EP0714980 - Hypermutagenesis [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 12.01.2001 Database last updated on 13.07.2024 | Most recent event Tooltip | 12.01.2001 | Application deemed to be withdrawn | published on 28.02.2001 [2001/09] | Applicant(s) | For all designated states INSTITUT PASTEUR 25-28, rue du Docteur Roux 75724 Paris Cedex 15 / FR | [N/P] |
Former [1996/23] | For all designated states INSTITUT PASTEUR 25-28, rue du Docteur Roux F-75724 Paris Cédex 15 / FR | Inventor(s) | 01 /
Martinez, Miguel Angel 223-225 rue de Charenton 75012 Paris / FR | 02 /
Wain-Hobson, Simon 3 rue Jean de la Fontaine 78180 Montigny le Bretonneux / FR | [1996/23] | Representative(s) | Desaix, Anne Ernest Gutmann - Yves Plasseraud S.A.S. 66, rue de la Chaussée d'Antin 75009 Paris / FR | [N/P] |
Former [1996/23] | Desaix, Anne Ernest Gutmann - Yves Plasseraud S.A. 3, rue Chauveau-Lagarde F-75008 Paris / FR | Application number, filing date | 94402774.7 | 02.12.1994 | [1996/23] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP0714980 | Date: | 05.06.1996 | Language: | EN | [1996/23] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 01.06.1995 | Classification | IPC: | C12N15/10, C12N9/12, C12Q1/68, C07K14/16, C07K16/10, G01N33/577, A61K38/00, A61K39/00, C12N9/06 | [1996/23] | CPC: |
C07K14/005 (EP,US);
C12N15/102 (EP,US);
C12N9/003 (EP,US);
C12N9/1252 (EP,US);
C12N9/1276 (EP,US);
A61K38/00 (EP,US);
C12N2740/16122 (EP,US)
(-)
| Designated contracting states | AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [1996/23] | Title | German: | Mehrfachmütagenese | [1996/23] | English: | Hypermutagenesis | [1996/23] | French: | Hypermutagénèse | [1996/23] | Examination procedure | 03.12.1995 | Loss of particular rights, legal effect: designated state(s) | 27.03.1996 | Despatch of communication of loss of particular rights: designated state(s) AT, BE, CH, DE, DK, ES, FR, GR, IE, IT, LI, LU, MC, NL, PT, SE | 04.12.1996 | Examination requested [1997/05] | 19.07.1999 | Despatch of a communication from the examining division (Time limit: M04) | 18.11.1999 | Reply to a communication from the examining division | 18.04.2000 | Despatch of a communication from the examining division (Time limit: M04) | 29.08.2000 | Application deemed to be withdrawn, date of legal effect [2001/09] | 22.09.2000 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2001/09] | Fees paid | Renewal fee | 18.12.1996 | Renewal fee patent year 03 | 22.12.1997 | Renewal fee patent year 04 | 18.12.1998 | Renewal fee patent year 05 | 23.12.1999 | Renewal fee patent year 06 | Penalty fee | Penalty fee Rule 85a EPC 1973 | 16.01.1996 | AT   M01   Not yet paid | 16.01.1996 | BE   M01   Not yet paid | 16.01.1996 | CH   M01   Not yet paid | 16.01.1996 | DE   M01   Not yet paid | 16.01.1996 | DK   M01   Not yet paid | 16.01.1996 | ES   M01   Not yet paid | 16.01.1996 | FR   M01   Not yet paid | 16.01.1996 | GR   M01   Not yet paid | 16.01.1996 | IE   M01   Not yet paid | 16.01.1996 | IT   M01   Not yet paid | 16.01.1996 | LI   M01   Not yet paid | 16.01.1996 | LU   M01   Not yet paid | 16.01.1996 | MC   M01   Not yet paid | 16.01.1996 | NL   M01   Not yet paid | 16.01.1996 | PT   M01   Not yet paid | 16.01.1996 | SE   M01   Not yet paid |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [DXY]EP0285123 (SUOMEN SOKERI OY [FI]) [DX] 25,31-33 * page 13, line 19 - line 39 * [Y] 1-24; | [Y]WO9218645 (DIAGEN INST MOLEKULARBIO [DE]) [Y] 1-24 * page 5, line 14 - line 26; claims 1-4 *; | [XY] - P.M. LEHTOVAARA ET AL., "A new method for random mutagenesis of complete genes: enzymatic generation of mutant libraries in vitro", PROTEIN ENGINEERING, IRL PRESS LIMITED OXFORD, ENGLAND, vol. 2, no. 1, pages 63 - 68, XP002019763 [X] 25,31-33 * page 67, column R, line 6 - page 68, column L, line 54 * [Y] 1-24 | [DX] - J.-P. VARTANIAN ET AL., "G to A hypermutation of the human immunodeficiency virus type 1 genome: Evidence for dCTP pool imbalance during reverse transcription", PROC. NATL.ACAD SCI., NATL. ACAD SCI.,WASHINGTON,DC,US;, (19940412), vol. 91, no. 8, pages 3092 - 3096 [DX] 25,31-33 * page 3092, column R, line 21 - page 3096, column L, line 2; table 1 * | [DXY] - P. PJURA ET AL., "Development of an in vivo method to identify mutants of phage T4 lysozyme of enhanced thermostability", PROTEIN SCIENCE, CAMBRIDGE UNIV. PRESS, ENGL., vol. 2, no. 12, pages 2217 - 2225, XP000672766 [DX] 25,31-33 * page 2218, column R, line 15 - page 2219, column R, line 3 * [Y] 1-24 | [X] - R. CATTANEO ET AL., "Biased hypermutation and other genetic changes in defective measles viruses in human brain infections", CELL, CELL PRESS,CAMBRIDGE,MA,US;, (19881021), vol. 55, no. 2, doi:doi:10.1016/0092-8674(88)90048-7, pages 255 - 1265, XP027462086 [X] 32 * page 255, column R, line 49 - page 262, column L, line 45 * DOI: http://dx.doi.org/10.1016/0092-8674(88)90048-7 | [Y] - S. KWOK ET AL., "Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies", NUCLEIC ACIDS RESEARCH, IRL PRESS LIMITED,OXFORD,ENGLAND, (19900225), vol. 18, no. 4, pages 999 - 1005 [Y] 1-24 * page 1001, column R, line 12 - page 1005, column L, line 34 * | [Y] - R. SOMMER AND D. TAUTZ, "Minimal homology requirements for PCR primers", NUCLEIC ACIDS RESEARCH, IRL PRESS LIMITED,OXFORD,ENGLAND, (19890825), vol. 17, no. 16, page 6749 [Y] 1-24 * page 6749, line 1 - line 24; table I * | [Y] - G.F. JOYCE, "Amplfication, mutation and selection of catalytic RNA", GENE, ELSEVIER SCIENCE PUBLISHERS,B.V.,AMSTERDAM,NL;, (19891015), vol. 82, no. 1, pages 83 - 87 [Y] 1-24 * the whole document;; figure 2 * | [DA] - J.-P. VARTANIAN ET AL., "Selection, recombination, and G to A hypermutation of human immunodeficiency virus type 1 geneomes", J. VIROLOGY, AM.SOC.MICROBIOL.,WASHINGTON,US, vol. 65, no. 4, pages 1779 - 1788, XP000672765 [DA] 1-33 * the whole document * | [T] - MARTINEZ, MIGUEL ANGEL ET AL, "Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations", PROC. NATL. ACAD. SCI. U. S. A. (1994), 91(25), 11787-91 CODEN: PNASA6;ISSN: 0027-8424 [T] 1-33 * the whole document * |