/bbrc.1994.2154
		[PX] - C. BONAVENTURA ET AL, "In vitro action of the enantiomers of alpha-lipoic acid.", NAUNYN-SCHMIEDEBERGS ARCH. PHARMACOL, vol. 349, no. SUPL., page R8, XP002119387 [PX] 4,5 * the whole document *
		[A] - J. JÖRG ET AL, "Zur medikamentösen Behandlung der diabetischen Polyneuropathie mit der Alpha-liponsäure oder Vitamin-B-Präparaten", NERVENARZT, vol. 59, no. 1, pages 36 - 44, XP002119388
		[A] - J. STUDT ET AL., "die diabetische autonome Neuropathie des Herzens und ihre Behandlung mit Thioctsäure.", DTSCH. ZSCHR. VERDAU. STOFFWECHSELKR., vol. 44, no. 4, pages 173 - 180, XP008036188
		[DA] - S.S. WAGH ET AL., "mode of action of lipoic acid in diabetes.", J. BIOSCI., vol. 11, no. 1-4, pages 59 - 74, XP008036199 DOI: http://dx.doi.org/10.1007/BF02704658

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