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Extract from the Register of European Patents

EP About this file: EP0714980

EP0714980 - Hypermutagenesis [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  12.01.2001
Database last updated on 13.07.2024
Most recent event   Tooltip12.01.2001Application deemed to be withdrawnpublished on 28.02.2001 [2001/09]
Applicant(s)For all designated states
INSTITUT PASTEUR
25-28, rue du Docteur Roux
75724 Paris Cedex 15 / FR
[N/P]
Former [1996/23]For all designated states
INSTITUT PASTEUR
25-28, rue du Docteur Roux
F-75724 Paris Cédex 15 / FR
Inventor(s)01 / Martinez, Miguel Angel
223-225 rue de Charenton
75012 Paris / FR
02 / Wain-Hobson, Simon
3 rue Jean de la Fontaine
78180 Montigny le Bretonneux / FR
[1996/23]
Representative(s)Desaix, Anne
Ernest Gutmann - Yves Plasseraud S.A.S.
66, rue de la Chaussée d'Antin
75009 Paris / FR
[N/P]
Former [1996/23]Desaix, Anne
Ernest Gutmann - Yves Plasseraud S.A. 3, rue Chauveau-Lagarde
F-75008 Paris / FR
Application number, filing date94402774.702.12.1994
[1996/23]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP0714980
Date:05.06.1996
Language:EN
[1996/23]
Search report(s)(Supplementary) European search report - dispatched on:EP01.06.1995
ClassificationIPC:C12N15/10, C12N9/12, C12Q1/68, C07K14/16, C07K16/10, G01N33/577, A61K38/00, A61K39/00, C12N9/06
[1996/23]
CPC:
C07K14/005 (EP,US); C12N15/102 (EP,US); C12N9/003 (EP,US);
C12N9/1252 (EP,US); C12N9/1276 (EP,US); A61K38/00 (EP,US);
C12N2740/16122 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1996/23]
TitleGerman:Mehrfachmütagenese[1996/23]
English:Hypermutagenesis[1996/23]
French:Hypermutagénèse[1996/23]
Examination procedure03.12.1995Loss of particular rights, legal effect: designated state(s)
27.03.1996Despatch of communication of loss of particular rights: designated state(s) AT, BE, CH, DE, DK, ES, FR, GR, IE, IT, LI, LU, MC, NL, PT, SE
04.12.1996Examination requested  [1997/05]
19.07.1999Despatch of a communication from the examining division (Time limit: M04)
18.11.1999Reply to a communication from the examining division
18.04.2000Despatch of a communication from the examining division (Time limit: M04)
29.08.2000Application deemed to be withdrawn, date of legal effect  [2001/09]
22.09.2000Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2001/09]
Fees paidRenewal fee
18.12.1996Renewal fee patent year 03
22.12.1997Renewal fee patent year 04
18.12.1998Renewal fee patent year 05
23.12.1999Renewal fee patent year 06
Penalty fee
Penalty fee Rule 85a EPC 1973
16.01.1996AT   M01   Not yet paid
16.01.1996BE   M01   Not yet paid
16.01.1996CH   M01   Not yet paid
16.01.1996DE   M01   Not yet paid
16.01.1996DK   M01   Not yet paid
16.01.1996ES   M01   Not yet paid
16.01.1996FR   M01   Not yet paid
16.01.1996GR   M01   Not yet paid
16.01.1996IE   M01   Not yet paid
16.01.1996IT   M01   Not yet paid
16.01.1996LI   M01   Not yet paid
16.01.1996LU   M01   Not yet paid
16.01.1996MC   M01   Not yet paid
16.01.1996NL   M01   Not yet paid
16.01.1996PT   M01   Not yet paid
16.01.1996SE   M01   Not yet paid
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[DXY]EP0285123  (SUOMEN SOKERI OY [FI]) [DX] 25,31-33 * page 13, line 19 - line 39 * [Y] 1-24;
 [Y]WO9218645  (DIAGEN INST MOLEKULARBIO [DE]) [Y] 1-24 * page 5, line 14 - line 26; claims 1-4 *;
 [XY]  - P.M. LEHTOVAARA ET AL., "A new method for random mutagenesis of complete genes: enzymatic generation of mutant libraries in vitro", PROTEIN ENGINEERING, IRL PRESS LIMITED OXFORD, ENGLAND, vol. 2, no. 1, pages 63 - 68, XP002019763 [X] 25,31-33 * page 67, column R, line 6 - page 68, column L, line 54 * [Y] 1-24
 [DX]  - J.-P. VARTANIAN ET AL., "G to A hypermutation of the human immunodeficiency virus type 1 genome: Evidence for dCTP pool imbalance during reverse transcription", PROC. NATL.ACAD SCI., NATL. ACAD SCI.,WASHINGTON,DC,US;, (19940412), vol. 91, no. 8, pages 3092 - 3096 [DX] 25,31-33 * page 3092, column R, line 21 - page 3096, column L, line 2; table 1 *
 [DXY]  - P. PJURA ET AL., "Development of an in vivo method to identify mutants of phage T4 lysozyme of enhanced thermostability", PROTEIN SCIENCE, CAMBRIDGE UNIV. PRESS, ENGL., vol. 2, no. 12, pages 2217 - 2225, XP000672766 [DX] 25,31-33 * page 2218, column R, line 15 - page 2219, column R, line 3 * [Y] 1-24
 [X]  - R. CATTANEO ET AL., "Biased hypermutation and other genetic changes in defective measles viruses in human brain infections", CELL, CELL PRESS,CAMBRIDGE,MA,US;, (19881021), vol. 55, no. 2, doi:doi:10.1016/0092-8674(88)90048-7, pages 255 - 1265, XP027462086 [X] 32 * page 255, column R, line 49 - page 262, column L, line 45 *

DOI:   http://dx.doi.org/10.1016/0092-8674(88)90048-7
 [Y]  - S. KWOK ET AL., "Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies", NUCLEIC ACIDS RESEARCH, IRL PRESS LIMITED,OXFORD,ENGLAND, (19900225), vol. 18, no. 4, pages 999 - 1005 [Y] 1-24 * page 1001, column R, line 12 - page 1005, column L, line 34 *
 [Y]  - R. SOMMER AND D. TAUTZ, "Minimal homology requirements for PCR primers", NUCLEIC ACIDS RESEARCH, IRL PRESS LIMITED,OXFORD,ENGLAND, (19890825), vol. 17, no. 16, page 6749 [Y] 1-24 * page 6749, line 1 - line 24; table I *
 [Y]  - G.F. JOYCE, "Amplfication, mutation and selection of catalytic RNA", GENE, ELSEVIER SCIENCE PUBLISHERS,B.V.,AMSTERDAM,NL;, (19891015), vol. 82, no. 1, pages 83 - 87 [Y] 1-24 * the whole document;; figure 2 *
 [DA]  - J.-P. VARTANIAN ET AL., "Selection, recombination, and G to A hypermutation of human immunodeficiency virus type 1 geneomes", J. VIROLOGY, AM.SOC.MICROBIOL.,WASHINGTON,US, vol. 65, no. 4, pages 1779 - 1788, XP000672765 [DA] 1-33 * the whole document *
 [T]  - MARTINEZ, MIGUEL ANGEL ET AL, "Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations", PROC. NATL. ACAD. SCI. U. S. A. (1994), 91(25), 11787-91 CODEN: PNASA6;ISSN: 0027-8424 [T] 1-33 * the whole document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.